| 1. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 2. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 3. |
- Justice, A. E., et al.
(författare)
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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
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| 4. |
- Kilpeläinen, Tuomas O, et al.
(författare)
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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.
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| 5. |
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| 6. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 7. |
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| 8. |
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| 9. |
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| 10. |
- Frödin, Kerstin
(musiker, creator_code:cre_t)
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Ska alla tecken låta? : Konsertprojekt med tre uruppföranden av svensk musik i iscensättning av Karl Dunér med ensemble Lipparella
- 2016
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Konstnärligt arbete (refereegranskat)abstract
- I projektet Ska alla tecken låta? framförde ensemblen Lipparella tre nyskrivna kompositioner av Per Mårtensson, Lisa Streich och Erik Peters. Den ”klassiska konserten” i en traditionell konsertsal förändras alltmer och ensemblen sökte med projektet nya former för närhet och dynamik i rummet mellan publiken och verken. Med projektet ville ensemblen erbjuda publiken ett spektrum av möjliga ingångar till de musikaliska och litterära verken, i lyssnandet, förståelsen och upplevelsen. Regissören Karl Dunér utvecklade det sceniska konceptet som anpassades efter olika rum och miljöer och utnyttjade olika lokalers egenart i helhetsupplevelsen.Lipparella:Mikael Bellini - kontratenorAnna lindahl - violinKerstin Frödin - blockflöjtLouise Agnani - viola da gambaPeter Söderberg - teorbSpelplatser: Baertlings foajé i första Hötorgshuset - 18 september 2016Svindersviks Paviljong i Nacka - 22 september 2016Färgfabriken - 29 september 2016Rönnells antikvariat - 13 oktober 2016Finansiärer:Statens Musikverk (projektbidrag) Diarienummer 1102/15 och Kulturrådet (samarbete med tonsättare) Projektnummer: 2014/5190
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| 11. |
- Klint, Erik, 1989, et al.
(författare)
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Mind the (reporting) gap—a scoping study comparing measured laundry decisions with self-reported laundry behaviour
- 2023
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Ingår i: International Journal of Life Cycle Assessment. - 1614-7502 .- 0948-3349. ; 28:9, s. 1211-1222
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Many environmental assessments of consumer products and household services rely on self-reported data. Life cycle assessments of domestic laundering are no exception. However, potential discrepancies between self-reported behaviour and actual everyday decisions are seldom investigated due to practical challenges in collecting relevant data. This means that environmental impacts relying on such self-reported data are much more uncertain than previously acknowledged. Method: Laundering data was collected at the Chalmers’ HSB Living lab (CHSBLL), a combined multi-family house and research facility in Gothenburg. The collection was both done passively (through the washing machines) as well as actively (through surveys to the tenants). RFID-readers were also installed in the machines and a number of clothing items tagged, allowing for identification. The site-specific data was later supplemented with a large statistical representative study for domestic laundering of Swedish households. This unique data quality allowed the comparison of passively collected data with survey data from tenants in a real-life setup, while validating the results from a national perspective. Result and conclusions: The results suggest that consumers have trouble remembering personal choices regarding domestic laundering, meaning that self-reported data are more uncertain than previously thought. In general, the participants overestimated the amount of laundry they washed and underestimated their frequency of washing. Additionally, many participants showed an interest in changing to alternative wash programs although this change failed to materialize when they were presented with this option in real-life. The findings have potential consequences for environmental assessments and implicate those previous estimations underestimate emissions per kg laundry washed.
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| 12. |
- Klint, Erik, 1989, et al.
(författare)
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No stain, no pain – A multidisciplinary review of factors underlying domestic laundering
- 2022
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Ingår i: Energy Research and Social Science. - : Elsevier BV. - 2214-6296. ; 84
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Forskningsöversikt (refereegranskat)abstract
- Today's washing appliances are much more efficient than those of a decade ago, but the environmental benefits of this efficiency are counteracted by shifts in consumer behavior. Initiatives to reverse these shifts have often proven futile, indicating a basic lack of clarity on why we clean our clothes. This article is an explorative review with the aim of identifying dominant factors that shape how we do our laundry. The results can be used both as an introduction to laundry research in general, as well as a baseline for future interdisciplinary research. Three guiding principles are presented that describe the most influential factors underlying laundering: (1) technology changes conventions, while social context dictates technology acceptance; (2) technological solutions are often suggested to influence consumers, but individual concerns seem to override the effect of such interventions; (3) consumers are guided by social conventions, rooted in underlying psychological dynamics (e.g. moral dimensions of cleanliness). Looking at these principles it is understandable why interventions for sustainability are failing. Many interventions address only a part of a principle while disregarding other parts. For example, consumers are often informed of the importance of sustainability (e.g. “washing at lower temperature is good for the environment”), while questions of social belonging are left out (e.g. “many of your neighbors and friends wash at lower temperature”). To increase the possibility of a lasting change, it would be beneficial if instead all of the three principles could be addressed given the specific consumer group of interest.
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| 13. |
- Klint, Erik, 1989, et al.
(författare)
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Pro-environmental behaviour is undermined by disgust sensitivity: The case of excessive laundering
- 2024
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Ingår i: PLoS ONE. - 1932-6203 .- 1932-6203. ; 19:6 June
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Tidskriftsartikel (refereegranskat)abstract
- The amount of laundry washed by European consumers has grown excessively for reasons that cannot be explained by demographics alone. Initiatives trying to curb this trend have repeatedly failed. Previous studies have largely overlooked the psychological dimensions of laundering behaviour. In three separate studies we investigate how disgust, shame, cleanliness norms and environmental identity, mediated through a set of preceding behaviours, affect washing frequency. Our results highlight how conflicting psychological goals between disgust sensitivity and pro-environmental identity can undermine willingness to change laundry behaviour. Policy recommendations are suggested, and future research challenges are discussed.
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| 14. |
- Klint, Erik, 1989, et al.
(författare)
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Sharing is caring - the importance of capital goods when assessing environmental impacts from private and shared laundry systems in Sweden
- 2021
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Ingår i: International Journal of Life Cycle Assessment. - : Springer Science and Business Media LLC. - 1614-7502 .- 0948-3349. ; 26, s. 1085-1099
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Previous studies on environmental impacts from domestic laundry have tended to focus solely on private washing machines and detergent. However, public procurement guidelines about the construction of laundry spaces may also be important. This article aims to expand the scope of previous work so that it also includes tumble drying and the building space. By doing this, we examine the potential for shared systems (which are common in Sweden) to reduce the environmental impacts of laundry activities, in comparison with consumer choices associated with machine operation (i.e., wash temperature and amount of detergent). Methods: An LCA model was created using product information data from the European Union. Emissions from building use were taken from Swedish cradle-to-grave reports on energy-efficient buildings. The resulting model was run with additional sensitivity analysis of the variables, and the associated emissions from each of the scenarios were calculated. Results and discussion: On average, greenhouse gas (GHG) emissions for private laundries in Sweden were estimated to be 190 g CO eq./kg laundry (washed and dried). If a shared laundry was used instead, the resulting emissions decreased by approximately 26%. The greatest contribution to GHG emissions was the use of detergent (22–33% of total emissions), followed by capital goods (11–38% of total emissions). Conclusion: Deciding to construct shared laundries in newly built apartment buildings in Sweden, rather than in-unit machines, would reduce the emissions from domestic laundry for these tenants by approximately 26%. This is because materials used for manufacturing whitegoods, as well as the emissions associated with the building itself, play a much bigger role than previously thought. Additionally, since the cleaning efficiency of warm water and some of the components used in detergents rises with temperature, emissions from domestic laundering could for some consumers be reduced further by washing at higher temperature but with less detergent. This pattern could be seen in Sweden within regions with hard water, where the emissions from domestic laundry could be reduced by 6–12%.
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| 15. |
- Klint, Erik, 1989, et al.
(författare)
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Återinför tvättstugan - för klimatets skull
- 2022
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Ingår i: Dagens samhälle. - 1652-6511. ; 2 mars
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Nya lägenheter byggs nästan uteslutande med privata tvättmaskiner i badrummet – trots att de ger betydligt större klimatpåverkande utsläpp per tvätt än tvättstugor. Allmännyttan borde göra gemensamma tvättutrymmen till standard.
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| 16. |
- Lango Allen, Hana, et al.
(författare)
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Hundreds of variants clustered in genomic loci and biological pathways affect human height.
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 467:7317, s. 832-8
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Tidskriftsartikel (refereegranskat)abstract
- Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
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| 17. |
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| 18. |
- Teumer, A, et al.
(författare)
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Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4130-
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Tidskriftsartikel (refereegranskat)abstract
- Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.
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| 19. |
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| 20. |
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| 21. |
- Yang, Jian, et al.
(författare)
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FTO genotype is associated with phenotypic variability of body mass index
- 2012
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 490:7419, s. 267-272
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Tidskriftsartikel (refereegranskat)abstract
- There is evidence across several species for genetic control of phenotypic variation of complex traits(1-4), such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using similar to 170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype)(5-7), is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of similar to 0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI8, possibly mediated by DNA methylation(9,10). Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000.
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| 22. |
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| 23. |
- Zillikens, M. C., et al.
(författare)
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 x 10(-8)) or suggestively genome wide (p < 2.3 x 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/ near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/ near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.
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