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1.	Abraham, B, et al. (author) The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma 2003 In: The European respiratory journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 22:3, s. 470-477 Journal article (peer-reviewed)
2.	Liesker, JJW, et al. (author) Effects of formoterol (Oxis (R) Turbuhaler (R)) and ipratropium on exercise capacity in patients with COPD 2002 In: Respiratory Medicine. - : Elsevier BV. - 1532-3064 .- 0954-6111. ; 96:8, s. 559-566 Journal article (peer-reviewed)abstract Although long-acting inhaled beta(2)-agonists improve various outcome measures in COPD, no double-blind study has yet shown a significant effect of these drugs on exercise capacity. In a randomized, double-blind, placebo-controlled, crossover study, patients received formoterol (4.5,9, or 18 mug b.i.d via Turbuhaler(R)), ipratroplum bromide (80 mug t.i.d via pMDI with spacer), or placebo for I week. Main endpoint was time to exhaustion (TTE) in an incremental cycle ergometer test. Secondary endpoints were Borg dyspnoea score during exercise, lung function, and adverse events. Thirty-four patients with COPD were included, mean age 64.8 years, FEV(1)55.6% predicted, reversibility 6.1% predicted. All doses of formoterol, and ipratropium significantly improved TTE, FEV1, FEF25-75%, FRC, IVC, RV and sGAW compared with placebo. A negative dose-response relationship was observed with formoterol. Ipratropium increased time to exhaustion more compared with formoterol, 18 mug, but not with formoterol, 4.5 and 9 mug. No changes in Borg score were found. There was no difference in the adverse event profile between treatments. In conclusion, I week of treatment with formoterol and ipratropium significantly improved exercise capacity and lung function compared with placebo. However, a negative dose-response relation for formoterol was unexpected and needs further investigation.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Kerstjens, HAM (2); Pauwels, RA (2); Wollmer, Per (1); Dahlen, SE (1); Djukanovic, R (1); Howarth, PH (1); show more...; Abraham, B (1); Anto, JM (1); Barreiro, E (1); Bel, EHD (1); Bonsignore, G (1); Bousquet, J (1); Castellsague, J (1); Chanez, P (1); Cibella, F (1); Cuttitta, G (1); Dahlen, B (1); Drews, N (1); Fabbri, LM (1); Folkerts, G (1); Gaga, M (1); Gratziou, C (1); Guerrera, G (1); Holgate, ST (1); Johnston, SL (1); Kanniess, F (1); Kips, JC (1); Kumlin, M (1); Magnussen, H (1); Nijkamp, FP (1); Papageorgiou, N (1); Papi, A (1); Postma, DS (1); Rabe, KF (1); Richter, K (1); Roldaan, AC (1); Romagnoli, M (1); Roquet, A (1); Sanjuas, C (1); Siafakas, NM (1); Timens, W (1); Tzanakis, N (1); Vachier, I (1); Vignola, AM (1); Watson, L (1); Yourgioti, G (1); Hansson, Lennart (1); Vincken, W (1); Liesker, JJW (1); Van de Velde, V (1); show less...

University: Lund University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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