| 1. |
- Pluščiauskaitė, Vilma, et al.
(författare)
-
An objective approach to identifying individual atrial fibrillation triggers : A simulation study
- 2024
-
Ingår i: Biomedical Signal Processing and Control. - 1746-8094. ; 87
-
Tidskriftsartikel (refereegranskat)abstract
- Background and Objective: Growing evidence shows that certain acute exposures, especially alcohol, may trigger episodes of paroxysmal atrial fibrillation (AF). However, there is a lack of methods for assessing the relation between triggers and AF episodes in individual patients. The present paper proposes an approach to identifying AF triggers based on the assumption that the post-trigger AF burden is larger than the pre-trigger AF burden during the analysis time interval. Method: For the purpose of identification, a measure of relational strength between pre- and post-trigger burden is introduced, accounting for the cumulative effect of the triggers contained in the observation interval. The proposed approach is explored for different types of AF episode pattern, generated using the alternating, bivariate Hawkes model, whose conditional intensity function is designed to account for the effect of alcohol. In total, 7200 different AF patterns were generated for different numbers of AF triggers and alcohol units. Results: The simulation study demonstrates that, depending on the pattern type, the relational strength increases 3–6 times with alcohol consumption in comparison with no consumption. Conclusions: The proposed approach to identifying triggers in individual patients with paroxysmal AF should facilitate the implementation of longitudinal studies for the objective assessment of trigger effect on AF occurrence.
|
|
| 2. |
- Plusciauskaite, Vilma, et al.
(författare)
-
Detection of Pre-and Post-Trigger Atrial Fibrillation in Long-Term Photoplethysmogram Signals Acquired in Free-Living
- 2023
-
Ingår i: Computing in Cardiology, CinC 2023. - 9798350382525
-
Konferensbidrag (refereegranskat)abstract
- Modifiable factors, such as alcohol or physical exertion, may trigger atrial fibrillation (AF) episodes. Identifying and eliminating these triggers can lead to effective strategies which reduce risk of AF recurrence. This study aims to evaluate pre-and post-trigger AF in long-term photo-plethysmogram (PPG) signals obtained during daily living from patients with paroxysmal AF. Thirty-seven patients were instructed to wear a wrist-worn device for a week. They were also asked to log suspected triggers using a smartphone app. Of these patients, 15 experienced AF episodes, resulting in an average AF burden of 0.15. The results indicate that longer post-trigger analysis time intervals resulted in better performance of PPG-based AF detection. The sensitivity was highest for the 16-h post-trigger interval (0.76) and lowest for the 4-h interval (0.43). In contrast, the specificity slightly decreased with an increasing longer post-trigger analysis time interval, being 0.98 and 0.95 for the 4-h and 16-h intervals, respectively. The PPG-based post-trigger AF burden was approximately half of that determined by the annotated ECG-based AF pattern. The study suggests that long-term PPG-based monitoring is a suitable alternative for detecting post-trigger AF instead of ECG-based. However, the accuracy of AF burden estimation using PPG-based technology still calls for improvement.
|
|
| 3. |
- Plusciauskaite, Vilma, et al.
(författare)
-
Modeling of the Effect of Alcohol on Episode Patterns in Atrial Fibrillation
- 2022
-
Ingår i: 2022 Computing in Cardiology, CinC 2022. - 2325-887X .- 2325-8861. - 9798350300970 ; 2022-September
-
Konferensbidrag (refereegranskat)abstract
- Growing evidence shows that alcohol triggers paroxysmal atrial fibrillation (PAF) in some patients. How-ever, there is a lack of methods for assessing the causality between triggers and atrial fibrillation (AF) episodes. Accordingly, this work aims to develop an approach to episode modeling under the influence of alcohol for the purpose of evaluating causality assessment methods. The alternating, bivariate Hawkes model is used to produce episode patterns, where the conditional intensity function λ1(t) defines the transitions from sinus rhythm (SR) to AF. The effect of alcohol consumption is characterized by a body reactivity function, defined by the base intensity μ1(t), which alters λ1(t). Different AF episode patterns were modeled for alcohol units ranging from 0 to 15. The mean AF burden without alcohol was 17.2%, which doubled with 9 alcohol units; the number of AF episodes doubled from 12.9 with 8 alcohol units. The aggregation of AF episodes tended to decrease after 6 alcohol units. The proposed model of alcohol-affected PAF patterns may be useful for assessing the methods for evaluation of causality between triggers and PAF occurrence.
|
|
