| 1. |
- Deng, Min, et al.
(författare)
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Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
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Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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| 2. |
- Peng, Changqing, et al.
(författare)
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LightFlow : Lightweight unsupervised defect detection based on 2D Flow
- 2024
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Ingår i: IEEE Transactions on Instrumentation and Measurement. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9456 .- 1557-9662. ; 73
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Tidskriftsartikel (refereegranskat)abstract
- In the industrial production process, unsupervised visual inspection methods have obvious advantages over supervised visual inspection methods due to the scarcity of defect samples, annotation costs and the uncertainty of defect generation. Currently, unsupervised defect detection and localization methods have demonstrated significant improvements in detection accuracy to find numerous applications in industrial inspection. Nonetheless, the complexity of these methods limits their practical application. In this paper, we integrate the FastFlow model plugin as a probability distribution by introducing a simpler and lightweight CNN pre-trained backbone. Concurrently, various training strategies are employed to optimize the 2D Flow module within the Lightweight unsupervised flow model (LightFlow). Notably, the number of model parameters in the LightFlow model is only 1/4 of the original model size of the typical Vision Transformer (ViT) model CaiT. Thereby, this offers heightened training efficiency and speed. Therefore, extensive experimental results on three challenging anomaly detection datasets (MVTec AD, VisA, and BTAD) using various CNN backbones and multiple current state-of-the-art vision algorithms demonstrate the effectiveness of our approach. Specifically, the existing method can achieve 99.1% and 95.2% image-level AUROC (area under the receiver operating characteristic) in MVTec AD and VisA, respectively. IEEE
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| 3. |
- Xu, Bo, et al.
(författare)
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Tailor-Making Low-Cost Spiro[fluorene-9,9′-xanthene]-Based 3D Oligomers for Perovskite Solar Cells
- 2017
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Ingår i: Chem. - : Elsevier. - 2451-9308 .- 2451-9294. ; 2:5, s. 676-687
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Tidskriftsartikel (refereegranskat)abstract
- The power-conversion efficiencies (PCEs) of perovskite solar cells (PSCs) have increased rapidly from about 4% to 22% during the past few years. One of the major challenges for further improvement of the efficiency of PSCs is the lack of sufficiently good hole transport materials (HTMs) to efficiently scavenge the photogenerated holes and aid the transport of the holes to the counter-electrode in the PSCs. In this study, we tailor-made two low-cost spiro[fluorene-9,9′-xanthene] (SFX)-based 3D oligomers, termed X54 and X55, by using a one-pot synthesis approach for PSCs. One of the HTMs, X55, gives a much deeper HOMO level and a higher hole mobility and conductivity than the state-of-the-art HTM, Spiro-OMeTAD. PSC devices based on X55 as the HTM show a very impressive PCE of 20.8% under 100 mW·cm−2 AM1.5G solar illumination, which is much higher than the PCE of the reference devices based on Spiro-OMeTAD (18.8%) and X54 (13.6%) under the same conditions.
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| 4. |
- Zhang, Jinbao, et al.
(författare)
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The Importance of Pendant Groups on Triphenylamine-Based Hole Transport Materials for Obtaining Perovskite Solar Cells with over 20% Efficiency
- 2018
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Ingår i: Advanced Energy Materials. - : Wiley. - 1614-6832 .- 1614-6840. ; 18:2
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Tidskriftsartikel (refereegranskat)abstract
- Tremendous progress has recently been achieved in the field of perovskite solar cells (PSCs) as evidenced by impressive power conversion efficiencies (PCEs); but the high PCEs of >20% in PSCs has so far been mostly achieved by using the hole transport material (HTM) spiro-OMeTAD; however, the relatively low conductivity and high cost of spiro-OMeTAD significantly limit its potential use in large-scale applications. In this work, two new organic molecules with spiro[fluorene-9,9-xanthene] (SFX)-based pendant groups, X26 and X36, have been developed as HTMs. Both X26 and X36 present facile syntheses with high yields. It is found that the introduced SFX pendant groups in triphenylamine-based molecules show significant influence on the conductivity, energy levels, and thin-film surface morphology. The use of X26 as HTM in PSCs yields a remarkable PCE of 20.2%. In addition, the X26-based devices show impressive stability maintaining a high PCE of 18.8% after 5 months of aging in controlled (20%) humidity in the dark. We believe that X26 with high device PCEs of >20% and simple synthesis show a great promise for future application in PSCs, and that it represents a useful design platform for designing new charge transport materials for optoelectronic applications.
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