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Sökning: WFRF:(Popek M)

  • Resultat 1-4 av 4
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1.
  • Jung, Christian, et al. (författare)
  • A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention
  • 2019
  • Ingår i: Journal of critical care. - : W B SAUNDERS CO-ELSEVIER INC. - 0883-9441 .- 1557-8615. ; 52, s. 141-148
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: We aimed to evaluate differences in outcome between patients admitted to intensive care unit (ICU) after elective versus acute surgery in a multinational cohort of very old patients (80 years; VIP). Predictors of mortality, with special emphasis on frailty, were assessed.Methods: In total, 5063 VIPs were induded in this analysis, 922 were admitted after elective surgery or intervention, 4141 acutely, with 402 after acute surgery. Differences were calculated using Mann-Whitney-U test and Wilcoxon test. Univariate and multivariable logistic regression were used to assess associations with mortality.Results: Compared patients admitted after acute surgery, patients admitted after elective surgery suffered less often from frailty as defined as CFS (28% vs 46%; p < 0.001), evidenced lower SOFA scores (4 +/- 5 vs 7 +/- 7; p < 0.001). Presence of frailty (CFS >4) was associated with significantly increased mortality both in elective surgery patients (7% vs 12%; p = 0.01), in acute surgery (7% vs 12%; p = 0.02).Conclusions: VIPs admitted to ICU after elective surgery evidenced favorable outcome over patients after acute surgery even after correction for relevant confounders. Frailty might be used to guide clinicians in risk stratification in both patients admitted after elective and acute surgery. 
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3.
  • Karlsson, J, 1966-, et al. (författare)
  • Sequencing of the Francisella tularensis strain Schu 4 genome reveals the shikimate and purine metabolic pathways, targets for the construction of a rationally attenuated auxotrophic vaccine.
  • 2000
  • Ingår i: Microbial & Comparative Genomics. - : Mary Ann Liebert Inc. - 1090-6592 .- 2168-6637. ; 5:1, s. 25-39
  • Tidskriftsartikel (refereegranskat)abstract
    • Francisella tularensis is the etiological agent of tularemia, a serious disease in several Northern hemisphere countries. The organism has fastidious growth requirements and is very poorly understood at the genetic and molecular levels. Given the lack of data on this organism, we undertook the sample sequencing of its genome. A random library of DNA fragments from a highly virulent strain (Schu 4) of F. tularensis was constructed and the nucleotide sequences of 13,904 cloned fragments were determined and assembled into 353 contigs. A total of 1.83 Mb of nucleotide sequence was obtained that had a G+C content of 33.2%. Genes located on plasmids pOM1 and pNFL10, which had been previously isolated from low virulence strains of F. tularensis, were absent but all of the other known F. tularensis genes were represented in the assembled data. F. tularensis Schu4 was able to grow in the absence of aromatic amino acids and orthologues of genes which could encode enzymes in the shikimate pathway in other bacteria were identified in the assembled data. Genes that could encode all of the enzymes in the purine biosynthetic and most of the en- zymes in the purine salvage pathways were also identified. This data will be used to develop defined rationally attenuated mutants of F. tularensis, which could be used as replacements for the existing genetically undefined live vaccine strain.
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4.
  • Raudaschl, M., et al. (författare)
  • Piezoelectric Textile Facade for the energy supply of active sensor technology with regard to data management for circular economy in building construction
  • 2022
  • Ingår i: <em>IOP Conference Series: Earth and Environmental Science, </em>Volume 1078, Issue 12022, Article number 012037. - : Institute of Physics.
  • Konferensbidrag (refereegranskat)abstract
    • The high GWP potential of construction requires a holistic approach such as circular economy. Currently, common joining, construction and planning practices result in heterogeneous assemblies of different components that are difficult to deconstruct. Furthermore, there is currently little information and data on building components used and the climatic impacts on them. In this context and with the intention of recording long-term (circular) processes in construction, the Piezo-Klett basic research project (FFG no. 879459) funded by the Austrian Research Promotion Agency (FFG) deals with the energy supply of active sensor technology in construction by combining the hook and loop fastener with piezoelectric components. The aim is to open new perspectives on sustainable energy production systems by transforming buildings into energy carriers and generators, analogous to a "battery". To this purpose, the result presented in this conference paper is a description of the constructive structure (climatic impacts, construction, piezo technology) of a "Piezoelectric Textile Facade" as well as test results on piezo tapes. This opens new possibilities in the context of the application of hook- and-loop fasteners, the energy supply of active sensor technologies as well as in the field of data acquisition and data management. 
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  • Resultat 1-4 av 4

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