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Sökning: WFRF:(Panopoulos N.)

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2.
  • Fragoulis, GE, et al. (författare)
  • SIMILAR CARDIOVASCULAR COMORBIDITY AND HIGHER DEPRESSION RATES IN PSORIATIC ARTHRITIS COMPARED TO AGE- AND SEX-MATCHED RHEUMATOID ARTHRITIS AND DIABETES MELLITUS PATIENTS
  • 2020
  • Ingår i: ANNALS OF THE RHEUMATIC DISEASES. - : BMJ. - 0003-4967 .- 1468-2060. ; 79, s. 758-759
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Comorbidities are frequent in psoriatic arthritis (PsA) but it is not known how they differ from other high comorbidity burden diseases like rheumatoid arthritis (RA) and diabetes mellitus (DM).Objectives:To compare the prevalence of comorbidities in PsA vs. RA and DM patients.Methods:215 PsA patients were age/gender-matched with 215 RA and 215 DM patients from two tertiary hospitals. Prevalence of comorbidities (hypertension, current smoking, hyperlipidemia, obesity (BMI≥30), coronary disease [CD], stroke, MACE [combined CD and stroke], depression, osteoporosis, history of malignancies) were compared across the three groups. Within PsA group, associations between comorbidities and demographic and clinical features (e.g entheitis), including PsA phenotypes (RA-like vs oligoarthritis pattern and Axial-involvment vs Non-Axial-involvement) were assessed.Results:Hyperlipidaemia, obesity and depression were more frequent in PsA vs. RA. Depression and osteoporosis were more common in PsA vs DM. In contrast, hypertension was more frequent in DM. All other comorbidities, including frequency of stroke, CD and major adverse cardiovascular events did not differ between groups. Results remain unchanged after adjustments (Table 1).Table 1.Comparison of comorbidities between psoriatic arthritis (PsA), rheumatoid (RA) arthritis and Diabetes mellitus (DM) patients. OR: odds ratio, MACE: major adverse cardiovascular events. CI: Confidence IntervalsPsA vs RAPsA vs DMComorbidityPsAn=215n (%)RAn=215n (%)DMN=215n (%)Crude OR(95% CI)Adjusted OR(95% CI)Crude OR(95% CI)Adjusted OR(95% CI)Smoking76 (35.4)62 (28.8)85 (39.5)1.35(0.90-2.03)0.84(0.57-1.24)Obesity50 (29.4)24 (12.8)79 (36.7)2.83(1.65-4.86)0.72(0.47-1.10)Hyperlipidemia101 (47.0)67 (31.2)101 (47.0)1.96(1.32-2.90)-1-Hypertension62 (28.8)51 (23.8)97 (45.1)1.30(0.84-1.99)-0.49(0.33-0.74)-Coronary disease10 (4.7)10 (4.7)16 (7.4)1(0.41-2.45)0.97(0.34-2.79)*0.61(0.27-1.37)0.66(0.23-1.91)*Stroke8 (3.7)2 (0.9)7 (3.3)4.12(0.86-19.6)3.74(0.73-19.3)*1.15(0.41-3.22)1.20(0.35-4.12)*MACE12 (5.6)12 (5.6)22 (10.2)1(0.44-2.28)0.94(0.36-2.46)*0.52(0.25-1.08)0.42(0.16-1.10)*Osteoporosis9 (5.5)24 (11.2)2 (0.9)0.46(0.21-1.03)0.67(0.28-1.64)**6.22(1.33-29.2)-Depression42 (19.5)15 (7.0)12 (5.6)3.24(1.74-6.04)3.02(1.57-5.81)***4.11(2.10-8.05)4.85(2.37-9.93)***Malignancy12 (5.6)7 (3.3)-1.76(0.68-4.55)1.60(0.60-4.26)****--* adjusted for age, gender, smoking, hypertension, dyslipidemia, body mass index, ** adjusted for steroids, *** adjusted for age, gender, disease duration, smoking, **** adjusted for age, disease durationWithin PsA group, depression was associated with female gender (p=0.02), older age (p=0.03), higher disease duration (p=0.04) and current smoking (p=0.04). MACEs in PsA, were associated with male gender (p=0.03), older age (p=0.0002), dyslipidaemia (p=0.003) and hypertension (p<0.0001). No differences were found between different phenotypes of PsA.Conclusion:PsA patients had higher BMI and hyperlipidaemia compared to RA but not to DM. MACE is comparable between PsA and RA or DM, while depression is more common in PsA. Taking into account certain risk factors, screening for and management of comorbidities in PsA is important in the clinical setting.Disclosure of Interests:George E. Fragoulis: None declared, Gerasimos Evangelatos: None declared, Nikolaos Tentolouris: None declared, Kalliopi Fragkiadaki: None declared, Stylianos Panopoulos: None declared, George Konstantonis: None declared, Alexios Iliopoulos: None declared, Katerina Chatzidionysiou Consultant of: AbbVie, Pfizer, Lilly., Petros Sfikakis Grant/research support from: Grant/research support from Abvie, Novartis, MSD, Actelion, Amgen, Pfizer, Janssen Pharmaceutical, UCB, Maria Tektonidou Grant/research support from: AbbVie, MSD, Novartis and Pfizer, Consultant of: AbbVie, MSD, Novartis and Pfizer
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3.
  • Papawassiliou, Wassilios, 1991-, et al. (författare)
  • Detection of Weyl fermions and the metal to Weyl-semimetal phase transition in WTe2via broadband high resolution NMR
  • 2022
  • Ingår i: Physical Review Research. - 2643-1564. ; 4:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Weyl fermions (WFs) in the type-II Weyl semimetal (WSM) WTe2 are difficult to resolve experimentally because the Weyl bands disperse in an extremely narrow region of the (E−k) space. Here, by using DFT-assisted high-resolution 125Te solid-state nuclear magnetic resonance (ssNMR) in the temperature range 50–700 K, we succeeded in detecting low energy WF excitations and monitoring their evolution with temperature. Remarkably, WFs are observed to emerge at T∼120 K, while at lower temperatures WTe2 behaves as a trivial metal. This intriguing phenomenon is induced by the rapid raise of the Fermi level upon heating, which crosses the Weyl bands only for T>120 K. The abrupt change of the NMR parameters at this temperature is signature of a topological Lifshitz transition instead of a cursive energy-bands crossing.
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4.
  • Wootton, K. P., et al. (författare)
  • Storage ring lattice calibration using resonant spin depolarization
  • 2013
  • Ingår i: Physical Review Special Topics. Accelerators and Beams. - 1098-4402. ; 16:7
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents measurements of the GeV-scale electron beam energy for the storage rings at the synchrotron light source facilities Australian Synchrotron (AS) and SPEAR3 at SLAC. Resonant spin depolarization was employed in the beam energy measurement, since it is presently the highest precision technique and an uncertainty of order 10(-6) was achieved at SPEAR3 and AS. Using the resonant depolarization technique, the beam energy was measured at various rf frequencies to measure the linear momentum compaction factor. This measured linear momentum compaction factor was used to evaluate models of the beam trajectory through combined-function bending magnets. The main bending magnets of both lattices are rectangular, horizontally defocusing gradient bending magnets. Four modeling approaches are compared for the beam trajectory through the bending magnet: a circular trajectory, linear and nonlinear hyperbolic cosine trajectories, and numerical evaluation of the trajectory through the measured magnetic field map. Within the uncertainty of the measurement the momentum compaction factor is shown to agree with the numerical model of the trajectory within the bending magnet, and disagree with the hyperbolic cosine approximation.
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