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Sökning: WFRF:(Poller Wolfgang)

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1.
  • Ammirati, Enrico, et al. (författare)
  • Acute Myocarditis Associated With Desmosomal Gene Variants
  • 2022
  • Ingår i: JACC. Heart failure. - : ELSEVIER SCI LTD. - 2213-1779 .- 2213-1787. ; 10:10, s. 714-727
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND The risk of adverse cardiovascular events in patients with acute myocarditis (AM) and desmosomal gene variants (DGV) remains unknown.OBJECTIVES The purpose of this study was to ascertain the risk of death, ventricular arrhythmias, recurrent myocarditis, and heart failure (main endpoint) in patients with AM and pathogenic or likely pathogenetic DGV.METHODS In a retrospective international study from 23 hospitals, 97 patients were included: 36 with AM and DGV (DGV[+]), 25 with AM and negative gene testing (DGV[-]), and 36 with AM without genetics testing. All patients had troponin elevation plus findings consistent with AM on histology or at cardiac magnetic resonance (CMR). In 86 patients, CMR changes in function and structure were re-assessed at follow-up.RESULTS In the DGV(+) AM group (88.9% DSP variants), median age was 24 years, 91.7% presented with chest pain, and median left ventricular ejection fraction (LVEF) was 56% on CMR (P = NS vs the other 2 groups). Kaplan-Meier curves demonstrated a higher risk of the main endpoint in DGV(+) AM compared with DGV(-) and without genetics testing patients (62.3% vs 17.5% vs 5.3% at 5 years, respectively; P < 0.0001), driven by myocarditis recurrence and ventricular arrhythmias. At follow-up CMR, a higher number of late gadolinium enhanced segments was found in DGV(+) AM. CONCLUSIONS Patients with AM and evidence of DGV have a higher incidence of adverse cardiovascular events compared with patients with AM without DGV. Further prospective studies are needed to ascertain if genetic testing might improve risk stratification of patients with AM who are considered at low risk. (J Am Coll Cardiol HF 2022;10:714-727) (c) 2022 by the American College of Cardiology Foundation.
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2.
  • Salaj-Kosla, Urszula, et al. (författare)
  • Direct electron transfer of Trametes hirsuta laccase adsorbed at unmodified nanoporous gold electrodes
  • 2013
  • Ingår i: Bioelectrochemistry. - : Elsevier. - 1567-5394 .- 1878-562X. ; 91, s. 15-20
  • Tidskriftsartikel (refereegranskat)abstract
    • The enzyme Trametes hirsuta laccase undergoes direct electron transfer at unmodified nanoporous gold electrodes, displaying a c.d. of 28 μA​/cm2. The response indicates that ThLc was immobilized at the surface of the nanopores in a manner which promoted direct electron transfer, in contrast to the absence of a response at unmodified polycryst. gold electrodes. The bioelectrocatalytic activity of ThLc modified nanoporous gold electrodes was strongly dependent on the presence of halide ions. Fluoride completely inhibited the enzymic response, whereas in the presence of 150 mM Cl-​, the current was reduced to 50​% of the response in the absence of Cl-​. The current increased by 40​% when the temp. was increased from 20 °C to 37 °C. The response is limited by enzymic and​/or enzyme electrode kinetics and is 30​% of that obsd. for ThLc co-​immobilized with an osmium redox polymer.
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