| 1. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 2. |
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| 3. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 4. |
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| 5. |
- Ariyawansa, Hiran A., et al.
(författare)
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Fungal diversity notes 111–252—taxonomic and phylogenetic contributions to fungal taxa
- 2015
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Ingår i: Fungal diversity. - : Springer Science and Business Media LLC. - 1560-2745 .- 1878-9129. ; 75, s. 27-274
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Tidskriftsartikel (refereegranskat)abstract
- This paper is a compilation of notes on 142 fungal taxa, including five new families, 20 new genera, and 100 new species, representing a wide taxonomic and geographic range. The new families, Ascocylindricaceae, Caryosporaceae and Wicklowiaceae (Ascomycota) are introduced based on their distinct lineages and unique morphology. The new Dothideomycete genera Pseudomassariosphaeria (Amniculicolaceae), Heracleicola, Neodidymella and P s e u d o m i c ros p h a e r i o p s i s ( D id y m e l l a c e a e ) , P s e u d o p i t h o m y c e s ( D i d y m o s p h a e r i a c e a e ) , Brunneoclavispora, Neolophiostoma and Sulcosporium (Halotthiaceae), Lophiohelichrysum (Lophiostomataceae), G a l l i i c o l a , Popul o c re s c e n t i a a nd Va g i c o l a (Phaeosphaeriaceae), Ascocylindrica (Ascocylindricaceae), E l o n g a t o p e d i c e l l a t a ( R o u s s o e l l a c e a e ) , Pseudoasteromassaria (Latoruaceae) and Pseudomonodictys (Macrodiplodiopsidaceae) are introduced. The newly described species of Dothideomycetes (Ascomycota) are Pseudomassariosphaeria bromicola (Amniculicolaceae), Flammeascoma lignicola (Anteagloniaceae), Ascocylindrica marina (Ascocylindricaceae) , Lembosia xyliae (Asterinaceae), Diplodia crataegicola and Diplodia galiicola ( B o t r yosphae r i a cea e ) , Caryospor a aquat i c a (Caryosporaceae), Heracleicola premilcurensis and Neodi dymell a thai landi cum (Didymellaceae) , Pseudopithomyces palmicola (Didymosphaeriaceae), Floricola viticola (Floricolaceae), Brunneoclavispora bambusae, Neolophiostoma pigmentatum and Sulcosporium thailandica (Halotthiaceae), Pseudoasteromassaria fagi (Latoruaceae), Keissleriella dactylidicola (Lentitheciaceae), Lophiohelichrysum helichrysi (Lophiostomataceae), Aquasubmersa japonica (Lophiotremataceae) , Pseudomonodictys tectonae (Macrodiplodiopsidaceae), Microthyrium buxicola and Tumidispora shoreae (Microthyriaceae), Alloleptosphaeria clematidis, Allophaeosphaer i a c y t i s i , Allophaeosphae r i a subcylindrospora, Dematiopleospora luzulae, Entodesmium artemisiae, Galiicola pseudophaeosphaeria, Loratospora(Basidiomycota) are introduced together with a new genus Neoantrodiella (Neoantrodiellaceae), here based on both morphology coupled with molecular data. In the class Agaricomycetes, Agaricus pseudolangei, Agaricus haematinus, Agaricus atrodiscus and Agaricus exilissimus (Agaricaceae) , Amanita m e l l e i a l b a , Amanita pseudosychnopyramis and Amanita subparvipantherina (Amanitaceae), Entoloma calabrum, Cora barbulata, Dictyonema gomezianum and Inocybe granulosa (Inocybaceae), Xerocomellus sarnarii (Boletaceae), Cantharellus eucalyptorum, Cantharellus nigrescens, Cantharellus tricolor and Cantharellus variabilicolor (Cantharellaceae), Cortinarius alboamarescens, Cortinarius brunneoalbus, Cortinarius ochroamarus, Cortinarius putorius and Cortinarius seidlii (Cortinariaceae), Hymenochaete micropora and Hymenochaete subporioides (Hymenochaetaceae), Xylodon ramicida (Schizoporaceae), Colospora andalasii (Polyporaceae), Russula guangxiensis and Russula hakkae (Russulaceae), Tremella dirinariae, Tremella graphidis and Tremella pyrenulae (Tremellaceae) are introduced. Four new combinations Neoantrodiella gypsea, Neoantrodiella thujae (Neoantrodiellaceae), Punctulariopsis cremeoalbida, Punctulariopsis efibulata (Punctulariaceae) are also introduced here for the division Basidiomycota. Furthermore Absidia caatinguensis, Absidia koreana and Gongronella koreana (Cunninghamellaceae), Mortierella pisiformis and Mortierella formosana (Mortierellaceae) are newly introduced in the Zygomycota, while Neocallimastix cameroonii and Piromyces irregularis (Neocallimastigaceae) ar e i n t roduced i n the Neocallimastigomycota. Reference specimens or changes in classification and notes are provided for Alternaria ethzedia, Cucurbitaria ephedricola, Austropleospora, Austropleospora archidendri, Byssosphaeria rhodomphala, Lophiostoma caulium, Pseudopithomyces maydicus, Massariosphaeria, Neomassariosphaeria and Pestalotiopsis montellica.
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| 6. |
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| 7. |
- Luo, Yifei, et al.
(författare)
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Technology Roadmap for Flexible Sensors
- 2023
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Ingår i: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 17:6, s. 5211-5295
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Forskningsöversikt (refereegranskat)abstract
- Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.
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| 8. |
- Darwich, Adam S., et al.
(författare)
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IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3 : Identifying gaps in system parameters by analysing In Silico performance across different compound classes
- 2017
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Ingår i: European Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0928-0987 .- 1879-0720. ; 96, s. 626-642
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Tidskriftsartikel (refereegranskat)abstract
- Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp (R) Simulator, and GastroPlus (TM)) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded "bottom-up" anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (F-oral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information. Foralwas also underpredicted for acidic compounds, suggesting overestimation of impact of ionisation on permeation, lack of information on intestinal transporters, or underestimation of solubilisation of weak acids due to less than optimal intestinal model pH settings or underestimation of bile micelle contribution. F-oral was overpredicted for weak bases, suggesting inadequate models for precipitation or lack of in vitro precipitation information to build informed models. Relative bioavailability was underpredicted for both high logP compounds as well as poorly water-soluble compounds, suggesting inadequate models for solubility/dissolution, underperforming bile enhancement models and/or lack of biorelevant solubility measurements. These results indicate areas for improvement in model software, modelling approaches, and generation of applicable input data. However, caution is required when interpreting the impact of drug-specific properties in this exercise, as the availability of input parameters was heterogeneous and highly variable, and the modellers generally used the data "as is" in this blinded bottom-up prediction approach.
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| 9. |
- Dely, H., et al.
(författare)
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High bitrate data transmission in the 8-14 µm atmospheric window using an external Stark-effect modulator with digital equalization
- 2023
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Ingår i: Optics Express. - : Optica Publishing Group (formerly OSA). - 1094-4087. ; 31:5, s. 7259-7264
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Tidskriftsartikel (refereegranskat)abstract
- High bitrate mid-infrared links using simple (NRZ) and multi-level (PAM-4) data coding schemes have been realized in the 8 µm to 14 µm atmospheric transparency window. The free space optics system is composed of unipolar quantum optoelectronic devices, namely a continuous wave quantum cascade laser, an external Stark-effect modulator and a quantum cascade detector, all operating at room-temperature. Pre- and post-processing are implemented to get enhanced bitrates, especially for PAM-4 where inter-symbol interference and noise are particularly detrimental to symbol demodulation. By exploiting these equalization procedures, our system, with a full frequency cutoff of 2 GHz, has reached transmission bitrates of 12 Gbit/s NRZ and 11 Gbit/s PAM-4 fulfilling the 6.25 % overhead hard-decision forward error correction threshold, limited only by the low signal-to-noise ratio of our detector.
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| 10. |
- Duan, Chunhui, et al.
(författare)
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Improving Performance of All-Polymer Solar Cells Through Backbone Engineering of Both Donors and Acceptors
- 2018
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Ingår i: Solar RRL. - : Wiley. - 2367-198X. ; 2:12
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Tidskriftsartikel (refereegranskat)abstract
- All-polymer solar cells (APSCs), composed of semiconducting donor and acceptor polymers, have attracted considerable attention due to their unique advantages compared to polymer-fullerene-based devices in terms of enhanced light absorption and morphological stability. To improve the performance of APSCs, the morphology of the active layer must be optimized. By employing a random copolymerization strategy to control the regularity of the backbone of the donor polymers (PTAZ-TPDx) and acceptor polymers (PNDI-Tx) the morphology can be systematically optimized by tuning the polymer packing and crystallinity. To minimize effects of molecular weight, both donor and acceptor polymers have number-average molecular weights in narrow ranges. Experimental and coarse-grained modeling results disclose that systematic backbone engineering greatly affects the polymer crystallinity and ultimately the phase separation and morphology of the all-polymer blends. Decreasing the backbone regularity of either the donor or the acceptor polymer reduces the local crystallinity of the individual phase in blend films, affording reduced short-circuit current densities and fill factors. This two-dimensional crystallinity optimization strategy locates a PCE maximum at highest crystallinity for both donor and acceptor polymers. Overall, this study demonstrates that proper control of both donor and acceptor polymer crystallinity simultaneously is essential to optimize APSC performance.
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| 11. |
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| 12. |
- Han, Mengyao, et al.
(författare)
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High Spectral Efficiency Long-wave Infrared Free-Space Optical Transmission with Multilevel Signals
- 2023
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Ingår i: Journal of Lightwave Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8724 .- 1558-2213. ; 41:20, s. 6514-
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Tidskriftsartikel (refereegranskat)abstract
- This study explores the potential of long-wave infrared free-space optical (FSO) transmission that leverages multilevel signals to attain high spectral efficiency. The FSO transmission system consists of a directly modulated-quantum cascade laser (DM-QCL) operating at 9.15 μm and a mercury cadmium telluride (MCT) detector. To fully understand the system, we conduct measurements on the DM-QCL chip and MCT detector and assess the overall amplitude response of the DM-QCL, MCT detector, and all electrical components. We apply various signals, including on-off keying (OOK), 4-level pulse amplitude modulation (PAM4), 6-level PAM (PAM6), and 8-level PAM (PAM8) to maximize the bit rate and spectral efficiency of the FSO transmission. Through a two-dimensional sweeping of the laser bias current and MCT detector photovoltage, we optimize the transmission performance. At the optimal operation point, the FSO system achieved impressive results which are up to 6 Gbaud OOK, 3.5 Gbaud PAM4, 3 Gbaud PAM6, and 2.7 Gbaud PAM8 signal transmissions, with a bit error rate performance below 6.25% overhead hard decision-forward error correction limit when the DM-QCL operates at 10 °C. We also evaluate the eye diagrams and stability of the system to showcase its remarkable transmission performance. Our findings suggest that the DMQCL and MCT detector-based FSO transceivers offer a highly competitive solution for the next generation of optical wireless communication systems
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| 13. |
- Han, Mengyao, et al.
(författare)
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High Spectral Efficiency Long-Wave Infrared Free-Space Optical Transmission With Multilevel Signals
- 2023
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Ingår i: Journal of Lightwave Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8724 .- 1558-2213. ; 41:20, s. 6514-6520
-
Tidskriftsartikel (refereegranskat)abstract
- This study explores the potential of long-wave infrared free-space optical (FSO) transmission that leverages multilevel signals to attain high spectral efficiency. The FSO transmission system consists of a directly modulated-quantum cascade laser (DM-QCL) operating at 9.15 mu m and a mercury cadmium telluride (MCT) detector. To fully understand the system, we conduct measurements on the DM-QCL chip and MCT detector and assess the overall amplitude response of the DM-QCL, MCT detector, and all electrical components. We apply various signals, including on-off keying (OOK), 4-level pulse amplitude modulation (PAM4), 6-level PAM (PAM6), and 8-level PAM (PAM8) to maximize the bit rate and spectral efficiency of the FSO transmission. Through a two-dimensional sweeping of the laser bias current and MCT detector photovoltage, we optimize the transmission performance. At the optimal operation point, the FSO system achieved impressive results which are up to 6 Gbaud OOK, 3.5 Gbaud PAM4, 3 Gbaud PAM6, and 2.7 Gbaud PAM8 signal transmissions, with a bit error rate performance below 6.25% overhead hard decision-forward error correction limit when the DM-QCL operates at 10 degrees C. We also evaluate the eye diagrams and stability of the system to showcase its remarkable transmission performance. Our findings suggest that the DM-QCL and MCT detector-based FSO transceivers offer a highly competitive solution for the next generation of optical wireless communication systems.
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| 14. |
- Han, Mengyao, et al.
(författare)
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Long-Wave Infrared Discrete Multitone Free-Space Transmission Using a 9.15-μm Quantum Cascade Laser
- 2023
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Ingår i: IEEE Photonics Technology Letters. - : Institute of Electrical and Electronics Engineers Inc.. - 1041-1135 .- 1941-0174. ; 35:9, s. 489-492
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Tidskriftsartikel (refereegranskat)abstract
- A free-space optical (FSO) transmission system is experimentally demonstrated in the long-wave infrared (LWIR, 9.15μ m ) using a directly modulated quantum cascade laser (DM-QCL) and a commercial mercury-cadmium-telluride infrared photovoltaic detector. At room temperature, the DM-QCL is current-modulated by discrete multitone signals pre-processed with bit-/power-loading. Up to 5.1 Gbit/s data rate is achieved with bit error rate performance below the 6.25% overhead hard-decision forward error correction limit of 4.5× 10-3 , enabled by a frequency domain equalizer. The stability study of the FSO system is also performed at multiple temperature values. This study can provide a valuable reference for future terrestrial and space communications.
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| 15. |
- Henriksson, Mats, et al.
(författare)
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On Transmission Error, Shuttling Forces and Friction Forces as Gear Noise Excitation
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Ingår i: International Journal of Acoustics and Vibration. - 1027-5851 .- 2415-1408.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Traditionally, transmission error (TE) has been used to asses the noise propertiesof gears. Measurements of gear noise for a complete truck gearbox have been used tocorrelate noise from a gear pair with calculated static transmission error, shuttling forceand friction forces. Two gear pairs with very similar macro geometry but differentmicro geometry was used. The measurement results show that there is a limitationif transmission error is considered as the only excitation mechanism when designingquiet gears. Often TE is multiplied with the gear mesh stiffness in order to calculatean excitation force. For gear not operating above the critical gear mesh resonance,this often overestimates the importance of TE, thus underestimating the importance ofother sources such as shuttling and friction forces.
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| 16. |
- Henriksson, Mats, et al.
(författare)
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Transmission error as gear noise excitation
- 2010
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Ingår i: DETC2009. - NEW YORK : AMER SOC MECHANICAL ENGINEERS. ; , s. 197-203
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Konferensbidrag (refereegranskat)abstract
- Traditionally, transmission error (TE) has been used in order to asses the noise properties of gears. Measurements of gear noise for a complete truck gearbox have been used to correlate noise from a gear parr with the concept of calculated static transmission error as noise excitation. Two gear pairs with very similar macro geometry but different micro geometry was used. Both transmission error as excitation and the excitation proposed by P Velex and M. Ajmi which is the difference between the loaded and unloaded transmission error; are compared with measured noise. The result shows that the difference between the loaded and unloaded TE correlates well with measure noise for gear pair A but no excitation correlates with the measurement result gear pair B. A big difference between gear pair A and B can be seen in the contact pattern. The contact pattern of gear pair B shows that despite a large tip relief edge contact occurs where the tip relief starts. This can be one explanation to the lack of correlation between TE and the measurement result for gear pair B. Another explanation can be other excitations such as friction and bending moments. The results show the limitations of only considering transmission error when designing quiet gears.
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| 17. |
- Hyde, K. D., et al.
(författare)
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Global consortium for the classification of fungi and fungus-like taxa
- 2023
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Ingår i: MYCOSPHERE. - : Mushroom Research Foundation. - 2077-7000 .- 2077-7019. ; 14:1, s. 1960-2012
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Tidskriftsartikel (refereegranskat)abstract
- The Global Consortium for the Classification of Fungi and fungus-like taxa is an international initiative of more than 550 mycologists to develop an electronic structure for the classification of these organisms. The members of the Consortium originate from 55 countries/regions worldwide, from a wide range of disciplines, and include senior, mid-career and early-career mycologists and plant pathologists. The Consortium will publish a biannual update of the Outline of Fungi and fungus-like taxa, to act as an international scheme for other scientists. Notes on all newly published taxa at or above the level of species will be prepared and published online on the Outline of Fungi website (https://www.outlineoffungi.org/), and these will be finally published in the biannual edition of the Outline of Fungi and fungus-like taxa. Comments on recent important taxonomic opinions on controversial topics will be included in the biannual outline. For example, 'to promote a more stable taxonomy in Fusarium given the divergences over its generic delimitation', or 'are there too many genera in the Boletales?' and even more importantly, 'what should be done with the tremendously diverse 'dark fungal taxa?' There are undeniable differences in mycologists' perceptions and opinions regarding species classification as well as the establishment of new species. Given the pluralistic nature of fungal taxonomy and its implications for species concepts and the nature of species, this consortium aims to provide a platform to better refine and stabilise fungal classification, taking into consideration views from different parties. In the future, a confidential voting system will be set up to gauge the opinions of all mycologists in the Consortium on important topics. The results of such surveys will be presented to the International Commission on the Taxonomy of Fungi (ICTF) and the Nomenclature Committee for Fungi (NCF) with opinions and percentages of votes for and against. Criticisms based on scientific evidence with regards to nomenclature, classifications, and taxonomic concepts will be welcomed, and any recommendations on specific taxonomic issues will also be encouraged; however, we will encourage professionally and ethically responsible criticisms of others' work. This biannual ongoing project will provide an outlet for advances in various topics of fungal classification, nomenclature, and taxonomic concepts and lead to a community-agreed classification scheme for the fungi and fungus-like taxa. Interested parties should contact the lead author if they would like to be involved in future outlines.
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| 18. |
- Joharifar, Mahdieh, et al.
(författare)
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16.9 Gb/s Single-Channel LWIR FSO Data Transmission with Directly Modulated QCL and MCT Detector
- 2024
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Ingår i: 2024 Optical Fiber Communications Conference and Exhibition, OFC 2024 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc..
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Konferensbidrag (refereegranskat)abstract
- We experimentally demonstrate a room-temperature LWIR FSO link with a 9.1-μm directly modulated QCL and an MCT detector. Net bitrate of up to 16.9 Gb/s is achieved at both 15°C and 20°C over a 1-meter distance.
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| 19. |
- Joharifar, Mahdieh, et al.
(författare)
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16.9 Gb/s Single-Channel LWIR FSO Data Transmission with Directly Modulated QCL and MCT Detector
- 2024
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Ingår i: <em>2024 Optical Fiber Communications Conference and Exhibition, OFC 2024 - Proceedings</em>. - : Institute of Electrical and Electronics Engineers Inc.. - 9781957171326
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Konferensbidrag (refereegranskat)abstract
- We experimentally demonstrate a room-temperature LWIR FSO link with a 9.1-μm directly modulated QCL and an MCT detector. Net bitrate of up to 16.9 Gb/s is achieved at both 15°C and 20°C over a 1-meter distance.
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| 20. |
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| 21. |
- Joharifar, Mahdieh, et al.
(författare)
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High-Speed 9.6-μm Long-Wave Infrared Free- Space Transmission with a Directly-Modulated QCL and a Fully-Passive QCD
- 2023
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Ingår i: Journal of Lightwave Technology. - : Institute of Electrical and Electronics Engineers Inc.. - 0733-8724 .- 1558-2213. ; 41:4, s. 1087-
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Tidskriftsartikel (refereegranskat)abstract
- Free-space optics (FSO) in the mid-infrared (mid- IR) contains rich spectral resources for future ultrahigh-speed wireless communications yet is currently under-exploited. Two atmospheric transmission windows at the mid-IR, namely, the mid-wave IR (MWIR, 3-5 µm) and the long-wave IR (LWIR, 8-12 µm), show great potential in supporting free-space communications for both terrestrial and space application scenarios. Particularly, the LWIR signal with a longer wavelength has high intrinsic robustness against aerosols' scattering and turbulence-induced scintillation and beam broadening effects, which are the main concerns hindering the wide deployment of practical FSO systems. In this context, high-bandwidth semiconductor-based mid-IR FSO transceivers will be desirable to meet the requirements of low energy consumption and small footprints for large-volume development and deployment. Quantum cascade devices, including quantum cascade lasers (QCLs) and quantum cascade detectors (QCDs), appear promising candidates to fulfill this role. In this work, we report a high-speed LWIR FSO transmission demonstration with a 9.6-µm directly-modulated (DM)-QCL and a fully passive QCD without any active cooling or bias voltage. Up to 8 Gb/s, 10 Gb/s, and 11 Gb/s signal transmissions are achieved when operating the DM- QCL at 10°C, 5°C, and 0°C, respectively. These results indicate a significant step towards an envisioned fully-connected mid-IR FSO solution empowered by the quantum cascade semiconductor devices.
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| 22. |
- Lozano, Rafael, et al.
(författare)
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Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - : Elsevier. - 1474-547X .- 0140-6736. ; 392:10159, s. 2091-2138
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Tidskriftsartikel (refereegranskat)abstract
- Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990–2017, projected indicators to 2030, and analysed global attainment. Methods: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0–100, with 0 as the 2·5th percentile and 100 as the 97·5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings: The global median health-related SDG index in 2017 was 59·4 (IQR 35·4–67·3), ranging from a low of 11·6 (95% uncertainty interval 9·6–14·0) to a high of 84·9 (83·1–86·7). SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attainment by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation: The GBD study offers a unique, robust platform for monitoring the health-related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health-related SDG indicators, NCDs, NCD-related risks, and violence-related indicators will require a concerted shift away from what might have driven past gains—curative interventions in the case of NCDs—towards multisectoral, prevention-oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the SDGs. What is clear is that our actions—or inaction—today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030.
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| 23. |
- Margolskee, Alison, et al.
(författare)
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IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2 : An introduction to the simulation exercise and overview of results
- 2017
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Ingår i: European Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0928-0987 .- 1879-0720. ; 96, s. 610-625
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Tidskriftsartikel (refereegranskat)abstract
- Orally administered drugs are subject to a number of barriers impacting bioavailability (F-oral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation development by providing quantitative predictions through a systems approach. The performance of three available PBPK software packages (GI-Sim, Simcyp (R), and GastroPlus (TM)) were evaluated by comparing simulated and observed pharmacokinetic (PK) parameters. Since the availability of input parameters was heterogeneous and highly variable, caution is required when interpreting the results of this exercise. Additionally, this prospective simulation exercise may not be representative of prospective modelling in industry, as API information was limited to sparse details. 43 active pharmaceutical ingredients (APIs) from the OrBiTo database were selected for the exercise. Over 4000 simulation output files were generated, representing over 2550 study arm-institution-software combinations and approximately 600 human clinical study arms simulated with overlap. 84% of the simulated study arms represented administration of immediate release formulations, 11% prolonged or delayed release, and 5% intravenous (i.v.). Higher percentages of i.v. predicted area under the curve (AUC) were within two-fold of observed (52.9%) compared to per oral (p.o.) (37.2%), however, F-oral and relative AUC (F-rel) between p.o. formulations and solutions were generally well predicted (64.7% and 75.0%). Predictive performance declined progressing from i.v. to solution and immediate release tablet, indicating the compounding error with each layer of complexity. Overall performance was comparable to previous large-scale evaluations. A general overprediction of AUC was observed with average fold error (AFE) of 1.56 over all simulations. AFE ranged from 0.0361 to 64.0 across the 43 APIs, with 25 showing overpredictions. Discrepancies between software packages were observed for a few APIs, the largest being 606, 171, and 81.7-fold differences in AFE between SimCYP and GI-Sim, however average performance was relatively consistent across the three software platforms.
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| 24. |
- Ong, Jiun Cai, et al.
(författare)
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Large eddy simulation of n-dodecane spray flame : Effects of injection pressure on spray combustion characteristics at low ambient temperature
- 2023
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Ingår i: Proceedings of the Combustion Institute. - : Elsevier BV. - 1540-7489. ; 39:2, s. 2631-2642
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Tidskriftsartikel (refereegranskat)abstract
- The present study uses large-eddy simulations (LES) to identify the underlying mechanism that governs the ignition and stabilization mechanisms of ECN Spray A flame for different injection pressures (Pinj) and ambient temperatures (Tam). Two Pinj of 50 MPa and 150 MPa, as well as two Tam of 750 K and 900 K are considered. The numerical model is validated against the experimental fuel penetration, radial mixture frac- tion distribution, ignition delay time, and lift-off length. The combustion characteristics of all four spray flames are well predicted, with a maximum relative difference of 15% to the measurements. At 900 K, hightemperature ignition (HTI) occurs in the fuel-rich mixture at the spray head of the high Pinj spray flame, but at the spray periphery of the low Pinj spray flame. This is due to the low Pinj case having fuel-richer mixture in the inner spray region. Nonetheless, the spray flames at both Pinj exhibit double-flame structure. At 750 K, HTI occurs at the fuel-rich and fuel-lean regions for spray flames with Pinj = 50 MPa and 150 MPa, respectively. Reducing the Pinj leads to a lower injection velocity, less turbulent fluctuation, slower mixing, and hence the occurrence of HTI at the fuel-rich mixtures. The spray flame in the low Pinj case at 750 K ex-hibits a triple-flame structure at the lift-off position, while the high Pinj case exhibits a lean premixed reaction zone. This difference is attributed to the distribution of fuel-rich mixtures. Despite differences in the flame structures, auto-ignition process plays a key role to stabilize the lift-off position for all four spray flames. The auto-ignition process is also found to be dependent on the cool-flame products upstream of the lift-off position. In particular for the low Tam cases, the heat transfer effect from the main flame to the fuel-rich regions is suggested to also contribute to the flame stabilization mechanisms.
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| 25. |
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| 26. |
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| 27. |
- Pang, Cheng, et al.
(författare)
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Distributed IEC 61499 material handling control based on time synchronization with IEEE 1588
- 2011
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Ingår i: ISPCS 2011. - Piscataway, NJ : IEEE Communications Society. - 9781612848921 ; , s. 126-131
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Konferensbidrag (refereegranskat)abstract
- This paper proposes a method of time-driven control with high-precision synchronous clocks in distributed control systems built following the IEC 61499 standard. It investigates the impact of applying time-driven control on performance of material handling systems. A time-driven control system for a multi-diverter conveyor line has been developed using IEC 61499 Function Blocks architecture with support of the IEEE 1588 Precision Time Protocol. Analytic performance model has been developed and comparisons between the time-driven and two other possible control designs have been conducted and elaborated in terms of costs, logic design, and system throughput
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| 28. |
- Pang, Cheng, et al.
(författare)
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Time-Complemented Event-Driven Architecture for Distributed Automation Systems
- 2015
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Ingår i: IEEE Transactions on Systems, Man & Cybernetics. Systems. - 2168-2216 .- 2168-2232. ; 45:8, s. 1165-1177
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Tidskriftsartikel (refereegranskat)abstract
- Time-driven and event-driven control models are two fundamental design paradigms applied in distributed control systems for synchronizing decentralized activities. This paper proposes a unified architecture for combining both approaches. The combination offers the best of both worlds’ properties, such as the expressiveness of event-driven programming and the determinism of time-driven logic. The foundations of this symbiosis are the IEC 61499 Function Block standard providing event-driven distributed control architecture and the IEEE 1588 Precision Time Protocol establishing the basis for highly-accurate time synchronization. The proposed time-complemented event-driven distributed control model aims at improving the modularity and flexibility of automation software with satisfactory control performance. The new control model has been compared with conventional centralized and distributed control approaches analytically and by simulation. The comparison results reveal that the proposed control model is efficient and flexible. Finally, a reference example has been used to demonstrate merits of the new approach.
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| 29. |
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| 30. |
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| 31. |
- Pang, Xiaodan, Dr., et al.
(författare)
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Bridging the Terahertz Gap: Photonics-assisted Free-Space Communications from the Submillimeter-Wave to the Mid-Infrared
- 2022
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Ingår i: Journal of Lightwave Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8724 .- 1558-2213. ; , s. 1-1
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Tidskriftsartikel (refereegranskat)abstract
- Since about one and half centuries ago, at the dawn of modern communications, the radio and the optics have been two separate electromagnetic spectrum regions to carry data. Differentiated by their generation/detection methods and propagation properties, the two paths have evolved almost independently until today. The optical technologies dominate the long-distance and high-speed terrestrial wireline communications through fiber-optic telecom systems, whereas the radio technologies have mainly dominated the short- to medium-range wireless scenarios. Now, these two separate counterparts are both facing a sign of saturation in their respective roadmap horizons, particularly in the segment of free-space communications. The optical technologies are extending into the mid-wave and long-wave infrared (MWIR and LWIR) regimes to achieve better propagation performance through the dynamic atmospheric channels. Radio technologies strive for higher frequencies like the millimeter-wave (MMW) and sub-terahertz (sub-THz) to gain broader bandwidth. The boundary between the two is becoming blurred and intercrossed. During the past few years, we witnessed technological breakthroughs in free-space transmission supporting very high data rates, many achieved with the assistance of photonics. This paper focuses on such photonics-assisted free-space communication technologies in both the lower and upper sides of the THz gap and provides a detailed review of recent research and development activities on some of the key enabling technologies. Our recent experimental demonstrations of high-speed free-space transmissions in both frequency regions are also presented as examples to show the system requirements for device characteristics and digital signal processing (DSP) performance.
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| 32. |
- Pang, Xiaodan, Dr., et al.
(författare)
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Direct Modulation and Free-Space Transmissions of up to 6 Gbps Multilevel Signals With a 4.65-μQuantum Cascade Laser at Room Temperature
- 2022
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Ingår i: Journal of Lightwave Technology. - : Institute of Electrical and Electronics Engineers Inc.. - 0733-8724 .- 1558-2213. ; 40:8, s. 2370-2377
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Tidskriftsartikel (refereegranskat)abstract
- A roadmap for future wireless communications is expected to exploit all transmission-suitable spectrum bands, from the microwave to the optical frequencies, to support orders of magnitude faster data transfer with much lower latency than the deployed solutions nowadays. The currently under-exploited mid-infrared (mid-IR) spectrum is an essential building block for such an envisioned all-spectra wireless communication paradigm. Free-space optical (FSO) communications in the mid-IR region have recently attracted great interest due to their intrinsic merits of low propagation loss and high tolerance of atmospheric perturbations. Future development of viable mid-IR FSO transceivers requires a semiconductor source to fulfill the high bandwidth, low energy consumption, and small footprint requirements. In this context, quantum cascade laser (QCL) appears as a promisingtechnological choice. In this work, we present an experimental demonstration of a mid-IR FSO link enabled by a 4.65-μm directly modulated (DM) QCL operating at room temperature. We achieve a transmission data rate of up to 6 Gbps over a 0.5-m link distance. This achievement is enabled by system-level characterization and optimization of transmitter and receiver power level and frequency response and assisted with advanced modulation and digital signal processing (DSP) techniques. This work pushes the QCL-based FSO technology one step closer to practical terrestrial applications, such as the fixed wireless access and the wireless mobile backhaul. Such a QCL-based solution offers a promising way towards the futuristic all-spectra wireless communication paradigm by potentially supporting the whole spectrum from the MIR to the terahertz (THz).
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| 33. |
- Pang, Xiaodan, Dr., et al.
(författare)
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Directly modulated quantum cascade laser and its application in free-space communications
- 2021
-
Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 9781510646377
-
Konferensbidrag (refereegranskat)abstract
- In this report, we summarize our recent achievements in free-space communications in the mid-infrared (MIR) region enabled by directly modulated quantum cascaded laser (QCL) at 4.65 μm (∼65 THz). We have experimentally demonstrated a multigigabit free-space transmission link in the lab environment with the QCL operating at room temperature. The QCL chip is mounted on a commercial QCL mount with a water-cooled Peltier element. Multilevel modulation formats at different baud rates are generated and combined with the laser driving current at a custom-made bias-Tee to drive and modulate the QCL. A commercial mercury cadmium telluride (MCT, HgCdTe) photovoltaic (PV) MIR detector with a built-in trans-impedance amplifier was used to receive the MIR free-space signal. With the receiver to be the bottleneck of the system bandwidth, the end-To-end 3-dB bandwidth was measured to be around 320 MHz, and the 6-dB bandwidth was around 450 MHz. We have successfully demonstrated up to 6 Gbps free space transmission with multilevel modulation formats, assisted with effective digital equalization techniques despite the limited bandwidth..
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| 34. |
- Pang, Xiaodan, Dr., et al.
(författare)
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Free Space Communication Enabled by Directly Modulated Quantum Cascade Laser
- 2024
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Ingår i: 2024 Optical Fiber Communications Conference and Exhibition, OFC 2024 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc..
-
Konferensbidrag (refereegranskat)abstract
- We summarize our recent experimental studies of free-space communications enabled by directly modulated quantum cascade lasers at both MWIR and LWIR regions. Different detector types with different characteristics are compared.
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| 35. |
- Pang, Xiaodan, Dr., et al.
(författare)
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Free-Space Transmissions in the Upper- and Lower-THz Bands Assisted with Photonics
- 2021
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Ingår i: 2021 European Conference on Optical Communication (ECOC). - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 1-4
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Konferensbidrag (refereegranskat)abstract
- We report our recent studies in photonics-assisted free-space transmissions in both the lower (0.3-0.5 THz) and upper- (~64.5 THz) terahertz bands. We adopt the hybrid electro-optical approach for the lower-THz signal transmission, whereas a directly modulated quantum cascade laser is used for the upper-THz band.
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| 36. |
- Pang, Xiaoying, et al.
(författare)
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The Present-day Mass Function of Star Clusters in the Solar Neighborhood
- 2024
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 966:2
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Tidskriftsartikel (refereegranskat)abstract
- This work analyzes the present-day mass function (PDMF) of 93 star clusters utilizing Gaia Data Release 3 data, with membership determined by the StarGo machine-learning algorithm. The impact of unresolved binary systems on mass estimation is rigorously assessed, adopting three mass ratio profiles for correction. The PDMF is characterized by the power-law index, α, derived through a robust maximum likelihood method that avoids biases associated with data binning. The value of α for stars between the completeness limited mass of Gaia (with a mean 0.3 M⊙ for our cluster samples) and 2 M⊙ exhibits stability for clusters younger than 200 Myr, decreasing for older clusters, particularly when considering stars within the half-mass radius. The PDMF of these star clusters is consistent with a dynamically evolved Kroupa initial mass function via the loss of low-mass stars. Cluster morphology shows a correlation with α, as α values exhibit a decreasing trend from filamentary to tidal-tail clusters, mirroring the sequence of increasing cluster age. The dependence of α on the total cluster mass is weak, with a subtle increase for higher-mass clusters, especially outside the half-mass radius. We do not observe a correlation between α and the mean metallicity of the clusters. Younger clusters have lower metallicity compared to their older counterparts, which indicates that the older clusters might have migrated to the solar neighborhood from the inner disk. A comparison with numerical models incorporating a black hole population suggests the need for observations of distant, older, massive open clusters to determine whether or not they contain black holes.
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| 37. |
- Pang, Xiaodan, Dr., et al.
(författare)
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Up to 6 Gbps Mid-Infrared Free-Space Transmission with a Directly Modulated Quantum Cascade Laser
- 2021
-
Ingår i: 2021 European Conference on Optical Communication (ECOC). - : Institute of Electrical and Electronics Engineers (IEEE).
-
Konferensbidrag (refereegranskat)abstract
- We report on an experimental demonstration of a mid-infrared free-space communication link enabled by a directly modulated quantum cascade laser operating at room temperature. A record high transmission rate up to 6 Gbps over 50-cm link distance is demonstrated at 4.65 µm wavelength.
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| 38. |
- Patil, Sandeep, et al.
(författare)
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On composition of mechatronic components enabled by interoperability and portability provisions of IEC 61499: A case study
- 2013
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Ingår i: Proceedings of 2013 IEEE 18th International Conference on Emerging Technologies & Factory Automation (ETFA 2013). - Piscataway, NJ : IEEE Communications Society. - 9781479908622 ; , s. 4-
-
Konferensbidrag (refereegranskat)abstract
- Interoperability is one of the most important features expected from distributed automation architectures. Achieving interoperability involves addressing issues related to synchronization of behavior, communication protocols, and data presentation formats. In this paper a case study on deployment of an automation application to a network of control devices with three different hardware/software platforms is presented to exploit benefits of the IEC 61499 architecture. Firstly, an overall control application with essentially distributed logic was created. This control application was then validated using closed-loop simulation and finally deployed to a network of control devices
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| 39. |
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| 40. |
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| 41. |
- Puerta, Rafael, et al.
(författare)
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Coherent Joint Transmission with 1024-QAM for 6G Distributed-MIMO Networks with Analog Radio-over-LWIR FSO Fronthaul Links
- 2023
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Ingår i: 2023 Asia Communications and Photonics Conference/2023 International Photonics and Optoelectronics Meetings, ACP/POEM 2023. - : Institute of Electrical and Electronics Engineers (IEEE).
-
Konferensbidrag (refereegranskat)abstract
- Distributed-MIMO (D-MIMO) is a prospective solution for next-generation mobile networks to increase capacity and coverage. We experimentally validate 1024-QAM coherent joint transmissions in a two transmitter D-MIMO network including radio-over-LWIR FSO fronthaul links facilitating deployment and achieving diversity and power gains close to theoretical values.
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| 42. |
- Puerta, Rafael, et al.
(författare)
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NR Conformance Testing of Analog Radio-over-LWIR FSO Fronthaul link for 6G Distributed MIMO Networks
- 2023
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Ingår i: Opt. Fiber Commun. Conf. Exhib., OFC - Proc.. - : Institute of Electrical and Electronics Engineers Inc..
-
Konferensbidrag (refereegranskat)abstract
- We experimentally test the compliance with 5G/NR 3GPP technical specifications of an analog radio-over-FSO link at 9 μm. The ACLR and EVM transmitter requirements are fulfilled validating the suitability of LWIR FSO for 6G fronthaul. © 2023 The Author(s).
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| 43. |
- Schunk, Stefan J., et al.
(författare)
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Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality
- 2021
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 42:18, s. 1742-1756
-
Tidskriftsartikel (refereegranskat)abstract
- AimsInflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality in humans are unknown.Methods and resultsWe explored the association of genetic NLRP3 variants with prevalent CVD and cardiovascular mortality in 538 167 subjects on the individual participant level in an explorative gene-centric approach without performing multiple testing. Functional relevance of single-nucleotide polymorphisms on NLRP3 inflammasome activation has been evaluated in monocyte-enriched peripheral blood mononuclear cells (PBMCs). Genetic analyses identified the highly prevalent (minor allele frequency 39.9%) intronic NLRP3 variant rs10754555 to affect NLRP3 gene expression. rs10754555 carriers showed significantly higher C-reactive protein and serum amyloid A plasma levels. Carriers of the G allele showed higher NLRP3 inflammasome activation in isolated human PBMCs. In carriers of the rs10754555 variant, the prevalence of coronary artery disease was significantly higher as compared to non-carriers with a significant interaction between rs10754555 and age. Importantly, rs10754555 carriers had significantly higher risk for cardiovascular mortality during follow-up. Inflammasome inducers (e.g. urate, triglycerides, apolipoprotein C3) modulated the association between rs10754555 and mortality.ConclusionThe NLRP3 intronic variant rs10754555 is associated with increased systemic inflammation, inflammasome activation, prevalent coronary artery disease, and mortality. This study provides evidence for a substantial role of genetically driven systemic inflammation in CVD and highlights the NLRP3 inflammasome as a therapeutic target.
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| 44. |
- Souza, João Paulo, et al.
(författare)
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Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health) : a cross-sectional study
- 2013
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 381:9879, s. 1747-1755
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: We report the main findings of the WHO Multicountry Survey on Maternal and Newborn Health (WHOMCS), which aimed to assess the burden of complications related to pregnancy, the coverage of key maternal health interventions, and use of the maternal severity index (MSI) in a global network of health facilities.METHODS: In our cross-sectional study, we included women attending health facilities in Africa, Asia, Latin America, and the Middle East that dealt with at least 1000 childbirths per year and had the capacity to provide caesarean section. We obtained data from analysis of hospital records for all women giving birth and all women who had a severe maternal outcome (SMO; ie, maternal death or maternal near miss). We regarded coverage of key maternal health interventions as the proportion of the target population who received an indicated intervention (eg, the proportion of women with eclampsia who received magnesium sulphate). We used areas under the receiver operator characteristic curves (AUROC) with 95% CI to externally validate a previously reported MSI as an indicator of severity. We assessed the overall performance of care (ie, the ability to produce a positive effect on health outcomes) through standardised mortality ratios.RESULTS: From May 1, 2010, to Dec 31, 2011, we included 314,623 women attending 357 health facilities in 29 countries (2538 had a maternal near miss and 486 maternal deaths occurred). The mean period of data collection in each health facility was 89 days (SD 21). 23,015 (7.3%) women had potentially life-threatening disorders and 3024 (1.0%) developed an SMO. 808 (26.7%) women with an SMO had post-partum haemorrhage and 784 (25.9%) had pre-eclampsia or eclampsia. Cardiovascular, respiratory, and coagulation dysfunctions were the most frequent organ dysfunctions in women who had an SMO. Reported mortality in countries with a high or very high maternal mortality ratio was two-to-three-times higher than that expected for the assessed severity despite a high coverage of essential interventions. The MSI had good accuracy for maternal death prediction in women with markers of organ dysfunction (AUROC 0.826 [95% CI 0.802-0.851]).INTERPRETATION: High coverage of essential interventions did not imply reduced maternal mortality in the health-care facilities we studied. If substantial reductions in maternal mortality are to be achieved, universal coverage of life-saving interventions need to be matched with comprehensive emergency care and overall improvements in the quality of maternal health care. The MSI could be used to assess the performance of health facilities providing care to women with complications related to pregnancy.
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| 45. |
- Stanaway, Jeffrey D., et al.
(författare)
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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
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Tidskriftsartikel (refereegranskat)abstract
- Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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| 46. |
- Strömberg, Axel, et al.
(författare)
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Semi-insulating InP:Fe growth by hydride vapor phase epitaxy for advanced buried heterostructure quantum cascade lasers
- 2023
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Ingår i: Novel In-Plane Semiconductor Lasers XXII. - : SPIE-Intl Soc Optical Eng.
-
Konferensbidrag (refereegranskat)abstract
- Buried heterostructure quantum cascade lasers (BH-QCLs) operating at high temperature in mid-infrared (MIR) to THz spectral range are desired for chemical sensing and free-space optical communication (FOC). In this work, Fe doped semi-insulating InP (SI-InP) regrowth is demonstrated in a hydride vapor phase epitaxy (HVPE) reactor for advanced MIR and THz BH-QCLs grown by MBE and MOCVD. SI-InP regrowth is implemented in THz QCL pillar arrays and narrow width and reverse-taper MIR BH-QCLs for efficient heat dissipation. By exploiting SI-InP regrowth, the parasitic capacitance in MIR distributed feedback BH-QCL can be suppressed, which is exploited for high speed FOC application.
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| 47. |
- Wei, Songrui, et al.
(författare)
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Recent Progress of Fluxgate Magnetic Sensors : Basic Research and Application
- 2021
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Ingår i: Sensors. - : MDPI. - 1424-8220. ; 21:4
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Forskningsöversikt (refereegranskat)abstract
- Fluxgate magnetic sensors are especially important in detecting weak magnetic fields. The mechanism of a fluxgate magnetic sensor is based on Faraday's law of electromagnetic induction. The structure of a fluxgate magnetic sensor mainly consists of excitation windings, core and sensing windings, similar to the structure of a transformer. To date, they have been applied to many fields such as geophysics and astro-observations, wearable electronic devices and non-destructive testing. In this review, we report the recent progress in both the basic research and applications of fluxgate magnetic sensors, especially in the past two years. Regarding the basic research, we focus on the progress in lowering the noise, better calibration methods and increasing the sensitivity. Concerning applications, we introduce recent work about fluxgate magnetometers on spacecraft, unmanned aerial vehicles, wearable electronic devices and defect detection in coiled tubing. Based on the above work, we hope that we can have a clearer prospect about the future research direction of fluxgate magnetic sensor.
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| 48. |
- Xu, Peng, et al.
(författare)
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Investigation of resistivity dependent microwave annealing on Si substrates
- 2015
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Konferensbidrag (refereegranskat)abstract
- Heating of silicon substrates featuring different resistivity values by microwave annealing is investigated. The absorption of microwave energy for silicon wafers is found to be consistent with ohmic conduction loss theory. The strongest absorption occurs when the resistivity was around 10 Ω·cm. As the carrier concentration and the conductivity of silicon increase with temperature, the absorption of microwave energy also varies during the annealing processes. Furthermore, it is found that the electric field density around the annealed silicon wafer is stronger for higher conductive silicon substrates at fixed microwave power.
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| 49. |
- Xu, Shuang Feng, et al.
(författare)
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Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice
- 2019
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Ingår i: Redox Biology. - : Elsevier BV. - 2213-2317. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- Brain iron accumulation is common in patients with Parkinson's disease (PD). Iron chelators have been investigated for their ability to prevent neurodegenerative diseases with features of iron overload. Given the non-trivial side effects of classical iron chelators, lactoferrin (Lf), a multifunctional iron-binding globular glycoprotein, was screened to identify novel neuroprotective pathways against dopaminergic neuronal impairment. We found that Lf substantially ameliorated PD-like motor dysfunction in the subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. We further showed that Lf could alleviate MPTP-triggered apoptosis of DA neurons, neuroinflammation, and histological alterations. As expected, we also found that Lf suppressed MPTP-induced excessive iron accumulation and the upregulation of divalent metal transporter (DMT1) and transferrin receptor (TFR), which is the main intracellular iron regulation protein, and subsequently improved the activity of several antioxidant enzymes. We probed further and determined that the neuroprotection provided by Lf was involved in the upregulated levels of brain-derived neurotrophic factor (BDNF), hypoxia-inducible factor 1α (HIF-1α) and its downstream protein, accompanied by the activation of extracellular regulated protein kinases (ERK) and cAMP response element binding protein (CREB), as well as decreased phosphorylation of c-Jun N-terminal kinase (JNK) and mitogen activated protein kinase (MAPK)/P38 kinase in vitro and in vivo. Our findings suggest that Lf may be an alternative safe drug in ameliorating MPTP-induced brain abnormalities and movement disorder.
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| 50. |
- Xu, Shijie, et al.
(författare)
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Large-eddy simulation of the injection timing effects on the dual-fuel spray flame
- 2022
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Ingår i: Fuel. - : Elsevier BV. - 0016-2361. ; 310
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Tidskriftsartikel (refereegranskat)abstract
- Large-eddy simulations (LES) coupled with a partially-stirred reactor model and a finite-rate chemistry are carried out to investigate the effects of n-heptane injection timing on the methanol fueled dual-fuel (DF) combustion. Methanol is premixed with air in a constant volume chamber (T=1000 K, ρ=14.8 kg/m3) to form a homogeneous mixture (equivalence ratio ϕm of 0.3). Liquid fuel n-heptane is provided from a high pressure injector to mimic the pilot fuel injection in DF engines. First, mesh sensitivity analysis and LES model validation are conducted. The experimental data of Spray-H (n-heptane fueled) from the Engine Combustion Network is used for model validation. It is shown that the present mesh and LES model are capable of replicating the liquid and vapor penetration length, mixture fraction, temperature distribution, pressure rise profile and ignition delay time (IDT). Second, the effects of n-heptane injection timing are investigated, by varying the start of injection (SOI) time. The LES results reveal that there are three stage heat releases in the DF combustion. With the delay of SOI, the mass fraction of hydrogen peroxide in the ambient mixture increases, leading to an early formation of hydroxyl. Therefore, the two-stage IDTs of n-heptane decrease, while the ambient methanol IDT increases. Results also show the cool flame and high-temperature flame evolution after methanol auto-ignition. The cool flame disappears while the high-temperature flame is found near the injector nozzle, which leads to a relatively high heat release rate.
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