| 1. |
|
|
| 2. |
- Lati, Monireh Pourghasemi, et al.
(författare)
-
Palladium Nanoparticles Immobilized on an Aminopropyl-functionalized Silica-Magnetite Composite as a Recyclable Catalyst for Suzuki-Miyaura Reactions
- 2018
-
Ingår i: Chemistryselect. - : Wiley. - 2365-6549. ; 3:27, s. 7970-7975
-
Tidskriftsartikel (refereegranskat)abstract
- Herein, we describe the straightforward synthesis and thorough characterization of a magnetically-separable heterogeneous catalyst comprised of 1-3nm-sized Pd nanoparticles immobilized on a mesoporous silica-magnetite composite (Pd-0-AmP-SMC). Catalytic evaluations were conducted using Suzuki-Miyaura cross-couplings as the model reactions, for which this Pd nanocatalyst exhibited high performance in an environmentally-friendly solvent mixture. Additionally, this Pd nanocatalyst could be re-used up to five cycles without any observable loss of activity, and separation of the catalyst could be conveniently done by a magnet.
|
|
| 3. |
- Meyer, Denise N., et al.
(författare)
-
Base-catalysed F-18-labelling of trifluoromethyl ketones. Application to the synthesis of F-18-labelled neutrophil elastase inhibitors
- 2021
-
Ingår i: Chemical Communications. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 57:68, s. 8476-8479
-
Tidskriftsartikel (refereegranskat)abstract
- A new method for the fluorine-18 labelling of trifluoromethyl ketones has been developed. This method is based on the conversion of a-COCF3 functional group to a difluoro enol silyl ether followed by halogenation and fluorine-18 labelling. The utility of this new method was demonstrated by the synthesis of fluorine-18 labelled neutrophil elastase inhibitors, which are potentially useful for detection of inflammatory disorders.
|
|
| 4. |
- Oschmann, Michael, 1985-, et al.
(författare)
-
Synthesis of Elaborate Benzofuran-2-Carboxamide Derivatives through a Combination of 8-Aminoquinoline Directed C–H Arylation and Transamidation Chemistry
- 2020
-
Ingår i: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 25:2
-
Tidskriftsartikel (refereegranskat)abstract
- Herein, we present a short and highly modular synthetic route that involves 8-aminoquinoline directed C–H arylation and transamidation chemistry, and which enables access to a wide range of elaborate benzofuran-2-carboxamides. For the directed C–H arylation reactions, Pd catalysis was used to install a wide range of aryl and heteroaryl substituents at the C3 position of the benzofuran scaffold in high efficiency. Directing group cleavage and further diversification of the C3-arylated benzofuran products were then achieved in a single synthetic operation through the utilization of a one-pot, two-step transamidation procedure, which proceeded via the intermediate N-acyl-Boc-carbamates. Given the high efficiency and modularity of this synthetic strategy, it constitutes a very attractive method for generating structurally diverse collections of benzofuran derivatives for small molecule screening campaigns.
|
|
| 5. |
- Pourghasemi Lati, Monireh, et al.
(författare)
-
A Study of an 8-Aminoquinoline-Directed C(sp2)–H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal
- 2021
-
Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 86:12, s. 8527-8537
-
Tidskriftsartikel (refereegranskat)abstract
- This work outlines a synthetic route that can be used to access chiral cyclobutane keto acids with two stereocenters in five steps from the inexpensive terpene myrtenal. Furthermore, the developed route includes an 8-aminoquinoline-directed C(sp2)–H arylation as one of its key steps, which allows a wide range of aryl and heteroaryl groups to be incorporated into the bicyclic myrtenal scaffold prior to the ozonolysis-based ring-opening step that furnishes the target cyclobutane keto acids. This synthetic route is expected to find many applications connected to the synthesis of natural product-like compounds and small molecule libraries.
|
|
| 6. |
- Verho, Oscar, et al.
(författare)
-
A Two-Step Procedure for the Overall Transamidation of 8-Aminoquinoline Amides Proceeding via the Intermediate N-Acyl-Boc-Carbamates
- 2018
-
Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 83:8, s. 4464-4476
-
Tidskriftsartikel (refereegranskat)abstract
- Herein a two-step strategy for achieving overall transamidation of 8-aminoquinoline amides has been explored. In this protocol, the 8-aminoquinoline amides were first treated with Boc(2)O and DMAP to form the corresponding N-acyl-Boc-carbamates, which were found to be sufficiently reactive to undergo subsequent aminolysis with different amines in the absence of any additional reagents or catalysts. To demonstrate the utility of this approach, it was applied on a number of 8-aminoquinoline amides from the recent C-H functionalization literature, enabling access to a range of elaborate amide derivatives in good to high yields
|
|
