| 1. |
- Pham, M. K., et al.
(författare)
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A new reference material for radionuclides in the mussel sample from the Mediterranean Sea (IAEA-437)
- 2010
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Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - : Springer Science and Business Media LLC. - 0236-5731 .- 1588-2780. ; 283:3, s. 851-859
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Tidskriftsartikel (refereegranskat)abstract
- A new Reference Material (RM) for radionuclides in mussel (Mytilus galloprovincialis) from the Mediterranean Sea (IAEA-437) is described and the results of the certification process are presented. Four radionuclides (K-40, U-234, U-238, and Pu239+240) have been certified, and information values on massic activities with 95% confidence intervals are given for nine radionuclides (Cs-137, Pb-210(Po-210), Ra-226, Ra-228, Th-228, Th-230, Th-232, U-235, and Am-241). Results for less frequently reported radionuclides (Sr-90, I-129, Pu-238, Pu-239, and Pu-240) are also reported. The RM can be used for quality assurance/quality control of the analysis of radionuclides in mussel samples, for the development and validation of analytical methods and for training purposes. The material is available in 200 g units.
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| 2. |
- Soldani, C, et al.
(författare)
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Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where?
- 2001
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Ingår i: Experimental cell research. - : Elsevier BV. - 0014-4827. ; 269:2, s. 193-201
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Tidskriftsartikel (refereegranskat)abstract
- Poly(ADP-ribose) polymerase-1 (PARP-1) plays the active role of "nick sensor" during DNA repair and apoptosis, when it synthesizes ADP-ribose from NAD(+) in the presence of DNA strand breaks. Moreover, PARP-1 becomes a target of apoptotic caspases, which originate two proteolytic fragments of 89 and 24 kDa. The precise relationship between PARP-1 activation and degradation during apoptosis is still a matter of debate. In human Hep-2 cells driven to apoptosis by actinomycin D, we have monitored PARP-1 activity by the mAb 10H, which is specific for the ADP-ribose polymers, and we have observed that poly(ADP-ribose) synthesis is a very early response to the apoptotic stimulus. The analysis of the presence and fate of the p89 proteolytic fragment revealed that PARP-1 proteolysis by caspases is concomitant with poly(ADP-ribose) synthesis and that p89 migrates from the nucleus into the cytoplasm in late apoptotic cells with advanced nuclear fragmentation.
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| 3. |
- Hochleitner, I., et al.
(författare)
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Intra- and inter-rater reliability of the Italian Fugl-Meyer assessment of upper and lower extremity
- 2023
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Ingår i: Disability and Rehabilitation. - : Informa UK Limited. - 0963-8288 .- 1464-5165. ; 45:18, s. 2989-2999
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Tidskriftsartikel (refereegranskat)abstract
- Purpose To assess the intra- and inter-rater reliability motor and sensory functioning, balance, joint range of motion and joint pain subscales of the Italian Fugl-Meyer Assessment (FMA) Upper Extremity (FMA-UE) and Lower Extremity (FMA-LE) at the item- subtotal- and total-level in patients with sub-acute stroke. Materials and methods The FMA was administered to 60 patients with sub-acute stroke (mean age +/- SD = 75.4 +/- 10.7 years; 58.3% men) and independently rated by two physiotherapists on two consecutive days. Intra- and inter-reliability was studied by a rank-based statistical method for paired ordinal data to detect any systematic or random disagreement. Results The item-level intra- and inter-rater reliability was satisfactory (>70%). Reliability level >70% was achieved at subscale and total score level when one- or two-points difference was considered. Systematic disagreements were reported for five items of the FMA-UE, but not for FMA-LE. Conclusions The Italian version of the FMA showed to be a reliable instrument that can therefore be recommended for clinical and research purposes.
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| 4. |
- Bottone, Maria Grazia, et al.
(författare)
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Multiple effects of paclitaxel are modulated by a high c-myc amplification level.
- 2003
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Ingår i: Experimental cell research. - 0014-4827. ; 290:1, s. 49-59
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Tidskriftsartikel (refereegranskat)abstract
- Paclitaxel affects microtubule stability by binding to beta-tubulin, thus leading to cell accumulation in the G(2)/M phase, polyploidization, and apoptosis. Because both cell proliferation and apoptosis could be somehow regulated by the protooncogene c-myc, in this work we have investigated whether the c-myc amplification level could modulate the multiple effects of paclitaxel. To this aim, paclitaxel was administered to SW613-12A1 and -B3 human colon carcinoma cell lines (which are characterized by a high and low c-myc endogenous amplification level, respectively), and to the B3mycC5 cell line, with an enforced exogenous expression of c-myc copies. In this experimental system, we previously demonstrated that a high endogenous/exogenous level of amplification of c-myc enhances serum deprivation- and DNA damage-induced apoptosis. Accordingly, the present results indicate that a high c-myc amplification level potentiates paclitaxel cytotoxicity, confers a multinucleated phenotype, and promotes apoptosis to a great extent, thus suggesting that c-myc expression level is relevant in modulating the cellular responses to paclitaxel. We have recently shown in HeLa cells that the phosphorylated form of c-Myc accumulates in the nucleus, as distinct nucleolar and extranucleolar spots; here, we demonstrated that, after the treatment with paclitaxel, phosphorylated c-Myc undergoes redistribution, becoming diffused in the nucleoplasm.
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| 5. |
- Pellicciari, M., et al.
(författare)
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AREUS — Innovative hardware and software for sustainable industrial robotics
- 2015
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Ingår i: IEEE International Conference on Automation Science and Engineering. - 2161-8070 .- 2161-8089. - 9781467381833 ; 2015-October, s. 1325-1332
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Konferensbidrag (refereegranskat)abstract
- Industrial Robotics (IR) may be envisaged as the key technology to keep the manufacturing industry at the leading edge. Unfortunately, at the current state-of-the-art, IR is intrinsically energy intensive, thus compromising factories sustainability in terms of ecological footprint and economic costs. Within this scenario, this paper presents a new framework called AREUS, focusing on eco-design, eco-programming and Life Cycle Assessment (LCA) of robotized factories. The objective is to overcome current IR energetic limitations by providing a set of integrated technologies and engineering platforms. In particular, novel energy-saving hardware is firstly introduced, which aim at exchanging/storing/recovering energy at factory level. In parallel, innovative engineering methods and software tools for energy-focused simulation are developed, as well as energy-optimal scheduling of multi-robot stations. At last, LCA methods are briefly described, which are capable to assess both environmental and economic costs, linked to the flows of Material, Energy and Waste (MEW). A selected list of industrially-driven demonstration case studies is finally presented, along with future directions of improvement.
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| 6. |
- Pellicciari, M., et al.
(författare)
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Object-oriented modeling of industrial manipulators with application to energy optimal trajectory scaling
- 2011
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Ingår i: ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011; Washington, DC; United States; 28 August 2011 through 31 August 2011. - 9780791854822 ; 5:A and B, s. 997-1006
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Konferensbidrag (refereegranskat)abstract
- The development of safe, energy efficient mechatronic systems is currently changing standard paradigms in the design and control of industrial manipulators. In particular, most optimization strategies require the improvement or the substitution of different system components. On the other hand, from an industry point of view, it would be desirable to develop energy saving methods applicable also to established manufacturing systems being liable of small possibilities for adjustments. Within this scenario, an engineering method is reported for optimizing the energy consumption of serial manipulators for a given operation. An object-oriented modeling technique, based on bond graph, is used to derive the robot electromechanical dynamics. The system power flow is then highlighted and parameterized as a function of the total execution times. Finally, a case study is reported show- ing the possibility to reduce the operation energy consumption when allowed by scheduling or manufacturing constraints.
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| 7. |
- Vergnano, Alberto, et al.
(författare)
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Embedding detailed robot energy optimization into high-level scheduling
- 2010
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Ingår i: 2010 IEEE International Conference on Automation Science and Engineering, CASE 2010. - 9781424454471 ; , s. 386-392
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Konferensbidrag (refereegranskat)abstract
- Reduction of energy consumption is important for reaching a sustainable future. This paper presents a novel method for optimizing the energy consumption of robotic manufacturing systems. The method embeds detailed evaluations of robots' energy consumptions into a scheduling model of the overall system. The energy consumption for each operation is modelled and parameterized as function of the operation execution time, and the energy-optimal schedule is derived by solving a mixed-integer nonlinear programming problem. The objective function for the optimization problem is then the total energy consumption for the overall system. A case study of a sample robotic manufacturing system is presented. It shows that there exists a possibility for a significant reduction of the energy consumption, in comparison to state-of-the-art scheduling approaches. © 2010 IEEE.
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| 8. |
- Vergnano, Alberto, et al.
(författare)
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Modeling and Optimization of Energy Consumption in Cooperative Multi-Robot Systems
- 2012
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Ingår i: IEEE Transactions on Automation Science and Engineering. - 1558-3783 .- 1545-5955. ; 9:2, s. 423-428
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Tidskriftsartikel (refereegranskat)abstract
- Reduction of energy consumption is important for reaching a sustainable future. This paper presents a novel method for optimizing the energy consumption of robotic manufacturing systems. The method embeds detailed evaluations of robots' energy consumptions into a scheduling model of the overall system. The energy consumption for each operation is modeled and parameterized as function of the operation execution time, and the energy-optimal schedule is derived by solving a mixed-integer nonlinear programming problem. The objective function for the optimization problem is then the total energy consumption for the overall system. A case study of a sample robotic manufacturing system and an experiment on an industrial robot are presented. They show that there exists a real possibility for a significant reduction of the energy consumption in comparison to state-of-the-art scheduling approaches. Note to Practitioners-The motivation for this work is the great interest of companies on energy consumption optimization, looking for cost reduction and sustainability in manufacturing. Existing optimization methods focus on different levels of details. A high-level model would be able to optimize the overall system. Unfortunately, due to the high computational cost, it can hardly consider the deep level of mechanical and electrical parameters, which determine the real energy consumption. This paper presents a novel method to embed detailed energy consumption models into a scheduling optimization problem. An effective parameterization of the time variables reduces the model complexity, allowing the optimizer to reschedule the complete sequence of operations for minimizing the total energy consumption, while keeping a fixed cycle time. The method has been integrated into a commercial tool for robot programming. The optimization is applicable both on new and existing robotic systems, since the required modifications are limited to the operations rescheduling, and no investments on new hardware are expected.
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