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Träfflista för sökning "WFRF:(Petersen Henrik) "

Search: WFRF:(Petersen Henrik)

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  • Ostergaard, Henrik, et al. (author)
  • Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide
  • 2011
  • In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 118:8, s. 2333-2341
  • Journal article (peer-reviewed)abstract
    • Current management of hemophilia B entails multiple weekly infusions of factor IX (FIX) to prevent bleeding episodes. In an attempt to make a longer acting recombinant FIX (rFIX), we have explored a new releasable protraction concept using the native N-glycans in the activation peptide as sites for attachment of polyethylene glycol (PEG). Release of the activation peptide by physiologic activators converted glycoPEGylated rFIX (N9-GP) to native rFIXa and proceeded with normal kinetics for FXIa, while the Km for activation by FVIIa-tissue factor (TF) was increased by 2-fold. Consistent with minimal perturbation of rFIX by the attached PEG, N9-GP retained 73%-100% specific activity in plasma and whole-blood-based assays and showed efficacy comparable with rFIX in stopping acute bleeds in hemophilia B mice. In animal models N9-GP exhibited up to 2-fold increased in vivo recovery and a markedly prolonged half-life in mini-pig (76 hours) and hemophilia B dog (113 hours) compared with rFIX (16 hours). The extended circulation time of N9-GP was reflected in prolonged correction of coagulation parameters in hemophilia B dog and duration of effect in hemophilia B mice. Collectively, these results suggest that N9-GP has the potential to offer efficacious prophylactic and acute treatment of hemophilia B patients at a reduced dosing frequency. (Blood. 2011; 118(8): 2333-2341)
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  • Aad, G., et al. (author)
  • 2014
  • In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 74:8
  • Journal article (peer-reviewed)
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21.
  • Aad, G., et al. (author)
  • 2014
  • In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 74:6
  • Journal article (peer-reviewed)
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22.
  • Aad, G., et al. (author)
  • 2014
  • In: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 90:2
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • In: Physical Review D. Particles and fields. - 0556-2821 .- 1089-4918. ; 89:9
  • Journal article (peer-reviewed)
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28.
  • Aad, G., et al. (author)
  • 2014
  • In: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; :6
  • Journal article (peer-reviewed)
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29.
  • Aad, G., et al. (author)
  • 2014
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
  • Journal article (peer-reviewed)
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30.
  • Aad, G., et al. (author)
  • 2014
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
  • Journal article (peer-reviewed)
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31.
  • Aad, G., et al. (author)
  • 2014
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :5
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 90:5
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2015
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :8
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
  • Journal article (peer-reviewed)
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37.
  • Aad, G, et al. (author)
  • 2014
  • In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 113:17
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :4
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :4
  • Journal article (peer-reviewed)
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  • Aad, G., et al. (author)
  • 2014
  • In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :5, s. 1-52
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  • Result 1-50 of 265
Type of publication
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Arai, Y. (158)
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Aad, G (157)
Abbott, B. (157)
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Gregersen, K. (157)
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Aoki, M. (157)
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