| 1. |
- Eriksson, Peter J, 1959, et al.
(författare)
-
Transcatheter Intervention for Coarctation of the Aorta A Nordic Population-Based Registry With Long-Term Follow-Up
- 2023
-
Ingår i: Jacc-Cardiovascular Interventions. - : Elsevier BV. - 1936-8798 .- 1876-7605. ; 16:4, s. 444-453
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Coarctation of the aorta (CoA), a congenital narrowing of the proximal descending thoracic aorta, is a relatively common form of congenital heart disease. Untreated significant CoA has a major impact on morbidity and mortality. In the past 3 decades, transcatheter intervention (TCI) for CoA has evolved as an alternative to surgery.OBJECTIVES The authors report on all TCIs for CoA performed from 2000 to 2016 in 4 countries covering 25 million inhabitants, with a mean follow-up duration of 6.9 years.METHODS During the study period, 683 interventions were performed on 542 patients.RESULTS The procedural success rate was 88%, with 9% considered partly successful. Complications at the intervention site occurred in 3.5% of interventions and at the access site in 3.5%. There was no in-hospital mortality. During follow-up, TCI for CoA reduced the presence of hypertension significantly from 73% to 34%, but despite this, many patients remained hypertensive and in need of continuous antihypertensive treatment. Moreover, 8% to 9% of patients needed aortic and/or aortic valve surgery during follow-up.CONCLUSIONS TCI for CoA can be performed with a low risk for complications. Lifetime follow-up after TCI for CoA seems warranted. (J Am Coll Cardiol Intv 2023;16:444-453) & COPY; 2023 by the American College of Cardiology Foundation.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Akhter, Naveed, et al.
(författare)
-
Growing, Developing, and Performing Family Business Groups : Introduction to the Handbook
- 2022
-
Ingår i: The Palgrave Handbook of Managing Family Business Groups. - Cham : Springer. - 9783031132056 - 9783031132087 - 9783031132063 ; , s. 1-12
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Family business groups (FBGs) are a fascinating phenomenon. They exist everywhere under different names and guises (Parada et al., Academia Revista Latinoamericana De Administración 20:19-30, 2016; Tu et al., Business Horizons 45:39-46, 2002). Their emergence and development showcase the dynamics of families in business and the decisions they proactively, or reactively, take to business opportunities or institutional and contextual challenges. More recent accounts underscore that we are just beginning to understand how they grow, develop, and perform over time (Rosa, P., Rautiainen, M., Pihkala, T., Parada, M. J., and Discua Cruz, A. (2019). Conclusions: Researching family business groups: Lessons learned and avenues for further research. In The family business group phenomenon (pp. 387-395). Palgrave Macmillan, Cham.).
|
|
| 8. |
- Akhter, Naveed, et al.
(författare)
-
Understanding the Dynamics of FBGs : Avenues for Further Research
- 2022
-
Ingår i: The Palgrave Handbook of Managing Family Business Groups. - Cham : Springer. - 9783031132056 - 9783031132087 - 9783031132063 ; , s. 619-630
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The main interest of this book has dealt with the inherent strengths of FBGs, widening our understanding of their sustainability, competitiveness, and development. This book highlights that research conducted on the internal dynamics of FBGs is sparse. The phenomenon has remained severely understudied around the world.
|
|
| 9. |
|
|
| 10. |
- Autti, Taina, et al.
(författare)
-
Bone marrow transplantation in aspartylglucosaminuria : histopathological and MRI study
- 1999
-
Ingår i: Neuropediatrics. - : Georg Thieme Verlag KG. - 0174-304X .- 1439-1899. ; 30:6, s. 283-8
-
Tidskriftsartikel (refereegranskat)abstract
- This study comprised two patients with aspartylglucosaminuria (AGU), who were followed up for 4 and 7 years. The patients underwent allogeneic bone marrow transplantation (BMT) at the ages of 2 and 2.6 years. Both patients had abnormal speech development and gross motor clumsiness. At the time of the BMT, they were mentally retarded. We report on follow-up data of these patients obtained by MRI, in addition to the histopathological, biochemical and clinical investigations. MR images of six non-transplanted patients and seven healthy children served as controls. In the non-transplanted patients, MRI revealed evident delay of myelination in contrast to the two transplanted patients showing fair or evident grey- vs. white matter differentiation on T2-weighted images. The aspartylglucosaminidase (AGA) activity in blood leukocytes reached a heterozygous level. Urinary excretion of aspartylglucosamine and glycoasparagines slowly decreased but remained about a third of the pre-BMT level 5 years after BMT. Storage lysosomes in electron microscopic investigations were not decreased 6 months after BMT, but after 1.5-2 years, rectal mucosa samples showed a decrease in the storage vacuoles of different cells. Three years after BMT, no cells with storage vacuoles were present. Allogeneic BMT slowly normalises the pathological, biochemical and MRI findings in patients with AGU.
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Saarinen-Pihkala, U. M., et al.
(författare)
-
Outcome of children with high-risk acute lymphoblastic leukemia (HR-ALL): Nordic results on an intensive regimen with restricted central nervous system irradiation
- 2004
-
Ingår i: Pediatr Blood Cancer. - 1545-5009. ; 42:1, s. 8-23
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Improvement in outcome of childhood high-risk (HR) ALL was sought with a very intensive Nordic protocol leaving most patients without CNS-RT. METHODS: A total of 426 consecutive children entered the NOPHO-92 HR-ALL program. HR criteria included WBC > or =50 x 10(9)/L, CNS or testicular involvement, T-cell, lymphomatous features, t(9;22), t(4;11), or slow response. Of these, 152 children had very high risk (VHR) with special definitions. CNS consolidation was based on high-dose MTX (8 g/m2) and ARA-C (12 g/m2) alternating. VHR patients also received cranial RT. RESULTS: The 9-year EFS was 61 +/- 3%, OS 74 +/- 2%, and EFS for T-ALL 62 +/- 4%. Cumulative incidence of isolated CNS relapse was 4.7 +/- 1%, and CNS relapse in total 9.9 +/- 2%. Poor prognostic factors were WBC > or =200 x 10(9)/L and a very slow response. CONCLUSIONS: HR-ALL was successfully treated on the NOPHO-92 regimen, with a relatively low CNS relapse rate for non-irradiated children. WBC > or =200 x 10(9)/L and very slow response emerged as strong poor prognostic factors.
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
-
The Palgrave Handbook of Managing Family Business Groups
- 2022
-
Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- Family business groups (FBGs) are ubiquitous, influential, and play a major role in national economies. While much of the current research around this topic has so far focused on emerging economies, more knowledge is needed on family business groups in developed economies; specifically, how they innovate, strategize, govern, and grow. Offering a comprehensive and global perspective on family business groups, this Handbook comprises international contributions from leading experts. Split into five sections, it covers strategy and business transformation; innovation strategies; management and governance; and new avenues for research on FBGs including the issues of sustainability and cultural alignment. An important resource for students and researchers of family business, strategy and management, this Handbook signals the emergence of the family business group phenomenon and solidifies research in this evolving area of study.
|
|
| 21. |
- Vakkila, J, et al.
(författare)
-
[Cancer immunotherapy]
- 1999
-
Ingår i: Duodecim. - 0012-7183. ; 115:7, s. 785-94
-
Tidskriftsartikel (refereegranskat)
|
|
| 22. |
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
- Westerholm-Ormio, M, et al.
(författare)
-
Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes
- 2003
-
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 52:9, s. 2287-2295
-
Tidskriftsartikel (refereegranskat)abstract
- Involvement of gut immune system has been implicated in the pathogenesis of type 1 diabetes. However, few studies have been performed on the gut mucosa from patients with type 1 diabetes. Thus, we characterized the stage of immune activation in jejunal biopsy samples from 31 children with type 1 diabetes by immunohistochemistry, in situ hybridization, and RT-PCR. We found enhanced expressions of HLA-DR, HLA-DP, and intercellular adhesion molecule-1 by immunohistochemistry even on structurally normal intestine of patients with type 1 diabetes and no signs of celiac disease. In addition, the densities of IL-1a- and IL-4-positive cells detected by immunohistochemistry and IL-4 mRNA-expressing cells evaluated by in situ hybridization were increased in the lamina propria in patients with type 1 diabetes and normal mucosa. Instead, the densities of IL-2, ?-interferon (IFN-?), and tumor necrosis factor a-positive cells, the density of IFN-? mRNA positive cells, and the amounts of IFN-? mRNA detected by RT-PCR correlated with the degree of celiac disease in patients with type 1 diabetes. Our study supports the hypothesis that a link exists between the gut immune system and type 1 diabetes.
|
|
| 29. |
|
|
| 30. |
|
|
