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| 4. |
- Adriani, O., et al.
(författare)
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Time Dependence of the Electron and Positron Components of the Cosmic Radiation Measured by the PAMELA Experiment between July 2006 and December 2015
- 2016
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 116:24
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Tidskriftsartikel (refereegranskat)abstract
- Cosmic-ray electrons and positrons are a unique probe of the propagation of cosmic rays as well as of the nature and distribution of particle sources in our Galaxy. Recent measurements of these particles are challenging our basic understanding of the mechanisms of production, acceleration, and propagation of cosmic rays. Particularly striking are the differences between the low energy results collected by the space-borne PAMELA and AMS-02 experiments and older measurements pointing to sign-charge dependence of the solar modulation of cosmic-ray spectra. The PAMELA experiment has been measuring the time variation of the positron and electron intensity at Earth from July 2006 to December 2015 covering the period for the minimum of solar cycle 23 (2006-2009) until the middle of the maximum of solar cycle 24, through the polarity reversal of the heliospheric magnetic field which took place between 2013 and 2014. The positron to electron ratio measured in this time period clearly shows a sign-charge dependence of the solar modulation introduced by particle drifts. These results provide the first clear and continuous observation of how drift effects on solar modulation have unfolded with time from solar minimum to solar maximum and their dependence on the particle rigidity and the cyclic polarity of the solar magnetic field.
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| 5. |
- Munini, R., et al.
(författare)
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Short-term variation in the galactic cosmic ray intensity measured with the PAMELA experiment
- 2017
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Ingår i: Proceedings of Science. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- New results on the galactic cosmic ray (GCR) short-term intensity variation associated with Forbush decrease and co-rotating interaction regions (CIRs) measured by the PAMELA instrument between November 2006 and March 2007 are presented. Most of the past measurements on Forbush decrease events were carried out with neutron monitor detector. This tecnique allows only indirect detection of the overall GCR intensity over an integrated energy range. For the first time, thanks to the unique features of the PAMELA magnetic spectrometer, the Forbush decrease associated with the December 13th coronal mass ejection (CME) was studied in a wide rigidity range (0.4 - 20 GV) and for different species of GCRs detected directly in space. Using GCR protons, the amplitude and the recovery time of the Forbush decrease were studied for ten rigidity interval with a temporal resolution of one day. For comparison the helium and the electron intensity over time were also studied. The temporal evolution of the helium and proton intensity was found in good agreement while the electrons show, on average, a faster recovery time. This was interpreted as a charge-sign dependence introduced by drift motion experienced by the low rigidity (< 5 GV) GCRs during their propagation through the heliosphere. Moreover a clear 13.5 days cyclical variation was observed in the GCR proton intensity after the Forbush decrease. This phenomena could be interpreted as an effect of prominent structures of compressed plasma in the solar wind, i.e. CIRs, or to the latitudinal gradient due to the crossing of the heliospheric current sheet (HCS).
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| 6. |
- Munini, R., et al.
(författare)
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Solar modulation of galactic cosmic rays electrons and positrons over the 23rd solar minimum with the pamela experiment
- 2013
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Ingår i: Proceedings of the 33rd International Cosmic Rays Conference, ICRC 2013. - : Sociedade Brasileira de Fisica. - 9788589064293
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Konferensbidrag (refereegranskat)abstract
- The satellite-borne PAMELA experiment has been continuously collecting data since 15th June 2006, when it was launched from the Baikonur cosmodrome to detect the charged component of cosmic rays over a wide energy range and with an unprecedented statistics. The apparatus design is particularly suited for particle and antiparticle identification. The satellite quasi-polar orbit, with an inclination of 70 degrees, allows particles to be measure down to 100 MeV/n. This makes the instrument suited for the investigation of phenomena related to galactic cosmic ray solar modulation in the inner heliosphere. Data for oppositely charged particles were collected from 2006 to 2009, during the A< 0 solar minimum of solar cycle 23. The time and rigidity dependence of galactic cosmic ray electron and positron fluxes were measured. These fluxes provide important information for the study of charge dependent solar modulation effects.
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| 7. |
- Adriani, O., et al.
(författare)
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Time Dependence Of The Proton Flux Measured By Pamela During The 2006 July-2009 December Solar Minimum
- 2013
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Ingår i: Astrophysical Journal. - : IOP Publishing. - 0004-637X .- 1538-4357. ; 765:2, s. 91-
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Tidskriftsartikel (refereegranskat)abstract
- The energy spectra of galactic cosmic rays carry fundamental information regarding their origin and propagation. These spectra, when measured near Earth, are significantly affected by the solar magnetic field. A comprehensive description of the cosmic radiation must therefore include the transport and modulation of cosmic rays inside the heliosphere. During the end of the last decade, the Sun underwent a peculiarly long quiet phase well suited to study modulation processes. In this paper we present proton spectra measured from 2006 July to 2009 December by PAMELA. The large collected statistics of protons allowed the time variation to be followed on a nearly monthly basis down to 400 MV. Data are compared with a state-of-the-art three-dimensional model of solar modulation.
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| 8. |
- Di Felice, V., et al.
(författare)
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Solar modulation of galactic hydrogen and helium over the 23rd solar minimum with the PAMELA experiment
- 2013
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Ingår i: Proceedings of the 33rd International Cosmic Rays Conference, ICRC 2013. - : Sociedade Brasileira de Fisica. - 9788589064293
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Konferensbidrag (refereegranskat)abstract
- PAMELA has been orbiting the Earth for more than six years, gathering data on solar, galactic and trapped cosmic rays during the time of the last solar minimum. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. The combination of these devices allows charged particle and antiparticle identification over a wide energy range and with an unprecedented precision. The quasi-polar orbit of the instrument, with an inclination of 70 degrees, makes it possible to measure low energy particles starting from about 100 MeV/n. In this work we present the time and rigidity dependence of the galactic proton and helium fluxes over the first 4 years of operation during the A < 0 solar minimum of solar cycle 23.
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| 9. |
- Menn, W., et al.
(författare)
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Lithium and beryllium isotopes in the pamela-experiment
- 2015
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Ingår i: Proceedings of Science. - : Proceedings of Science (PoS).
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Konferensbidrag (refereegranskat)abstract
- On the 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus comprises a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anti-coincidence system, a shower tail counter scintillator and a neutron detector. The scientific objectives addressed by the mission are the measurement of the antiprotons and positrons spectra in cosmic rays, the hunt for antinuclei as well as the determination of light nuclei fluxes from hydrogen to oxygen in a wide energy range and with very high statistics. In this paper the identification capability for lithium and beryllium isotopes for two different techniques are presented, combining the rigidity measurement from the magnetic spectrometer with the velocity information derived either with the time-of-flight or with multiple dE/dx measurements in the calorimeter. Preliminary results of the isotopic ratios will be presented.
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| 10. |
- Menn, W., et al.
(författare)
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Measurement of the isotopic composition of hydrogen and helium nuclei in cosmic rays with the pamela-experiment
- 2015
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Ingår i: Proceedings of Science. - : Proceedings of Science (PoS).
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Konferensbidrag (refereegranskat)abstract
- The cosmic-ray hydrogen and helium (1H,2H,3He,4He) isotopic composition between 100 MeV/n and 1.4 GeV/n has been measured with the satellite-borne experiment PAMELA, which was launched into low-Earth orbit on-board the Resurs-DK1 satellite on June 15th 2006. The rare isotopes 2H and 3He in cosmic rays are believed to originate mainly from the interaction of high energy protons and helium with the galactic interstellar medium. The energy spectrum of these components carries fundamental information regarding the propagation of cosmic rays in the galaxy which are competitive with those obtained from other secondary to primary measurements such as B/C. The isotopic composition was measured between 100 and 1100 MeV/n for hydrogen and between 100 and 1400 MeV/n for helium isotopes using two different detector systems over the 23rd solar minimum from July 2006 to December 2007.
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| 11. |
- Munini, R., et al.
(författare)
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Evidence of Energy and Charge Sign Dependence of the Recovery Time for the 2006 December Forbush Event Measured by the PAMELA Experiment
- 2018
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Ingår i: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 853:1
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Tidskriftsartikel (refereegranskat)abstract
- New results on the short-term galactic cosmic-ray (GCR) intensity variation (Forbish decrease) in 2006 December measured by the PAMELA instrument are presented. Forbush decreases are sudden suppressions of the GCR intensities, which are associated with the passage of interplanetary transients such as shocks and interplanetary coronal mass ejections (ICMEs). Most of the past measurements of this phenomenon were carried out with groundbased detectors such as neutron monitors or muon telescopes. These techniques allow only the indirect detection of the overall GCR intensity over an integrated energy range. For the first time, thanks to the unique features of the PAMELA magnetic spectrometer, the Forbush decrease, commencing on 2006 December 14 and following a CME at the Sun on 2006 December 13, was studied in a wide rigidity range (0.4-20 GV) and for different species of GCRs detected directly in space. The daily averaged GCR proton intensity was used to investigate the rigidity dependence of the amplitude and the recovery time of the Forbush decrease. Additionally, for the first time, the temporal variations in the helium and electron intensities during a Forbush decrease were studied. Interestingly, the temporal evolutions of the helium and proton intensities during the Forbush decrease were found to be in good agreement, while the low rigidity electrons (<2 GV) displayed a faster recovery. This difference in the electron recovery is interpreted as a charge sign dependence introduced by drift motions experienced by the GCRs during their propagation through the heliosphere.
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| 12. |
- Munini, R., et al.
(författare)
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Solar modulation of galactic cosmic ray electrons and positrons over the 23rd solar minimum with the PAMELA experiment
- 2015
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Ingår i: Proceedings of Science. - : Proceedings of Science (PoS).
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Konferensbidrag (refereegranskat)abstract
- The satellite-borne PAMELA experiment has been continuously collecting data since 15th June 2006, when it was launched from the Baikonur cosmodrome to detect the charged component of cosmic rays over a wide energy range and with unprecedented statistics. The apparatus design is particularly suited for particle and antiparticle identification. The PAMELA experiment has measured the time variation of electron and positron spectrum at Earth in great detail, extending the measurement down to 70 MeV and 200 MeV respectively. The spectra have been evaluated with data collected from July 2006 to December 2009, i.e. during the A<0 solar minimum of solar cycle 23, over six-months intervals. These spectra provide important information for the study of CR propagation inside the heliosphere and the investigation of the charge-dependent solar modulation.
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| 13. |
- Munini, R., et al.
(författare)
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Solar modulation of GCR electrons over the 23rd solar minimum with PAMELA
- 2015
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Ingår i: 24TH EUROPEAN COSMIC RAY SYMPOSIUM (ECRS). - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- The satellite-borne PAMELA experiment has been continuously collecting data since 15th June 2006, when it was launched from the Baikonur cosmodrome to detect the charged component of cosmic rays over a wide energy range and with unprecedented statistics. The apparatus design is particularly suited for particle and antiparticle identification. The PAMELA experiment has measured the electron spectrum at Earth in great detail, extending up to about 100 GeV and down to about 200 MeV. The galactic cosmic ray electron spectra for 2007 and 2009, i.e. measured during the A<0 solar minimum of solar cycle 23, are presented. These fluxes provide important information for the study of charge dependent solar modulation effects.
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| 14. |
- Munini, R., et al.
(författare)
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Ten years of positron and electron solar modulation measured by the PAMELA experiment
- 2017
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Ingår i: Proceedings of Science. - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- The satellite-borne PAMELA experiment was launched on the 15th June 2006 from the Baikonur cosmodrome. Till January 2016 PAMELA has detected the charged component of cosmic-rays (CRs) over a wide energy range. Due to its long flight duration PAMELA represents an ideal detector for cosmic-ray solar modulation studies. Moreover, the capability to measure particles of the same mass with opposite charge allows to investigate the charge-sign dependent solar modulation. The results on the positron and electron intensity variation at Earth over the 23rd solar minimum (July 2006 - January 2009) till the middle of the 24rd solar maximum (December 2015), will be presented. The positron to electron ratio shows a clear time variation interpreted as solar modulation sign-charge dependence introduced by particle drifts. The effect of the polarity reversal of the heliospheric magnetic field, which took place between 2013 and 2014, is also distinctly visible from the PAMELA data. These results provide the first clear indication of how drift effects unfold with time during different phases of the solar activity and their dependence on the particle rigidity and the cyclic polarity of the solar magnetic field.
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| 15. |
- Vannuccini, E., et al.
(författare)
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Measurement of Lithium and Beryllium cosmic-ray abundances by the PAMELA experiment
- 2015
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Ingår i: Proceedings of Science. - : Proceedings of Science (PoS).
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Konferensbidrag (refereegranskat)abstract
- The PAMELA experiment is collecting particles along a low Earth semi-polar orbit on board of Resurs-DK1 satellite since June 2006. The combined information of a silicon tracking system and a scintillator hodoscope provides redundant light-element identification capabilities, via multiple ionization energy-loss measurements. The instrument design is not optimized for nuclei detection, whose high ionization signal progressively saturates the detectors. However, Li and Be nuclei can still be identified by using the full set of information, which allows to efficiently select the two elements against the background of more abundant elements. The main issues of the analysis aiming to optimize the Li and Be selection are discussed in this paper. Preliminary results on the elemental abundances will be presented at the conference.
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| 16. |
- Martucci, M., et al.
(författare)
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Proton Fluxes Measured by the PAMELA Experiment from the Minimum to the Maximum Solar Activity for Solar Cycle 24
- 2018
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Ingår i: Astrophysical Journal Letters. - : Institute of Physics Publishing (IOPP). - 2041-8205 .- 2041-8213. ; 854:1
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Tidskriftsartikel (refereegranskat)abstract
- Precise measurements of the time-dependent intensity of the low-energy (<50 GeV) galactic cosmic rays (GCRs) are fundamental to test and improve the models that describe their propagation inside the heliosphere. In particular, data spanning different solar activity periods, i.e., from minimum to maximum, are needed to achieve comprehensive understanding of such physical phenomena. The minimum phase between solar cycles 23 and 24 was peculiarly long, extending up to the beginning of 2010 and followed by the maximum phase, reached during early 2014. In this Letter, we present proton differential spectra measured from 2010 January to 2014 February by the PAMELA experiment. For the first time the GCR proton intensity was studied over a wide energy range (0.08-50 GeV) by a single apparatus from a minimum to a maximum period of solar activity. The large statistics allowed the time variation to be investigated on a nearly monthly basis. Data were compared and interpreted in the context of a state-of-the-art three-dimensional model describing the GCRs propagation through the heliosphere.
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| 18. |
- Clarke, Robert, et al.
(författare)
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Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials
- 1998
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Ingår i: British Medical Journal. - : BMJ. - 0959-8146. ; 316:7135, s. 894-898
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Forskningsöversikt (refereegranskat)abstract
- Objective: To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. Design: Meta-analysis of randomised controlled trials that assessed the effects of folic acid based supplements on blood homocysteine concentration. Multivariate regression analysis was used to determine the effects on homocysteine concentrations of different doses of folic acid and of the addition of vitamin B-12 or B-6. Subjects: Individual data on 1114 people included in 12 trials. Findings: The proportional and absolute reductions in blood homocysteine produced by folic acid supplements were greater at higher pretreatment blood homocysteine concentrations (P < 0.001) and at lower pretreatment blood folate concentrations (P < 0.001). After standardisation to pretreatment blood concentrations of homocysteine of 12 μmol/l and of folate of 12 nmol/l (approximate average concentrations for Western populations), dietary folic acid reduced blood homocysteine concentrations by 25% (95% confidence interval 23% to 28%; P < 0.001), with similar effects in the range of 0.5-5 mg folic acid daily. Vitamin B-12 (mean 0.5 mg daily) produced an additional 7% (3% to 10%) reduction in blood homocysteine. Vitamin B-6 (mean 16.5 mg daily) did not have a significant additional effect. Conclusions: Typically in Western populations, daily supplementation with both 0.5-5 mg folic acid and about 0.5 mg vitamin B-12 would be expected to reduce blood homocysteine concentrations by about a quarter to a third (for example, from about 12 μmol/l to 8-9 μmol/l). Large scale randomised trials of such regimens in high risk populations are now needed to determine whether lowering blood homocysteine concentrations reduces the risk of vascular disease.
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| 19. |
- Knot, J, et al.
(författare)
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How to set up an effective national primary angioplasty network : Lessons learned from five European countries
- 2009
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Ingår i: EuroIntervention. - 1774-024X. ; 3:299, s. 301-309
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: Percutaneous coronary interventions (PCI) are used to treat acute and chronic forms of coronary artery disease. While in chronic forms the main goal of PCI is to improve the quality of life, in acute coronary syndromes (ACS) timely PCI is a life-saving procedure - especially in the setting of ST-elevation myocardial infarction (STEMI). The aim of this study was to describe the experience of countries with successful nationwide implementation of PCI in STEMI, and to provide general recommendations for other countries. METHODS AND RESULTS: The European Association of Percutaneous Cardiovascular Interventions (EAPCI) recenty launched the Stent For Life Initiative (SFLI). The initial phase of this pan-European project was focused on the positive experience of five countries to provide the best practice examples. The Netherlands, the Czech Republic, Sweden, Denmark and Austria were visited and the logistics of ACS treatment was studied. Public campaigns improved patient access to acute PCI. Regional networks involving emergency medical services (EMS), non-PCI hospitals and PCI centres are useful in providing access to acute PCI for most patients. Direct transfer from the first medical contact site to the cathlab is essential to minimise the time delays. Cathlab staff work is organised to provide acute PCI services 24 hours a day / seven days a week (24/7). Even in those regions where thrombolysis is still used due to long transfer distances to PCI, patients should still be transferred to a PCI centre (after thrombolysis). The highest risk non-ST elevation acute myocardial infarction patients should undergo emergency coronary angiography within two hours of hospital admission, i.e. similar to STEMI patients. CONCLUSIONS: Three realistic goals for other countries were defined based on these experiences: 1) primary PCI should be used for >70% of all STEMI patients, 2) primary PCI rates should reach >600 per million inhabitants per year and 3) existing PCI centres should treat all their STEMI patients by primary PCI, i.e. should offer a 24/7 service
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| 20. |
- Potgieter, Danielle, et al.
(författare)
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N-terminal pro-B-type Natriuretic Peptides Prognostic Utility Is Overestimated in Meta-analyses Using Study-specific Optimal Diagnostic Thresholds
- 2015
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Ingår i: Anesthesiology. - : LIPPINCOTT WILLIAMS and WILKINS. - 0003-3022 .- 1528-1175. ; 123:2, s. 264-271
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Tidskriftsartikel (refereegranskat)abstract
- Background:N-terminal fragment B-type natriuretic peptide (NT-proBNP) prognostic utility is commonly determined post hoc by identifying a single optimal discrimination threshold tailored to the individual study population. The authors aimed to determine how using these study-specific post hoc thresholds impacts meta-analysis results. Methods: The authors conducted a systematic review of studies reporting the ability of preoperative NT-proBNP measurements to predict the composite outcome of all-cause mortality and nonfatal myocardial infarction at 30 days after noncardiac surgery. Individual patient-level data NT-proBNP thresholds were determined using two different methodologies. First, a single combined NT-proBNP threshold was determined for the entire cohort of patients, and a meta-analysis conducted using this single threshold. Second, study-specific thresholds were determined for each individual study, with meta-analysis being conducted using these study-specific thresholds. Results: The authors obtained individual patient data from 14 studies (n = 2,196). Using a single NT-proBNP cohort threshold, the odds ratio (OR) associated with an increased NT-proBNP measurement was 3.43 (95% CI, 2.08 to 5.64). Using individual study-specific thresholds, the OR associated with an increased NT-proBNP measurement was 6.45 (95% CI, 3.98 to 10.46). In smaller studies (less than100 patients) a single cohort threshold was associated with an OR of 5.4 (95% CI, 2.27 to 12.84) as compared with an OR of 14.38 (95% CI, 6.08 to 34.01) for study-specific thresholds. Conclusions:Post hoc identification of study-specific prognostic biomarker thresholds artificially maximizes biomarker predictive power, resulting in an amplification or overestimation during meta-analysis of these results. This effect is accentuated in small studies.
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| 22. |
- van Velden, J. L., et al.
(författare)
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Futures for invasive alien species management : using bottom-up innovations to envision positive systemic change
- 2023
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Ingår i: Sustainability Science. - 1862-4065 .- 1862-4057. ; 18:6, s. 2567-2587
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Tidskriftsartikel (refereegranskat)abstract
- Invasive alien species (IAS) pose a key threat to biodiversity, the economy and human well-being, and continue to increase in abundance and impact worldwide. Legislation and policy currently dominate the global agenda for IAS, although translation to localised success may be limited. This calls for a wider range of responses to transform IAS management. An under-appreciated strategy to achieve success may come from bottom-up, experimental innovations (so-called “seeds”), which offer alternative visions of what may be possible for IAS management in the future. We present an application of a participatory process that builds on such innovations to create alternative visions of the future, with actionable pathways to guide change. Through a series of workshops with practitioners and academics, we used this process to explore alternative positive futures for IAS management in South Africa. We then identified a set of domains of change, that could enable these visions to be actioned by appropriate stakeholders. The domains of change highlight the social–ecological nature of the IAS sector, with interconnected actions needed in financial, cultural, social, technological and governance spheres. Key domains identified were the need to shift mindsets and values of society regarding IAS, as well as the need for appropriate and functional financing. This participatory futuring process offers a way to interrogate and scale bottom-up innovations, thereby creating optimism and allowing stakeholders to engage constructively with the future. This represents an important step in fostering the potential of bottom-up innovations to transform IAS management.
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