| 1. |
- Ambrozova, I., et al.
(författare)
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Microdosimetry for a carbon ion beam using track-etched detectors
- 2015
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 166:1-4, s. 247-252
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Tidskriftsartikel (refereegranskat)abstract
- Track-etched detectors (TED) have been used as linear energy transfer (LET) spectrometers in heavy ion beams for many years. LET spectra and depth-dose distribution of a carbon ion beam were measured behind polymethylmethacrylate degraders at Heavy Ion Medical Accelerator in Chiba, Japan. The measurements were performed along monoenergetic beam with energy 290 MeV u-1 in different positions: (1) at beam extraction area, (2) at beginning, (3) maximum and (4) behind the Bragg peak region (0, 117, 147 and 151 mm of water-equivalent depth, respectively). The LET spectra inside and outside of the primary ion beam have been evaluated. TED record only heavy charged particles with LET above 8-10 keV μm-1, while electrons and ions with lower LET are not detected. The Geant4 simulation toolkit version 4.9.6.P01 has been used to estimate the contribution of non-detected particles to absorbed dose. Presented results demonstrate the applicability of TED for microdosimetry measurements in therapeutic carbon ion beams.
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| 2. |
- Osinga, J. M., et al.
(författare)
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Single track coincidence measurements of fluorescent and plastic nuclear track detectors in therapeutic carbon beams
- 2014
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Ingår i: Journal of Instrumentation. - : IOP Publishing. - 1748-0221. ; 9:4
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we present a method for single track coincidence measurements using two different track detector materials. We employed plastic and fluorescent nuclear track detectors (PNTDs and FNTDs) in the entrance channel of a monoenergetic carbon ion beam covering the therapeutic energy range from 80 to 425 MeV/u. About 99% of all primary particle tracks detected by both detectors were successfully matched, while 1% of the particles were only detected by the FNTDs because of their superior spatial resolution. We conclude that both PNTDs and FNTDs are suitable for clinical carbon beam dosimetry with a detection efficiency of at least 98.82% and 99.83% respectively, if irradiations are performed with low fluence in the entrance channel of the ion beam. The investigated method can be adapted to other nuclear track detectors and offers the possibility to characterize new track detector materials against well-known detectors. Further, by combining two detectors with a restricted working range in the presented way a hybrid-detector system can be created with an extended and optimized working range.
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| 3. |
- Pachnerova Brabcová, Katerina, 1978, et al.
(författare)
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Clustered DNA damage on subcellular level: effect of scavengers
- 2014
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Ingår i: Radiation and Environmental Biophysics. - : Springer Science and Business Media LLC. - 1432-2099 .- 0301-634X. ; 53:4, s. 705-712
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Tidskriftsartikel (refereegranskat)abstract
- Clustered DNA damages are induced by ionizing radiation, particularly of high linear energy transfer (LET). Compared to isolated DNA damage sites, their biological effects can be more severe. We investigated a clustered DNA damage induced by high LET radiation (C 290 MeV u(-1) and Fe 500 MeV u(-1)) in pBR322 plasmid DNA. The plasmid is dissolved in pure water or in aqueous solution of one of the three scavengers (coumarin-3-carboxylic acid, dimethylsulfoxide, and glycylglycine). The yield of double strand breaks (DSB) induced in the DNA plasmid-scavenger system by heavy ion radiation was found to decrease with increasing scavenging capacity due to reaction with hydroxyl radical, linearly with high correlation coefficients. The yield of non-DSB clusters was found to occur twice as much as the DSB. Their decrease with increasing scavenging capacity had lower linear correlation coefficients. This indicates that the yield of non-DSB clusters depends on more factors, which are likely connected to the chemical properties of individual scavengers.
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| 4. |
- Pachnerova Brabcová, Katerina, 1978, et al.
(författare)
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CONTRIBUTION OF INDIRECT EFFECTS TO CLUSTERED DAMAGE IN DNA IRRADIATED WITH PROTONS
- 2015
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 166:1-4, s. 44-48
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Tidskriftsartikel (refereegranskat)abstract
- Protons are the dominant particles both in galactic cosmic rays and in solar particle events and, furthermore, proton irradiation becomes increasingly used in tumour treatment. It is believed that complex DNA damage is the determining factor for the consequent cellular response to radiation. DNA plasmid pBR322 was irradiated at U120-M cyclotron with 30 MeV protons and treated with two Escherichia coli base excision repair enzymes. The yields of SSBs and DSBs were analysed using agarose gel electrophoresis. DNA has been irradiated in the presence of hydroxyl radical scavenger (coumarin-3-carboxylic acid) in order to distinguish between direct and indirect damage of the biological target. Pure scavenger solution was used as a probe for measurement of induced OH center dot radical yields. Experimental OH center dot radical yield kinetics was compared with predictions computed by two theoretical models-RADAMOL and Geant4-DNA. Both approaches use Geant4-DNA for description of physical stages of radiation action, and then each of them applies a distinct model for description of the pre-chemical and chemical stage.
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| 5. |
- Pachnerova Brabcová, Katerina, 1978, et al.
(författare)
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Dose Distribution Outside the Target Volume for 170-Mev Proton Beam
- 2014
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 161:1-4, s. 410-416
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Tidskriftsartikel (refereegranskat)abstract
- Dose delivered outside the proton field during radiotherapy can potentially lead to secondary cancer development. Measurements with a 170-MeV proton beam were performed with passive detectors (track etched detectors and thermoluminescence dose-meters) in three different depths along the Bragg curve. The measurement showed an uneven decrease of the dose outside of the beam field with local enhancements. The major contribution to the delivered dose is due to high-energy protons with linear energy transfer (LET) up to 10 keV mu m(-1). However, both measurement and preliminary Monte Carlo calculation also confirmed the presence of particles with higher LET.
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| 6. |
- Pachnerova Brabcová, Katerina, 1978, et al.
(författare)
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Uncertainties in linear energy transfer spectra measured with track-etched detectors in space
- 2013
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576. ; 713, s. 5-10
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Tidskriftsartikel (refereegranskat)abstract
- Polyallyldiglycol carbonate-based track-etched detectors can measure linear energy transfer (LET) spectra of charged particles. Accuracy of the spectra is affected by many factors whose effects are difficult to quantify. Typically, only uncertainty arising from the randomness of particle detection is reported in scientific literature. The aim of this paper is to classify the sources of uncertainties of an LET spectrum measurement and provide a simple model for the calculation of the combined uncertainty. The model was used for a spectrum measured with the track-etched detector (Harzlas TD-1) on board of the International Space Station from May-October 2009. For some spectrum bins the largest contribution to the combined uncertainty came from the uncertainty arising from the randomness of particle detection. For other bins it came from the uncertainty of the calibration curve. Contribution from the cross talk between bins was small for most of the bins as the width of the bins was relatively large compared to the intrinsic resolution of the track-etched detector. The analysis showed that sources of uncertainties other than the randomness of particle detection should not, in general, be neglected.
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