| 1. |
- Gopalakrishnan, Shyam, et al.
(författare)
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The population genomic legacy of the second plague pandemic
- 2022
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Ingår i: Current Biology. - : Elsevier. - 0960-9822 .- 1879-0445. ; 32:21, s. 4743-4751.e6
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Tidskriftsartikel (refereegranskat)abstract
- Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned for over 300 years, with typical village and town mortality estimated at 10%–40%.1 It is assumed that this high mortality affected the gene pools of these populations. First, local population crashes reduced genetic diversity. Second, a change in frequency is expected for sequence variants that may have affected survival or susceptibility to the etiologic agent (Yersinia pestis).2 Third, mass mortality might alter the local gene pools through its impact on subsequent migration patterns. We explored these factors using the Norwegian city of Trondheim as a model, by sequencing 54 genomes spanning three time periods: (1) prior to the plague striking Trondheim in 1,349 CE, (2) the 17th–19th century, and (3) the present. We find that the pandemic period shaped the gene pool by reducing long distance immigration, in particular from the British Isles, and inducing a bottleneck that reduced genetic diversity. Although we also observe an excess of large FST values at multiple loci in the genome, these are shaped by reference biases introduced by mapping our relatively low genome coverage degraded DNA to the reference genome. This implies that attempts to detect selection using ancient DNA (aDNA) datasets that vary by read length and depth of sequencing coverage may be particularly challenging until methods have been developed to account for the impact of differential reference bias on test statistics.
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| 2. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Thompson, Paul M., et al.
(författare)
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The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
- 2014
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Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
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Tidskriftsartikel (refereegranskat)abstract
- The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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| 4. |
- Abbasi, Rasha, et al.
(författare)
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IceCube search for neutrinos from GRB 221009A
- 2023
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Ingår i: Proceedings of 38th International Cosmic Ray Conference (ICRC 2023). - : Sissa Medialab Srl.
-
Konferensbidrag (refereegranskat)abstract
- GRB 221009A is the brightest Gamma Ray Burst (GRB) ever observed. The observed extremelyhigh flux of high and very-high-energy photons provide a unique opportunity to probe the predictedneutrino counterpart to the electromagnetic emission. We have used a variety of methods to searchfor neutrinos in coincidence with the GRB over several time windows during the precursor, promptand afterglow phases of the GRB. MeV scale neutrinos are studied using photo-multiplier ratescalers which are normally used to search for galactic core-collapse supernovae neutrinos. GeVneutrinos are searched starting with DeepCore triggers. These events don’t have directionallocalization, but instead can indicate an excess in the rate of events. 10 GeV - 1 TeV and >TeVneutrinos are searched using traditional neutrino point source methods which take into accountthe direction and time of events with DeepCore and the entire IceCube detector respectively. The>TeV results include both a fast-response analysis conducted by IceCube in real-time with timewindows of T0 − 1 to T0 + 2 hours and T0 ± 1 day around the time of GRB 221009A, as well asan offline analysis with 3 new time windows up to a time window of T0 − 1 to T0 + 14 days, thelongest time period we consider. The combination of observations by IceCube covers 9 ordersof magnitude in neutrino energy, from MeV to PeV, placing upper limits across the range forpredicted neutrino emission.
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| 5. |
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| 6. |
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| 7. |
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| 8. |
- Billing, Peter, et al.
(författare)
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Paradoxes of football professionalisation in Sweden : A club approch
- 2004
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Ingår i: Soccer & Society. - : Frank Cass Publishers. - 1466-0970 .- 1743-9590. ; 5:1, s. 82-99
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Tidskriftsartikel (refereegranskat)abstract
- The dismantling of the amateur rules of Swedish football in 1967 initiated the professionalization of the game in Sweden. This article analyses the impact and consequences of this development by using a comparative approach based on an examination of two clubs. The expected domination by Malmo FF in the new professionalized era is contrasted with the most unexpected success achieved by Hammarby IF The paradoxical differences in the recent histories of these clubs reveal a differentiated picture of Swedish soccer professionalism.
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| 9. |
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| 10. |
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| 11. |
- Bjärsholm, Daniel, et al.
(författare)
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A methodological tool for researching Sport and Social Entrepreneurship
- 2018
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Ingår i: Sport and Social Entrepreneurship in Sweden. - Cham : Palgrave Macmillan. - 9783319724959 - 3319724959 - 9783319724966 ; , s. 113-122
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Bokkapitel (refereegranskat)abstract
- The last chapter introduces a methodological tool for analyzing social entrepreneurship in a sport policy context, built on a number of steps in relation to the five theses. This tool has become useful in the research process as well as being valuable when communicating the analysis. On the basis of the seven cases, a comparison is conducted in which similarities but also differences between the cases are identified and analyzed.
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| 12. |
- Bjärsholm, Daniel, et al.
(författare)
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Ethical considerations in researching sport and social entrepreneurship
- 2018
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Ingår i: European Journal for Sport and Society. - : Routledge. - 1613-8171 .- 2380-5919. ; 15:3, s. 216-233
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article is to discuss ethical dilemmas that occur in doing research on social entrepreneurial sport ventures. Three cases that highlight ethical dilemmas in research on social entrepreneurship and sport are presented and ethically reflected upon. The data comprise interviews with representatives, field notes from observations and analyses of documents concerning the ventures. Three things make research in this area extra problematic: first, ‘social good’ in social entrepreneurship and sport implies a normative perspective. It is permeated by ideology and ethics. Second, what is considered as ‘social good’ may differ between sectors of society as the entrepreneur crosses boundaries. What is valid as a resource and capital in one sector might not be so in another one, and what is legal within one sector may be illegal in another. Third, social entrepreneurs may have their own intentions with regard to participating in research, which may challenge our credibility as researchers. Therefore, we need, as professionals, to take a step back and be both critical of our work and make this criticism visible, which is to some extent what we are doing by writing this article.
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| 13. |
- Bjärsholm, Daniel, et al.
(författare)
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Ethics in Researching Sport and Social Entrepreneurship
- 2018
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Ingår i: Sport and Social Entrepreneurship in Sweden. - Cham : Palgrave Macmillan. - 9783319724959 - 3319724959 - 9783319724966 ; , s. 99-112
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Bokkapitel (refereegranskat)abstract
- When researching sport and social entrepreneurship, several ethical dilemmas may arise. The authors highlight the importance of being aware of these. By examining four sport-related cases, this chapter explores some of the ethical dilemmas that researchers might face. The authors conclude that the entrepreneurs may prefer not to be anonymous informants in research ventures, that they may become part of the brand and the branding process, and that the researchers, on their part, have to navigate in different sectors of society and thus run the risk of being accused of becoming accomplices in the venture.
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| 14. |
- Bjärsholm, Daniel, et al.
(författare)
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Idrott och socialt entreprenörskap : en utmaning för idrottsrörelsen
- 2016
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Ingår i: Idrottsforskaren. - : SVEBI. - 0348-9787. ; :2, s. 38-47
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Tidskriftsartikel (refereegranskat)abstract
- Socialt entreprenörskap kan ses som en kritik mot att samhällsstödet inte är tillräckligt. Kritiken kan vara riktad mot såväl det offentliga som det privata. De sociala entreprenörerna skapar en verksamhet som de erbjuder en viss målgrupp, som uppfattas vara i behov av just denna verksamhet. Och liksom målgruppen kan vara i behov av denna verksamhet så kan samhället också uppfattas behöva verksamheten. Ibland är det till och med så att staten ringar in problemen och ger idrottsrörelsen i uppdrag att lösa dem, vilket då kräver att den utmanar och utvecklar sin egen verksamhet.
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| 15. |
- Bjärsholm, Daniel, et al.
(författare)
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The Cases
- 2018
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Ingår i: Sport and Social Entrepreneurship in Sweden. - Cham : Palgrave Macmillan. - 9783319724959 - 3319724959 - 9783319724966 ; , s. 61-70
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Bokkapitel (refereegranskat)abstract
- Throughout the anthology, a number of cases illustrating the authors’ understanding of social entrepreneurship are used. The reason for choosing these particular cases is that they are heterogeneous, e.g., in terms of location, history, organization, preconditions and size, and that they represent various aspects of social entrepreneurship in sport. In this chapter, a description of the cases introduced in chapter three, except KIOSK, is presented, including Enjoy water, Equestrian ventures, Football for integration, Mapping orienteering, Pre-emptive activity and The sports club on the island.
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| 16. |
- Bratteby, Klas, et al.
(författare)
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In Vivo Veritas : 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors
- 2020
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 63:2, s. 747-755
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Tidskriftsartikel (refereegranskat)abstract
- Glycomimetic drugs have attracted increasing interest as unique targeting vectors or surrogates for endogenous biomolecules. However, it is generally difficult to determine the in vivo pharmacokinetic profile of these compounds. In this work, two galectin-3 inhibitors were radiolabeled with fluorine-18 and used as surrogate PET tracers of TD139 and GB1107. Both compounds are promising drugs for clinical applications. In vivo evaluation revealed that both surrogates strongly differed with respect to their biodistribution profile. The disaccharide (TD139 surrogate) was rapidly eliminated from blood while the monosaccharide (GB1107 surrogate) showed no sign of excretion. The data obtained allowed us to infer the different in vivo fate of TD139 and GB1107 and rationalize how different administration routes could boost efficacy. Whereas the fast excretion profile of the TD139 surrogate indicated that systemic application of disaccharides is unfavorable, the extended biological half-life of the GB1107 surrogate indicated that systemic administration is possible for monosaccharides.
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| 17. |
- Cerne, Olof, et al.
(författare)
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Rena Turen - Utvärdering av miljöanpassade bränslen i fritidsbåtar
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Fritidsbåtars avgasutsläpp till vatten och luft har undersökts. Tre inombords dieselmotorer och en 2-takts utombordsmotor har testats med standardbränslen och miljöanpassade bränslen. För dieselmotorerna användes standarddiesel, syntetisk diesel (GTL), rapsmetylester (RME), jetbränsle samt olika blandningar av diesel och RME. 2-taktsmotorn testades med standardbensin, alkylatbensin samt etanol (E85). För testerna med etanol krävdes en konvertering av motorn. Ekotoxikologiska tester har gjorts på kylvatten från dieselmotorer och på vatten som bubblats med avgaser från utombordsmotor. GTL gav något lägre utsläpp till luft av partiklar, kolväten, kolmonoxid och kväveoxider än vad standarddiesel gav. RME gav betydligt lägre halt partiklar och kolväten men något mer kväveoxider. Kylvatten från en inombords dieselmotor var giftigt mot sebrafiskar och kräftdjur. kylvatten. GTL och RME gav ett kylvatten som var betydligt mindre giftigt mot sebrafiskar än vad standarddiesel gav. PAH-utsläppen till vatten från dieselmotorerna var 10-20 mg per liter diesel. Utsläppen från de traditionella 2-takts utombordarna dominerar tydligt utsläppsmängderna. Standardbensin gav höga halter av miljö- och hälsofarliga ämnen, bland annat bensen, PAHer och formaldehyd. En liter bensin gav cirka 2,3 g PAH. Alkylatbensin och etanolbränslet E85 gav betydligt mindre utsläpp. Sveriges fritidsbåtar släpper uppskattningsvis ut 75 ton PAH per år. Avgasvatten från utombordare var giftigt för bakterier, alger och kräftdjur. Standardbensin var giftigast för bakterier och kräftdjur. Alkylatbensin var mindre giftig mot bakterier och kräftdjur. För alger var skillnaden liten mellan standardbensin, alkylatbensin och E85. Merparten av fritidsbåtarnas förbrukning av bensin och diesel sker i kustvatten. Trots det kan det vara i sjöar och mindre vattendrag som effekterna av utsläppen är störst. Traditionella tvåtaktare används även i sjöar som utnyttjas till dricksvatten och fiske av matfisk och kräftor. Studien visar relativt stor miljöpåverkan från den traditionella 2-takts utombordare som undersökts. Resultaten indikerar att alkylatbensin ger betydligt mindre risker. E85 kan också vara ett alternativ till standardbensin. Det går utmärkt att köra en utombordare på E85, men det kräver en konvertering av motorn vilket gör att det inte är aktuellt för flertalet användare. De observerade emissionerna av aldehyder ger anledning till att studera detta närmare. Det verkar som om bensin ger mer formaldehyd än etanol, medan etanol ger mer acetaldehyd, men testerna är inte tillräckligt omfattande för att göra en fullständig bedömning. Projektet föreslår ytterligare undersökningar bland annat av kylvatten från inombordare och aldehyder i avgaser från utombordare
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| 18. |
- Dahlgren, Anita, et al.
(författare)
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Idrott och hälsa i skolan, och föreningsidrott på fritiden – eller?
- 2007
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Ingår i: Resultatdialog 2007. - : Vetenskapsrådet. - 9789173071154 ; , s. 29-35
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Skolans verksamhet är ständigt i fokus och föremål för mångas tänkande och tyckande. Alla är eller har på något sätt varit berörda av den. Skolan är en komplex verksamhet, som skall uppfylla både samhällets och individens behov och krav. Verksamheten studeras och utvärderas för att göra den så givande och bra som möjligt för varje enskild individ. I ett skolämne som Idrott och hälsa finns även en tydlig relation till föreningsliv (idrott) och en betydelse för samhället (hälsa). På senare tid har ett ökat antal studier fokuserat på ämnet och dess förutsättningar och effekter. Många av dessa studier har koncentrerat sig på lärares/elevers uppfattning av verksamheten och är inte i första hand studier av de processer som sker i själva verksamheten. Det finns således ett behov av kunskap om de organiserade lärandesituationerna i skolan. Syftet med projektet är att, med den organiserade lärandesituationen i centrum, dvs., lektionen i Idrott och hälsa, studera och beskriva olika faktorer som påverkar skeendet, och en central del är att studera det faktiska skeendet. Lärarnas och elevernas förståelse för och erfarenhet av idrott och ämnet Idrott och hälsa utgör en andra del av studien. En tredje del syftar till att belysa de sociala sammanhang elever och lärare befinner sig i med hänsyn bland annat till kön och social bakgrund.
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| 19. |
- Duffy, J. Emmett, et al.
(författare)
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A Pleistocene legacy structures variation in modern seagrass ecosystems
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:32
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Tidskriftsartikel (refereegranskat)abstract
- Distribution of Earth's biomes is structured by the match between climate and plant traits, which in turn shape associated communities and ecosystem processes and services. However, that climate-trait match can be disrupted by historical events, with lasting ecosystem impacts. As Earth's environment changes faster than at any time in human history, critical questions are whether and how organismal traits and ecosystems can adjust to altered conditions. We quantified the relative importance of current environmental forcing versus evolutionary history in shaping the growth form (stature and biomass) and associated community of eelgrass (Zostera marina), a widespread foundation plant of marine ecosystems along Northern Hemisphere coastlines, which experienced major shifts in distribution and genetic composition during the Pleistocene. We found that eelgrass stature and biomass retain a legacy of the Pleistocene colonization of the Atlantic from the ancestral Pacific range and of more recent within-basin bottlenecks and genetic differentiation. This evolutionary legacy in turn influences the biomass of associated algae and invertebrates that fuel coastal food webs, with effects comparable to or stronger than effects of current environmental forcing. Such historical lags in phenotypic acclimatization may constrain ecosystem adjustments to rapid anthropogenic climate change, thus altering predictions about the future functioning of ecosystems.
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| 20. |
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| 21. |
- Edgerton, David, et al.
(författare)
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Skattning av övergångssannolikheter
- 1989
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Ingår i: "Vi mot dom". Det dubbla främlingsskapet i Sjöbo. ; , s. 176-186
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 22. |
- Edgerton, David, et al.
(författare)
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Systemvalet
- 1994
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Ingår i: Det politiska missnöjets Sverige. ; , s. 69-144
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 23. |
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| 24. |
- Ek, Staffan, et al.
(författare)
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Relative Age Effect of Sport Academy Adolescents, a Physiological Evaluation
- 2020
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Ingår i: Sports. - Basel : MDPI. - 2075-4663. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- The relationship between birth quarter distribution and physiological characteristics related to athletic skills, in adolescent sport academy students has not been fully investigated. In a cross-sectional study, we recruited 86 boys and 52 girls aged 12-14 years during their first term at a sport academy school. We measured body size, cardiac size, pulmonary function, body composition, lower body power, cardiorespiratory fitness parameters, and running endurance by standard methods and analyzed these estimates in relation to birth quarter by ANOVA. Birth quarter distribution in our cohort was compared with birth quarter distribution in the same ages in the whole of Sweden and analyzed by logistic regression. The academy had an overrepresentation of students born in the first quartile of the year compared to those born in the last quartile (odds ratio 2.3 (95% CI: 1.1-4.7)). When comparing the physiological characteristics between birth quarters, uniformity is prominent since out of 26 performed physiological and anthropometric tests only four showed statistically significant group differences. We thus believe that the selection process to the sport academy favours athletes with higher chronological age, i.e., a so-called relative age effect is present. © 2020 MDPI (Basel, Switzerland).
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| 25. |
- Evans Axelsson, Susan, et al.
(författare)
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Targeting free prostate-specific antigen for in vivo imaging of prostate cancer using a monoclonal antibody specific for unique epitopes accessible on free prostate-specific antigen alone
- 2012
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Ingår i: Cancer Biotherapy and Radiopharmaceuticals. - : Mary Ann Liebert Inc. - 1084-9785 .- 1557-8852. ; 27:4, s. 243-251
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated the feasibility of targeting the free, unbound forms of prostate-specific antigen (fPSA) for in vivo imaging of prostate adenocarcinomas (PCa), as PSA is produced and secreted at abundance during every clinical stage and grade of PCa, including castration-resistant disease. We injected 125I-labeled monoclonal antibody PSA30 (specific for an epitope uniquely accessible on fPSA alone) intravenously in male nude mice carrying subcutaneous xenografts of LNCaP tumors (n=36). Mice were sacrificed over a time course from 4 hours to 13 days after injecting 125I-labeled PSA30. Tissue uptake of 125I-PSA30 at 48 and 168 hours after intravenous injection was compared with two clinically used positron emission tomography radiopharmaceuticals, 18F-fluoro-deoxy-glucose (18F-FDG) or 18F-choline, in cryosections using Digital AutoRadiography (DAR) and also compared with immunohistochemical staining of PSA and histopathology. On DAR, the areas with high 125I-PSA30 uptake corresponded mainly to morphologically intact and PSA-producing LNCaP cells, but did not associate with the areas of high uptake of either 18F-FDG or 18F-choline. Biodistribution of 125I-PSA30 measured in dissected organs ex vivo during 4 to 312 hours after intravenous injection demonstrated maximum selective tumor uptake 24–48 hours after antibody injection. Our data showed selective uptake in vivo of a monoclonal antibody highly specific for fPSA in LNCaP cells. Hence, in vivo imaging of fPSA may be feasible with putative usefulness in disseminated PCa.
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| 26. |
- Franzén, Cecilia, et al.
(författare)
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Trust as an analytical concept for the study of welfare programmes to reduce child health disparities : the case of a Swedish postnatal home visiting programme
- 2020
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Ingår i: Children and youth services review. - : Elsevier. - 0190-7409 .- 1873-7765. ; 118, s. 1-7
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article is to outline a theoretical framework for how the concept of trust can be used as analytical tool for a study of the aim, design, output and societal legitimacy of a Swedish welfare programme conducted to reduce disparities in health and social inequities and to give newborn a positive start in life. This programme, labelled Grow Safely, implies that home visits will be conducted at six occasions at first-time parents by different professionals: child health care nurses, midwifes, dental hygienists and counsellors from the social services. Prior to when the intervention is carried out, the involved professionals in the programme will be participating in training in order to increase the possibility that the home visits will be carried out in similar ways and be followed the same manual throughout the programme.The welfare programme will be based on relationships on different levels: between professionals and parents, between different professionals, between professionals and managers, and between organisations. Trust is believed to be of significance for the development of relationships as well as for the social legitimacy of the implantation of welfare programmes. Therefore, our ambition is to embrace a broad perspective on trust, combining insights from a variety of research traditions and analyses on macro, meso and micro levels in the outline a model for how the concept of trust can be used as an analytical tool for studying welfare programmes like Grow Safely. We argue for that the model can capture the significance of trust at different levels: individual, professional, organisational and societal levels as well as interplays between these levels, and consequently be useful in to analyse implementations of welfare programmes.
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| 27. |
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| 28. |
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| 29. |
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| 30. |
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| 31. |
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| 32. |
- Gross, C. P., et al.
(författare)
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The biogeography of community assembly: latitude and predation drive variation in community trait distribution in a guild of epifaunal crustaceans
- 2022
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Ingår i: Proceedings of the Royal Society B: Biological Sciences. - : The Royal Society. - 1471-2954 .- 0962-8452. ; 289:1969
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Tidskriftsartikel (refereegranskat)abstract
- While considerable evidence exists of biogeographic patterns in the intensity of species interactions, the influence of these patterns on variation in community structure is less clear. Studying how the distributions of traits in communities vary along global gradients can inform how variation in interactions and other factors contribute to the process of community assembly. Using a model selection approach on measures of trait dispersion in crustaceans associated with eelgrass (Zostera marina) spanning 30° of latitude in two oceans, we found that dispersion strongly increased with increasing predation and decreasing latitude. Ocean and epiphyte load appeared as secondary predictors; Pacific communities were more overdispersed while Atlantic communities were more clustered, and increasing epiphytes were associated with increased clustering. By examining how species interactions and environmental filters influence community structure across biogeographic regions, we demonstrate how both latitudinal variation in species interactions and historical contingency shape these responses. Community trait distributions have implications for ecosystem stability and functioning, and integrating large-scale observations of environmental filters, species interactions and traits can help us predict how communities may respond to environmental change.
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| 33. |
- Hedenborg, Susanna, et al.
(författare)
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Fler stannar men färre börjar?
- 2012
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Ingår i: Svensk Idrottsforskning. - Stockholm : Centrum för idrottsforskning. - 1103-4629. ; 21:1, s. 51-54
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Idrottslyftet har allt mer blivit en del av förbundens ordinarie verksamhet.Satsningen har öppnat dörrarna för fler, men få har klivit övertröskeln. En stor del av medlen har hamnat i stora idrotter och hos desocioekonomiskt välmående i tätbefolkade kommuner.
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| 34. |
- Hedenborg, Susanna, et al.
(författare)
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Fler stannar men färre börjar?
- 2012
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Ingår i: Svensk Idrottsforskning. - 1103-4629. ; 21:1, s. 51-54
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- I den här artikeln diskuterar vi generella iakttagelser av Idrottslyftet utifrån Idrottsstödsutredningens slutsatser om Handslaget (1). Vi gör en kvalitativ bedömning utifrån erfarenheterna från våra fem förbundsvisa utvärderingar (Klätter-, Orientering-, Ridsport-, Sim och Taekwondoförbundet) men också utifrån kunskap om andra förbund, från andra utvärderare och från i sammanhanget relevanta nyckelpersoner inom idrottsrörelsen. RF är mer intresserade av kvalitativa data än kvantitativa, eftersom de kvantitativa uppgifterna ändå kommer in via projektrapporteringen. Här följer således ett försök att tolka och karakterisera ett antal iakttagelser som vi bedömer är generella för idrottsrörelsens idrottslyftsarbete.
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| 35. |
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| 36. |
- Hedenborg, Susanna, et al.
(författare)
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Sport and the Swedish Welfare State
- 2016
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Ingår i: Routledge handbook of Sport and Politics. - Milton Park, Abingdon, Oxon ; New York, NY : : Routledge. - 9781138792548 - 9780367896843 - 9781315761930 ; , s. 106-114
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Bokkapitel (refereegranskat)abstract
- The purpose of the chapter is to describe and analyse the development of the Swedish sport model in relation to the development of the Swedish Social Democracy and the welfare state in order to explain the strong position of the Swedish Sport Confederation. The sport model is problematised as several conflicting ideas have and continue to influence the model, including the notion of 'Sport for all', elite sport, voluntarism, amateurism, professionalisation and commercialisation. In addition, societal expectations regarding competencies that children and young people should learn and develop while participating in organised sports will be elucidated and problematised. Finally, the sport model will be discussed in relation to patterns of gender relations.
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| 37. |
- Hedenborg, Susanna, et al.
(författare)
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Utvärdering av Idrottslyftet : Svenska Ridsportförbundet, Svenska Klätterförbundet, Svenska Orienteringsförbundet, Svenska Simförbundet och Svenska Taekwondoförbundet
- 2012
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Rapport (populärvet., debatt m.m.)abstract
- Genom regeringens satsning, kallad” Idrottslyftet”, fick den svenska idrottsrörelsen under perioden 2007–2011 möjlighet att genomföra den hittills största satsningen någonsin för att utveckla barn-och ungdomsidrotten. Idrottsrörelsen har sammanlagt fått två miljarder kronor för att öppna dörrarna till idrotten för fler barn och ungdomar och utveckla verksamheten, så att de väljer att idrotta längre upp i åldrarna. Arbetet skulle utgå från ett jämställdhets-och jämlikhetsperspektiv och genomsyras av riktlinjerna i” Idrotten vill”.Denna rapport utvärderar detta arbete i fyra specialidrottsförbund: Svenska Ridsportförbundet, Svenska Klätterförbundet, Svenska Orienteringsförbundet, Svenska Simförbundet och Svenska Taekwondoförbundet.
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| 38. |
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Hur är det i praktiken? : Lärare utforskar ämnet idrott och hälsa
- 2016
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Vad ska elever lära sig i idrott och hälsa? Hur lägger man upp undervisning som stödjer alla elever i deras lärande? Hur kan lärare göra likvärdiga bedömningar av elevers kunskaper? Detta är några av de frågor som behandlas i denna bok. Boken sammanfattar den forskning som genomförts inom Forskarskolan i idrott och hälsas didaktik (FIHD). FIHD startade år 2011 som ett led i den statliga satsningen Lärarlyftet, där särskilda medel avsattes för genomförandet av forskarskolor för lärare och förskollärare. Deltagarna i FIHD är alla verksamma lärare i idrott och hälsa. I denna bok presenterar de översiktligt resultat och slutsatser från sina olika forskningsprojekt. Kapitlen behandlar aktuella teman som lärande, hälsa, etnicitet och genus samt betyg och bedömning i idrott och hälsa.Boken finns fritt tillgänglig på webben.Innehåll:Forskarskolan i idrott och hälsas didaktik: praktiknära idrottsdidaktikTräffar vi alltid rätt? Elevers lärande i idrott och hälsa / Andreas JacobssonElevers förståelse av hälsa i idrott och hälsa / Annika AhlbergÄr grönsaker alltid hälsosamt? / Magnus BrolinHitta lätt – så blir det rätt! / Kerstin NilssonDansspel som läromedel / Béatrice GibbsDokumentation i idrott och hälsa – en omöjlig ekvation? / Rickard HåkansonPassar jag in? Nyanlända ungas möte med idrott och hälsa / Åke HuitfeldtAtt göra tudelning – idrott och hälsa i åk 1 ur ett genusperspektiv / Inga OliynykBedömning för lärande (BFL) i ämnet idrott och hälsa / Björn TolgforsVad är ”kroppslig förmåga”? Om behovet av ett yrkesspråk i idrott och hälsa / Jenny KroonBetygsättning – ett (o)möjligt uppdrag? / Izabela Seger
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| 39. |
- Ison, Jon, et al.
(författare)
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The bio.tools registry of software tools and data resources for the life sciences
- 2019
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Ingår i: Genome Biology. - : BMC. - 1465-6906 .- 1474-760X. ; 20:1
-
Tidskriftsartikel (refereegranskat)abstract
- Bioinformaticians and biologists rely increasingly upon workflows for the flexible utilization of the many life science tools that are needed to optimally convert data into knowledge. We outline a pan-European enterprise to provide a catalogue () of tools and databases that can be used in these workflows. bio.tools not only lists where to find resources, but also provides a wide variety of practical information.
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| 40. |
- Jones, Geraint H., et al.
(författare)
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The Comet Interceptor Mission
- 2024
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Ingår i: Space Science Reviews. - : Springer Nature. - 0038-6308 .- 1572-9672. ; 220:1
-
Tidskriftsartikel (refereegranskat)abstract
- Here we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What are the surface composition, shape, morphology, and structure of the target object? What is the composition of the gas and dust in the coma, its connection to the nucleus, and the nature of its interaction with the solar wind? The mission was proposed to the European Space Agency in 2018, and formally adopted by the agency in June 2022, for launch in 2029 together with the Ariel mission. Comet Interceptor will take advantage of the opportunity presented by ESA’s F-Class call for fast, flexible, low-cost missions to which it was proposed. The call required a launch to a halo orbit around the Sun-Earth L2 point. The mission can take advantage of this placement to wait for the discovery of a suitable comet reachable with its minimum Δ V capability of 600 ms − 1 . Comet Interceptor will be unique in encountering and studying, at a nominal closest approach distance of 1000 km, a comet that represents a near-pristine sample of material from the formation of the Solar System. It will also add a capability that no previous cometary mission has had, which is to deploy two sub-probes – B1, provided by the Japanese space agency, JAXA, and B2 – that will follow different trajectories through the coma. While the main probe passes at a nominal 1000 km distance, probes B1 and B2 will follow different chords through the coma at distances of 850 km and 400 km, respectively. The result will be unique, simultaneous, spatially resolved information of the 3-dimensional properties of the target comet and its interaction with the space environment. We present the mission’s science background leading to these objectives, as well as an overview of the scientific instruments, mission design, and schedule.
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| 41. |
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| 42. |
- Larsson, Håkan, et al.
(författare)
-
Forskarskolan i idrott och hälsas didaktik : praktiknära idrottsdidaktik
- 2016
-
Ingår i: Hur är det i praktiken?. - Stockholm : Gymnastik- och idrottshögskolan, GIH. - 9789198086287 ; , s. 5-16
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Vad ska elever lära sig i idrott och hälsa? Hur lägger man upp undervisning som stödjer alla elever i deras lärande? Hur kan lärare göra likvärdiga bedömningar av elevers kunskaper? Detta är några av de frågor som behandlas i boken du nu håller i. Boken sammanfattar den forskning som genomförts inom Forskarskolan i idrott och hälsas didaktik (FIHD). FIHD startade år 2011 som ett led i den statliga satsningen Lärarlyftet, där särskilda medel avsattes för genomförandet av forskarskolor för lärare och förskollärare. Deltagarna i FIHD är alla verksamma lärare i idrott och hälsa. Detta har en central betydelse i sammanhanget. Skolämnet idrott och hälsa har funnits länge i den svenska skolan, men den vetenskapliga förankringen och utforskningen av ämnet har varit svag. Den forskning som existerat har inte i första hand genomförts av, eller på initiativ av, lärare i ämnet. Initiativen har istället kommit från annat håll, ofta från olika myndigheter. Forskningsresultaten har speglat myndigheternas intressen snarare än lärarnas. Därför är det ett stort nöje att i denna bok få möjlighet att presentera forskningsresultat som bygger på lärares frågor och där lärare har varit forskare. I detta inledande kapitel presenterar FIHD:s styrgrupp, bestående av medarbetare vid Gymnastik- och idrottshögskolan (GIH), Malmö högskola och Örebro universitet, bakgrunden till FIHD, den forskning som fanns till hands då lärarna påbörjade sina forskningsprojekt samt de ambitioner som varit förknippade med forskarskolan.
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| 43. |
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| 44. |
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| 45. |
- Leiding, Thom, et al.
(författare)
-
Precise detection of pH inside large unilamellar vesicles using membrane-impermeable dendritic porphyrin-based nanoprobes.
- 2009
-
Ingår i: Analytical Biochemistry. - : Elsevier BV. - 1096-0309 .- 0003-2697. ; 388, s. 296-305
-
Tidskriftsartikel (refereegranskat)abstract
- Accurate real-time measurements of proton concentration gradients are pivotal to mechanistic studies of proton translocation by membrane-bound enzymes. Here we report a detailed characterization of the pH-sensitive fluorescent nanoprobe Glu(3), which is well suited for pH measurements in microcompartmentalized biological systems. The probe is a polyglutamic porphyrin dendrimer in which multiple carboxylate termini ensure its high water solubility and prevent its diffusion across phospholipid membranes. The probe's pK is in the physiological pH range, and its protonation can be followed ratiometrically by absorbance or fluorescence in the ultraviolet (UV)-visible spectral region. The usefulness of the probe was enhanced by using a semiautomatic titration system coupled to a charge-coupled device (CCD) spectrometer, enabling fast and accurate titrations and full spectral coverage of the system at millisecond time resolution. The probe's pK was measured in bulk solutions as well as inside large unilamellar vesicles in the presence of physiologically relevant ions. Glu(3) was found to be completely membrane impermeable, and its distinct spectroscopic features permit pH measurements inside closed membrane vesicles, enabling quantitative mechanistic studies of membrane-spanning proteins. Performance of the probe was demonstrated by monitoring the rate of proton leakage through the phospholipid bilayer in large vesicles with and without the uncoupler gramicidin present. Overall, as a probe for biological proton translocation measurements, Glu(3) was found to be superior to the commercially available pH indicators.
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| 46. |
- Limbach, Maia, et al.
(författare)
-
Epigenetic profiling in CD4+and CD8+T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling
- 2016
-
Ingår i: Journal of Autoimmunity. - : Elsevier BV. - 0896-8411 .- 1095-9157. ; 67, s. 46-56
-
Tidskriftsartikel (refereegranskat)abstract
- In Graves' disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identify the epigenetic changes involved in GD, we performed a genome-wide analysis of DNA methylation and enrichment of H3K4me3 and H3K27ac histone marks in sorted CD4+ and CD8+ T cells. We found 365 and 3322 differentially methylated CpG sites in CD4+ and CD8+ T cells, respectively. Among the hypermethylated CpG sites, we specifically found enrichment of genes involved in T cell signaling (CD247, LCK, ZAP70, CD3D, CD3E, CD3G, CTLA4 and CD8A) and decreased expression of CD3 gene family members. The hypermethylation was accompanied with decreased levels of H3K4me3 and H3K27ac marks at several T cell signaling genes in ChIP-seq analysis. In addition, we found hypermethylation of the TSHR gene first intron, where several GD-associated polymorphisms are located. Our results demonstrate an involvement of dysregulated DNA methylation and histone modifications at T cell signaling genes in GD patients.
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| 47. |
- Linnman, Clas, et al.
(författare)
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Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow
- 2016
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:9
-
Tidskriftsartikel (refereegranskat)abstract
- Substance P is released in painful and inflammatory conditions, affecting both peripheral processes and the central nervous system neurokinin 1 (NK1) receptor. There is a paucity of data on human brain alterations in NK1 expression, how this system may be affected by treatment, and interactions between central and peripheral tissue alterations. Ten subjects with chronic tennis elbow (lateral epicondylosis) were selected out of a larger (n = 120) randomized controlled trial evaluating graded exercise as a treatment for chronic tennis elbow (lateral epicondylosis). These ten subjects were examined by positron emission tomography (PET) with the NK1-specific radioligand 11C-GR205171 before, and eight patients were followed up after treatment with graded exercise. Brain binding in the ten patients before treatment, reflecting NK1-receptor availability (NK1-RA), was compared to that of 18 healthy subjects and, longitudinally, to the eight of the original ten patients that agreed to a second PET examination after treatment. Before treatment, patients had significantly lower NK1-RA in the insula, vmPFC, postcentral gyrus, anterior cingulate, caudate, putamen, amygdala and the midbrain but not the thalamus and cerebellum, with the largest difference in the insula contralateral to the injured elbow. No significant correlations between brain NK1-RA and pain, functional severity, or peripheral NK1-RA in the affected limb were observed. In the eight patients examined after treatment, pain ratings decreased in everyone, but there were no significant changes in NK1-RA. These findings indicate a role for the substance P (SP) / NK1 receptor system in musculoskeletal pain and tissue healing. As neither clinical parameters nor successful treatment response was reflected in brain NK1-RA after treatment, this may reflect the diverse function of the SP/NK1 system in CNS and peripheral tissue, or a change too small or slow to capture over the three-month treatment.
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| 48. |
- Nesse, Martin, et al.
(författare)
-
Organisational knowledge creation in Norwegian football : From talk to text
- 2017
-
Ingår i: Idrottsforum.org/Nordic sport science forum. - : idrottsforum.org. - 1652-7224. ; :2017-10-12
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This article discusses knowledge creation in Norwegian football, how and to what extent work is done to externalise and preserve tacit knowledge at association and club level, and the differences in approach to knowledge management at those two levels. It is based on a qualitative research design with fourteen interviews. Five of the interviewees work for the Norwegian Football Association (Norges Fotballforbund, NFF), and nine of them work in two leading clubs. The theoretical starting point for the study is Nonaka’s (1994) Organizational Knowledge Creation Theory. The results of the study show that at both association and club level cultural norms for knowledge creation exist in varying degrees. Tacit knowledge is based on a selection of experiences drawn largely from the world of football in which different career patterns, education and work experience contribute to variation in the process of knowledge creation. There are also organisational cultures at both association and club level which are well suited to this kind of knowledge creation. These cultures manifest themselves in cultural norms and rules for the social contexts in which knowledge is created. These include coaches’ meetings and observation at the training ground. There are a number of challenges for the development of good knowledge creation practices in Norwegian football. The most significant one relates to the ability of the organisational culture to record new knowledge in written form. This ability is either totally lacking or exists in a form which is only effective for the transmission of established knowledge. The way the association and the clubs create written records is critical for further progress. As the association is at the top of the hierarchy and sets the direction for clubs at grass-roots level, the way it records knowledge has consequences which go beyond its own culture.
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| 49. |
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| 50. |
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