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- Ambrosio, M, et al.
(författare)
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The MACRO detector at Gran Sasso
- 2002
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576. ; 486:3, s. 663-707
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Tidskriftsartikel (refereegranskat)abstract
- MACRO was an experiment that ran in the Laboratori Nazionali del Gran Sasso from 1988 to 2000. Its principal goal was to observe magnetic monopoles or set significantly lower experimental flux limits than had been previously available in the velocity range from about beta = 10(-4) to unity. In addition it made a variety of other observations. Examples are: setting flux limits on other so far unobserved particles such as nuclearites and lightly ionizing particles, searching for WIMP annihilations in the Earth and the Sun and for neutrino bursts from stellar collapses in or near our Galaxy, and making measurements relevant to high energy muon and neutrino astronomy and of the flux of up-going muons as a function of nadir angle showing evidence for neutrino oscillations. The apparatus consisted of three principal types of detectors: liquid scintillator counters, limited streamer tubes, and nuclear track etch detectors. In addition, over part of its area it contained a transition radiation detector. The general design philosophy emphasized redundancy and complementarity. This paper describes the technical aspects of the complete MACRO detector, its operational performance, and the techniques used to calibrate it and verify its proper operation. It supplements a previously published paper which described the first portion of the detector that was built and operated. (C) 2002 Elsevier Science B.V. All rights reserved.
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| 2. |
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| 4. |
- Drakulic, D, et al.
(författare)
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Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD
- 2020
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Ingår i: Molecular autism. - : Springer Science and Business Media LLC. - 2040-2392. ; 11:1, s. 42-
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Tidskriftsartikel (refereegranskat)abstract
- Patients diagnosed with chromosome microdeletions or duplications, known as copy number variants (CNVs), present a unique opportunity to investigate the relationship between patient genotype and cell phenotype. CNVs have high genetic penetrance and give a good correlation between gene locus and patient clinical phenotype. This is especially effective for the study of patients with neurodevelopmental disorders (NDD), including those falling within the autism spectrum disorders (ASD). A key question is whether this correlation between genetics and clinical presentation at the level of the patient can be translated to the cell phenotypes arising from the neurodevelopment of patient induced pluripotent stem cells (iPSCs).Here, we examine how iPSCs derived from ASD patients with an associated CNV inform our understanding of the genetic and biological mechanisms underlying the aetiology of ASD. We consider selection of genetically characterised patient iPSCs; use of appropriate control lines; aspects of human neurocellular biology that can capture in vitro the patient clinical phenotype; and current limitations of patient iPSC-based studies. Finally, we consider how future research may be enhanced to maximise the utility of CNV patients for research of pathological mechanisms or therapeutic targets.
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| 6. |
- Kordatzaki, G., et al.
(författare)
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A diachronic investigation of 'local' pottery production and supply at the sanctuary of Zeus, Mount Lykaion, Arcadia, Peloponnese
- 2016
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Ingår i: Journal of Archaeological Science: Reports. - : Elsevier BV. - 2352-409X .- 2352-4103. ; 7, s. 526-529
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Tidskriftsartikel (refereegranskat)abstract
- © 2016 Elsevier Ltd. The present paper reports results of an integrated study of a selection of pottery recovered from the altar of Zeus, Mount Lykaion, Arcadia, in the Peloponnese, Greece, dating from the Neolithic to the Early Iron Age. A multi-analytical approach based on petrographic and chemical analysis, supported by refiring tests and geological sampling, has been employed to tackle issues of technology and provenance. Results shed light on patterns of raw material sources exploitation and pottery production and supply at the site over time.
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