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- Tomić, I., et al.
(författare)
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Shake-table testing of a stone masonry building aggregate : overview of blind prediction study
- 2023
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Ingår i: Bulletin of Earthquake Engineering. - : Springer Science and Business Media LLC. - 1570-761X .- 1573-1456.
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Tidskriftsartikel (refereegranskat)abstract
- City centres of Europe are often composed of unreinforced masonry structural aggregates, whose seismic response is challenging to predict. To advance the state of the art on the seismic response of these aggregates, the Adjacent Interacting Masonry Structures (AIMS) subproject from Horizon 2020 project Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe (SERA) provides shake-table test data of a two-unit, double-leaf stone masonry aggregate subjected to two horizontal components of dynamic excitation. A blind prediction was organized with participants from academia and industry to test modelling approaches and assumptions and to learn about the extent of uncertainty in modelling for such masonry aggregates. The participants were provided with the full set of material and geometrical data, construction details and original seismic input and asked to predict prior to the test the expected seismic response in terms of damage mechanisms, base-shear forces, and roof displacements. The modelling approaches used differ significantly in the level of detail and the modelling assumptions. This paper provides an overview of the adopted modelling approaches and their subsequent predictions. It further discusses the range of assumptions made when modelling masonry walls, floors and connections, and aims at discovering how the common solutions regarding modelling masonry in general, and masonry aggregates in particular, affect the results. The results are evaluated both in terms of damage mechanisms, base shear forces, displacements and interface openings in both directions, and then compared with the experimental results. The modelling approaches featuring Discrete Element Method (DEM) led to the best predictions in terms of displacements, while a submission using rigid block limit analysis led to the best prediction in terms of damage mechanisms. Large coefficients of variation of predicted displacements and general underestimation of displacements in comparison with experimental results, except for DEM models, highlight the need for further consensus building on suitable modelling assumptions for such masonry aggregates.
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- Ercan, Ayse Bahar, et al.
(författare)
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Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
- 2024
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Ingår i: The Lancet Oncology. - : ELSEVIER SCIENCE INC. - 1470-2045 .- 1474-5488. ; 25:5, s. 668-682
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Tidskriftsartikel (refereegranskat)abstract
- Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD.In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries. Clinical data were extracted from the IRRDC database, medical records, and physician-completed case record forms. The primary objective was to describe the clinical features, cancer spectrum, and biology of the condition. Secondary objectives included estimations of cancer incidence and of the impact of the specific mismatch-repair gene and genotype on cancer onset and survival, including after cancer surveillance and immunotherapy interventions.We analysed data from 201 patients (103 males, 98 females) enrolled between June 5, 2007 and Sept 9, 2022. Median age at diagnosis of CMMRD or a related cancer was 8·9 years (IQR 5·9-12·6), and median follow-up from diagnosis was 7·2 years (3·6-14·8). Endogamy among minorities and closed communities contributed to high homozygosity within countries with low consanguinity. Frequent dermatological manifestations (117 [93%] of 126 patients with complete data) led to a clinical overlap with neurofibromatosis type 1 (35 [28%] of 126). 339 cancers were reported in 194 (97%) of 201 patients. The cumulative cancer incidence by age 18 years was 90% (95% CI 80-99). Median time between cancer diagnoses for patients with more than one cancer was 1·9 years (IQR 0·8-3·9). Neoplasms developed in 15 organs and included early-onset adult cancers. CNS tumours were the most frequent (173 [51%] cancers), followed by gastrointestinal (75 [22%]), haematological (61 [18%]), and other cancer types (30 [9%]). Patients with CNS tumours had the poorest overall survival rates (39% [95% CI 30-52] at 10 years from diagnosis; log-rank p<0·0001 across four cancer types), followed by those with haematological cancers (67% [55-82]), gastrointestinal cancers (89% [81-97]), and other solid tumours (96% [88-100]). All cancers showed high mutation and microsatellite indel burdens, and pathognomonic mutational signatures. MLH1 or MSH2 variants caused earlier cancer onset than PMS2 or MSH6 variants, and inferior survival (overall survival at age 15 years 63% [95% CI 55-73] for PMS2, 49% [35-68] for MSH6, 19% [6-66] for MLH1, and 0% for MSH2; p<0·0001). Frameshift or truncating variants within the same gene caused earlier cancers and inferior outcomes compared with missense variants (p<0·0001). The greater deleterious effects of MLH1 and MSH2 variants as compared with PMS2 and MSH6 variants persisted despite overall improvements in survival after surveillance or immune checkpoint inhibitor interventions.The very high cancer burden and unique genomic landscape of CMMRD highlight the benefit of comprehensive assays in timely diagnosis and precision approaches toward surveillance and immunotherapy. These data will guide the clinical management of children and patients who survive into adulthood with CMMRD.The Canadian Institutes for Health Research, Stand Up to Cancer, Children's Oncology Group National Cancer Institute Community Oncology Research Program, Canadian Cancer Society, Brain Canada, The V Foundation for Cancer Research, BioCanRx, Harry and Agnieszka Hall, Meagan's Walk, BRAINchild Canada, The LivWise Foundation, St Baldrick Foundation, Hold'em for Life, and Garron Family Cancer Center.
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- Aydin, Osman, et al.
(författare)
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EU FP7 INFSO-ICT-317669 METIS, D 4.1 Summary on preliminary trade-off investigations and first set of potential network-level solutions
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- METIS WP4 covers research activities in network-level aspects of the advancement of wireless network technologies towards the year 2020 and beyond. The aim is to develop novel network-level technology concepts to address the challenges foreseen in future scenarios with regard to interference, traffic and mobility management issues. Moreover, another task of this work package is to propose functional enablers which can support the above potential solutions.This document provides* a report of the ongoing progress in WP4 regarding the research topics agreed upon in IR 4.1,* a high level description of the proposed concepts and approaches adopted by different partners.More specifically, the document describes, first set of potential network-level solutions and presents some first research results in order to position them with regards to the state of the art approaches. It also gives an overview of research activities to be considered later in WP4.
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- Pellegrino, Luca, et al.
(författare)
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A Hybrid Superconductor/Nanomechanical Magnetic Field Detector for Biomagnetism
- 2023
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Ingår i: 2023 IEEE Nanotechnology Materials and Devices Conference, NMDC 2023. ; , s. 770-771
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Konferensbidrag (refereegranskat)abstract
- We report the results of the OXiNEMS project (www.oxinems.eu) concerning the realization of a high-sensitivity magnetometer made by a magnetic nanomechanical resonator coupled to a nanopatterned superconducting thin film structure integrated with a superconducting loop. We discuss the basic working principle of the device, its first characterizations and the instrumentation we developed to measure the device performances in view of its application in the field of biomagnetism.
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- Penna, Nigel T., et al.
(författare)
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Assessing the accuracy of predicted ocean tide loading displacement
- 2008
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Ingår i: Journal of Geodesy. - : Springer Science and Business Media LLC. - 0949-7714 .- 1432-1394. ; 82:12, s. 893-907
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Tidskriftsartikel (refereegranskat)abstract
- The accuracy of ocean tide loading (OTL)displacement values has long been assumed to be dominatedby errors in the ocean tide models used, with errorsdue to the convolution scheme used considered very small(2–5%). However, this paper shows that much larger convolutionerrors can arise at sites within approximately 150kmof the coastline, depending on the method used to refine thediscrete regularly spaced grid cells of the ocean tide modelto better fit the coastline closest to the site of interest. If thelocal water mass redistribution approach is implemented, asused in the OLFG/OLMPP software recommended in theIERS 2003 conventions, OTL height displacement errors ofup to around 20% can arise, depending on the ocean tidemodel used. Bilinear interpolation only, as used in theSPOTLand CARGA softwares for example, is shown from extensiveglobal and regional comparisons of OTL displacement valuesderived from the different methods and softwares to bemore appropriate. This is verified using GPS observations.The coastal refinement approach used in the OLFG/OLMPPsoftware was therefore changed in August 2007 to usebilinear interpolation only. It is shown that with this change, OTL displacement values computed using OLFG/OLMPP,SPOTL and CARGA invariably agree to the millimetre levelfor coastal sites, and better than 0.2mm for sites more thanabout 150km inland.
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