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- Sandgren, M., Gualfetti, P.J., Paech, C., Paech, S., Shaw, A., Gross, L.S., Saldajeno, M., Berglund, G.I., Jones, T.A. & Mitchinson, C.
(författare)
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The Humicloa grisea Cel12A enzyme structure at 1.2 Å resolution and the impact of its free cysteine residues on thermal stability
- 2003
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Ingår i: Protein Science. ; 12, s. 2782-2793
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Zhou, Jinyuan, et al.
(författare)
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Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T : Application to brain tumors
- 2022
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Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 1522-2594 .- 0740-3194. ; 88:2, s. 546-574
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Tidskriftsartikel (refereegranskat)abstract
- Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3 T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi-center trials in larger patient cohorts and, ultimately, routine clinical use.
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| 3. |
- Amanullah, R., et al.
(författare)
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A HIGHLY MAGNIFIED SUPERNOVA AT z=1.703 BEHIND THE MASSIVE GALAXY CLUSTER A1689
- 2011
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Ingår i: ASTROPHYS J LETT. - 2041-8205. ; 742:1, s. L7-
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Tidskriftsartikel (refereegranskat)abstract
- Our ability to study the most remote supernova explosions, crucial for the understanding of the evolution of the high-redshift universe and its expansion rate, is limited by the light collection capabilities of telescopes. However, nature offers unique opportunities to look beyond the range within reach of our unaided instruments thanks to the light-focusing power of massive galaxy clusters. Here we report on the discovery of one of the most distant supernovae ever found, at redshift z = 1.703. Due to a lensing magnification factor of 4.3 +/- 0.3, we are able to measure a light curve of the supernova, as well as spectroscopic features of the host galaxy with a precision comparable to what would otherwise only be possible with future generation telescopes.
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| 4. |
- Petrushevska, Tanja, et al.
(författare)
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High-redshift supernova rates measured with the gravitational telescope A 1689
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 594
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We present a ground-based, near-infrared search for lensed supernovae behind the massive cluster Abell 1689 at z = 0.18, which is one of the most powerful gravitational telescopes that nature provides. Methods. Our survey was based on multi-epoch J-band observations with the HAWK-I instrument on VLT, with supporting optical data from the Nordic Optical Telescope. Results. Our search resulted in the discovery of five photometrically classified, core-collapse supernovae with high redshifts of 0.671 < z < 1.703 and magnifications in the range Delta m = -0.31 to -1.58 mag, as calculated from lensing models in the literature. Owing to the power of the lensing cluster, the survey had the sensitivity to detect supernovae up to very high redshifts, z similar to 3, albeit for a limited region of space. We present a study of the core-collapse supernova rates for 0.4 < z < 2.9, and find good agreement with previous estimates and predictions from star formation history. During our survey, we also discovered two Type Ia supernovae in A 1689 cluster members, which allowed us to determine the cluster Ia rate to be 0.14(-0.09)(+0.19) SNuB h(2) (SNuB 10(-12) SNe L-circle dot,B(-1) yr(-1)), where the error bars indicate 1 sigma confidence intervals, statistical and systematic, respectively. The cluster rate normalized by the stellar mass is 0.10(-0.06)(+0.13) +/- 0.02 in SNuM h(2) (SNuM = 10(-12) SNe M-1 yr(-1)). Furthermore, we explore the optimal future survey for improving the core-collapse supernova rate measurements at z greater than or similar to 2 using gravitational telescopes, and for detections with multiply lensed images, and we find that the planned WFIRST space mission has excellent prospects. Conclusions. Massive clusters can be used as gravitational telescopes to significantly expand the survey range of supernova searches, with important implications for the study of the high-z transient Universe.
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| 5. |
- Petrushevska, Tanja, et al.
(författare)
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Searching for supernovae in the multiply-imaged galaxies behind the gravitational telescope A370
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 614
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Strong lensing by massive galaxy clusters can provide magnification of the flux and even multiple images of the galaxies that he behind them. This phenomenon facilitates observations of high-redshift supernovae (SNe) that would otherwise remain undetected. Type la supernovae (SNe la) detections are of particular interest because of their standard brightness, since they can be used to improve either cluster lensing models or cosmological parameter measurements.Methods. We present a ground-based, near-infrared search for lensed SNe behind the galaxy cluster Abell 370. Our survey was based on 15 epochs of J-band observations with the HAWK-I instrument on the Very Large Telescope (VLT). We use Hubble Space Telescope (HST) photometry to infer the global properties of the multiply-imaged galaxies. Using a recently published lensing model of Abell 370, we also present the predicted magnifications and time delays between the images.Results. In our survey, we did not discover any live SNe from the 13 lensed galaxies with 47 multiple images behind Abell 370. This is consistent with the expectation of 0.09 +/- 0.02 SNe calculated based on the measured star formation rate. We compare the expectations of discovering strongly lensed SNe in our survey and that performed with HST during the Hubble Frontier Fields (HFF) programme. We also show the expectations of search campaigns that can be conducted with future facilities, such as the James Webb Space Telescope (JWST) or the Wide-Field Infrared Survey Telescope (WFIRST). We show that the NIRCam instrument aboard the JWST will be sensitive to most SN multiple images in the strongly lensed galaxies and thus will be able to measure their time delays if observations are scheduled accordingly.
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| 7. |
- Rixen, M., et al.
(författare)
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First Real-Life Data on the Diving Response in Healthy Children
- 2024
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Ingår i: Pediatric Cardiology. - : Springer Nature. - 0172-0643 .- 1432-1971. ; 45:2, s. 314-322
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Tidskriftsartikel (refereegranskat)abstract
- Swimming and diving are popular recreational activities, representing an effective option in maintaining and improving cardiovascular fitness in healthy people. To date, only little is known about the cardiovascular adaption to submersion in children. This study was conducted to improve an understanding thereof. We used a stepwise apnea protocol with apnea at rest, apnea with facial immersion, and at last apnea during whole body submersion. Continuous measurement of heart rate, oxygen saturation, and peripheral resistance index was done. Physiologic data and analysis of influencing factors on heart rate, oxygen saturation, and peripheral vascular tone response are reported. The current study presents the first data of physiologic diving response in children. Data showed that facial or whole body submersion leads to a major drop in heart rate, and increase of peripheral resistance, while the oxygen saturation seems to be unaffected by static apnea in most children, with apnea times of up to 75 s without change in oxygen saturation.
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