| 1. |
- Berrout, Jonathan, et al.
(författare)
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TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD), where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression through aberrant protein-protein interactions mediated via its C-terminal proline-rich motif. Here we report that the N-terminal ankyrin repeats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompting LUAD progression and metastasis. Furthermore, we show that upon metastasis to the brain, TRPA1 gets depleted, an effect triggered by the transfer of TRPA1-targeting exosomal microRNA (miRNA-142-3p) from brain astrocytes to cancer cells. This downregulation, in turn, inhibits TRPA1-mediated activation of FGFR2, hindering the metastatic process. Our study reveals a direct binding event and characterizes the role of TRPA1 ankyrin repeats in regulating FGFR2-driven oncogenic process; a mechanism that is hindered by miRNA-142-3p.
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| 2. |
- Peers, Laura, et al.
(författare)
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Introduction : Repatriation and Ritual, Repatriation as Ritual
- 2017
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Ingår i: Museum Worlds. - : Berghahn Books. - 2049-6729 .- 2049-6737. ; :5, s. 1-8
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This special section of Museum Worlds explores the entire process of repatriation as a set of rituals enacted by claimants and museum staff: a set of highlighted performances enacting multiple sets of cosmological beliefs, symbolic systems, and political structures. Some of the rituals of repatriation occur within the space of Indigenous ceremonies; others happen within the museum spaces of collections storage and the boardroom; others, such as handover ceremonies, are coproduced and culturally hybrid. From the often obsessive bureaucracy associated with repatriation claims to the affective moment of handover, repatriation articulates a moral landscape where memory, responsibility, guilt, identity, sanctity, place, and ownership are given a ritual form. Theory about ritual is used here to situate the articles in this section, which together form a cross-cultural examination of ritual meaning and form across repatriation processes.
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| 3. |
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Special Section: Ritual Repatriation
- 2017
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- This special section of Museum Worlds explores the entire process of repatriation as a set of rituals enacted by claimants and museum staff: a set of highlighted performances enacting multiple sets of cosmological beliefs, symbolic systems, and political structures. Some of the rituals of repatriation occur within the space of Indigenous ceremonies; others happen within the museum spaces of collections storage and the boardroom; others, such as handover ceremonies, are coproduced and culturally hybrid. From the often obsessive bureaucracy associated with repatriation claims to the affective moment of handover, repatriation articulates a moral landscape where memory, responsibility, guilt, identity, sanctity, place, and ownership are given a ritual form. Theory about ritual is used here to situate the articles in this section, which together form a cross-cultural examination of ritual meaning and form across repatriation
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