| 1. |
- Blomberg, Anders, et al.
(författare)
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Chronic Airflow Limitation, Emphysema and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-Aged Population.
- 2024
-
Ingår i: Annals of the American Thoracic Society. - 2329-6933 .- 2325-6621.
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Tidskriftsartikel (refereegranskat)abstract
- RATIONALE: Chronic obstructive pulmonary disease (COPD) includes respiratory symptoms and chronic airflow limitation (CAL). In some cases, emphysema and impaired diffusing capacity for carbon monoxide (DLCO) are present, but characteristics and symptoms vary with smoking exposure.OBJECTIVES: To study the prevalence of CAL, emphysema and impaired DLCO in relation to smoking and respiratory symptoms in a middle-aged population.METHODS: We investigated 28,746 randomly invited individuals (52% women) aged 50-64 years across six Swedish sites. We performed spirometry, DLCO, high-resolution computed tomography (HRCT) and asked for smoking habits and respiratory symptoms. CAL was defined as post-bronchodilator forced expiratory volume in 1 second divided by forced expiratory volume (FEV1/FVC)<0.7.RESULTS: The overall prevalence was for CAL 8.8%, for impaired DLCO (DLCOCONCLUSIONS: In this large population-based study of middle-aged people, CAL and impaired DLCO were associated with common respiratory symptoms. Self-reported asthma was not associated with CAL in never-smokers. Our findings suggest that CAL in never-smokers signifies a separate clinical phenotype that may be monitored and, possibly, treated differently from smoking-related COPD. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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| 2. |
- Lagedal, Rickard, et al.
(författare)
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Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients
- 2022
-
Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 11:12
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: the pathophysiologic mechanisms explaining differences in clinical outcomes following COVID-19 are not completely described. This study aims to investigate antibody responses in critically ill patients with COVID-19 in relation to inflammation, organ failure and 30-day survival. Methods: All patients with PCR-verified COVID-19 and gave consent, and who were admitted to a tertiary Intensive care unit (ICU) in Sweden during March-September 2020 were included. Demography, repeated blood samples and measures of organ function were collected. Analyses of anti-SARS-CoV-2 antibodies (IgM, IgA and IgG) in plasma were performed and correlated to patient outcome and biomarkers of inflammation and organ failure. Results: A total of 115 patients (median age 62 years, 77% male) were included prospectively. All patients developed severe respiratory dysfunction, and 59% were treated with invasive ventilation. Thirty-day mortality was 22.6% for all included patients. Patients negative for any anti-SARS-CoV-2 antibody in plasma during ICU admission had higher 30-day mortality compared to patients positive for antibodies. Patients positive for IgM had more ICU-, ventilator-, renal replacement therapy- and vasoactive medication-free days. IgA antibody concentrations correlated negatively with both SAPS3 and maximal SOFA-score and IgM-levels correlated negatively with SAPS3. Patients with antibody levels below the detection limit had higher plasma levels of extracellular histones on day 1 and elevated levels of kidney and cardiac biomarkers, but showed no signs of increased inflammation, complement activation or cytokine release. After adjusting for age, positive IgM and IgG antibodies were still associated with increased 30-day survival, with odds ratio (OR) 7.1 (1.5-34.4) and 4.2 (1.1-15.7), respectively. Conclusion: In patients with severe COVID-19 requiring intensive care, a poor antibody response is associated with organ failure, systemic histone release and increased 30-day mortality.
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| 3. |
- Andersson, Lena, 1965-, et al.
(författare)
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Respiratory Health and Inflammatory Markers : Exposure to Cobalt in the Swedish Hard Metal Industry
- 2020
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Ingår i: Journal of Occupational and Environmental Medicine. - : Lippincott Williams & Wilkins. - 1076-2752 .- 1536-5948. ; 62:10, s. 820-829
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study the relationship between inhalable dust and cobalt and respiratory symptoms, lung function, exhaled nitric oxide in expired air and CC16 in the Swedish hard metal industry.METHODS: Personal sampling of inhalable dust and cobalt, medical examination including blood sampling was performed for 72 workers. Exposure-response relationships was determined using logistic, linear and mixed model analysis.RESULTS: The average inhalable dust and cobalt concentrations were 0.079 and 0.0017 mg/m, respectively. Statistically significant increased serum levels of CC16 were determined when the high and low cumulative exposures for cobalt were compared. Non-significant exposure-response relationships was observed between cross-shift inhalable dust or cobalt exposures and asthma, nose dripping and bronchitis.CONCLUSIONS: Our findings suggest an exposure-response relationship between inhalable cumulative cobalt exposure and CC16 levels in blood, which may reflect an injury or a reparation process in the lungs.
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| 4. |
- Berntsson, Thore, 1947, et al.
(författare)
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Towards Sustainabel Oil Refinery - Pre-study for larger co-operation project
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this report, the Chalmers EnergiCentrum (CEC) presents the results of a pre-study commissioned by Preem relating to the effective production of future vehicle fuels.This pre-study was made up of three studies focusing on energy streamlining, the utilisation of waste heat and carbon-dioxide separation and biorefinement relating to the gasification and hydration of vegetable oils. One of the common starting points for these studies was the current situation at the Preem refineries in Göteborg and Lysekil from where the measurement data were obtained and analysed. The report summarises the knowledge situation based on current research in the individual technical fields. The results present some interesting future opportunities for developing the sustainable production of future vehicle fuels. The sections vary, as the areas that have been examined differ and the sections have been written by different people. The reports ends with some joint conclusions and a number of questions which could be included and answered in a more extensive future main study, as part of a developed research partnership between Preem and the Chalmers University of Technology. The preliminary results of this work were analysed with the client at workshops on 1 October and 29 November 2007. The report is written in English combined with an extensive summary in Swedish including a proposal on a future main study. The study was conducted by the Chalmers EnergiCentrum (CEC), in collaboration with a number of researchers in the CEC’s network. They included Thore Berntsson, Jessica Algehed, Erik Hektor and Lennart Persson Elmeroth, all from Heat and Power Technology, Börje Gevert, Chemical and Biological Engineering, Tobias Richards, Forest Products and Chemical Engineering, Filip Johnsson and Anders Lyngfelt, Energy Technology, and Per-Åke Franck and Anders Åsblad, CIT Industriell Energianalys AB. The client, Preem, was represented by Bengt Ahlén, Sören Eriksson, Johan Jervehed, Bertil Karlsson, Gunnar Olsson, Ulf Kuylenstierna, Stefan Nyström, Martin Sjöberg and Thomas Ögren. Tobias Richards was responsible for compiling the report and Bertil Pettersson was the project manager.
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| 5. |
- Boman, Christoffer, et al.
(författare)
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Development of innovative small(micro)-scale biomass-based CHP technologies
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- To enhance the overall efficiency of the use of biomass in the energy sector in Europe, the large electricity production potential from small-scale biomass heating systems should be utilised. So far, no technologically sound (in terms of efficiency and reliability) and economically affordable micro- and small-scale biomass CHP technologies are, however, available. Therefore, the present ERA-NET project (MiniBioCHP) aimed at the further development and test of new CHP technologies based on small-scale biomass combustion in the electric capacity range between some W and 100 kW. Within the project, an international consortium consisting of 12 partners from 4 countries, including university institutions, institutes and industry (both engineering and manufacturing), collaborated closely to perform high level R&D on three promising micro/small-scale biomass based CHP technologies which are covering a broad range of applications in the residential heating sector. The Austrian engineering company BIOS, coordinated the international project. The project was based on earlier basic research and development work related to these promising new technologies and aimed at the achievement of a technological level which allows a first (commercial) demonstration after the end of the project. The three CHP concepts included in the MiniBioCHP project were;1. Pellet stoves with a thermoelectric generator (TEG)2. Small-scale biomass boilers (10-30 kWth) with a micro-ORC process3. High temperature heat exchanger (HT-HE) for an externally fired gas turbine (EFGT)The Swedish part of the project was focused on the development of the concept of biomass based EFGT with dedicated R&D activities related to the development of the HT-HE system. The Swedish project consisted of the research partners Umeå University (project leader), Luleå University of Technology, Chalmers University of Technology and RISE Research Institutes of Sweden, together with the industrial partners Enertech AB/Osby Parca and Ecergy. The expertise of the Swedish partners regarding ash related problems, grate boiler combustion and modelling, deposit formation and high temperature corrosion, were combined with the know-how of a Polish partner regarding HT-HE design, construction, testing and optimisation.The HT-HE is the most crucial component in EFGT processes significantly influencing the investment costs, availabilities as well as the efficiencies that can be achieved. With a thermal capacity from several hundred kW up to 2-3 MWth) the CHP technology based on a biomass boiler and an EFGT is suitable for district heating systems, or process heat consumers. The electricity produced by the gas turbine (up to some 100 kWel) can be used to cover the own electricity consumption of a company and/or fed into the grid. Even though the concept of biomass based EFGT has been an interesting alternative for small-scale CHP production for some decades, and R&D activities have been undertaken, tackling both economic and technical aspects, only a few pilot-plants have been in operation and no initiative has so far reached the level of commercial implementation. Thus, the concept of EFGT fed with biomass is still considered to be in a rather early development stage and the main technical challenges are related to alkali deposit induced corrosion and thermal stress of the HT-HE material, turbine design/operation and system integration.Within the present project, a HT-HE prototype aimed for an EFGT system was therefore designed, constructed and successfully tested at flue gas temperatures up to 900°C. Thus, appropriate guidelines for a compact design of the HT-HE and recommendations have been worked out to minimize thermal stresses as well as ash related problems regarding ash deposit formation and high temperature corrosion in a biomass boiler system. Furthermore, different concepts for the overall biomass based EFGT system have been worked out and evaluated. The outcome of the project will hopefully be used in the further development work and form the basis for a first testing and demonstration plant within the coming years.
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| 6. |
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| 7. |
- Sönnerfors, Pernilla, et al.
(författare)
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The challenges of recruiting never-smokers with chronic obstructive pulmonary disease from the large population-based Swedish CArdiopulmonary bioImage study (SCAPIS) cohort.
- 2024
-
Ingår i: European Clinical Respiratory Journal. - : Taylor & Francis. - 2001-8525. ; 11:1, s. 2372903-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A substantial proportion of individuals with COPD have never smoked, and it is implied to be more common than previously anticipated but poorly studied.AIM: To describe the process of recruitment of never-smokers with COPD from a population-based cohort (n = 30 154).METHODS: We recruited never-smokers with COPD, aged 50-75 years, from six University Hospitals, based on: 1) post broncho-dilator forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) < 0.70 and 2) FEV1 50-100% of predicted value and 3) being never-smokers (self-reported). In total 862 SCAPIS participants were identified, of which 652 were reachable and agreed to a first screening by telephone. Altogether 128 (20%) were excluded due to previous smoking or declined participation. We also applied a lower limit of normal (LLN) of FEV1/FVC (z-score<-1.64) according to the Global Lung Initiative to ensure a stricter definition of airflow obstruction.RESULTS: Data on respiratory symptoms, health status, and medical history were collected from 492 individuals, since 32 were excluded at a second data review (declined or previous smoking), prior to the first visit. Due to not matching the required lung function criteria at a second spirometry, an additional 334 (68%) were excluded. These exclusions were by reason of: FEV1/FVC ≥0.7 (49%), FEV1 > 100% of predicted (26%) or z-score ≥ -1,64 (24%). Finally, 154 never-smokers with COPD were included: 56 (36%) women, (mean) age 60 years, FEV1 84% of predicted, FEV1/FVC: 0.6, z-score: -2.2, Oxygen saturation: 97% and BMI: 26.8 kg/m2.CONCLUSIONS: The challenges of a recruitment process of never-smokers with COPD were shown, including the importance of correct spirometry testing and strict inclusion criteria. Our findings highlight the importance of repeated spirometry assessments for improved accuracy in diagnosing COPD.
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| 8. |
- Torén, Kjell, 1952, et al.
(författare)
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Chronic airflow limitation and its relation to respiratory symptoms among ever-smokers and never-smokers: a cross-sectional study
- 2020
-
Ingår i: Bmj Open Respiratory Research. - : BMJ. - 2052-4439. ; 7:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background The diagnosis of chronic obstructive pulmonary disease is based on the presence of persistent respiratory symptoms and chronic airflow limitation (CAL). CAL is based on the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1:FVC) after bronchodilation, and FEV1:FVC less than the fifth percentile is often used as a cut-off for CAL. The aim was to investigate if increasing percentiles of FEV1:FVC were associated withany respiratory symptom(cough with phlegm, dyspnoea or wheezing) in a general population sample of never-smokers and ever-smokers. Methods In a cross-sectional study comprising 15 128 adults (50-64 years), 7120 never-smokers and 8008 ever-smokers completed a respiratory questionnaire and performed FEV(1)and FVC after bronchodilation. We calculated theirz-scores for FEV1:FVC and defined the fifth percentile using the Global Lung Function Initiative (GLI) reference value, GLI(5)and increasing percentiles up to GLI(25). We analysed the associations between different strata of percentiles and prevalence ofany respiratory symptomusing multivariable logistic regression for estimation of OR. Results Among all subjects, regardless of smoking habits, the odds ofany respiratory symptomwere elevated up to the GLI(15-20)strata. Among never-smokers, the odds ofany respiratory symptomwere elevated at GLI(<5)(OR 3.57, 95% CI 2.43 to 5.23) and at GLI(5-10)(OR 2.57, 95% CI 1.69 to 3.91), but not at higher percentiles. Among ever-smokers, the odds ofany respiratory symptomwere elevated from GLI(<5)(OR 4.64, 95% CI 3.79 to 5.68) up to GLI(>= 25)(OR 1.33, 95% CI 1.00 to 1.75). Conclusions The association between percentages of FEV1:FVC and respiratory symptoms differed depending on smoking history. Our results support a higher percentile cut-off for FEV1:FVC for never-smokers and, in particular, for ever-smokers.
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| 9. |
- Andersson, Lena, 1965-, et al.
(författare)
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Respiratory health and inflammatory markers : Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries
- 2019
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Ingår i: PLOS ONE. - : PLOS. - 1932-6203. ; 14:11
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To study the relationship between respirable dust, quartz and chemical binders in Swedish iron foundries and respiratory symptoms, lung function (as forced expiratory volume FEV1 and vital capacity FVC), fraction of exhaled nitric oxide (FENO) and levels of club cell secretory protein 16 (CC16) and CRP.METHODS: Personal sampling of respirable dust and quartz was performed for 85 subjects in three Swedish iron foundries. Full shift sampling and examination were performed on the second or third day of a working week after a work free weekend, with additional sampling on the fourth or fifth day. Logistic, linear and mixed model analyses were performed including, gender, age, smoking, infections, sampling day, body mass index (BMI) and chemical binders as covariates.RESULTS: The adjusted average respirable quartz and dust concentrations were 0.038 and 0.66 mg/m3, respectively. Statistically significant increases in levels of CC16 were associated with exposure to chemical binders (p = 0.05; p = 0.01) in the regression analysis of quartz and respirable dust, respectively. Non-significant exposure-responses were identified for cumulative quartz and the symptoms asthma and breathlessness. For cumulative chemical years, non-significant exposure-response were observed for all but two symptoms. FENO also exhibited a non significant exposure-response for both quartz and respirable dust. No exposure-response was determined for FEV1 or FVC, CRP and respirable dust and quartz.CONCLUSIONS: Our findings suggest that early markers of pulmonary effect, such as increased levels of CC16 and FENO, are more strongly associated with chemical binder exposure than respirable quartz and dust in foundry environments.
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| 10. |
- Axelsson, Emil, 1978, et al.
(författare)
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Feldspar: A Domain Specific Language for Digital Signal Processing algorithms
- 2010
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Ingår i: Eighth ACM/IEEE International Conference on Formal Methods and Models for Codesign. - 9781424478859 ; , s. 169-178
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Konferensbidrag (refereegranskat)abstract
- A new language, Feldspar, is presented, enabling high-level and platform-independent description of digital signal processing (DSP) algorithms. Feldspar is a pure functional language embedded in Haskell. It offers a high-level dataflow style of programming, as well as a more mathematical style based on vector indices. The key to generating efficient code from such descriptions is a high-level optimization technique called vector fusion. Feldspar is based on a low-level, functional core language which has a relatively small semantic gap to machine-oriented languages like C. The core language serves as the interface to the back-end code generator, which produces C. For very small examples, the generated code performs comparably to hand-written C code when run on a DSP target. While initial results are promising, to achieve good performance on larger examples, issues related to memory access patterns and array copying will have to be addressed.
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| 11. |
- Axelsson, Emil, 1978, et al.
(författare)
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The Design and Implementation of Feldspar: An Embedded Language for Digital Signal Processing
- 2011
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Ingår i: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. - 9783642242755 ; 6647, s. 121-136
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Konferensbidrag (refereegranskat)abstract
- Feldspar is a domain specific language, embedded in Haskell, for programming digital signal processing algorithms. The final aim of a Feldspar program is to generate low level code with good performance. Still, we chose to provide the user with a purely functional DSL. The language is implemented as a minimal, deeply embedded core language, with shallow extensions built upon it. This paper presents full details of the essential parts of the implementation. Our initial conclusion is that this approach works well in our domain, although much work remains.
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| 12. |
- Axelsson, Emil, 1978, et al.
(författare)
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The Design and Implementation of Feldspar: an Embedded Language for Digital Signal Processing
- 2010
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Ingår i: IFL 2010, the 22nd Symposium on Implementation and Application of Functional Languages.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Feldspar is a Domain Specific Language, embedded in Haskell, for programming Digital Signal Processing algorithms. The final aim of a Feldspar program is to generate low level code with good performance. Still, we chose to provide the user with a purely functional DSL. The language is implemented as a minimal, deeply embedded core language, with shallow extensions built upon it. This paper presents full details of the essential parts of the implementation. Our initial conclusion is that this approach works well in our domain, although much work remains.
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| 13. |
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| 14. |
- Axelsson, Karin, 1968-, et al.
(författare)
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Communication Analysis of Public Forms : Discovering Multi-functional Purposes in Citizen and Government Communication
- 2007
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Ingår i: International Journal of Public Information Systems. - Sundsvall : MidSweden University. - 1653-4360. ; :3, s. 161-181
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Tidskriftsartikel (refereegranskat)abstract
- This paper adopts a communication perspective on forms in public e-services. This perspective emphasizes that the main purpose of such forms is to facilitate communication between citizens and government agencies. The form is perceived as a tool for performing communicative actions. A communication analysis (CA) method, originally developed for systems requirements engineering, is applied on a public form; i.e. the medical certificate used in connection with a citizen’s application for a provisional driving license in Sweden. The CA method consists of a set of questions related tothree communicative categories; conditions, actions, and consequences. The CA method is used in order to explore the communicative roles of forms in public e-services. As a result of the communication analysis four multi-functional purposes of citizen and government agency communication are discovered. These purposes contribute to the understanding and evaluation of forms in public e-services. The communicative roles, and their multi-functional purposes, are important design features to focus in the development of e-services and electronic forms. Besides these findings, another outcomeis that the CA method has been tested in an e-government context. The communication perspective, as well as the CA method, contribute with useful insights in this context.
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| 15. |
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| 16. |
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| 17. |
- Bresell, Anders, 1978-
(författare)
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Characterization of protein families, sequence patterns, and functional annotations in large data sets
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Bioinformatics involves storing, analyzing and making predictions on massive amounts of protein and nucleotide sequence data. The thesis consists of six papers and is focused on proteins. It describes the utilization of bioinformatics techniques to characterize protein families and to detect patterns in gene expression and in polypeptide occurrences. Two protein families were bioinformatically characterized - the membrane associated proteins in eicosanoid and glutathione metabolism (MAPEG) and the Tripartite motif (TRIM) protein families.In the study of the MAPEG super-family, application of different bioinformatic methods made it possible to characterize many new members leading to a doubling of the family size. Furthermore, the MAPEG members were subdivided into families. Remarkably, in six families with previously predominantly mammalian members, fish representatives were also now detected, which dated the origin of these families back to the Cambrium ”species explosion”, thus earlier than previously anticipated. Sequence comparisons made it possible to define diagnostic sequence patterns that can be used in genome annotations. Upon publication of several MAPEG structures, these patterns were confirmed to be part of the active sites.In the TRIM study, the bioinformatic analyses made it possible to subdivide the proteins into three subtypes and to characterize a large number of members. In addition, the analyses showed crucial structural dependencies between the RING and the B-box domains of the TRIM memberRo52. The linker region between the two domains, denoted RBL, is knownto be disease associated. Now, an amphipathic helix was found to be acharacteristic feature of the RBL region, which also was used to divide the family into three subtypes.The ontology annotation treebrowser (OAT) tool was developed to detect functional similarities or common concepts in long lists of proteins or genes, typically generated from proteomics or microarray experiments. OAT was the first annotation browser to include both Gene Ontology (GO) and Medical Subject Headings (MeSH) into the same framework. The complementarity of these two ontologies was demonstrated. OAT was used in the TRIM study to detect differences in functional annotations between the subtypes.In the oligopeptide study, we investigated pentapeptide patterns that were over- or under-represented in the current de facto standard database of protein knowledge and a set of completed genomes, compared to what could be expected from amino acid compositions. We found three predominant categories of patterns: (i) patterns originating from frequently occurring families, e.g. respiratory chain-associated proteins and translation machinery proteins; (ii) proteins with structurally and/or functionally favored patterns; (iii) multicopy species-specific retrotransposons, only found in the genome set. Such patterns may influence amino acid residue based prediction algorithms. These findings in the oligopeptide study were utilized for development of a new method that detects translated introns in unverified protein predictions, which are available in great numbers due to the many completed and ongoing genome projects.A new comprehensive database of protein sequences from completed genomes was developed, denoted genomeLKPG. This database was of central importance in the MAPEG, TRIM and oligopeptide studies. The new sequence database has also been proven useful in several other studies.
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| 18. |
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| 19. |
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| 20. |
- de Brun, Maryam, 1991-, et al.
(författare)
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Changing diagnostic criteria for gestational diabetes (CDC4G) in Sweden : A stepped wedge cluster randomised trial
- 2024
-
Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 21:7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The World Health Organisation (WHO) 2013 diagnostic criteria for gestational diabetes mellitus (GDM) has been criticised due to the limited evidence of benefits on pregnancy outcomes in different populations when switching from previously higher glycemic thresholds to the lower WHO-2013 diagnostic criteria. The aim of this study was to determine whether the switch from previous Swedish (SWE-GDM) to the WHO-2013 GDM criteria in Sweden following risk factor-based screening improves pregnancy outcomes.METHODS AND FINDINGS: A stepped wedge cluster randomised trial was performed between January 1 and December 31, 2018 in 11 clusters (17 delivery units) across Sweden, including all pregnancies under care and excluding preexisting diabetes, gastric bypass surgery, or multifetal pregnancies from the analysis. After implementation of uniform clinical and laboratory guidelines, a number of clusters were randomised to intervention (switch to WHO-2013 GDM criteria) each month from February to November 2018. The primary outcome was large for gestational age (LGA, defined as birth weight >90th percentile). Other secondary and prespecified outcomes included maternal and neonatal birth complications. Primary analysis was by modified intention to treat (mITT), excluding 3 clusters that were randomised before study start but were unable to implement the intervention. Prespecified subgroup analysis was undertaken among those discordant for the definition of GDM. Multilevel mixed regression models were used to compare outcome LGA between WHO-2013 and SWE-GDM groups adjusted for clusters, time periods, and potential confounders. Multiple imputation was used for missing potential confounding variables. In the mITT analysis, 47 080 pregnancies were included with 6 882 (14.6%) oral glucose tolerance tests (OGTTs) performed. The GDM prevalence increased from 595/22 797 (2.6%) to 1 591/24 283 (6.6%) after the intervention. In the mITT population, the switch was associated with no change in primary outcome LGA (2 790/24 209 (11.5%) versus 2 584/22 707 (11.4%)) producing an adjusted risk ratio (aRR) of 0.97 (95% confidence interval 0.91 to 1.02, p = 0.26). In the subgroup, the prevalence of LGA was 273/956 (28.8%) before and 278/1 239 (22.5%) after the switch, aRR 0.87 (95% CI 0.75 to 1.01, p = 0.076). No serious events were reported. Potential limitations of this trial are mainly due to the trial design, including failure to adhere to guidelines within and between the clusters and influences of unidentified temporal variations.CONCLUSIONS: In this study, implementing the WHO-2013 criteria in Sweden with risk factor-based screening did not significantly reduce LGA prevalence defined as birth weight >90th percentile, in the total population, or in the subgroup discordant for the definition of GDM. Future studies are needed to evaluate the effects of treating different glucose thresholds during pregnancy in different populations, with different screening strategies and clinical management guidelines, to optimise women's and children's health in the short and long term.TRIAL REGISTRATION: The trial is registered with ISRCTN (41918550).
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| 21. |
- Dévai, Gergely, et al.
(författare)
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Efficient Code Generation from the High-level Domain-specific Language Feldspar for DSPs
- 2010
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Ingår i: ODES-8: 8th Workshop on Optimizations for DSP and Embedded Systems, workshop associated with IEEE/ACM International Symposium on Code Generation and Optimization (CGO).
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Konferensbidrag (refereegranskat)abstract
- Software for digital signal processors (DSPs) is traditionally highly hardware-dependent and hence porting it to new processors usually requires significant design effort. In this paper we present Feldspar (Functional Embedded Language for DSP and Parallelism), an embedded, high-level, domain-specific language for DSP algorithm design and the compilation techniques we developed for generating C code from specifications written in Feldspar. While Feldspar allows description of algorithms on specification level, we show that with the right set of abstractions and transformations this high level, functional specification can be transformed into C code that is comparable or better than reference, hand-crafted C language implementations. The Feldspar compiler is highly modular and plugin-based, hence future hardware-specific plugins will enable automatic generation of efficient, hardware-specific code. This approach enables the encapsulation of knowledge of hardware completely in the compiler and thus allows description of algorithms in completely hardware-independent, portable manner.
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| 22. |
- Ellgardt, Anders, 1978-, et al.
(författare)
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Characteristics of a broad-band wide-scan fragmented aperture phased array antenna
- 2006
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Konferensbidrag (refereegranskat)abstract
- In this paper a phased array antenna is described that is designed with the help of a genetic algorithm for scan angles out to 60° from broadside. The focus is on simplifying the manufacturing of the diagonally adjoining pixels and on numerical results for thin antennas. The effects of the corner to corner contacts are studied and results for two synthesized elements ar Test and measurement requirements on wireless devices
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| 23. |
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| 24. |
- Flodén, Liselott, 1967-, et al.
(författare)
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A myriad shades of green
- 2009
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Ingår i: Proceedings of Bridges 2009, Banff, Alberta, Canada.
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Konferensbidrag (refereegranskat)abstract
- We discuss the possible application of techniques inspired by the theories of G-convergence and homogenization to understand mixtures of colors and how they appear as observed by the human eye. The ideas are illustrated by pictures describing the equivalent of a convergence process for different kinds of mixtures of colors.
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| 25. |
- Flodén, Liselott, 1967-, et al.
(författare)
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Detection of scales of heterogeneity and parabolic homogenization applying very weak multiscale convergence
- 2011
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Ingår i: Annals of Functional Analysis. - Mashdad, Iran : TSMG. - 2008-8752. ; 2:1, s. 84-99
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Tidskriftsartikel (refereegranskat)abstract
- We apply a new version of multiscale convergence named very weak multiscale convergence to find possible frequencies of oscillation in an unknown coefficient of a diffeential equation from its solution. We also use thís notion to study homogenization of a certain linear parabolic problem with multiple spatial and temporal scales
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| 26. |
- Flodén, Liselott, et al.
(författare)
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Homogenization of a Hyperbolic-Parabolic Problem with Three Spatial Scales
- 2017
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Ingår i: Progress in Industrial Mathematics at ECMI 2016. - Cham : Springer. - 9783319630816 ; , s. 617-623
-
Konferensbidrag (refereegranskat)abstract
- We study the homogenization of a certain linear hyperbolic-parabolic problem exhibiting two rapid spatial scales {ε; ε2}. The homogenization is performed by means of evolution multiscale convergence, a generalization of the concept of two-scale convergence to include any number of scales in both space and time. In particular we apply a compactness result for gradients. The outcome of the homogenization procedure is that we obtain a homogenized problem of hyperbolic-parabolic type together with two elliptic local problems, one for each rapid scale, for the correctors.
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| 27. |
- Flodén, Liselott, 1967-, et al.
(författare)
-
Homogenization of parabolic equations with an arbitrary number of scales in both space and time
- 2014
-
Ingår i: Journal of Applied Mathematics. - Boston : Hindawi Publishing Corporation. - 1110-757X .- 1687-0042. ; , s. Art. no. 101685-
-
Tidskriftsartikel (refereegranskat)abstract
- The main contribution of this paper is the homogenization of the linearparabolic equationtu (x, t) − ·axq1, ...,xqn,tr1, ...,trmu (x, t)= f(x, t)exhibiting an arbitrary finite number of both spatial and temporal scales.We briefly recall some fundamentals of multiscale convergence and providea characterization of multiscale limits for gradients in an evolution settingadapted to a quite general class of well-separated scales, which we nameby jointly well-separated scales (see Appendix for the proof). We proceedwith a weaker version of this concept called very weak multiscale convergence.We prove a compactness result with respect to this latter typefor jointly well-separated scales. This is a key result for performing thehomogenization of parabolic problems combining rapid spatial and temporaloscillations such as the problem above. Applying this compactnessresult together with a characterization of multiscale limits of sequences ofgradients we carry out the homogenization procedure, where we togetherwith the homogenized problem obtain n local problems, i.e. one for eachspatial microscale. To illustrate the use of the obtained result we apply itto a case with three spatial and three temporal scales with q1 = 1, q2 = 2and 0 < r1 < r2.MSC: 35B27; 35K10
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| 28. |
- Flodén, Liselott, 1967-, et al.
(författare)
-
On the determination of effective properties of certain structures with non-periodic temporal oscillations
- 2009
-
Ingår i: MATHMOD 2009 - 6th Vienna International Conference on Mathematical Modelling. - Wien : Vienna University Press (WUV). - 9783901608353 ; , s. 2627-2630
-
Konferensbidrag (refereegranskat)abstract
- We investigate the homogenization of an evolution problem modelled by a parabolic equation, where the coefficient describing the structure is periodic in space but may vary in time in a non-periodic way. This is performed applying a generalization of two-scale convergence called λ-scale convergence. We give a result on the characterization of the λ-scale limit of gradients under certain boundedness assumptions. This is then applied to perform the homogenization procedure. It turns out that, under a certain condition on the rate of change of the temporal variations, the effective property of the given structure can be determined the same way as in periodic cases.
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| 29. |
- Flodén, Liselott, 1967-, et al.
(författare)
-
Two-scale convergence: Some remarks and extensions
- 2013
-
Ingår i: Pure and Applied Mathematics Quarterly. - : International press of Boston. - 1558-8599 .- 1558-8602. ; 9:3, s. 461-486
-
Tidskriftsartikel (refereegranskat)abstract
- We first study the fundamental ideas behind two-scale conver-gence to enhance an intuitive understanding of this notion. The classicaldefinitions and ideas are motivated with geometrical arguments illustratedby illuminating figures. Then a version of this concept, very weak two-scaleconvergence, is discussed both independently and brie°y in the context ofhomogenization. The main features of this variant are that it works alsofor certain sequences of functions which are not bounded inL2 and atthe same time is suited to detect rapid oscillations in some sequences whichare strongly convergent inL2 . In particular, we show how very weaktwo-scale convergence explains in a more transparent way how the oscilla-tions of the governing coe±cient of the PDE to be homogenized causes thedeviation of theG-limit from the weak L2 NxN-limit for the sequence ofcoe±cients. Finally, we investigate very weak multiscale convergence andprove a compactness result for separated scales which extends a previousresult which required well-separated scales.
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| 30. |
- Frost, Rickard, 1979, et al.
(författare)
-
Core−Shell Nanoplasmonic Sensing for Characterization of Biocorona Formation and Nanoparticle Surface Interactions
- 2016
-
Ingår i: ACS Sensors. - : American Chemical Society (ACS). - 2379-3694. ; 1:6, s. 798-806
-
Tidskriftsartikel (refereegranskat)abstract
- Surface properties of nanoparticles imposed by particle size, shape, and surface chemistry are key features that largely determine their environmental fate and effects on biological systems. Consequently, development of analytical tools to characterize surface properties of nanomaterials and their relation to toxicological properties must occur in parallel with applications. As a contribution to this quest, we present a nanoplasmonic sensing strategy that enables systematic in situ characterization of molecule−nanoparticle interactions under well-controlled conditions, in terms of both nanoparticle size and surface chemistry, with particular focus on the importance of surface faceting in crystalline nanoparticles. We assess the performance of our sensing strategy by presenting two case studies. (i) The first is protein corona formation on faceted Au core−SiO2 shell nanoparticles of different sizes, and thus different surface facet-to-edge ratios. Based on 2D and 3D models of the investigated structures, we find that for small particles the curved regions between adjacent facets dominate the response of the corona formation process, whereas the facets dominate the response in the large particle regime. (ii) The second is in situ functionalization of Au core−SiO2 shell nanoparticle surfaces, and analysis of the subsequent protein repellent behavior. Due to the versatility of the presented sensing strategy in studies of nanoparticle surface properties, including in situ surface modifications, and their interactions with (bio)molecules during corona formation, we foresee it to become a valuable tool in the areas of nanomedicine and nanotoxicology.
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| 31. |
- Goldkuhl, Göran, 1949-, et al.
(författare)
-
Characteristics of Public E-services : Investigating the E-diamond Model
- 2006
-
Ingår i: First International Conference on the Pragmatic Web, PragWeb 2006. - Bonn : Gesellschaft für Informatik. - 3885791838 - 9783885791836
-
Konferensbidrag (refereegranskat)abstract
- The issue of the paper is how to characterize public e-services mediated through the web. One common kind of characterization is made through stage models (e-ladders). Such models are frequently used for pol-icy-planning, evaluation and bench-marking of public e-services. E-ladder models have been criticized and as an alternative the e-diamond model has been formulated, which consists of twelve categories in three polarities (in-formative vs performative; general vs individualized; separate vs coordi-nated). The differences between e-ladder and e-diamond models are de-scribed in the paper. Empirical investigations of some public e-services based on the e-diamond model are pursued. A theoretical analysis of the e-diamond model based on the language-action perspective is performed. This follows the view that public e-services are seen as government – citizen communication. The empirical and theoretical investigations give further support to the e-diamond model.
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| 32. |
- Goldkuhl, Göran, 1949-, et al.
(författare)
-
From e-ladder to e-diamond - re-conceptualising models for public e-services
- 2006
-
Ingår i: Proceedings of the 14th European Conference on Information Systems,2006. - Göteborg : Göteborgs universitet. - 9789163198946 ; , s. 584-595
-
Konferensbidrag (refereegranskat)abstract
- There is rapid growth in the development and launching of new public e-services to citizens. In doing this, government agencies base their work on national and international programs for e-government development. Many such programs include a stage model for public e-services. Many such models comprise stages of 1) information, 2) interaction, 3) transaction and 4) interaction. The wide spread use of such stage models (e-ladders) give rise to several questions. Are the categories of a stage model well chosen? Do e-services evolve through such a series of stages? Is there a real advancement between the different stages? Should one always strive for higher stages? Are higher stages inherently better than lower stages? Is a stage model a proper yardstick for evaluation and benchmarking? The paper pursues a critical examination of such stage models (called e-ladder). A conceptual analysis of stage models is performed based on a socio-pragmatic foundation. Empirical examples are given that show weaknesses in the assumptions and conceptualisations of stage models. An alternative model -the e-diamond - is presented consisting of three polarities (informative vs performative; standardized vs individualized; separate vs coordinated).
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| 33. |
- Hultström, Michael, 1978-, et al.
(författare)
-
Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation : A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients
- 2022
-
Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 10:6
-
Tidskriftsartikel (refereegranskat)abstract
- Hypercoagulation and endothelial dysfunction play central roles in severe forms of COVID-19 infections, but the molecular mechanisms involved are unclear. Increased plasma levels of the inflammatory cytokine and TIE2 receptor antagonist Angiopoietin-2 were reported in severely ill COVID-19 patients. In vitro experiments suggest that Angiopoietin-2 bind and inhibits thrombomodulin. Thrombomodulin is expressed on the luminal surface of endothelial cells where it is an important member of the intrinsic anticoagulant pathway through activation of protein C. Using clinical data, mouse models, and in vitro assays, we tested if Angiopoietin-2 plays a causal role in COVID-19-associated hypercoagulation through direct inhibition of thrombin/thrombomodulin-mediated physiological anticoagulation. Angiopoietin-2 was measured in 61 patients at admission, and after 10 days in the 40 patients remaining in the ICU. We found that Angiopoietin-2 levels were increased in COVID-19 patients in correlation with disease severity, hypercoagulation, and mortality. In support of a direct effect of Angiopoietin-2 on coagulation, we found that injected Angiopoietin-2 in mice associated to thrombomodulin and resulted in a shortened tail bleeding time, decreased circulating levels of activated protein C, and increased plasma thrombin/antithrombin complexes. Conversely, bleeding time was increased in endothelial-specific Angiopoietin-2 knockout mice, while knockout of Tie2 had no effect on tail bleeding. Using in vitro assays, we found that Angiopoietin-2 inhibited thrombomodulin-mediated anticoagulation and protein C activation in human donor plasma. Our data suggest a novel in vivo mechanism for Angiopoietin-2 in COVID-19-associated hypercoagulation, implicating that Angiopoietin-2 inhibitors may be effective in the treatment of hypercoagulation in severe COVID-19 infection.
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| 34. |
- Johnsen, Pernilla
(författare)
-
Homogenization of Partial Differential Equations using Multiscale Convergence Methods
- 2021
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The focus of this thesis is the theory of periodic homogenization of partial differential equations and some applicable concepts of convergence. More precisely, we study parabolic problems exhibiting both spatial and temporal microscopic oscillations and a vanishing volumetric heat capacity type of coefficient. We also consider a hyperbolic-parabolic problem with two spatial microscopic scales. The tools used are evolution settings of multiscale and very weak multiscale convergence, which are extensions of, or closely related to, the classical method of two-scale convergence. The novelty of the research in the thesis is the homogenization results and, for the studied parabolic problems, adapted compactness results of multiscale convergence type.
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| 35. |
- Larsson, Ida, 1978-, et al.
(författare)
-
Development of a screening test based on isothermal calorimetry for determination of self-heating potential of biomass pellets
- 2017
-
Ingår i: Fire and Materials. - : John Wiley & Sons. - 0308-0501 .- 1099-1018. ; 41:8, s. 940-952
-
Tidskriftsartikel (refereegranskat)abstract
- For the risk for spontaneous combustion in storage of biomass pellets to be assessed, it is important to know how prone the fuel is to self-heating. There are traditional methods that are used to determine self-heating characteristics of fuels, eg, basket heating tests. The results from basket heating tests indirectly give the reactivity from a series of tests at high temperatures. This paper presents a sensitive screening test procedure for biomass pellets using isothermal calorimetry for direct measurement of the heat production rate at typical bulk storage temperatures. This method can be used to directly compare the reactivity of different batches of biomass pellets. The results could be used, eg, by storage security managers to gain better knowledge of their fuels propensity for self-heating and thereby for safer storage. A large number of tests have been performed to develop the test procedure presented. Different parameters, such as temperature, type of the test sample (powder/crushed or pellets), mass of test sample, and preheating time, have been varied. Furthermore, gas concentrations in the sample ampoule have been measured before and after some tests to study the oxygen consumption and the formation of CO and CO2. Three different types of pellets with different characteristics were tested to assess the variation in behaviour. Based on these tests, a screening test procedure is presented with a test temperature of 60°C, a sample size of 4 g, a 15-minute preheating period at the test temperature, and 24-hour test duration.
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| 36. |
- Malinovschi, Andrei, 1978-, et al.
(författare)
-
Assessment of Global Lung Function Initiative (GLI) reference equations for diffusing capacity in relation to respiratory burden in the Swedish CArdioPulmonary bioImage Study (SCAPIS)
- 2020
-
Ingår i: European Respiratory Journal. - Lausanne, Switzerland : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 56:2
-
Tidskriftsartikel (refereegranskat)abstract
- The Global Lung Function Initiative (GLI) has recently published international reference values for diffusing capacity of the lung for carbon monoxide (DLCO). Lower limit of normal (LLN), i.e. the 5th percentile, usually defines impaired DLCO. We examined if the GLI LLN for DLCO differs from the LLN in a Swedish population of healthy, never-smoking individuals and how any such differences affect identification of subjects with respiratory burden.Spirometry, DLCO, chest high-resolution computed tomography (HRCT) and questionnaires were obtained from the first 15 040 participants, aged 50–64 years, of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Both GLI reference values and the lambda-mu-sigma (LMS) method were used to define the LLN in asymptomatic never-smokers without respiratory disease (n=4903, of which 2329 were women).Both the median and LLN for DLCO from SCAPIS were above the median and LLN from the GLI (p<0.05). The prevalence of DLCO DLCO >GLI LLN but DLCO >GLI LLN but versus 4.5%, p<0.001), chronic airflow limitation (8.5% versus 3.9%, p<0.001) and chronic bronchitis (8.3% versus 4.4%, p<0.01) than subjects (n=13 600) with normal DLCO (>GLI LLN and >SCAPIS LLN). No differences were found with regard to physician-diagnosed asthma.The GLI LLN for DLCO is lower than the estimated LLN in healthy, never-smoking, middle-aged Swedish adults. Individuals with DLCO above the GLI LLN but below the SCAPIS LLN had, to a larger extent, an increased respiratory burden. This suggests clinical implications for choosing an adequate LLN for studied populations.
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| 37. |
- Nyberg, Lars, et al.
(författare)
-
Age-related and genetic modulation of frontal cortex efficiency
- 2014
-
Ingår i: Journal of cognitive neuroscience. - : MIT Press. - 0898-929X .- 1530-8898. ; 26:4, s. 746-754
-
Tidskriftsartikel (refereegranskat)abstract
- The dorsolateral pFC (DLPFC) is a key region for working memory. It has been proposed that the DLPFC is dynamically recruited depending on task demands. By this view, high DLPFC recruitment for low-demanding tasks along with weak DLPFC upregulation at higher task demands reflects low efficiency. Here, the fMRI BOLD signal during working memory maintenance and manipulation was examined in relation to aging and catechol-O-methyltransferase (COMT) Val(158)Met status in a large representative sample (n = 287). The efficiency hypothesis predicts a weaker DLPFC response during manipulation, along with a stronger response during maintenance for older adults and COMT Val carriers compared with younger adults and COMT Met carriers. Consistent with the hypothesis, younger adults and met carriers showed maximal DLPFC BOLD response during manipulation, whereas older adults and val carriers displayed elevated DLPFC responses during the less demanding maintenance condition. The observed inverted relations support a link between dopamine and DLPFC efficiency.
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| 38. |
- Persson, Anders, 1978-, et al.
(författare)
-
e-Government challenges : Exploring inter-organisational aspects of e-service development
- 2006
-
Ingår i: Proceedings of the Fourteenth European Conference on Information Systems, ECIS 2006, Göteborg, Sweden, 2006. - Göteborg : University of Gothenburg. - 9163198940 ; , s. 1419-1430
-
Konferensbidrag (refereegranskat)abstract
- In this paper we are applying inter-organizational concepts from the industrial/business network approach on empirical findings from an e-government case, in order to describe and better understand challenges in one-stop government e-service development. We analyze our case by using concepts that characterize an inter-organizational relationship in terms of its level of continuity, complexity, symmetry, informality, and its dimensions (links, bonds, and ties). The purpose of the paper is to explore how these theoretical concepts can help us focus on certain aspects of e-service development challenges. The empirical findings are collected within an on-going action research project for e-service development in the public sector in Sweden. The aim of the project is to develop one-stop government e-services for driver’s license matters as well as a web-based portal where these e-services and information about the driver’s license process will be easily accessible. Our conclusions are that the theoretical concepts helped us reach further understanding of the empirical case. In the spirit of the network approach, we focused on the present situation and been able to give a rather detailed and fine-grained picture of the problems and challenges in this context.
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| 39. |
- Persson, Anders, 1972, et al.
(författare)
-
Generic Monadic Constructs for Embedded Languages
- 2012
-
Ingår i: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). - Berlin, Heidelberg : Springer Berlin Heidelberg. - 1611-3349 .- 0302-9743. ; 7257
-
Konferensbidrag (refereegranskat)abstract
- We present a library of generic monadic constructs for embedded languages. It is an extension of Syntactic, a Haskell library for defining and processing generic abstract syntax. Until now, Syntactic has been mostly suited to implement languages based on pure, side effect free, expressions. The presented extension allows the pure expressions to also contain controlled side effects, enabling the representation of expressions that rely on destructive updates for efficiency. We demonstrate the use- fulness of the extension by giving examples from the embedded language Feldspar which is implemented using Syntactic.
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| 40. |
- Persson, Anders, 1972, et al.
(författare)
-
Generic monadic constructs for embedded languages
- 2011
-
Ingår i: IFL 2011, the 23rd Symposium on Implementation and Application of Functional Languages.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We present a library for generic monadic constructs for em- bedded languages. It is an extension of Syntactic, a Haskell library for defining and processing generic abstract syntax. Syntactic works best to implement languages based on pure, side effect free, expressions. The presented extension allows the pure expressions to also contain controlled side effects, enabling efficient representation of expressions that rely on destructive updates for efficiency.
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| 41. |
- Persson, Anders, 1972, et al.
(författare)
-
Programmable Signatures
- 2015
-
Ingår i: Trends in Functional Programming.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- When compiling EDSLs into other languages, types in the source language must be translated into corresponding types in the target language. The translation is often driven by a small set of rules that map a single type in the source language into a single type in the target language. However, this simple approach is limiting when there are multiple possible mappings, and it may lead to poor interoperability and performance in the generated code. Instead of hard-wiring a single set of translation rules into a compiler, this paper introduces a small language that lets the programmer describe the mapping of each argument and function separately.
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| 42. |
- Persson, Anders, 1972, et al.
(författare)
-
Programmable Signatures
- 2016
-
Ingår i: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). - Cham : Springer International Publishing. - 1611-3349 .- 0302-9743. ; 9547, s. 124-135
-
Konferensbidrag (refereegranskat)abstract
- When compiling Embedded Domain Specific Languages (EDSLs) into other languages, the compiler translates types in the source language into corresponding types in the target language. The translation is often driven by a small set of rules that map a single type in the source language into a single type in the target language. This simple approach is limiting when there are multiple possible mappings, and it may lead to poor interoperability and poor performance in the generated code. Instead of hard-wiring a single set of translation rules into a compiler, this paper introduces a small language that lets the programmer describe the mapping of each argument and function separately.
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| 43. |
- Persson, Anders, 1978-, et al.
(författare)
-
Stage-models for public e-services - investigating conceptual foundations
- 2005
-
Ingår i: the 2nd Scandinavian Workshop on e-Government,2005.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Information technology has since the turn of the millennia been one of the core issues in the reform of public administration in government agencies. Aiding this development has in some countries and in the research community been discussed through the development of stage models describing the evolution of services in stages. This is the case in Sweden where the Swedish agency for administrative development has been using a model to describe, evaluate and promote the emerging services. This paper pivots on the discussion about the conceptual foundation for models such as the Swedish model and other models. The discussion is conceptually founded in information systems actability theory and IS usage situations. This paper addresses the issue of stage models and the concept of stages itself. The models discussed lack in the categorization of the described stages; borders between stages are undistinguishable and unclear. A refined model that addresses the discovered issues is presented in the paper.
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| 44. |
- Persson, Fredrik, 1979, et al.
(författare)
-
Local conformation of confined DNA studied using emission polarization anisotropy
- 2010
-
Ingår i: Biophysical Society 54th Annual Meeting.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- When confined in nanochannels with dimensions smaller than the DNA radius of gyration, DNA will extend along the channel. We investigate long DNA confined in nanochannels, using fluorescence microscopy and intercalated dyes. Studies of the dynamics and statics of DNA in such nanoscale confinements as a function of e.g. degree of confinement and ionic strength have yielded new insights into the physical properties of DNA with relevance for applications in genomics as well as fundamental understanding of DNA packaging in vivo. Our work extends the field by not only studying the location of the emitting dyes along a confined DNA molecule but also monitoring the polarization of the emitted light. By measuring the emission polarized parallel and perpendicular to the extension axis of the stretched DNA, information on the local spatial distribution of the DNA backbone can be obtained. Comparing polarizations in two directions for DNA confined in channels of effective diameters of 85 nm and 170 nm reveals a striking difference. Whereas the DNA in the larger channels shows an isotropic polarization of the emitted light, the light is to a large extent polarized perpendicular to the elongation of the DNA in the smaller channels. We expect this technique to have a large impact on the studies of changes in DNA conformation induced by protein binding or during DNA compactation as well as in fundamental polymer physics studies of DNA in confined environments, for example in bacterial spores and viruses.
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| 45. |
- Persson, Fredrik, 1979, et al.
(författare)
-
Local conformation of confined DNA studied using emission polarization anisotropy
- 2010
-
Ingår i: NanoBioTech-Montreux 2009.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In nanochannels with dimensions smaller than the DNA radius of gyration, DNA will extend along the channel. We investigate long DNA confined in nanochannels using fluorescence microscopy and intercalated dyes. Studies of the dynamics and statics of the DNA extension or position in such nanoscale confinements as a function of e.g. DNA contour length, degree and shape of confinement as well as ionic strength have yielded new insights in the physical properties of DNA with relevance for applications in genomics as well as fundamental understanding of DNA packaging in vivo. Our work extends the field by not only studying the location of the emitting dyes along a confined DNA molecule but also monitoring the polarization of the emitted light. We use intercalating dyes (YOYO-1) whose emission is polarized perpendicular to the DNA extension axis, and by measuring the emission polarized parallel and perpendicular to the extension axis of the stretched DNA, information on the local spatial distribution of the DNA backbone can be obtained. The results obtained are analogous to linear dichroism (LD) but on a single-molecule level, and obtained in a highly parallel fashion. We will discuss results in shallow (60 nm) and deep (180 nm) channels and describe an example of how the technique can be used to investigate non-uniform stretching of DNA on the single molecule level. Comparing polarizations in two directions for DNA confined in channels of effective diameters of 85 nm and 170 nm reveals a striking difference. Whereas the DNA in the larger channels shows an isotropic polarization of the emitted light, the light is to a large extent polarized perpendicular to the elongation of the DNA in the smaller channels. The ratio of the polarization parallel and perpendicular to the elongation direction, I|| / I⊥, is a measure of the relative local orientation of the DNA backbone. We believe that this technique will have a large impact on the studies of changes in DNA conformation induced by protein binding or during DNA compactation as well as in fundamental polymer physics studies of DNA in confined environments, for example in bacterial spores and viruses.
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| 46. |
- Persson, Jens, 1978-
(författare)
-
Homogenization of Some Selected Elliptic and Parabolic Problems Employing Suitable Generalized Modes of Two-Scale Convergence
- 2010
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present thesis is devoted to the homogenization of certain elliptic and parabolic partial differential equations by means of appropriate generalizations of the notion of two-scale convergence. Since homogenization is defined in terms of H-convergence, we desire to find the H-limits of sequences of periodic monotone parabolic operators with two spatial scales and an arbitrary number of temporal scales and the H-limits of sequences of two-dimensional possibly non-periodic linear elliptic operators by utilizing the theories for evolution-multiscale convergence and λ-scale convergence, respectively, which are generalizations of the classical two-scale convergence mode and custom-made to treat homogenization problems of the prescribed kinds. Concerning the multiscaled parabolic problems, we find that the result of the homogenization depends on the behavior of the temporal scale functions. The temporal scale functions considered in the thesis may, in the sense explained in the text, be slow or rapid and in resonance or not in resonance with respect to the spatial scale function. The homogenization for the possibly non-periodic elliptic problems gives the same result as for the corresponding periodic problems but with the exception that the local gradient operator is everywhere substituted by a differential operator consisting of a product of the local gradient operator and matrix describing the geometry and which depends, effectively, parametrically on the global variable.
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| 47. |
- Persson, Jens, 1978-
(författare)
-
Selected Topics in Homogenization
- 2012
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The main focus of the present thesis is on the homogenization of some selected elliptic and parabolic problems. More precisely, we homogenize: non-periodic linear elliptic problems in two dimensions exhibiting a homothetic scaling property; two types of evolution-multiscale linear parabolic problems, one having two spatial and two temporal microscopic scales where the latter ones are given in terms of a two-parameter family, and one having two spatial and three temporal microscopic scales that are fixed power functions; and, finally, evolution-multiscale monotone parabolic problems with one spatial and an arbitrary number of temporal microscopic scales that are not restricted to be given in terms of power functions. In order to achieve homogenization results for these problems we study and enrich the theory of two-scale convergence and its kins. In particular the concept of very weak two-scale convergence and generalizations is developed, and we study an application of this convergence mode where it is employed to detect scales of heterogeneity.
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| 48. |
- Redjai Sani, Sohrab, et al.
(författare)
-
Mutually synchronized bottom-up multi-nanocontact spin-torque oscillators
- 2013
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 4, s. 2731-
-
Tidskriftsartikel (refereegranskat)abstract
- Spin-torque oscillators offer a unique combination of nanosize, ultrafast modulation rates and ultrawide band signal generation from 100 MHz to close to 100 GHz. However, their low output power and large phase noise still limit their applicability to fundamental studies of spin-transfer torque and magnetodynamic phenomena. A possible solution to both problems is the spin-wave-mediated mutual synchronization of multiple spin-torque oscillators through a shared excited ferromagnetic layer. To date, synchronization of high-frequency spin-torque oscillators has only been achieved for two nanocontacts. As fabrication using expensive top-down lithography processes is not readily available to many groups, attempts to synchronize a large number of nanocontacts have been all but abandoned. Here we present an alternative, simple and cost-effective bottom-up method to realize large ensembles of synchronized nanocontact spin-torque oscillators. We demonstrate mutual synchronization of three high-frequency nanocontact spin-torque oscillators and pairwise synchronization in devices with four and five nanocontacts.
|
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| 49. |
- Svenningsson, Josef, 1976, et al.
(författare)
-
Efficient Monadic Streams
- 2015
-
Ingår i: Trends in Functional Programming.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Functional stream representations allow for a high-level, compositional way of programming digital signal processing algorithms. However, some algorithms, such as filters, cannot be efficiently implemented using purely functional techniques, due to excessive copying of data. We present a monadic representation of streams which introduces the ability to use mutation for efficiency when implementing algorithms. Still, our representation enjoys many of the benefits of purely functional streams, such as a functional API and fusion. Our representation enables further optimizations: we show how to remove duplicate loop variables, and how to keep buffers entirely in references. Our measurements show that the new monadic representation consistently outperforms the functional representation by at least a factor of four when evaluated in the context of the Feldspar embedded DSL.
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| 50. |
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