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1.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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2.
  • Arndt, D. S., et al. (författare)
  • STATE OF THE CLIMATE IN 2017
  • 2018
  • Ingår i: Bulletin of The American Meteorological Society - (BAMS). - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 99:8, s. S1-S310
  • Forskningsöversikt (refereegranskat)
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3.
  • Arndt, D. S., et al. (författare)
  • State of the Climate in 2016
  • 2017
  • Ingår i: Bulletin of The American Meteorological Society - (BAMS). - 0003-0007 .- 1520-0477. ; 98:8, s. S1-S280
  • Tidskriftsartikel (refereegranskat)abstract
    • In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs. The 3.5 +/- 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest annual increase observed in the 58-year measurement record. The annual global average carbon dioxide concentration at Earth's surface surpassed 400 ppm (402.9 +/- 0.1 ppm) for the first time in the modern atmospheric measurement record and in ice core records dating back as far as 800000 years. One of the strongest El Nino events since at least 1950 dissipated in spring, and a weak La Nina evolved later in the year. Owing at least in part to the combination of El Nino conditions early in the year and a long-term upward trend, Earth's surface observed record warmth for a third consecutive year, albeit by a much slimmer margin than by which that record was set in 2015. Above Earth's surface, the annual lower troposphere temperature was record high according to all datasets analyzed, while the lower stratospheric temperature was record low according to most of the in situ and satellite datasets. Several countries, including Mexico and India, reported record high annual temperatures while many others observed near-record highs. A week-long heat wave at the end of April over the northern and eastern Indian peninsula, with temperatures surpassing 44 degrees C, contributed to a water crisis for 330 million people and to 300 fatalities. In the Arctic the 2016 land surface temperature was 2.0 degrees C above the 1981-2010 average, breaking the previous record of 2007, 2011, and 2015 by 0.8 degrees C, representing a 3.5 degrees C increase since the record began in 1900. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 24 March, the sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, tying with 2015 at 7.2% below the 1981-2010 average. The September 2016 Arctic sea ice minimum extent tied with 2007 for the second lowest value on record, 33% lower than the 1981-2010 average. Arctic sea ice cover remains relatively young and thin, making it vulnerable to continued extensive melt. The mass of the Greenland Ice Sheet, which has the capacity to contribute similar to 7 m to sea level rise, reached a record low value. The onset of its surface melt was the second earliest, after 2012, in the 37-year satellite record. Sea surface temperature was record high at the global scale, surpassing the previous record of 2015 by about 0.01 degrees C. The global sea surface temperature trend for the 21st century-to-date of +0.162 degrees C decade(-1) is much higher than the longer term 1950-2016 trend of +0.100 degrees C decade(-1). Global annual mean sea level also reached a new record high, marking the sixth consecutive year of increase. Global annual ocean heat content saw a slight drop compared to the record high in 2015. Alpine glacier retreat continued around the globe, and preliminary data indicate that 2016 is the 37th consecutive year of negative annual mass balance. Across the Northern Hemisphere, snow cover for each month from February to June was among its four least extensive in the 47-year satellite record. Continuing a pattern below the surface, record high temperatures at 20-m depth were measured at all permafrost observatories on the North Slope of Alaska and at the Canadian observatory on northernmost Ellesmere Island. In the Antarctic, record low monthly surface pressures were broken at many stations, with the southern annular mode setting record high index values in March and June. Monthly high surface pressure records for August and November were set at several stations. During this period, record low daily and monthly sea ice extents were observed, with the November mean sea ice extent more than 5 standard deviations below the 1981-2010 average. These record low sea ice values contrast sharply with the record high values observed during 2012-14. Over the region, springtime Antarctic stratospheric ozone depletion was less severe relative to the 1991-2006 average, but ozone levels were still low compared to pre-1990 levels. Closer to the equator, 93 named tropical storms were observed during 2016, above the 1981-2010 average of 82, but fewer than the 101 storms recorded in 2015. Three basins-the North Atlantic, and eastern and western North Pacific-experienced above-normal activity in 2016. The Australian basin recorded its least active season since the beginning of the satellite era in 1970. Overall, four tropical cyclones reached the Saffir-Simpson category 5 intensity level. The strong El Nino at the beginning of the year that transitioned to a weak La Nina contributed to enhanced precipitation variability around the world. Wet conditions were observed throughout the year across southern South America, causing repeated heavy flooding in Argentina, Paraguay, and Uruguay. Wetter-than-usual conditions were also observed for eastern Europe and central Asia, alleviating the drought conditions of 2014 and 2015 in southern Russia. In the United States, California had its first wetter-than-average year since 2012, after being plagued by drought for several years. Even so, the area covered by drought in 2016 at the global scale was among the largest in the post-1950 record. For each month, at least 12% of land surfaces experienced severe drought conditions or worse, the longest such stretch in the record. In northeastern Brazil, drought conditions were observed for the fifth consecutive year, making this the longest drought on record in the region. Dry conditions were also observed in western Bolivia and Peru; it was Bolivia's worst drought in the past 25 years. In May, with abnormally warm and dry conditions already prevailing over western Canada for about a year, the human-induced Fort McMurray wildfire burned nearly 590000 hectares and became the costliest disaster in Canadian history, with $3 billion (U.S. dollars) in insured losses.
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4.
  • Lawrenson, Kate, et al. (författare)
  • Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
  • 2016
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk.
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5.
  • Lozano, Rafael, et al. (författare)
  • Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
  • 2018
  • Ingår i: The Lancet. - : Elsevier. - 1474-547X .- 0140-6736. ; 392:10159, s. 2091-2138
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990–2017, projected indicators to 2030, and analysed global attainment. Methods: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0–100, with 0 as the 2·5th percentile and 100 as the 97·5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings: The global median health-related SDG index in 2017 was 59·4 (IQR 35·4–67·3), ranging from a low of 11·6 (95% uncertainty interval 9·6–14·0) to a high of 84·9 (83·1–86·7). SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attainment by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation: The GBD study offers a unique, robust platform for monitoring the health-related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health-related SDG indicators, NCDs, NCD-related risks, and violence-related indicators will require a concerted shift away from what might have driven past gains—curative interventions in the case of NCDs—towards multisectoral, prevention-oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the SDGs. What is clear is that our actions—or inaction—today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030.
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6.
  • Naghavi, Mohsen, et al. (författare)
  • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
  • 2015
  • Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 385:9963, s. 117-171
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specifi c all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specifi c causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65.3 years (UI 65.0-65.6) in 1990, to 71.5 years (UI 71.0-71.9) in 2013, while the number of deaths increased from 47.5 million (UI 46.8-48.2) to 54.9 million (UI 53.6-56.3) over the same interval. Global progress masked variation by age and sex: for children, average absolute diff erences between countries decreased but relative diff erences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative diff erences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10.7%, from 4.3 million deaths in 1990 to 4.8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specifi c mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade.
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7.
  • Adriani, O., et al. (författare)
  • Cosmic-Ray Electron Flux Measured by the PAMELA Experiment between 1 and 625 GeV
  • 2011
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 106:20, s. 201101-
  • Tidskriftsartikel (refereegranskat)abstract
    • Precision measurements of the electron component in the cosmic radiation provide important information about the origin and propagation of cosmic rays in the Galaxy. Here we present new results regarding negatively charged electrons between 1 and 625 GeV performed by the satellite-borne experiment PAMELA. This is the first time that cosmic-ray e(-) have been identified above 50 GeV. The electron spectrum can be described with a single power-law energy dependence with spectral index -3.18 +/- 0.05 above the energy region influenced by the solar wind (> 30 GeV). No significant spectral features are observed and the data can be interpreted in terms of conventional diffusive propagation models. However, the data are also consistent with models including new cosmic-ray sources that could explain the rise in the positron fraction.
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8.
  • Hollestelle, Antoinette, et al. (författare)
  • No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
  • 2016
  • Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
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9.
  • McConnell, Mark L., et al. (författare)
  • The LargE Area burst Polarimeter (LEAP) A NASA Mission of Opportunity for the ISS
  • 2021
  • Ingår i: Uv, x-ray, and gamma-ray space instrumentation for astronomy xxii. - : SPIE-Intl Soc Optical Eng.
  • Konferensbidrag (refereegranskat)abstract
    • The LargE Area Burst Polarimeter (LEAP) will radically improve our understanding of some of the most energetic phenomena in our Universe by exposing the underlying physics that governs astrophysical jets and the extreme environment surrounding newborn compact objects. LEAP will do this by making the highest fidelity polarization measurements to date of the prompt gamma-ray emission from a large sample of Gamma-Ray Bursts (GRBs). The LEAP science objectives are met with a single instrument - a wide FOV Compton polarimeter that measures GRB polarization over the energy range from 50-500 keV and performs GRB spectroscopy from 20 keV to 5 MeV. It will be deployed as an external payload on the International Space Station (ISS) in 2025 for a three year mission. The instrument is based on standard, well-proven technologies that requires no new technology development. LEAP measures polarization using seven independent polarimeter modules, each with a 12x12 array of optically isolated high-Z and low-Z scintillation detectors read out by individual PMTs. The large FOV derives from the random distribution of GRBs in both space and time, and means that there is no preferred pointing direction on the celestial sphere. This feature, combined with the resources, and well-understood operations of ISS, provide the foundation for a straightforward mission design. LEAP is one of two NASA Missions of Opportunity proposals that are currently in a Phase A Concept Study, with a final selection due later this year.
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10.
  • Stanaway, Jeffrey D., et al. (författare)
  • Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
  • 2018
  • Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
  • Tidskriftsartikel (refereegranskat)abstract
    • Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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11.
  • Vos, Theo, et al. (författare)
  • Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
  • 2015
  • Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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12.
  • Wang, Haidong, et al. (författare)
  • Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015 : a systematic analysis for the Global Burden of Disease Study 2015
  • 2016
  • Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 388:10053, s. 1459-1544
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures.METHODS: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child and adult mortality and corresponding uncertainty, parameter selection for under-5 mortality synthesis by spatiotemporal Gaussian process regression, and sibling history data processing. We also expanded the database of vital registration, survey, and census data to 14 294 geography-year datapoints. For GBD 2015, eight causes, including Ebola virus disease, were added to the previous GBD cause list for mortality. We used six modelling approaches to assess cause-specific mortality, with the Cause of Death Ensemble Model (CODEm) generating estimates for most causes. We used a series of novel analyses to systematically quantify the drivers of trends in mortality across geographies. First, we assessed observed and expected levels and trends of cause-specific mortality as they relate to the Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Second, we examined factors affecting total mortality patterns through a series of counterfactual scenarios, testing the magnitude by which population growth, population age structures, and epidemiological changes contributed to shifts in mortality. Finally, we attributed changes in life expectancy to changes in cause of death. We documented each step of the GBD 2015 estimation processes, as well as data sources, in accordance with Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER).FINDINGS: Globally, life expectancy from birth increased from 61·7 years (95% uncertainty interval 61·4-61·9) in 1980 to 71·8 years (71·5-72·2) in 2015. Several countries in sub-Saharan Africa had very large gains in life expectancy from 2005 to 2015, rebounding from an era of exceedingly high loss of life due to HIV/AIDS. At the same time, many geographies saw life expectancy stagnate or decline, particularly for men and in countries with rising mortality from war or interpersonal violence. From 2005 to 2015, male life expectancy in Syria dropped by 11·3 years (3·7-17·4), to 62·6 years (56·5-70·2). Total deaths increased by 4·1% (2·6-5·6) from 2005 to 2015, rising to 55·8 million (54·9 million to 56·6 million) in 2015, but age-standardised death rates fell by 17·0% (15·8-18·1) during this time, underscoring changes in population growth and shifts in global age structures. The result was similar for non-communicable diseases (NCDs), with total deaths from these causes increasing by 14·1% (12·6-16·0) to 39·8 million (39·2 million to 40·5 million) in 2015, whereas age-standardised rates decreased by 13·1% (11·9-14·3). Globally, this mortality pattern emerged for several NCDs, including several types of cancer, ischaemic heart disease, cirrhosis, and Alzheimer's disease and other dementias. By contrast, both total deaths and age-standardised death rates due to communicable, maternal, neonatal, and nutritional conditions significantly declined from 2005 to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42·1%, 39·1-44·6), malaria (43·1%, 34·7-51·8), neonatal preterm birth complications (29·8%, 24·8-34·9), and maternal disorders (29·1%, 19·3-37·1). Progress was slower for several causes, such as lower respiratory infections and nutritional deficiencies, whereas deaths increased for others, including dengue and drug use disorders. Age-standardised death rates due to injuries significantly declined from 2005 to 2015, yet interpersonal violence and war claimed increasingly more lives in some regions, particularly in the Middle East. In 2015, rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146 000 deaths, 118 000-183 000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower respiratory infections (393 000 deaths, 228 000-532 000), although pathogen-specific mortality varied by region. Globally, the effects of population growth, ageing, and changes in age-standardised death rates substantially differed by cause. Our analyses on the expected associations between cause-specific mortality and SDI show the regular shifts in cause of death composition and population age structure with rising SDI. Country patterns of premature mortality (measured as years of life lost [YLLs]) and how they differ from the level expected on the basis of SDI alone revealed distinct but highly heterogeneous patterns by region and country or territory. Ischaemic heart disease, stroke, and diabetes were among the leading causes of YLLs in most regions, but in many cases, intraregional results sharply diverged for ratios of observed and expected YLLs based on SDI. Communicable, maternal, neonatal, and nutritional diseases caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death.INTERPRETATION: At the global scale, age-specific mortality has steadily improved over the past 35 years; this pattern of general progress continued in the past decade. Progress has been faster in most countries than expected on the basis of development measured by the SDI. Against this background of progress, some countries have seen falls in life expectancy, and age-standardised death rates for some causes are increasing. Despite progress in reducing age-standardised death rates, population growth and ageing mean that the number of deaths from most non-communicable causes are increasing in most countries, putting increased demands on health systems.
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13.
  • Abarr, Q., et al. (författare)
  • Observations of a GX 301-2 Apastron Flare with the X-Calibur Hard X-Ray Polarimeter Supported by NICER, the Swift XRT and BAT, and Fermi GBM
  • 2020
  • Ingår i: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 891:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The accretion-powered X-ray pulsar GX 301-2 was observed with the balloon-borne X-Calibur hard X-ray polarimeter during late 2018 December, with contiguous observations by the Neutron star Interior Composition Explorer Mission (NICER) X-ray telescope, the Swift X-ray Telescope and Burst Alert Telescope, and the Fermi Gamma-ray Burst Monitor spanning several months. The observations detected the pulsar in a rare apastron flaring state coinciding with a significant spin up of the pulsar discovered with the Fermi Gamma-ray Burst Monitor. The X-Calibur, NICER, and Swift observations reveal a pulse profile strongly dominated by one main peak, and the NICER and Swift data show strong variation of the profile from pulse to pulse. The X-Calibur observations constrain for the first time the linear polarization of the 15-35 keV emission from a highly magnetized accreting neutron star, indicating a polarization degree of % (90% confidence limit) averaged over all pulse phases. We discuss the spin up and the X-ray spectral and polarimetric results in the context of theoretical predictions. We conclude with a discussion of the scientific potential of future observations of highly magnetized neutron stars with the more sensitive follow-up mission XL-Calibur.
  •  
14.
  • Abarr, Q., et al. (författare)
  • Performance of the X-Calibur hard X-ray polarimetry mission during its 2018/19 long-duration balloon flight
  • 2022
  • Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 143, s. 102749-
  • Tidskriftsartikel (refereegranskat)abstract
    • X-Calibur is a balloon-borne telescope that measures the polarization of high-energy X-rays in the 15-50 keV energy range. The instrument makes use of the fact that X-rays scatter preferentially perpendicular to the polarization direction. A beryllium scattering element surrounded by pixellated CZT detectors is located at the focal point of the InFOC mu S hard X-ray mirror. The instrument was launched for a long-duration balloon (LDB) flight from McMurdo (Antarctica) on December 29, 2018, and obtained the first constraints of the hard X-ray polarization of an accretion-powered pulsar. Here, we describe the characterization and calibration of the instrument on the ground and its performance during the flight, as well as simulations of particle backgrounds and a comparison to measured rates. The pointing system and polarimeter achieved the excellent projected performance. The energy detection threshold for the anticoincidence system was found to be higher than expected and it exhibited unanticipated dead time. Both issues will be remedied for future flights. Overall, the mission performance was nominal, and results will inform the design of the follow-up mission XL-Calibur, which is scheduled to be launched in summer 2022.
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15.
  • Abarr, Quincy, et al. (författare)
  • "XL-Calibur", the Next-Generation Balloon-Borne Hard X-ray Polarimeter
  • 2021
  • Ingår i: Space Telescopes and Instrumentation 2020. - : SPIE-Intl Soc Optical Eng.
  • Konferensbidrag (refereegranskat)abstract
    • This paper introduces a second-generation balloon-borne hard X-ray polarimetry mission, XL-Calibur.(1) The XL-Calibur will follow up on the X-Calibur mission which was flown from Dec. 29, 2018 for a 2.5 days balloon flight from McMurdo (the Antarctic). X-ray polarimetry promises to give qualitatively new information about high-energy astrophysical sources, such as pulsars and binary black hole systems. The XL-Calibur contains a grazing incidence X-ray telescope with a focal plane detector unit that is sensitive to linear polarization. The telescope is very similar in design to the ASTRO-H HXT telescopes that has the world's largest effective area above 10 keV. XL-Calibur will use the same type of mirror. The detector unit combines a low atomic number Compton scatterer with a CdZnTe detector assembly to measure the polarization making use of the fact that polarized photons Compton scatter preferentially perpendicular to the electric field orientation. It also contains a CdZnTe imager at the bottom. The detector assembly is surrounded by a BGO anticoincidence shield. The pointing system with arcsecond accuracy will be achieved by the WASP (Wallops Arc Second Pointer) from NASA's Wallops Flight Facility. A first flight of the XL-Calibur is currently foreseen for 2022, flying from Sweden.
  •  
16.
  • Abdo, A. A., et al. (författare)
  • FERMI LARGE AREA TELESCOPE OBSERVATIONS OF THE VELA PULSAR
  • 2009
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 696:2, s. 1084-1093
  • Tidskriftsartikel (refereegranskat)abstract
    • The Vela pulsar is the brightest persistent source in the GeV sky and thus is the traditional first target for new gamma-ray observatories. We report here on initial Fermi Large Area Telescope observations during verification phase pointed exposure and early sky survey scanning. We have used the Vela signal to verify Fermi timing and angular resolution. The high-quality pulse profile, with some 32,400 pulsed photons at E >= 0.03 GeV, shows new features, including pulse structure as fine as 0.3 ms and a distinct third peak, which shifts in phase with energy. We examine the high-energy behavior of the pulsed emission; initial spectra suggest a phase-averaged power-law index of Gamma = 1.51(-0.04)(+0.05) with an exponential cutoff at E-c = 2.9 +/- 0.1 GeV. Spectral fits with generalized cutoffs of the form e(-(E/Ec)b) require b <= 1, which is inconsistent with magnetic pair attenuation, and thus favor outer-magnetosphere emission models. Finally, we report on upper limits to any unpulsed component, as might be associated with a surrounding pulsar wind nebula.
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17.
  • Adriani, O., et al. (författare)
  • A statistical procedure for the identification of positrons in the PAMELA experiment
  • 2010
  • Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 34:1, s. 1-11
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA satellite experiment has measured the cosmic-ray positron fraction between 1.5 GeV and 100 GeV. The need to reliably discriminate between the positron signal and proton background has required the development of an ad hoc analysis procedure. In this paper, a method for positron identification is described and its stability and capability to yield a correct background estimate is shown. The analysis includes new experimental data, the application of three different fitting techniques for the background sample and an estimate of systematic uncertainties due to possible inaccuracies in the background selection. The new experimental results confirm both solar modulation effects on cosmic-rays with low rigidities and an anomalous positron abundance above 10 GeV. (c) 2010 Elsevier B.V. All rights reserved.
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18.
  • Adriani, O., et al. (författare)
  • An anomalous positron abundance in cosmic rays with energies 1.5-100 GeV
  • 2009
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 458:7238, s. 607-609
  • Tidskriftsartikel (refereegranskat)abstract
    • Antiparticles account for a small fraction of cosmic rays and are known to be produced in interactions between cosmic-ray nuclei and atoms in the interstellar medium(1), which is referred to as a 'secondary source'. Positrons might also originate in objects such as pulsars(2) and microquasars(3) or through dark matter annihilation(4), which would be 'primary sources'. Previous statistically limited measurements(5-7) of the ratio of positron and electron fluxes have been interpreted as evidence for a primary source for the positrons, as has an increase in the total electron+positron flux at energies between 300 and 600 GeV (ref. 8). Here we report a measurement of the positron fraction in the energy range 1.5-100 GeV. We find that the positron fraction increases sharply overmuch of that range, in a way that appears to be completely inconsistent with secondary sources. We therefore conclude that a primary source, be it an astrophysical object or dark matter annihilation, is necessary.
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19.
  • Adriani, O., et al. (författare)
  • Antiprotons in primary cosmic radiation with PAMELA experiment
  • 2013
  • Ingår i: Proceedings of the 33rd International Cosmic Rays Conference, ICRC 2013. - : Sociedade Brasileira de Fisica. - 9788589064293
  • Konferensbidrag (refereegranskat)abstract
    • The latest measurements of antiprotons spectrum and antiproton-to-proton ratio in primary cosmic rays with PAMELA experiment are presented. They are in good agreement with model of secondary production of antiprotons in Galaxy, but they do not completely rule other sources at the high-energies. 
  •  
20.
  • Adriani, O., et al. (författare)
  • Cosmic-Ray Positron Energy Spectrum Measured by PAMELA
  • 2013
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 111:8, s. 081102-
  • Tidskriftsartikel (refereegranskat)abstract
    • Precision measurements of the positron component in the cosmic radiation provide important information about the propagation of cosmic rays and the nature of particle sources in our Galaxy. The satellite-borne experiment PAMELA has been used to make a new measurement of the cosmic-ray positron flux and fraction that extends previously published measurements up to 300 GeV in kinetic energy. The combined measurements of the cosmic-ray positron energy spectrum and fraction provide a unique tool to constrain interpretation models. During the recent solar minimum activity period from July 2006 to December 2009, approximately 24 500 positrons were observed. The results cannot be easily reconciled with purely secondary production, and additional sources of either astrophysical or exotic origin may be required.
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21.
  • Adriani, O., et al. (författare)
  • Design of an Antimatter Large Acceptance Detector In Orbit (ALADInO)
  • 2022
  • Ingår i: Instruments. - : MDPI AG. - 2410-390X. ; 6:2
  • Tidskriftsartikel (refereegranskat)abstract
    • A new generation magnetic spectrometer in space will open the opportunity to inves-tigate the frontiers in direct high-energy cosmic ray measurements and to precisely measure the amount of the rare antimatter component in cosmic rays beyond the reach of current missions. We propose the concept for an Antimatter Large Acceptance Detector In Orbit (ALADInO), designed to take over the legacy of direct measurements of cosmic rays in space performed by PAMELA and AMS-02. ALADInO features technological solutions conceived to overcome the current limi-tations of magnetic spectrometers in space with a layout that provides an acceptance larger than 10 m2 sr. A superconducting magnet coupled to precision tracking and time-of-flight systems can provide the required matter–antimatter separation capabilities and rigidity measurement resolution with a Maximum Detectable Rigidity better than 20 TV. The inner 3D-imaging deep calorimeter, designed to maximize the isotropic acceptance of particles, allows for the measurement of cosmic rays up to PeV energies with accurate energy resolution to precisely measure features in the cosmic ray spectra. The operations of ALADInO in the Sun–Earth L2 Lagrangian point for at least 5 years would enable unique revolutionary observations with groundbreaking discovery poten-tials in the field of astroparticle physics by precision measurements of electrons, positrons, and antiprotons up to 10 TeV and of nuclear cosmic rays up to PeV energies, and by the possible unam-biguous detection and measurement of low-energy antideuteron and antihelium components in cosmic rays. 
  •  
22.
  • Adriani, O., et al. (författare)
  • Gamma-ray performance study of the HERD payload
  • 2022
  • Ingår i: 37th International Cosmic Ray Conference, ICRC 2021. - : Sissa Medialab Srl.
  • Konferensbidrag (refereegranskat)abstract
    • The High Energy cosmic-Radiation Detection (HERD) facility has been proposed as a space astronomy payload onboard the future China's Space Station. HERD is planned for operation starting around 2027 for about 10 years In addition to the unprecedented sensitivity for dark matter searches and cosmic-ray measurements up to the knee energy, it should perform gamma-ray monitoring and full sky survey from few hundred MeV up to tens of TeV. We present the first study of the HERD gamma-ray performance obtained with full simulations of the whole detector geometry. HERD will be a cubic detector composed with 5 active faces. We present a study conducted inside the HERD analysis software package, which includes a detailed description of the detector materials. In this work we present the HERD effective area, the point spread function and the resulting gamma-ray sensitivity.
  •  
23.
  • Adriani, O., et al. (författare)
  • Latest results from the Pamela experiment
  • 2009
  • Ingår i: Proceedings of Science. ; , s. 1-6
  • Konferensbidrag (refereegranskat)abstract
    • In this paper we present the latest results of the Pamela satellite experiment, focusing in particular on the p̄/p and the e +/(e+ +e-) ratios.
  •  
24.
  • Adriani, O., et al. (författare)
  • Measurement of Boron and Carbon Fluxes in Cosmic Rays with the Pamela Experiment
  • 2014
  • Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 791:2, s. 93-
  • Tidskriftsartikel (refereegranskat)abstract
    • The propagation of cosmic rays inside our galaxy plays a fundamental role in shaping their injection spectra into those observed at Earth. One of the best tools to investigate this issue is the ratio of fluxes for secondary and primary species. The boron-to-carbon (B/C) ratio, in particular, is a sensitive probe to investigate propagation mechanisms. This paper presents new measurements of the absolute fluxes of boron and carbon nuclei as well as the B/C ratio from the PAMELA space experiment. The results span the range 0.44-129 GeV/n in kinetic energy for data taken in the period 2006 July to 2008 March.
  •  
25.
  • Adriani, O., et al. (författare)
  • Measurement of the flux of primary cosmic ray antiprotons with energies of 60 MeV to 350 GeV in the PAMELA experiment
  • 2013
  • Ingår i: JETP Letters. - 0021-3640 .- 1090-6487. ; 96:10, s. 621-627
  • Tidskriftsartikel (refereegranskat)abstract
    • It is interesting to measure the antiproton galactic component in cosmic rays in order to study the mechanisms by which particles and antiparticles are generated and propagate in the Galaxy and to search for new sources of, e.g., annihilation or decay of dark matter hypothetical particles. The antiproton spectrum and the ratio of the fluxes of primary cosmic ray antiprotons to protons with energies of 60 MeV to 350 GeV found from the data obtained from June 2006 to January 2010 in the PAMELA experiment are presented. The usage of the advanced data processing method based on the data classification mathematical model made it possible to increase statistics and analyze the region of higher energies than in the earlier works.
  •  
26.
  • Adriani, O., et al. (författare)
  • Measurement of the isotopic composition of hydrogen and helium nuclei in cosmic rays with the PAMELA experiment
  • 2013
  • Ingår i: Astrophysical Journal. - : IOP Publishing. - 0004-637X .- 1538-4357. ; 770:1, s. 2-
  • Tidskriftsartikel (refereegranskat)abstract
    • The satellite-borne experiment PAMELA has been used to make new measurements of cosmic ray H and He isotopes. The isotopic composition was measured between 100 and 600 MeV /n for hydrogen and between 100 and 900 MeV /n for helium isotopes over the 23rd solar minimum from 2006 July to 2007 December. The energy spectrum of these components carries fundamental information regarding the propagation of cosmic rays in the galaxy which are competitive with those obtained from other secondary to primary measurements such as B/C.
  •  
27.
  • Adriani, O., et al. (författare)
  • MEASUREMENTS OF COSMIC-RAY HYDROGEN AND HELIUM ISOTOPES WITH THE PAMELA EXPERIMENT
  • 2016
  • Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 818:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The cosmic-ray hydrogen and helium (H-1, H-2, He-3, He-4) isotopic composition has been measured with the satellite-borne experiment PAMELA, which was launched into low-Earth orbit on board the Resurs-DK1 satellite on 2006 June 15. The rare isotopes H-2 and He-3 in cosmic rays are believed to originate mainly from the interaction of high-energy protons and helium with the galactic interstellar medium. The isotopic composition was measured between 100 and 1100 MeV/n for hydrogen and between 100 and 1400 MeV/n for helium isotopes using two different detector systems over the 23rd solar minimum from 2006 July to 2007 December.
  •  
28.
  • Adriani, O., et al. (författare)
  • Measurements of cosmic-ray proton and helium spectra with the PAMELA calorimeter
  • 2013
  • Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 219-226
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a new measurement of the cosmic ray proton and helium spectra by the PAMELA experiment performed using the "thin" (in terms of nuclei interactions) sampling electromagnetic calorimeter. The described method, optimized by using Monte Carlo simulation, beam test and experimental data, allows the spectra to be measured up to 10 TeV, thus extending the PAMELA observational range based on the magnetic spectrometer measurement.
  •  
29.
  • Adriani, O., et al. (författare)
  • Measurements of quasi-trapped electron and positron fluxes with PAMELA
  • 2009
  • Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114, s. A12218-
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents precise measurements of the differential energy spectra of quasi-trapped secondary electrons and positrons and their ratio between 80 MeV and 10 GeV in the near-equatorial region (altitudes between 350 km and 600 km). Latitudinal dependences of the spectra are analyzed in detail. The results were obtained from July until November 2006 onboard the Resurs-DK satellite by the PAMELA spectrometer, a general purpose cosmic ray detector system built around a permanent magnet spectrometer and a silicon-tungsten calorimeter.
  •  
30.
  • Adriani, O., et al. (författare)
  • New Measurement of the Antiproton-to-Proton Flux Ratio up to 100 GeV in the Cosmic Radiation
  • 2009
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:5
  • Tidskriftsartikel (refereegranskat)abstract
    • A new measurement of the cosmic-ray antiproton-to-proton flux ratio between 1 and 100 GeV is presented. The results were obtained with the PAMELA experiment, which was launched into low-Earth orbit on-board the Resurs-DK1 satellite on June 15th 2006. During 500 days of data collection a total of about 1000 antiprotons have been identified, including 100 above an energy of 20 GeV. The high-energy results are a tenfold improvement in statistics with respect to all previously published data. The data follow the trend expected from secondary production calculations and significantly constrain contributions from exotic sources, e. g., dark matter particle annihilations.
  •  
31.
  • Adriani, O, et al. (författare)
  • New Upper Limit on Strange Quark Matter Abundance in Cosmic Rays with the PAMELA Space Experiment
  • 2015
  • Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 115:11
  • Tidskriftsartikel (refereegranskat)abstract
    • In this work we present results of a direct search for strange quark matter (SQM) in cosmic rays with the PAMELA space spectrometer. If this state of matter exists it may be present in cosmic rays as particles, called strangelets, having a high density and an anomalously high mass-to-charge (A/Z) ratio. A direct search in space is complementary to those from ground-based spectrometers. Furthermore, it has the advantage of being potentially capable of directly identifying these particles, without any assumption on their interaction model with Earth's atmosphere and the long-term stability in terrestrial and lunar rocks. In the rigidity range from 1.0 to similar to 1.0 x 10(3) GV, no such particles were found in the data collected by PAMELA between 2006 and 2009. An upper limit on the strangelet flux in cosmic rays was therefore set for particles with charge 1 <= Z <= 8 and mass 4 <= A <= 1.2 x 10(5). This limit as a function of mass and as a function of magnetic rigidity allows us to constrain models of SQM production and propagation in the Galaxy.
  •  
32.
  • Adriani, O., et al. (författare)
  • OBSERVATIONS OF THE 2006 DECEMBER 13 AND 14 SOLAR PARTICLE EVENTS IN THE 80 MeV n(-1)-3 GeV n(-1) RANGE FROM SPACE WITH THE PAMELA DETECTOR
  • 2011
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 742:2, s. 102-
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the space spectrometer PAMELA observations of proton and helium fluxes during the 2006 December 13 and 14 solar particle events. This is the first direct measurement of the solar energetic particles in space with a single instrument in the energy range from similar to 80 MeV n(-1) up to similar to 3 GeV n(-1). For the December 13 event, measured energy spectra of solar protons and helium are compared with results obtained by neutron monitors and other detectors. Our measurements show a spectral behavior different from those derived from the neutron monitor network. No satisfactory analytical fitting was found for the energy spectra. During the first hours of the December 13 event, solar energetic particles spectra were close to the exponential form, demonstrating rather significant temporal evolution. Solar He with energy up to 1 GeV n(-1) was recorded on December 13. For the December 14 event, energy of solar protons reached 600 MeV, whereas the maximum energy of He was below 100 MeV n(-1). The spectra were slightly bent in the lower energy range and preserved their form during the second event. Differences in the particle flux appearance and temporal evolution of these two events may argue for special conditions leading to the acceleration of solar particles up to relativistic energies.
  •  
33.
  • Adriani, O., et al. (författare)
  • PAMELA Measurements of Cosmic-Ray Proton and Helium Spectra
  • 2011
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 332:6025, s. 69-72
  • Tidskriftsartikel (refereegranskat)abstract
    • Protons and helium nuclei are the most abundant components of the cosmic radiation. Precise measurements of their fluxes are needed to understand the acceleration and subsequent propagation of cosmic rays in our Galaxy. We report precision measurements of the proton and helium spectra in the rigidity range 1 gigavolt to 1.2 teravolts performed by the satellite-borne experiment PAMELA (payload for antimatter matter exploration and light-nuclei astrophysics). We find that the spectral shapes of these two species are different and cannot be described well by a single power law. These data challenge the current paradigm of cosmic-ray acceleration in supernova remnants followed by diffusive propagation in the Galaxy. More complex processes of acceleration and propagation of cosmic rays are required to explain the spectral structures observed in our data.
  •  
34.
  • Adriani, O., et al. (författare)
  • PAMELA Results on the Cosmic-Ray Antiproton Flux from 60 MeV to 180 GeV in Kinetic Energy
  • 2010
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 105:12, s. 121101-
  • Tidskriftsartikel (refereegranskat)abstract
    • The satellite-borne experiment PAMELA has been used to make a new measurement of the cosmic-ray antiproton flux and the antiproton-to-proton flux ratio which extends previously published measurements down to 60 MeV and up to 180 GeV in kinetic energy. During 850 days of data acquisition approximately 1500 antiprotons were observed. The measurements are consistent with purely secondary production of antiprotons in the Galaxy. More precise secondary production models are required for a complete interpretation of the results.
  •  
35.
  • Adriani, O., et al. (författare)
  • PAMELA's measurements of geomagnetic cutoff variations during the 14 December 2006 storm
  • 2016
  • Ingår i: Space Weather. - : Blackwell Publishing. - 1542-7390. ; 14:3, s. 210-220
  • Tidskriftsartikel (refereegranskat)abstract
    • Data from the Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) satellite experiment were used to measure the geomagnetic cutoff for high-energy ( 80MeV) protons during the 14 December 2006 geomagnetic storm. The variations of the cutoff latitude as a function of rigidity were studied on relatively short timescales, corresponding to spacecraft orbital periods (approximate to 94 min). Estimated cutoff values were compared with those obtained by means of a trajectory-tracing approach based on a dynamical empirical modeling of the Earth's magnetosphere. We found significant variations in the cutoff latitude, with a maximum suppression of approximate to 7 degrees at lowest rigidities during the main phase of the storm. The observed reduction in the geomagnetic shielding and its temporal evolution were related to the changes in the magnetospheric configuration, investigating the role of interplanetary magnetic field, solar wind, and geomagnetic parameters. PAMELA's results represent the first direct measurement of geomagnetic cutoffs for protons with kinetic energies in the sub-GeV and GeV region.
  •  
36.
  • Adriani, O., et al. (författare)
  • Pamela's measurements of magnetospheric effects on high-energy solar particles
  • 2015
  • Ingår i: Astrophysical Journal Letters. - 2041-8205 .- 2041-8213. ; 801:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The nature of particle acceleration at the Sun, whether through flare reconnection processes or through shocks driven by coronal mass ejections, is still under scrutiny despite decades of research. The measured properties of solar energetic particles (SEPs) have long been modeled in different particle-acceleration scenarios. The challenge has been to disentangle the effects of transport from those of acceleration. The Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) instrument enables unique observations of SEPs including the composition and angular distribution of the particles about the magnetic field, i.e., pitch angle distribution, over a broad energy range (>80 MeV)-bridging a critical gap between space-based and ground-based measurements. We present high-energy SEP data from PAMELA acquired during the 2012 May 17 SEP event. These data exhibit differential anisotropies and thus transport features over the instrument rigidity range. SEP protons exhibit two distinct pitch angle distributions: a low-energy population that extends to 90 degrees and a population that is beamed at high energies (>1 GeV), consistent with neutron monitor measurements. To explain a low-energy SEP population that exhibits significant scattering or redistribution accompanied by a high-energy population that reaches the Earth relatively unaffected by dispersive transport effects, we postulate that the scattering or redistribution takes place locally. We believe that these are the first comprehensive measurements of the effects of solar energetic particle transport in the Earth's magnetosheath.
  •  
37.
  • Adriani, O., et al. (författare)
  • Positrons and electrons in primary cosmic rays as measured in the PAMELA experiment
  • 2009
  • Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 73:5, s. 568-570
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA experiment is being carried out on board the Russian satellite Resurs DK1 placed in the near-earth near-polar orbit on June 15, 2006. The apparatus comprising a silicon-strip magnetic spectrometer and an electromagnetic calorimeter allows measurement of electron and positron fluxes in cosmic rays in a wide energy interval from ∼100 MeV to hundreds of GeV. The high-energy electron and positron separation technique is discussed and the data on positron-to-electron ratio in primary cosmic rays up to E ≃ 10 GeV from the 2006 - 2007 measurements are reported in this work.
  •  
38.
  • Adriani, O., et al. (författare)
  • Reentrant albedo proton fluxes measured by the PAMELA experiment
  • 2015
  • Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 120:5, s. 3728-3738
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a precise measurement of downward going albedo proton fluxes for kinetic energy above similar to 70 MeV performed by the Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) experiment at an altitude between 350 and 610 km. On the basis of a trajectory tracing simulation, the analyzed protons were classified into quasi-trapped, concentrating in the magnetic equatorial region, and untrapped spreading over all latitudes, including both short-lived (precipitating) and long-lived (pseudotrapped) components. In addition, features of the penumbra region around the geomagnetic cutoff were investigated in detail. PAMELA results significantly improve the characterization of the high-energy albedo proton populations at low-Earth orbits.
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39.
  • Adriani, O, et al. (författare)
  • SEARCH FOR ANISOTROPIES IN COSMIC-RAY POSITRONS DETECTED BY THE PAMELA EXPERIMENT
  • 2015
  • Ingår i: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 811:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The. Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) detector was launched on board the Russian Resurs-DK1 satellite on 2006 June 15. The data collected during the first four years have been used to search for large-scale anisotropies in the arrival directions of cosmic ray positrons. The PAMELA experiment allows for a full sky investigation, with sensitivity to global anisotropies in any angular window of the celestial sphere. Data samples of positrons in the rigidity range of 10 GV <= R <= 200 GV were analyzed. This article discusses the method and the results of the search for possible local sources through the analysis of anisotropy in positron data compared to the proton background. The resulting distributions of arrival directions are found to be isotropic. Starting from the angular power spectrum, a dipole anisotropy upper limit of delta = 0.076 at the 95% confidence level is determined. An additional search is carried out around the Sun. No evidence of an excess correlated with that direction was found.
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40.
  •  
41.
  • Adriani, O., et al. (författare)
  • Secondary electron and positron fluxes in the near-Earth space observed in the ARINA and PAMELA experiments
  • 2009
  • Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 73:3, s. 364-366
  • Tidskriftsartikel (refereegranskat)abstract
    • Secondary electron and positron fluxes in the energy range from 3 MeV to 7 GeV were measured with the ARINA and PAMELA spectrometers onboard the Resurs-DK satellite launched on June 15, 2006 into an elliptical orbit with an inclination of 70.4° and an altitude of 350-600 km. It is shown that positrons dominate over electrons by a factor of up to 4-5 in the geomagnetic equator region (L < 1.2 and B > 0.25).
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42.
  • Adriani, O., et al. (författare)
  • Ten years of PAMELA in space
  • 2017
  • Ingår i: La Rivista del nuovo cimento della Società italiana di fisica. - : Società Italiana di Fisica. - 0393-697X .- 1826-9850. ; 40:10, s. 473-522
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA cosmic-ray detector was launched on June 15th 2006 on board the Russian Resurs-DK1 satellite, and during ten years of nearly continuous data-taking it has observed new interesting features in cosmic rays (CRs). In a decade of operation it has provided plenty of scientific data, covering different issues related to cosmic-ray physics. Its discoveries might change our basic vision of the mechanisms of production, acceleration and propagation of cosmic rays in the Galaxy. The antimatter measurements, focus of the experiment, have set strong constraints to the nature of Dark Matter. Search for signatures of more exotic processes (such as the ones involving Strange Quark Matter) was also pursued. Furthermore, the long-term operation of the instrument had allowed a constant monitoring of the solar activity during its maximum and a detailed and prolonged study of the solar modulation, improving the comprehension of the heliosphere mechanisms. PAMELA had also measured the radiation environment around the Earth, and it detected for the first time the presence of an antiproton radiation belt surrounding our planet. The operation of Resurs-DK1 was terminated in 2016. In this article we will review the main features of the PAMELA instrument and its constructing phases. The main part of the article will be dedicated to the summary of the most relevant PAMELA results over a decade of observation.
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43.
  • Adriani, O., et al. (författare)
  • The discovery of geomagnetically trapped cosmic-ray antiprotons
  • 2011
  • Ingår i: Astrophysical Journal Letters. - 2041-8205. ; 737:2, s. L29-
  • Tidskriftsartikel (refereegranskat)abstract
    • The existence of a significant flux of antiprotons confined to Earth's magnetosphere has been considered in several theoretical works. These antiparticles are produced in nuclear interactions of energetic cosmic rays with the terrestrial atmosphere and accumulate in the geomagnetic field at altitudes of several hundred kilometers. A contribution from the decay of albedo antineutrons has been hypothesized in analogy to proton production by neutron decay, which constitutes the main source of trapped protons at energies above some tens of MeV. This Letter reports the discovery of an antiproton radiation belt around the Earth. The trapped antiproton energy spectrum in the South Atlantic Anomaly (SAA) region has been measured by the PAMELA experiment for the kinetic energy range 60-750 MeV. A measurement of the atmospheric sub-cutoff antiproton spectrum outside the radiation belts is also reported. PAMELA data show that the magnetospheric antiproton flux in the SAA exceeds the cosmic-ray antiproton flux by three orders of magnitude at the present solar minimum, and exceeds the sub-cutoff antiproton flux outside radiation belts by four orders of magnitude, constituting the most abundant source of antiprotons near the Earth.
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44.
  • Adriani, O., et al. (författare)
  • The PAMELA experiment on satellite and its capability in cosmic rays measurements
  • 2002
  • Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 478:02-jan, s. 114-118
  • Tidskriftsartikel (refereegranskat)abstract
    • The PAMELA equipment will be assembled in 2001 and installed on board the Russian satellite Resurs. PAMELA is conceived mainly to study the antiproton and positron fluxes in cosmic rays up to high energy (190 GeV for (p) over bar and 270 GeV for e(+)) and to search antinuclei, up to 30 GeV/n, with a sensitivity of 10(-7) in the He/He ratio. The PAMELA telescope consists of. a magnetic spectrometer made up of a permanent magnet system equipped with double sided microstrip silicon detectors a transition radiation detector made up of active layers of proportional straw tubes interleaved with carbon fibre radiators; and a silicon-tungsten imaging calorimeter made up of layers of tungsten absorbers and silicon detector planes. A time-of-flight system and anti-coincidence counters complete the PAMELA equipment. In the past years, tests have been done on each subdetector of PAMELA; the main results are presented and their implications on the anti-particles identification capability in cosmic rays are discussed here.
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45.
  • Adriani, O., et al. (författare)
  • The Pamela experiment ready for flight
  • 2007
  • Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 572:1, s. 471-473
  • Tidskriftsartikel (refereegranskat)abstract
    • The Pamela apparatus will allow precise measurements of cosmic rays in Low Earth Orbit, mainly focusing on the antiparticles component. The apparatus is now ready for flight, and the launch is foreseen during June 2006. The paper briefly reports the status of the experiment, and the performances of the various components as measured before the launch.
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46.
  • Adriani, O., et al. (författare)
  • The PAMELA Mission : Heralding a new era in precision cosmic ray physics
  • 2014
  • Ingår i: Physics reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 544:4, s. 323-370
  • Forskningsöversikt (refereegranskat)abstract
    • On the 15th of June 2006, the PAMELA (Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics) satellite-borne experiment was launched onboard the Russian Resurs-DK1 satellite by a Soyuz rocket from the Baikonur space centre. The satellite was placed in a quasi-polar 70 degrees inclination orbit at an altitude varying between 350 km and 600 km. New results on the antiparticle component of the cosmic radiation were obtained. The positron energy spectrum and positron fraction were measured from 400 MeV up to 200 GeV revealing a positron excess over the predictions of commonly used propagation models. This can be interpreted either as evidence that the propagation models should be revised or in terms of dark matter annihilation or a pulsar contribution. The antiproton spectrum was measured over the energy range from 60 MeV to 350 GeV. The antiproton spectrum is consistent with secondary production and significantly constrains dark matter models. The energy spectra of protons and helium nuclei were measured up to 1.2 TV. The spectral shapes of these two species are different and cannot be described well by a single power law. For the First time the electron spectrum was measured up to 600 GeV complementing the information obtained from the positron data. Nuclear and isotopic composition was obtained with unprecedented precision. The variation of the low energy proton, electron and positron energy spectra was measured from July 2006 until December 2009 accurately sampling the unusual conditions of the most recent solar minimum activity period (2006-2009). Low energy particle spectra were accurately measured also for various solar events that occurred during the PAMELA mission. The Earth's magnetosphere was studied measuring the particle radiation in different regions of the magnetosphere. Energy spectra and composition of sub-cutoff and trapped particles were obtained. For the first time a belt of trapped antiprotons was detected in the South Atlantic Anomaly region. The flux was found to exceed that for galactic cosmic-ray antiprotons by three order of magnitude.
  •  
47.
  • Adriani, O., et al. (författare)
  • The PAMELA space mission
  • 2008
  • Ingår i: Astroparticle, Part. Space Phys., Detect. Med. Phys. Appl. - Proc. Conf.. - : WORLD SCIENTIFIC. - 9812819088 - 9789812819086 ; , s. 858-864
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA (a Payload for Antimatter-Matter Exploration and Light-nuclei Astrophysics) experiment, is a satellite-borne particle spectrometer. It was launched on 15th June 2006 from the Baikonur cosmodrome in Kazakhstan, is installed into the Russian Resurs-DK1 satellite. PAMELA is composed of a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. Among the PAMELA major objectives are the study of charged particles in the cosmic radiation, the investigation of the nature of dark matter, by mean of the measure of the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved. PAMELA has been in a nearly continuous data taking mode since llth July 2006. The status of the apparatus and performances will be presented.
  •  
48.
  • Adriani, O., et al. (författare)
  • The PAMELA space mission
  • 2009
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA (a Payload for Antimatter-Matter Exploration and Light-nuclei Astrophysics) space mission has been launched on-board the Resurs-DK1 satellite on June 15(th) 2006 from the Baikonur cosmodrome, in Kazakhstan. PAMELA is a particle spectrometer designed to study charged particles in the cosmic radiation with special focus on the investigation of the nature of dark matter, by mean of the measure of the cosmic-ray antiproton and positron spectra over the largest energy range ever achieved.
  •  
49.
  • Adriani, O., et al. (författare)
  • The PAMELA Space Mission for Antimatter and Dark Matter Searches in Cosmic Rays
  • 2010
  • Ingår i: SCIENCE WITH THE NEW GENERATION OF HIGH-ENERGY GAMMA-RAY EXPERIMENTS. - : AIP. - 9780735407671 ; , s. 33-42
  • Konferensbidrag (refereegranskat)abstract
    • On the 15(th) of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The instrument allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV - 100's GeV) with high statistics. The primary scientific goal is the measurement of the antiproton and positron energy spectrum in order to search for exotic sources, such as dark matter particle annihilations. PAMELA is also searching for primordial antinuclei (anti-helium), and testing cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and precision studies of light nuclei and their isotopes. Moreover, PAMELA is investigating phenomena connected with solar and earth physics. Results of the antiproton and positron data will be presented.
  •  
50.
  • Adriani, O., et al. (författare)
  • TIME DEPENDENCE of the e- FLUX MEASURED by PAMELA during the 2006 July-2009 DECEMBER SOLAR MINIMUM
  • 2015
  • Ingår i: Astrophysical Journal. - : Institute of Physics (IOP). - 0004-637X .- 1538-4357. ; 810:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Precision measurements of the electron component of cosmic radiation provide important information about the origin and propagation of cosmic rays in the Galaxy not accessible from the study of cosmic-ray nuclear components due to their differing diffusion and energy-loss processes. However, when measured near Earth, the effects of propagation and modulation of Galactic cosmic rays in the heliosphere, particularly significant for energies up to at least 30 GeV, must be properly taken into account. In this paper the electron (e-) spectra measured by the Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics down to 70 MeV from 2006 July to 2009 December over six-month time intervals are presented. Fluxes are compared with a state-of-the-art three-dimensional model of solar modulation that reproduces the observations remarkably well.
  •  
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