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- Hudson, Lawrence N, et al.
(författare)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Tidskriftsartikel (refereegranskat)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 3. |
- Hudson, Lawrence N., et al.
(författare)
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The PREDICTS database : a global database of how local terrestrial biodiversity responds to human impacts
- 2014
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Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 4:24, s. 4701-4735
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Tidskriftsartikel (refereegranskat)abstract
- Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups - including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems - ). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
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| 4. |
- Baumann, Stefan, et al.
(författare)
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Gender differences in the diagnostic performance of machine learning coronary CT angiography-derived fractional flow reserve -results from the MACHINE registry
- 2019
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Ingår i: European Journal of Radiology. - : ELSEVIER IRELAND LTD. - 0720-048X .- 1872-7727. ; 119
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: This study investigated the impact of gender differences on the diagnostic performance of machine-learning based coronary CT angiography (cCTA)-derived fractional flow reserve (CT-FFR mL ) for the detection of lesion-specific ischemia. Method: Five centers enrolled 351 patients (73.5% male) with 525 vessels in the MACHINE (Machine leArning Based CT angiograpHy derIved FFR: a Multi-ceNtEr) registry. CT-FFRML and invasive FFR amp;lt;= 0.80 were considered hemodynamically significant, whereas cCTA luminal stenosis amp;gt;= 50% was considered obstructive. The diagnostic performance to assess lesion-specific ischemia in both men and women was assessed on a per-vessel basis. Results: In total, 398 vessels in men and 127 vessels in women were included. Compared to invasive FFR, CT-FFRML reached a sensitivity, specificity, positive predictive value, and negative predictive value of 78% (95%CI 72-84), 79% (95%CI 73-84), 75% (95%CI 69-79), and 82% (95%CI: 76-86) in men vs. 75% (95%CI 58-88), 81 (95%CI 72-89), 61% (95%CI 50-72) and 89% (95%CI 82-94) in women, respectively. CT-FFRML showed no statistically significant difference in the area under the receiver-operating characteristic curve (AUC) in men vs. women (AUC: 0.83 [95%CI 0.79-0.87] vs. 0.83 [95%CI 0.75-0.89], p = 0.89). CT-FFRML was not superior to cCTA alone [AUC: 0.83 (95%CI: 0.75-0.89) vs. 0.74 (95%CI: 0.65-0.81), p = 0.12] in women, but showed a statistically significant improvement in men [0.83 (95%CI: 0.79-0.87) vs. 0.76 (95%CI: 0.71-0.80), p = 0.007]. Conclusions: Machine-learning based CT-FFR performs equally in men and women with superior diagnostic performance over cCTA alone for the detection of lesion-specific ischemia.
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| 6. |
- Eriksson, Lina, 1976, et al.
(författare)
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Klimatomställning och krav på kompensation
- 2022
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Ingår i: Tidskrift för politisk filosofi. - 1402-2710. ; 26:1, s. 21-32
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Tidskriftsartikel (refereegranskat)abstract
- En aktuell fråga på energirättvisans område är hur vi ska för- dela de kostnader som uppstår när vi ska fasa ut fossila bränslen och ställa om våra energisystem till nollutsläpp. Enligt vissa kan en sådan omställning bara vara rättvis (man talar då om ”just transi- tion”) om de hårdast drabbade aktörerna ersätts på olika sätt. Ar- gumenten för ersättning är ibland pragmatiska, och säger då att kli- matomställningen är svår att genomföra i praktiken om inte de som drabbas negativt av den ersätts, eftersom motståndet annars blir för stort (Abram et al. 2020). Men det finns även ett moraliskt argu- ment som säger att de som drabbas utsätts för en orättvisa och där- med förtjänar kompensation. De negativa konsekvenserna behöver inte vara rent ekonomiska – de kan även vara emotionella – men er- sättningen tar alltid formen av att staten överför extra ekonomiska medel till olika ändamål. I denna artikel utgår vi från att graden av kompensation bör bero på i vilken grad det kan anses vara orättvist att olika aktörer drabbas på olika sätt, vilket i sin tur beror på hur moraliskt ansvariga dessa aktörer är för de utsläpp som har skett. Vi tillämpar denna tanke i två konkreta klimatpolitiska fall – nedläggningar av kol- kraftverk och höjningar av bensinskatten – och argumenterar för att de krav som ibland ställs på kompensation för aktörer som kol- kraftsarbetare och bilister sällan är rimliga.
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| 7. |
- Gummesson, Bertil, 1977, et al.
(författare)
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Increased RNA polymerase availability directs resources towards growth at the expense of maintenance. : RNAP overproduction
- 2009
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Ingår i: The EMBO journal. - : Wiley. - 1460-2075 .- 0261-4189. ; 28:15, s. 2209-2219
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Tidskriftsartikel (refereegranskat)abstract
- Nutritionally induced changes in RNA polymerase availability have been hypothesized to be an evolutionary primeval mechanism for regulation of gene expression and several contrasting models have been proposed to explain how such 'passive' regulation might occur. We demonstrate here that ectopically elevating Escherichia coli RNA polymerase (Esigma(70)) levels causes an increased expression and promoter occupancy of ribosomal genes at the expense of stress-defense genes and amino acid biosynthetic operons. Phenotypically, cells overproducing Esigma(70) favours growth and reproduction at the expense of motility and damage protection; a response reminiscent of cells with no or diminished levels of the alarmone guanosine tetraphosphate (ppGpp). Consistently, we show that cells lacking ppGpp displayed markedly elevated levels of free Esigma(70) compared with wild-type cells and that the repression of ribosomal RNA expression and reduced growth rate of mutants with constitutively elevated levels of ppGpp can be suppressed by overproducing Esigma(70). We conclude that ppGpp modulates the levels of free Esigma(70) and that this is an integral part of the alarmone's means of regulating a trade-off between growth and maintenance.
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| 9. |
- Ingason, Arni Sigurdur, et al.
(författare)
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A Nanolaminated Magnetic Phase: Mn2GaC
- 2014
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Ingår i: Materials Research Letters. - : Taylor & Francis. - 2166-3831. ; 2:2, s. 89-93
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Tidskriftsartikel (refereegranskat)abstract
- Layered magnetic materials are fascinating from the point of view of fundamental science as well as applications. Discoveries such as giant magnetoresistance (GMR) in magnetic multilayers have revolutionized data storage and magnetic recording, and concurrently initiated the search for new layered magnetic materials. One group of inherently nanolaminated compounds are the so called Mn+1AXn (MAX) phases. Due to the large number of isostructural compositions, researchers are exploring the wide range of interesting properties, and not primarily functionalization through optimization of structural quality. Magnetic MAX phases have been discussed in the literature, though this is hitherto an unreported phenomenon. However, such materials would be highly interesting, based on the attractive and useful properties attained with layered magnetic materials to date. Here we present a new MAX phase, (Cr1–xMnx)2GeC, synthesized as thin film in heteroepitaxial form, showing single crystal material with unprecedented structural MAX phase quality. The material was identified using first-principles calculations to study stability of hypothetical MAX phases, in an eort to identify a potentially magnetic material. The theory predicts a variety of magnetic behavior depending on the Mn concentration and Cr/Mn atomic conguration within the sublattice. The analyzed thin films display a magnetic signal well above room temperature and with partly ferromagnetic ordering. These very promising results open up a field of new layered magnetic materials, with high potential for electronics and spintronics applications.
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| 12. |
- Ran, Ylva, et al.
(författare)
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Effects of public policy interventions for environmentally sustainable food consumption: a systematic map of available evidence
- 2024
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Ingår i: Environmental Evidence. - 2047-2382. ; 13
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Forskningsöversikt (refereegranskat)abstract
- Background The global food system is inflicting substantial environmental harm, necessitating a shift towards more environmentally sustainable food consumption practices. Policy interventions, for example, information campaigns, taxes and subsidies and changes in the choice context are essential to stimulate sustainable change, but their effectiveness in achieving environmental goals remains inadequately understood. Existing literature lacks a comprehensive synthesis of evidence on the role of public policies in promoting sustainable food consumption. Our systematic map addressed this gap by collecting and categorising research evidence on public policy interventions aimed at establishing environmentally sustainable food consumption patterns, in order to answer the primary research question: What evidence exists on the effects of public policy interventions for achieving environmentally sustainable food consumption?Methods Searches for relevant records (in English) were performed in WoS, Scopus, ASSIA, ProQuest Dissertation and Theses, EconLit, Google Scholar and in bibliographies of relevant reviews. A grey literature search was also performed on 28 specialist websites (searches were made in the original language of the webpages and publications in English, Swedish, Danish and Norwegian were eligible) and Google Scholar (search in English). Screening was performed at title/abstract and full-text levels, with machine learning-aided priority screening at title/abstract level. Eligibility criteria encompassed settings, interventions (public policies on sustainable food consumption), target groups and outcomes. No critical appraisal of study validity was conducted. Data coding covered bibliographic details, study characteristics, intervention types and outcomes. Evidence was categorised into intervention types and subcategories. Visual representation utilised bar plots, diagrams, heatmaps and an evidence atlas. This produced a comprehensive overview of effects of public policy interventions on sustainable food consumption patterns.Review findings The evidence base included 227 articles (267 interventions), with 92% of studies in high-income countries and only 4% in low-income countries. Quantitative studies dominated (83%), followed by mixed methods (16%) and qualitative studies (1%). Most interventions were information-based and 50% of reviewed studies looked at labels. Information campaigns/education interventions constituted 10% of the sample, and menu design changes and restriction/editing of choice context 8% each. Market-based interventions represented 13% of total interventions, of which two-thirds were taxes. Administrative interventions were rare (< 1%). Proxies for environmental impact (85%) were more frequent outcome measures than direct impacts (15%). Animal-source food consumption was commonly used (19%) for effects of interventions on, for example, greenhouse gas emissions. Most studies used stated preferences (61%) to evaluate interventions.Conclusions The literature assessing policies for sustainable food consumption is dominated by studies on non-intrusive policy instruments; labels, information campaigns, menu design changes and editing choice contexts. There is a strong need for research on sustainable food policies to leave the lab and enter the real world, which will require support and cooperation of public and private sector stakeholders. Impact evaluations of large-scale interventions require scaling-up of available research funding and stronger multidisciplinary research, including collaborations with industry and other societal actors. Future research in this field should also go beyond the European and North American context, to obtain evidence on how to counteract increasing environmental pressures from food consumption worldwide.
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