| 1. |
- Björk, Ann-Kristin, et al.
(författare)
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Occupational allergic contact dermatitis to gloves, follow-up of investigated patients
- 2014
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 70:Suppl s1, s. 94-94
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: In the Department of Occupational and Environmental Dermatology there has been an increase in the inflow of patients, working as surgical nurses or surgeons. They have been referred due to presumed occupational contact dermatitis. Results from investigated patients have in part been presented previously, where the investigation has shownmultiple contact allergies caused by their occupational use of gloves. Allergens such as diphenylguanidine were found in the gloves and contact allergies to their rubber gloves were found. Many of the patients have been working for decades in their present occupation, but the hand dermatitis had often been present for less than a year. Objectives: To present a follow-up of patientswith hand dermatitis due to gloves. Methods: A follow-up of the patients and a structure for the investigation of the individual patient are given. Results: The cases will be presented with their contact allergies, howtheinvestigation isperformedandtheoutcomeof theprevention by avoiding gloves containing the allergens diagnosed in the individual patients. Conclusions: For health care personnel hand hygiene and the wearing of protective gloves are mandatory. Our findings indicate that the increased need to use rubber gloves and at the same time the exclusion of latex gloves give rise to new contact allergies which are clinically relevant. In the investigation, and the advice given to the patients, several factors have to be taken into consideration, including the fast change of glove material. The cases indicate the importance of close cooperation between chemists and dermatologists and the possibility to perform chemical analysis. Furthermore, and just as important for this patient group, is that with correct diagnosis and advice the contact dermatitis can actually heal completely and the patients continue in their work.
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| 2. |
- Li, Xuri, et al.
(författare)
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Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
- 2005
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Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 115:1, s. 118-127
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Tidskriftsartikel (refereegranskat)abstract
- The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
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| 3. |
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| 4. |
- Rosén, Gunnar, et al.
(författare)
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Samverkan : förutsättningar och möjligheter till stärkt arbetsmiljöarbete genom regional samverkan.
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rosén G, Hedlund A, Andersson I, Antonsson A, Bornberger-Dankvardt S, Klusell L, Pontén P. Samverkan. Förutsättningar och möjligheter till stärkt arbetsmiljöarbete genom regional eller lokal samverkan. Inom ramen för Tema SMARTA vid Arbetslivsinstitutet har ett delprojekt utgående från forskningsfrågan ”Hur bör en regional samverkan utformas för att stödja arbetsmiljöarbete i en region?” genomförts. Projektet har varit uppdelat i två etapper där den första delen givit förslag till en modell som beskriver hur en regional samverkan kring arbetsmiljöfrågor kan utvecklas från det att ett initiativ tas till avslut. Syftet med den andra etappen i projektet som redovisas i denna rapport har varit att ge stöd till aktörer, såväl drivande som medverkande, som avser att genom regional samverkan i projekt förbättra arbetsmiljö och arbetsmiljöarbete. Detta syfte nås genom att skapa underlag för utformning av stödmaterial. Den under första etappen beskrivna modellen för samverkan har använts som utgångspunkt för ett antal intervjuer av möjliga aktörer i en samverkan på en lokal nivå inom kommunen Borlänge och regionalt inom träbranschen i Bergslagen. Intervjuer har också gjorts på motsvarande sätt med centrala aktörer inom träbranschen och med personer som ingått i en referensgrupp. Förutom detta har också arbetsmöten genomförts tillsammans med centrala och regionala aktörer. Analysen av de samlade resultaten har genomförts i form av tre koncensusmöten där författarna deltagit. Den framtagna processmodellen ansågs av de intervjuade aktörerna ge en bra beskrivning av olika stadier i en samverkan. Intervjuerna av potentiella regionala och lokala aktörer visar på ett tydligt behov av och intresse för samverkan inom det aktuella området. Resultaten av dessa intervjuer tillsammans med övriga intervjuer och arbetsmöten visar vidare på vikten av att någon extern resurs kopplas in som drivande genom hela samverkan. De viktigaste förutsättningarna för en framgångsrik samverkan kan sammanfattas i åtta punkter: Förtroende och tillit; Gemensam värdegrund och tydliga mål; Egen nytta; Tydlighet; Interaktivitet; Tid; Resurser; Eldsjäl. Med utgångspunkt i resultaten bör ett fortsatt arbete inriktas mot att utveckla stödmaterial för intresserade aktörer samt att sprida kunskap genom kurser, seminarier etc.
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| 5. |
- Andersson, Ann-Catrin, et al.
(författare)
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Analysis of protein expression in cell microarrays : A tool for antibody-based proteomics
- 2006
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Ingår i: Journal of Histochemistry and Cytochemistry. - 0022-1554 .- 1551-5044. ; 54:12, s. 1413-1423
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Tidskriftsartikel (refereegranskat)abstract
- Tissue microarray (TMA) technology provides a possibility to explore protein expression patterns in a multitude of normal and disease tissues in a high-throughput setting. Although TMAs have been used for analysis of tissue samples, robust methods for studying in vitro cultured cell lines and cell aspirates in a TMA format have been lacking. We have adopted a technique to homogeneously distribute cells in an agarose gel matrix, creating an artificial tissue. This enables simultaneous profiling of protein expression in suspension- and adherent-grown cell samples assembled in a microarray. In addition, the present study provides an optimized strategy for the basic laboratory steps to efficiently produce TMAs. Presented modifications resulted in an improved quality of specimens and a higher section yield compared with standard TMA production protocols. Sections from the generated cell TMAs were tested for immunohistochemical staining properties using 20 well-characterized antibodies. Comparison of immunoreactivity in cultured dispersed cells and corresponding cells in tissue samples showed congruent results for all tested antibodies. We conclude that a modified TIVIA technique, including cell samples, provides a valuable tool for high-throughput analysis of protein expression, and that this technique can be used for global approaches to explore the human proteome.
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| 6. |
- Andersson, Ann-Catrin, et al.
(författare)
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Elevated levels of the human endogenous retrovirus ERV3 in human sebaceous glands
- 1996
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Ingår i: Journal of Investigative Dermatology. - : Elsevier BV. - 0022-202X .- 1523-1747. ; 106:1, s. 125-128
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Tidskriftsartikel (refereegranskat)abstract
- ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. Long terminal repeat-envelope (env) gene spliced mRNAs of 9 and 3.5 kb are widely expressed in human tissues and cells, but gag-pol mRNAs have not been found. Furthermore, the env gp70 gene contains an open reading frame throughout its length. The highest expression of ERV3 mRNA detected so far is in placenta and the lowest in choriocarcinoma cell lines. We have previously shown that the human monoblastic cell line U-937 and some normal and neoplastic tissues also express high levels of ERV3 env message by Northern blot analysis; however, this method does not distinguish between mRNA expression in different cell types in tissues. In this report, we have studied the ERV3 mRNA expression in specific cell types of human skin by in situ hybridization. We found high levels expression of ERV3 env mRNA in human sebaceous glands in normal skin and dermoid cysts of the ovary. In all glands, the expression is maximal in the periphery of the lobule and ceases towards the center in the region of characteristic holocrine secretion. Since it is known that the regulation of sebaceous glands is primarily via steroid hormones, particularly androgens, it is possible that expression of ERV3 is hormone dependent.
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| 7. |
- Andersson, Siv GE, et al.
(författare)
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The genome sequence of Rickettsia prowazekii and the origin of mitochondria
- 1998
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 396:6707, s. 133-140
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Tidskriftsartikel (refereegranskat)abstract
- We describe here the complete genome sequence (1,111,523 base pairs) of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus. This genome contains 834 protein-coding genes. The functional profiles of these genes show similarities to those of mitochondrial genes: no genes required for anaerobic glycolysis are found in either R. prowazekii or mitochondrial genomes, but a complete set of genes encoding components of the tricarboxylic acid cycle and the respiratory-chain complex is found in R. prowazekii. In effect, ATP production in Rickettsia is the same as that in mitochondria. Many genes involved in the biosynthesis and regulation of biosynthesis of amino acids and nucleosides in free-living bacteria are absent from R. prowazekii and mitochondria. Such genes seem to have been replaced by homologues in the nuclear (host) genome. The R. prowazekii genome contains the highest proportion of non-coding DNA (24%) detected so far in a microbial genome. Such non-coding sequences may be degraded remnants of 'neutralized' genes that await elimination from the genome. Phylogenetic analyses indicate that R. prowazekii is more closely related to mitochondria than is any other microbe studied so far.
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| 8. |
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| 9. |
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| 10. |
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| 11. |
- Carstensen, Ole, et al.
(författare)
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The validity of a questionnaire-based epidemiological study of occupational dermatosis
- 2006
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 55:5, s. 295-300
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to evaluate the validity of a questionnaire and medical anamnesis to identify persons with dermatitis in an occupational setting. The design was a clinical epidemiological cross-sectional study. The study was performed between the second and fourth week of January 2001. A questionnaire was followed a week later by a medical occupational interview and a clinical dermatological examination, including a comprehensive patch test with potential workplace chemicals. The anamnesis and the clinical examination were made independently by occupational and dermatological physicians, and the skin examination was performed blinded to anamnestic data. The setting was the mother plants of a Danish-based international company producing wind turbine systems. The study population was a workplace cohort, highly exposed to epoxy resin systems and other chemicals, and totalled 724 production workers at 4 facilities. The rate of participation was 84.7%. Using enquete questions of current skin rash against the clinical presence of dermatitis, we found a sensitivity of 22% and a specificity of 89%, compared to 45% and 87%, respectively, when the anamnestic work history, taken by an occupational physician, was the screening parameter. Using 'workplace periodic prevalence' of dermatitis, we found sensitivities in the range of 63-76% by a questionnaire and 70-83% by medical anamnesis. Questionnaire screening by skin symptoms gave the highest values for redness, a sensitivity of 33% and a specificity of 76%, and decreasing validity parameters as more symptoms were added to the list of screening questions. We found that the use of a questionnaire and medical anamnesis were problematic, when the purpose was screening for contact dermatitis and allergy, in this industrial cohort manufacturing reinforced plastic products. But these instruments might be useful for epidemiological surveillance, when the questionnaire has been validated in the given occupational setting.
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| 12. |
- Chu, CY, et al.
(författare)
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Concomitant contact allergy to the resins, reactive diluents and hardener of a bisphenol A/F-based epoxy resin in subway construction workers
- 2006
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 54:3, s. 131-139
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Tidskriftsartikel (refereegranskat)abstract
- An outbreak of suspected contact dermatitis among subway construction workers was suspected to be due to a new bisphenol A/F-based epoxy resin system (ERS). The construction workers used ERSs during the insertion of iron bars into concrete walls. The objective of the study was to determine the components (if any) of the ERS responsible for the contact allergy. Patch testing was performed on 20 of the 22 construction workers who had had contact with the ERS, and to the various subcomponents of component A on 5 of the 7 who reacted to this component. 9 patients (9/22, 40.9%) had clinical symptoms and signs of suspected contact dermatitis at presentation. 7 of these 9, but none of the 11 asymptomatic individuals, were positive to component A, while all were negative to component B. Of the 5 cases receiving further patch testing, all reacted to m-xylylene diamine, 4 to 1,6-hexanediol diglycidyl ether, 3 to epoxy resins of the bisphenol F-type and trimethylolpropane triglycidyl ether 0.25% petrolatum, and only 1 to epoxy resins of the bisphenol A-type. Contact allergy to ERSs may involve hardeners and diluents as well as resins, and patch testing for reaction to all components should be performed.
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| 13. |
- Dubnika Hauksson, Inese, et al.
(författare)
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Clinically relevant contact allergy to formaldehyde may be missed by testing with formaldehyde 1.0%.
- 2011
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Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 1365-2133 .- 0007-0963. ; 164:3, s. 568-572
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Tidskriftsartikel (refereegranskat)abstract
- Background: It has been found that patch testing with 15μl formaldehyde 2.0% aq detects twice more allergies than testing with 1.0%. The clinical relevance of positive patch test reactions is often difficult to determine. Use tests are simple to do and help to evaluate the significance of patch test results. Objectives: To study the clinical relevance of contact allergy to formaldehyde detected by 2.0% (0.60 mg/cm²) but not by 1.0%. Patients/Methods: 18 patients positive to formaldehyde 2.0% but negative to 1.0% and a control group of 19 dermatitis patients without allergy to parabens, formaldehyde and formaldehyde releasers were included in the study. Formaldehyde 2000 ppm, the maximum concentration permitted in leave-on cosmetics according to the EU Cosmetics Directive, was added to a batch of a moisturiser preserved with parabens. The same batch without formaldehyde served as control. The study was double-blinded and randomised. The patients were provided with both moisturisers and instructed to apply one of them twice a day on a marked-out 5×5 cm area on the inside of one upper arm and the other moisturiser on the other arm. Reading of the test sites was done once a week for a maximum of 4 weeks. Results: In the control group there were no allergic reactions to any of the moisturisers. 9 of the 17 formaldehyde-allergic patients reacted with an allergic reaction to the moisturiser which contained formaldehyde (p<0.001). No positive reactions were observed to the moisturiser without formaldehyde. Conclusions: Our results demonstrate that contact allergy to formaldehyde 2.0% may be clinically relevant.
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| 14. |
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| 15. |
- Dubnika Hauksson, Inese, et al.
(författare)
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Routine diagnostic patch-testing with formaldehyde 2.0% (0.6 mg/cm2) may be an advantage compared to 1.0%.
- 2010
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 1651-2057 .- 0001-5555. ; 90:5, s. 480-484
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Tidskriftsartikel (refereegranskat)abstract
- Our clinical experience has suggested that the presently recommended patch-test concentration (1.0%) for formaldehyde in the baseline series might be too low. Therefore, consecutively patch-tested dermatitis patients were tested simultaneously with formaldehyde 1.0% and 2.0% (w/v) in aqua. Formaldehyde 1.0% and 2.0% were applied with a micro-pipette (15 microl) to filter paper discs in Finn Chambers (0.30 mg/cm(2) and 0.60 mg/cm(2), respectively). A total of 1397 patients with dermatitis were patch-tested. In all, 68 (4.9%) patients reacted positively to formaldehyde; 37 reacted only to 2.0%, 29 reacted to both concentrations, and 2 reacted only to 1.0%. Significantly more patients were thus diagnosed with contact allergy to formaldehyde 2.0% compared with 1.0% (p < 0.001). We detected 0.1%, 0.4%, and 29.6% irritant reactions to 1.0%, 2.0%, and 3.0% formaldehyde, respectively. We conclude that, with an optimized patch-test technique, doubling the dose per area detects significantly more contact allergies to formaldehyde, but an even higher test concentration causes too many irritant reactions to be usable.
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| 16. |
- Dubnika Hauksson, Inese, et al.
(författare)
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Skin care products containing low concentrations of formaldehyde detected by the chromotropic acid method can not be safely used in formaldehyde-allergic patients.
- 2015
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Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 1365-2133 .- 0007-0963.
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Tidskriftsartikel (refereegranskat)abstract
- Preservatives are widely used to prevent microbial growth both for skin care products and in the industry. Many of them have allergic potential. Allergic contact dermatitis caused by preservatives can often be chronic, probably because it is difficult to suspect contact allergy to these chemicals based on the patient's history only. Formaldehyde is a common cause of contact allergy and has been included in the baseline series since the 1930s (1) . The prevalence of formaldehyde allergy has been reported to be 2-3% in European countries and 8-9% in the US (2) . The use of free formaldehyde as a preservative has decreased and formaldehyde-releasing agents are used instead. Individuals who are allergic to formaldehyde are recommended not only to avoid products preserved with formaldehyde but also products containing formaldehyde-releasers. This article is protected by copyright. All rights reserved.
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| 17. |
- Elkabets, Moshe, et al.
(författare)
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Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice
- 2011
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Ingår i: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 121:2, s. 784-799
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Tidskriftsartikel (refereegranskat)abstract
- Systemic instigation is a process by which endocrine signals sent from certain tumors (instigators) stimulate BM cells (BMCs), which are mobilized into the circulation and subsequently foster the growth of otherwise indolent carcinoma cells (responders) residing at distant anatomical sites. The identity of the BMCs and their specific contribution or contributions to responder tumor growth have been elusive. Here, we have demonstrated that Scal(+)cKit(-) hematopoietic BMCs of mouse hosts bearing instigating tumors promote the growth of responding tumors that form with a myofibroblast-rich, desmoplastic stroma. Such stroma is almost always observed in malignant human adenocarcinomas and is an indicator of poor prognosis. We then identified granulin (GRN) as the most upregulated gene in instigating Scal(+)cKit(-) BMCs relative to counterpart control cells. The GRN(+) BMCs that were recruited to the responding tumors induced resident tissue fibroblasts to express genes that promoted malignant tumor progression; indeed, treatment with recombinant GRN alone was sufficient to promote desmoplastic responding tumor growth. Further, analysis of tumor tissues from a cohort of breast cancer patients revealed that high GRN expression correlated with the most aggressive triple-negative, basal-like tumor subtype and reduced patient survival. Our data suggest that GRN and the unique hematopoietic BMCs that produce it might serve as novel therapeutic targets.
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| 18. |
- Engfeldt, Malin, et al.
(författare)
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Comparison of three different techniques for application of water solutions to Finn Chambers®.
- 2010
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 63:5, s. 284-288
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: With regard to contact allergy, the dose of a sensitizer per unit skin area is an important factor for both sensitization and elicitation, and therefore a known amount/volume of test preparation should be applied at patch testing. OBJECTIVES: To compare three different techniques for the application of aqueous solutions to Finn Chambers, in order to determine the precision and accuracy of each technique when the recommended 15 µl volume is applied. METHODS: Four technicians applied formaldehyde 1.0% aq. (wt/vol) and methylchloroisothiazolinone/methylisothiazolinone 200 ppm (wt/vol) in sets of 10 onto Finn Chambers, with three different techniques: (i) micro-pipetting; (ii) dripping the solutions; and (iii) dripping the solutions followed by removal of excess solution with a soft tissue. Assessment of the variations was performed with the use of descriptive data. The ability to apply the exact amount was assessed by Fisher's exact test by categorizing each application as in or out of the range 12-18 µl. RESULTS/CONCLUSIONS: The micro-pipette technique had the best accuracy and precision, as well as the lowest inter-individual variation. The technique in which excess solution was removed had good precision, but failed in the application of the defined amount, i.e. 15 µl.
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| 19. |
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| 20. |
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| 21. |
- Gremel, Gabriela, et al.
(författare)
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In situ Protein Detection for Companion Diagnostics
- 2013
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Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 3, s. Article 271-
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Tidskriftsartikel (refereegranskat)abstract
- The emergence of targeted therapies for cancer has created a need for the development of companion diagnostic tests. Assays developed in recent years are aimed at determining both the effectiveness and safety of specific drugs for a defined group of patients, thus, enabling the more efficient design of clinical trials and also supporting physicians when making treatment-related decisions. Immunohistochemistry (IHC) is a widely accepted method for protein expression analyses in human tissues. Immunohistochemical assays, used to localize and quantitate relative protein expression levels within a morphological context, are frequently used as companion diagnostics during clinical trials and also following drug approval. Herein, we describe established immunochemistry-based methods and their application in routine diagnostics. We also explore the possibility of using IHC to detect specific protein mutations in addition to DNA-based tests. Finally, we review alternative protein binders and proximity ligation assays and discuss their potential to facilitate the development of novel, targeted therapies against cancer.
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| 22. |
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| 23. |
- Hamnerius, Nils, et al.
(författare)
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Factors influencing the skin exposure to diphenylguanidine in surgical gloves
- 2014
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 70:Suppl s1, s. 59-60
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: For health care personnelhandhygieneandwearing appropriate protective gloves are compulsory. We have noticed an increase of hand eczema caused by contact allergy from rubber chemicals such as diphenylguanidine (DPG) in synthetic rubber gloves used by surgeons and surgical nurses. The exposure time to surgical gloves as well as the number of gloves used per day vary. Furthermore surgery very often includes the use of skin disinfectants before glove donning. Objectives: Does the exposure time influence the amount of DPG released from the gloves? Does the exposure of skin disinfectants before glove donning influence the release of DPG? Methods: Using synthetic sweat, the amount of DPG released from the inside of the gloves at different timeswas measured by HPLC. The remaining extractable DPG was estimated by washing the inside of the gloves with ethanol (50% in water) for 10min. The amount of DPG found on the hands exposed to 3ml skin disinfectant allowed to dry prior to glove donning was compared to the amount found on unexposed hands. After wearing gloves for 60 min the handswerewashedwith ethanol and the amount of DPG recovered was analysed with HPLC. Results: After 10, 30, 60 and 180 min approximately 73%, 79%, 82%, 87% of the total amount of DPG was released. For all comparisons the amount of DPG released was higher on the hand exposed to disinfectants compared with the unexposed hand. Conclusions: A comparatively short exposure time to gloves (10min) implies a substantial exposure to DPG. Thus, repeated usage of glovesmight enhance skin exposure to this rubber chemical. Skin disinfectants does increase the amount of DPG released from the gloves. Thus, possibly the components of the disinfectant remaining on the skin or some othermechanism add to the exposure to DPG.
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| 24. |
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| 25. |
- Hamnerius, Nils, et al.
(författare)
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Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives
- 2018
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 79:3, s. 149-156
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Tidskriftsartikel (refereegranskat)abstract
- Background: Hand eczema (HE) in healthcare workers (HCWs) is common. Besides wet work, healthcare work also implies exposure to contact allergens. Objectives: To assess HE and contact allergy related to occupational exposures in HCWs. Methods: In a cross-sectional study, 311 HCWs with HE within the preceding 12 months and a control group of 114 HCWs without HE were investigated with the baseline series and a special patch test series based on substances found in the gloves, soaps, alcoholic hand disinfectants and hand creams provided at the hospitals. Results: Contact allergy to rubber additives was significantly more common in HCWs with HE (6%) than in HCWs without HE (1%, P =.02). The corresponding percentages for fragrances were 11% and 3%, respectively (P =.004). Occupational HE was found in 193 of 311 (62%) HCWs. Of these, 22 of 193 (11%) had occupational allergic contact dermatitis, including 17 with glove-related rubber contact allergy. Contact allergy to diphenylguanidine was as common as contact allergy to thiurams. Occupational contact allergy to rubber additives was significantly associated with sick-leave related to HE. Conclusion: Contact allergy to rubber additives in medical gloves is the most common cause of occupational allergic contact dermatitis in HCWs. Aimed patch testing with relevant rubber additives is mandatory when HE in HCWs is investigated.
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| 26. |
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| 27. |
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| 28. |
- Hamnerius, Nils, et al.
(författare)
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Skin exposure to the rubber accelerator diphenylguanidine in medical gloves—An experimental study
- 2019
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 81:1, s. 9-16
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Tidskriftsartikel (refereegranskat)abstract
- Background: Dermatitis caused by occupational contact allergy to rubber additives such as diphenylguanidine (DPG) in medical gloves is a hazard for healthcare workers. Both the duration of exposure to medical gloves and the number of gloves used per day vary. The use of alcoholic skin disinfectants before glove donning is mandatory. Objectives: To assess whether skin exposure to the rubber accelerator DPG released from glove material is influenced by alcoholic hand disinfectants, time, and pH. Methods: With the use of ethanol washes, the amount of DPG left on the hands after wearing of gloves for 60 minutes was measured, and comparisons between hands exposed and not exposed to alcoholic disinfectant before glove donning were made. With the use of artificial sweat buffered at pH 4, 5, and 6, DPG release from the insides of gloves at different times was measured. Results: The use of alcoholic disinfectant prior to polyisoprene glove donning increased the amount of DPG recovered from the hands. Of the DPG released from polyisoprene gloves into artificial sweat, almost 84% was released within 10 minutes. pH did not influence the rate of release. Conclusions: The use of alcoholic disinfectant increased skin exposure to the rubber accelerator DPG. Even a short duration of use of gloves results in substantial exposure to DPG.
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| 29. |
- Hamnerius, Nils, et al.
(författare)
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Skin Exposures, Hand Eczema and Facial Skin Disease in Healthcare Workers During the COVID-19 Pandemic: A Cross-sectional Study
- 2021
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 101:9
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Tidskriftsartikel (refereegranskat)abstract
- The COVID-19 pandemic has led to enhanced hygiene procedures and use of personal protective equipment, but also to increased attention to occupational skin disease in healthcare workers. The occurrence of hand and facial skin disease in > 5,000 Swedish healthcare workers was investigated in a questionnaire survey. Levels of skin exposure related to hygiene procedures and personal protective equipment were recorded. Caring for patients with COVID-19 entailed higher levels of wet work and face mask exposures, and was associated with higher 1-year prevalence of both hand eczema (36%) and facial skin disease (32%) compared with not being directly engaged in COVID-19 care (28% and 22%, respectively). Acne and eczema were the most common facial skin diseases; for both, a dose-dependent association with face mask use was found. Dose-dependent associations could be shown between hand eczema and exposure to soap and gloves, but not to alcohol-based hand disinfectants.
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| 30. |
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| 31. |
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| 32. |
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| 33. |
- Hedlund, Ann, et al.
(författare)
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Attractive work
- 2009
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Ingår i: 7:th Seminar on Worklife Development. - Lappeenranta and Ruokolahti, Finland.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The model of Attractive Work was published 2004 (Åteg, Hedlund m fl. 2004). A questionnaire Questionnaire concerning Attractive Work was developed from the model (Högskolan Dalarna 2008). The questionnaire has been used during some years and at most occasions as a part in the Attractive Work Process. It is mostly researchers at Theme Working Life that have been using it, but also some supporting service companies. Data has been collected by the questionnaire during development work at companies or organizations. The results that will be presented are gathered from 16 different studies. Totally 1440 persons have filled in the questionnaire. They were employed at workplaces in different branches, for example estate management, parish work, museum, and elderly care. The results represent only these groups and are not representative for Swedish work force. The results shows that work is a relatively important aspect in the respondents life (3,8 on a scale 1-5). The main reason for working is to more than half of them “Earning a living and survival” (55,1%), two fifth says “Self-realization and good quality of life” (39,9%), and only a minor part says “material gain and a high standard of living” ( 5,0%). Most of them consider their current job as attractive to a big extent. The most important qualities to make a job attractive concern working conditions related to relations and leadership, as well as work satisfaction related to be sought after, stimulated and have inner acknowledgement. The two most important qualities are “I consider what I do to be important” and “I feel that I do a good job”. These important qualities correspond to a relatively high degree in the respondents’ current job, but there are still opportunities for development. The Attractive Work Process has been developed within interactive research and development projects. The process contains six steps – 1) Inform, plan and motivate, 2) Complete the questionnaire, 3) Analyze results, 4) Report results and prioritize, 5) Action plan, 6) Measure/evaluate. Central and important aspects of the process have been identified based on the experiences of participating researchers and companies. General important aspects are that the process is built on a promoting approach and engagement from all the employees. It is thereby important that the behavior of the process leader supports that approach. To make changes takes time and taking small steps in the right direction keeps the process moving forward. The process must be “living” all the time in order to be continuous. Högskolan Dalarna (2008). Questionnaire concerning Attractive Work. Borlänge: 5. Åteg, M., A. Hedlund, m fl. (2004). Attraktivt arbete. Från anställdas uttalanden till skapandet av en modell. Stockholm, Arbetslivsinstitutet.
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| 34. |
- Hedlund, Ann, et al.
(författare)
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Införande av systematisk arbetsmiljöarbete på träföretag : utvärdeling av en metod, dess resultat och påverkan på arbetets attraktivitet
- 2006
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Ingår i: Arbete och hälsa. - Stockholm : Arbetslivsinstitutet. - 0346-7821. ; :15
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Tidskriftsartikel (refereegranskat)abstract
- Träföretag i Dalarna förväntade sig att ett förbättrat och systematiskt arbetsmiljöarbete(SAM) leder till attraktivare och bättre arbete, vilket i sin tur leder till förbättradrekrytering av personal. Fem träföretag valde att delta i ett projekt därSAM infördes med en utvecklad metod kallad TräSAM. Projektet innehöll tredelar – genomförande av SAM, konsultstöd och revision. TräSAM-metodenbestod av ett utbildningsprogram som involverade alla anställda på företaget.Det övergripande syftet var att praktiskt prova och utvärdera TräSAM-metoden,samt att undersöka hur arbetets attraktivitet förändrats.I projektet ingick företag som tillverkade dörrar (25 anställda), hus (22), kökssnickerier(16) och träkomponenter (22) samt ett sågverk (90). Enkäter, deltagandeoch intervjuer i kombination med litteraturstudier användes för att utvärderaTräSAM. Samtliga anställda på företagen deltog i utvärderingen. Utvärderingengjordes med avseende på process (metodens styrkor och svagheter),resultat och effekt, med utgångspunkt i företagens och deras personals behov.TräSAM-metoden innehåller till stor del de framgångsfaktorer som tidigareforskning identifierat för fungerande SAM i småföretag. Därtill har metodenmotivations- och engagemangsskapande egenskaper.Metodens förtjänster är främst att företagen själva stegvis inför SAM, som ettlagarbete, med stöd av arbetsmiljöintermediärer.TräSAM-metoden har visat sig kunna genomföras på små företag som ärberedda att avsätta de resurser som krävs för metodens genomförande.Arbetena blev attraktivare enligt de anställda på alla företag som deltog iTräSAM. Många kvaliteter i ett Attraktivt Arbete ökade signifikant, enligtpersonalen på fyra av de fem företagen. Såväl arbetsförhållanden, arbetsinnehållsom arbetstillfredsställelse ökade.Ett attraktivt arbete bidrar till att behålla, engagera och attrahera personal. Utvärderingenvisar att genomförandet av TräSAM har bidragit till att öka arbetetsattraktivitet. Ett företags önskan att erbjuda attraktiva arbeten kan alltså varamotiverande till att införa SAM. En väl genomförd implementering och ettfungerande SAM kan därmed också förbättra rekryteringen av personal.
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| 35. |
- Hedlund, Ann, et al.
(författare)
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Uppföljning av ”Ny kunskap ger Nya affärer” 2007
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Tema Arbetsliv vid Högskolan Dalarna har tillsammans med företag och arbetsplatser utvecklat konkreta metoder och processer för attraktivare arbeten. Vår vilja är att dessa metoder sprids till många små och medelstora företag. Att stödja och utbilda ”stödjande tjänsteföretag”, såsom företagshälsovård, organisationskonsulter, m.fl., så att de kan kommersialisera de utvecklade metoderna ses som en bra strategi. ”Stödjande tjänsteföretag” i Dalarna bjöds in till 3-timmars informationsseminarier och halvdagarskurser för sex olika metoder. Totalt deltog 37 personer i planeringen och/eller i aktiviteterna. En uppföljning gjordes efter ett och ett halvt år genom intervjuer med 25 av dessa avseende det praktiska utförandet av aktiviteterna, metodernas design, den praktiska användningen av metoderna, kommersiell användning av metoderna och framtida samverkan. Följande slutsatser kan dras från uppföljningen av genomförda aktiviteter: • Informationsseminarierna och kursdagarna genomfördes på ett bra sätt. • Kursdagarna hade resulterat i ”nya affärer” för 9 av de 20 intervjuade kursdeltagarna och flera av dem sökte aktivt kunder. Metodernas ansats, möjligheten att engagera och motivera de anställda och de konkreta resultaten uppskattades av kunderna. • Ett mer långsiktigt stöd till de som ska genomföra metoderna kommersiellt kan behövas. • Strukturen och innehållet i metoderna fungerade bra i kommersiell användning. De kunde enkelt kombineras med andra metoder. • Metoderna upplevdes som imponerande, konkreta och användbara, men de behöver utvecklas så att det skapade engagemanget kan behållas på en hög nivå. De behöver också utvärderas i ekonomiska termer och mätbara förbättringar. • Alla intervjuade ville lära sig fler metoder och näringslivsrepresentanterna bistår gärna med kontakter och träffar. Flera av de ”stödjande tjänsteföretagen” och alla näringslivsrepresentanterna ville fortsätta med ytterligare samverkan med Tema Arbetsliv, Högskolan Dalarna.
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| 36. |
- Isaksson, Marléne, et al.
(författare)
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Active sensitization to dimethylthiocarbamylbenzothiazol sulphide : An unexpectedly strong rubber contact allergen
- 2023
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 88:6, s. 472-479
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Tidskriftsartikel (refereegranskat)abstract
- Background: The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl-thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio-carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity. Objectives: To investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used. Methods: Sixty-eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested. Results: At the initial reading Days 3 and 7, no reactions were noted to DMTBS or DETBS. At retesting, 10 of the 68 (15%) patients reacted positively to lower concentrations of DMTBS than the initial test concentration. Seven of 8 also reacted to TMTM. Three of them had positive reactions to DEBTS. All 10 patients had reactions to more diluted solutions to DMBTS than to DEBTS (p = 0.0077; Mc-Nemar test, two-sided). Conclusions: Results speak for patch test sensitization to DMTBS with cross-reactivity to TMTM and also DEBTS. DMTBS and DEBTS could be new markers of rubber allergy but a safe test concentration must be found.
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| 37. |
- Isaksson, Marléne, et al.
(författare)
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Methylisothiazolinone Contact Allergy is Rising to Alarming Heights Also in Southern Sweden.
- 2015
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 1651-2057 .- 0001-5555. ; 95:1, s. 31-34
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Tidskriftsartikel (refereegranskat)abstract
- The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known sensitiser and present in most baseline series since at least 20 years. The proportions of MCI/MI are 3:1. MI alone has been used as a preservative in occupational and household products, and cosmetics since less than 10 years. MCI/MI tested at 100 ppm fails to detect a significant percentage of contact-allergic reactions to MI. Our aim was to investigate whether a separate test preparation with MI picks up additional cases of contact allergy to MI not detected with MCI/MI 200 ppm. MI was inserted into the baseline series of the Malmö clinic in 2003 starting at 475 ppm, then 900 ppm, then 1,000 ppm, 1,500 ppm and finally 2,000 ppm. In 5,881 consecutively tested dermatitis patients the contact allergy rate for MI varied between 0.5 and 6.5%, with a marked increase in recent years. The contact allergy rate to MI 2,000 ppm alone, not traced by MCI/MI 200 ppm, varied between 0 and 1.9%. In conclusion, due to the increase of contact allergy to MI not traced by MCI/MI 200 ppm, MI in water at 2,000 ppm should be tested in a baseline series. Independent of patch test technique a dose of 60 µg/cm should not be exceeded to avoid adverse reactions and particularly patch test sensitisation.
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| 38. |
- Isaksson, Marléne, et al.
(författare)
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Occupational allergic contact dermatitis from epoxy resin in a golf club repairman.
- 2008
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Ingår i: Dermatitis. - 1710-3568. ; 19:5, s. 30-32
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Tidskriftsartikel (refereegranskat)abstract
- A golfer presented with facial and hand eczema. He had exacerbations of his hand eczema prior to golf tournaments. Being an authorized golf club repairman, he had been working with a two-part glue containing an epoxy resin (ER) based on diglycidyl ether of bisphenol A (DGEBA) and the hardener diethylenetriamine (DETA) for approximately 4 years before he developed any skin problems. He was patch-tested with the standard, which contains an ER based on DGEBA (DGEBA-R), epoxy (containing DETA), and rubber glove series and had positive reactions to DGEBA-R only. Other work materials (a latex glove, a golf glove made of leather, and part of the handle of his own golf club "as is" and in a methyl tert-butyl ether extract) were tested, with negative results. Allergic contact dermatitis from ER affects the skin by direct contact; the dermatitis is usually localized to the hands and forearms. If the face and eyelids are involved, the dermatitis may be due to exposure to airborne hardeners or reactive diluents, exposure to airborne dust from residual monomers, or ectopic allergic reactions. Our repairman had sandpapered an old glued surface, which may have led to possible airborne dust formation, thus explaining the facial eczema. Therefore, a worker with contact allergy to ER may continue working provided the skin is protected from contamination.
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| 39. |
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| 40. |
- Jedlinski, Adam, 1978-, et al.
(författare)
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Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment-induced reduction in EGFR, pEGFR, and pSrc.
- 2017
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Ingår i: Journal of Oral Pathology & Medicine. - : Wiley. - 0904-2512 .- 1600-0714. ; 46:9, s. 717-724
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The aims of this study were to validate in vitro drug sensitivity testing of head and neck squamous cell carcinoma (HNSCC) cell lines in an in vivo xenograft model and to identify treatment-induced changes in the epidermal growth factor receptor (EGFR) signaling pathway that could be used as markers for cetuximab treatment response.MATERIALS AND METHODS: The in vitro and in vivo cetuximab sensitivity of two HNSCC cell lines, UT-SCC-14 and UT-SCC-45, was assessed using a crystal violet assay and xenografts in nude mice, respectively. The expression of EGFR, phosphorylated EGFR (pEGFR), phosphorylated Src (pSrc), and Ki-67 was investigated by immunohistochemistry. To verify these results, the in vitro expression of EGFR and pEGFR was analyzed with ELISA in a panel of 10 HNSCC cell lines.RESULTS: A close correlation was found between in vitro and in vivo cetuximab sensitivity data in the two investigated HNSCC cell lines. In treatment sensitive UT-SCC-14 xenografts, there was a decrease in EGFR, pEGFR, and pSrc upon cetuximab treatment. Interestingly, in insensitive UT-SCC-45 xenografts, an increased expression of these three proteins was found. The change in EGFR and pEGFR expression in vivo was confirmed in cetuximab-sensitive and cetuximab-insensitive HNSCC cell lines using ELISA.CONCLUSION: High sensitivity to cetuximab was strongly associated with a treatment-induced reduction in pEGFR both in vivo and in vitro in a panel of HNSCC cell lines, suggesting that EGFR and pEGFR dynamics could be used as a predictive biomarker for cetuximab treatment response.
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| 41. |
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| 42. |
- Lejding, Tina, et al.
(författare)
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A retrospective investigation of hexavalent chromium allergy in southern Sweden
- 2018
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 78:6, s. 386-392
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Tidskriftsartikel (refereegranskat)abstract
- Background: Historically, allergic contact dermatitis caused by hexavalent chromium [Cr(VI)] in cement was the most common cause of invalidity attributable to skin disease in Sweden. Since the legislation to reduce Cr(VI) in cement was introduced in 1989, we rarely see allergic contact dermatitis caused by cement. Objectives: To examine the frequency of contact allergy to Cr(VI) in southern Sweden in 2005-2014. Methods: We investigated the occurrence of positive reactions to potassium dichromate 0.5% pet. in consecutively tested dermatitis patients, and compared the occurrence of atopic dermatitis, localization of dermatitis and simultaneous positive reactions to cobalt chloride and nickel sulfate in the Cr(VI)-positive patients with those in a group of patients with a similar age and sex distribution. Results: In total, 6482 patients were tested, and 233 Cr(VI)-allergic individuals were found (3.6%). A significantly higher proportion of atopic dermatitis was found among Cr(VI)-allergic patients, and a significantly higher share of foot dermatitis was found among Cr(VI)-allergic women, than among controls. Cr(VI) allergy was less likely when both nickel allergy and cobalt allergy were present. Conclusion: A relatively high frequency of contact allergy to Cr(VI) was found. The cause has shifted from cement exposure to other exposures, probably mainly leather.
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| 43. |
- Mowitz, Martin, et al.
(författare)
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Chromate and amine contact allergies in workers manufacturing precast concrete elements
- 2016
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 75:6, s. 363-369
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Tidskriftsartikel (refereegranskat)abstract
- Background: Five workers from a plant manufacturing concrete wall panels and beams were referred to our department because of suspected occupational dermatitis. When patch tested, 3 workers reacted to potassium dichromate. Four workers reacted to ethylenediamine dihydrochloride, without any obvious exposure. Owing to the high proportion of workers with recent-onset skin disease, an investigation of all workers at the plant was initiated. Objectives: To investigate the prevalence of occupational dermatitis and contact allergy in the workers at the plant. Methods: All 24 workers at the plant underwent a clinical investigation and were patch tested. Results: Four cases of allergic occupational contact dermatitis and 3 cases of irritant occupational contact dermatitis were diagnosed. Contact allergy to potassium dichromate was found in 4 workers. All 4 also reacted to ethylenediamine dihydrochloride and/or amines that were present as additives in the cement. Conclusions: Chromate contact allergy can still be found in concrete workers, despite the legislation regulating the amount of hexavalent chromium (chromate) in cement. Occupational contact allergy to amines can be found in workers exposed to cement and concrete, so amines should be tested in these workers.
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| 44. |
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| 45. |
- Mowitz, Martin, et al.
(författare)
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N,N-dimethylacrylamide—A new sensitizer in the FreeStyle Libre glucose sensor
- 2019
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 81:1, s. 27-31
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Tidskriftsartikel (refereegranskat)abstract
- Background: Isobornyl acrylate (IBOA) has recently been identified as one sensitizer in the FreeStyle Libre glucose sensor. Analyses with gas chromatography-mass spectrometry (GC-MS) have indicated the presence of N,N-dimethylacrylamide (DMAA) in the sensor. Material and methods: Seven patients were referred for patch testing after developing skin reactions when using FreeStyle Libre. All patients were patch tested with IBOA and DMAA. Two patients were tested with adhesive patches that had been removed from the sensors “as is,” and two patients were tested with acetone extracts of materials from the sensor. The extracts were analysed with GC-MS. Results: Six patients reacted to both IBOA and DMAA, and one patient reacted only to DMAA. Positive reactions were also observed in both patients tested with the adhesive patch "as is". One patient reacted to both an extract of the adhesive patch and an extract of the sensor itself. When analysed with GC-MS, IBOA was found in both extracts and DMAA was found in the extract of the sensor. Conclusion: Both IBOA and DMAA may be present in adhesives used in medical devices such as glucose sensors or insulin pumps, and should be patch tested when suspected contact allergic reactions to these products are investigated.
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| 46. |
- Mowitz, Martin, et al.
(författare)
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Simultaneous patch testing with fragrance mix I, fragrance mix II and their ingredients in southern Sweden between 2009 and 2015
- 2017
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 77:5, s. 280-287
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Tidskriftsartikel (refereegranskat)abstract
- Background: Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy. Objectives: To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients. Materials and methods: A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. Results: Of the patients, 6.5% were FM I-positive and 3.2% were FM II-positive. Forty-five per cent of FM I-positive patients did not have positive reactions to FM I ingredients. Thirty-five per cent of those who were FM II-positive did not have positive reactions to FM II ingredients. Twenty-seven per cent of those with positive reactions to one or more of the FM I ingredients were FM I-negative, and 36% of those who had positive reactions to one or more of the FM II ingredients were FM II-negative. The allergens with the highest pick-up rates were Evernia prunastri (1.8%), cinnamal (1.3%), citral (1.2%), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (1.2%). Significant differences were observed in the proportions of positive reactions to FM I, FM II, eugenol, isoeugenol, and farnesol when results from patch testing with materials from different suppliers were compared. Conclusions: There is a risk of missing fragrance contact allergy when testing with only the fragrance mixes is performed. The use of preparations from different suppliers may affect the patch test results.
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| 47. |
- Nilsson, Peter, et al.
(författare)
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Towards a human proteome atlas : high-throughput generation of mono-specific antibodies for tissue profiling
- 2005
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Ingår i: Proteomics. - : Wiley. - 1615-9853 .- 1615-9861. ; 5:17, s. 4327-4337
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Tidskriftsartikel (refereegranskat)abstract
- A great need exists for the systematic generation of specific antibodies to explore the human proteome. Here, we show that antibodies specific to human proteins can be generated in a high-throughput manner involving stringent affinity purification using recombinant protein epitope signature tags (PrESTs) as immunogens and affinity-ligands. The specificity of the generated affinity reagents, here called mono-specific antibodies (msAb), were validated with a novel protein microarray assay. The success rate for 464 antibodies generated towards human proteins was more than 90% as judged by the protein array assay. The antibodies were used for parallel profiling of patient biopsies using tissue microarrays generated from 48 human tissues. Comparative analysis with well-characterized monoclonal antibodies showed identical or similar specificity and expression patterns. The results suggest that a comprehensive atlas containing extensive protein expression and subcellular localization data of the human proteome can be generated in an efficient manner with mono-specific antibodies.
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| 48. |
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| 49. |
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| 50. |
- Pontén, Ann, et al.
(författare)
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Can simultaneous contact allergies to phenyl glycidyl ether and epoxy resins of the bisphenol A/F-types be explained by contamination of the epoxy resins?
- 2008
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 59:5, s. 273-279
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Simultaneous contact allergies to epoxy resins based on diglycidyl ether of bisphenol A (DGEBA-R) or epoxy resins of the bisphenol F-type and the reactive diluent phenyl glycidyl ether (PGE) have been reported. The reason might be cross-reactivity, exposure to an epoxy resin system with PGE as a component, or contamination by PGE in the epoxy resin. AIMS: To study contamination by PGE, 20 commercial epoxy resins were analysed for the presence of PGE. To study contact allergy to PGE and its relation to epoxy resins by inserting PGE in the standard series. RESULTS: Among 2227 patients, 7 reacted to PGE. Of 23 (30%) patients, 7 with contact allergy to DGEBA-R and 7/19 (37%) with contact allergy to an epoxy resin of the bisphenol F-type reacted to PGE. All 7 patients with contact allergy to PGE reacted both to the DGEBA-R and to the epoxy resin of the bisphenol F-type. PGE was found in 90% of the investigated resins. The amounts of PGE ranged between 0.004% w/w and 0.18% w/w. CONCLUSION: Most probably, the presence of PGE as a contaminant in epoxy resins is of minor importance for the sensitization, but possibly the contamination of PGE might elicit contact dermatitis in individuals with a high reactivity to PGE.
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