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- Forouzanfar, Mohammad H, et al.
(författare)
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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.
- 2015
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 386:10010, s. 2287-2323
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.FINDINGS: All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.INTERPRETATION: Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.FUNDING: Bill & Melinda Gates Foundation.
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| 4. |
- Amann, F., et al.
(författare)
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A search for murarregamma at the level of 10-13
- 1991
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Ingår i: Proceedings of the 25th International Conference on High Energy Physics. - 9810024347 ; , s. 1070-1071
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Konferensbidrag (refereegranskat)abstract
- The MEGA experiment, which is a search for the decay murarregamma with a branching ratio sensitivity of about 10-13, employs highly modular, fast detectors, state-of-the-art electronics, and a staged trigger with on-line filters. The detectors are contained in a 1.5-T solenoidal field produced by a superconducting magnet. Positrons are confined to the central region and are measured by a set of thin MWPCs. Photons are measured by one of four layers of pair spectrometers in the outer region. Most aspects of the design have been validated in engineering runs; data taking will begin in 1990 with much of the electron arm and one pair spectrometer layer installed.
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| 7. |
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Preface
- 2018
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Samlingsverk (redaktörskap) (refereegranskat)
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| 8. |
- Brink, Lars, 1943, et al.
(författare)
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Preface - Topological phase transitions and new developments
- 2018
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Ingår i: Topological phase transitions and new developments. ; , s. v-vi
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Geometry and topology have been a fascination in physics since the start of the 20th century. A leading example is Einstein's geometrical theory of gravity. At the beginning of the 1970s, topological ideas entered areas of condensed matter physics. These advances were driven by new seminal ideas resolving a serious contradiction between experiment and the standard interpretation of a rigorous mathematical theorem which led to the study of new exotic topological phases of matter. Topological defect driven phase transitions in thin, two dimensional films of superfluids, superconductors and crystals have provided great insight into the mechanism governing these topological phases present in those physical systems. Moreover, many of these topological properties remain 'protected' against disorder and topological distortion perturbations. An example of possible applications of such robustness to perturbations is in the search for encoding information in quantum computers, potentially providing the platform for fault-tolerant quantum computations. In the past four decades, the discovery of topological phases engendered great interest in condensed matter physics. It also attracted the attention of researchers working on quantum information, quantum materials and simulations, high energy physics and string theory. This unique volume contains articles written by some of the most prominent names in the field, including Nobel Laureate John Michael Kosterlitz and Professor Jorge V José. They originate from talks and discussions by leading experts at a recent workshop. They review previous works as well as addressing contemporary developments in the most pressing and important issues on various aspects of topological phases and topological phase transitions.
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| 9. |
- Brink, Lars, 1943, et al.
(författare)
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Topological Phase Transitions and New Developments
- 2018
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Geometry and topology have been a fascination in physics since the start of the 20th century. A leading example is Einstein's geometrical theory of gravity. At the beginning of the 1970s, topological ideas entered areas of condensed matter physics. These advances were driven by new seminal ideas resolving a serious contradiction between experiment and the standard interpretation of a rigorous mathematical theorem which led to the study of new exotic topological phases of matter. Topological defect driven phase transitions in thin, two dimensional films of superfluids, superconductors and crystals have provided great insight into the mechanism governing these topological phases present in those physical systems. Moreover, many of these topological properties remain 'protected' against disorder and topological distortion perturbations. An example of possible applications of such robustness to perturbations is in the search for encoding information in quantum computers, potentially providing the platform for fault-tolerant quantum computations. In the past four decades, the discovery of topological phases engendered great interest in condensed matter physics. It also attracted the attention of researchers working on quantum information, quantum materials and simulations, high energy physics and string theory. This unique volume contains articles written by some of the most prominent names in the field, including Nobel Laureate John Michael Kosterlitz and Professor Jorge V José. They originate from talks and discussions by leading experts at a recent workshop. They review previous works as well as addressing contemporary developments in the most pressing and important issues on various aspects of topological phases and topological phase transitions.
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