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- Peyrot, Daniel, et al.
(författare)
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The greening of Western Australian landscapes: the Phanerozoic plant record
- 2019
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Ingår i: Journal of the Royal Society of Western Australia. - Perth : Royal Society of Western Australia. - 0035-922X. ; 102, s. 52-82
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Tidskriftsartikel (refereegranskat)abstract
- Western Australian terrestrial floras first appeared in the Middle Ordovician (c. 460 Ma) and developed Gondwanan affinities in the Permian. During the Mesozoic, these floras transitioned to acquire a distinctly austral character in response to further changes in the continent’s palaeolatitude and its increasing isolation from other parts of Gondwana. This synthesis of landscape evolution is based on palaeobotanical and palynological evidence mostly assembled during the last 60 years. The composition of the plant communities and the structure of vegetation changed markedly through the Phanerozoic. The Middle Ordovician –Middle Devonian was characterised by diminutive vegetation in low-diversity communities. An increase in plant size is inferred from the Devonian record, particularly from that of the Late Devonian when a significant part of the flora was arborescent. Changes in plant growth-forms accompanied a major expansion of vegetation cover to episodically or permanently flooded lowland settings and, from the latest Mississippian onwards, to dry hinterland environments. Wetter conditions during the Permian yielded waterlogged environments with complex swamp communities dominated by Glossopteris. In response to the Permian–Triassic extinction event, a transitional vegetation characterised by herbaceous lycopsids became dominant but was largely replaced by the Middle Triassic with seed ferns and shrubs or trees attributed to Dicroidium. Another floristic turnover at the Triassic–Jurassic boundary introduced precursors of Australia’s modern vegetation and other southern hemisphere regions. Most importantly, flowering plants gained ascendancy during the Late Cretaceous. Characteristics of the state’s modern vegetation, such as sclerophylly and xeromorphy, arose during the Late Cretaceous and Paleogene. The vegetation progressively developed its present-day structure and composition in response to the increasing aridity during the Neogene–Quaternary.
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| 2. |
- Jhavar, Sameer, et al.
(författare)
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Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer
- 2009
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Ingår i: BJU International. - 1464-4096. ; 103:9, s. 1256-1269
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE To integrate the mapping of ERG alterations with the collection of expression microarray (EMA) data, as previous EMA analyses have failed to consider the genetic heterogeneity and complex patterns of ERG alteration frequently found in cancerous prostates. MATERIALS AND METHODS We determined genome-wide expression levels with GeneChip Human Exon 1.0 ST arrays (Affymetrix, Santa Clara, CA, USA) using RNA prepared from 35 specimens of prostate cancer from 28 prostates. RESULTS The expression profiles showed clustering, in unsupervised hierarchical analyses, into two distinct prostate cancer categories, with one group strongly associated with indicators of poor clinical outcome. The two categories are not tightly linked to ERG status. By analysis of the data we identified a subgroup of cancers lacking ERG rearrangements that showed an outlier pattern of SPINK1 mRNA expression. There was a major distinction between ERG rearranged and non-rearranged cancers that involves the levels of expression of genes linked to exposure to beta-oestradiol, and to retinoic acid. CONCLUSIONS Expression profiling of prostate cancer samples containing single patterns of ERG alterations can provide novel insights into the mechanism of prostate cancer development, and support the view that factors other than ERG status are the major determinants of poor clinical outcome.
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