| 1. |
- Andrei, Constantin Octavian, et al.
(författare)
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Galileo l10 satellites: Orbit, clock and signal-in-space performance analysis
- 2021
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 21:5, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- The tenth launch (L10) of the European Global Navigation Satellite System Galileo filled in all orbital slots in the constellation. The launch carried four Galileo satellites and took place in July 2018. The satellites were declared operational in February 2019. In this study, we report on the performance of the Galileo L10 satellites in terms of orbital inclination and repeat period parameters, broadcast satellite clocks and signal in space (SiS) performance indicators. We used all available broadcast navigation data from the IGS consolidated navigation files. These satellites have not been reported in the previous studies. First, the orbital inclination (56.7 ± 0.15°) and repeat period (50680.7 ± 0.22 s) for all four satellites are within the nominal values. The data analysis reveals also 13.5-, 27-, 177-and 354-days periodic signals. Second, the broadcast satellite clocks show different correction magnitude due to different trends in the bias component. One clock switch and several other minor correction jumps have occurred since the satellites were declared operational. Short-term discontinuities are within ±1 ps/s, whereas clock accuracy values are constantly below 0.20 m (root-mean-square—rms). Finally, the SiS performance has been very high in terms of availability and accuracy. Monthly SiS availability has been constantly above the target value of 87% and much higher in 2020 as compared to 2019. Monthly SiS accuracy has been below 0.20 m (95th percentile) and below 0.40 m (99th percentile). The performance figures depend on the content and quality of the consolidated navigation files as well as the precise reference products. Nevertheless, these levels of accuracy are well below the 7 m threshold (95th percentile) specified in the Galileo service definition document.
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| 2. |
- Andrei, Constantin-Octavian, et al.
(författare)
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GPS Time Series Analysis from Aboa the Finnish Antarctic Research Station
- 2018
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Ingår i: Remote Sensing. - : MDPI AG. - 2072-4292. ; 10:12
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Tidskriftsartikel (refereegranskat)abstract
- Continuous Global Positioning System (GPS) observations have been logged at the Finnish Antarctic research station (Aboa) since February 2003. The station is located in Dronning Maud Land, East Antarctica. Almost 5000 daily observation files have been archived based on yearly scientific expeditions. These files have not been fully analysed until now. This study reports for the first time on the consistent and homogeneous data processing and analysis of the 15-year long time series. Daily coordinates are obtained using Precise Point Positioning (PPP) processing based on two approaches. The first approach is based on the Kalman filter and uses the RTKLIB open source library to produce daily solutions by unconventionally running the filter in the forward and backward direction. The second approach uses APPS web service and is based on GIPSY scientific processing engine. The two approaches show an excellent agreement with less than 3 mm rms error horizontally and 6 mm rms error vertically. The derived position time series is analysed in terms of trend, periodicity and noise characteristics. The noise of the time series was found to be power-law noise model with spectral index closer to flicker noise. In addition, several periodic signals were found at 5, 14, 183 and 362 days. Furthermore, most of the horizontal movement was found to be in the North direction at a rate of 11.23 +/- 0.09 mm/y, whereas the rate in the East direction was estimated to be 1.46 +/- 0.05 mm/y. Lastly, the 15-year long time series revealed a movement upwards at a rate of 0.79 +/- 0.35 mm/y. Despite being an unattended station, Aboa provides one of the most continuous and longest GPS time series in Antarctica. Therefore, we believe that this research increases the awareness of local geophysical phenomena in a less reported area of the Antarctic continent.
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| 3. |
- Andrei, Constantin Octavian, et al.
(författare)
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Signal performance analysis of the latest quartet of Galileo satellites during the first operational year
- 2020
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Ingår i: 2020 International Conference on Localization and GNSS, ICL-GNSS 2020 - Proceedings.
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Konferensbidrag (refereegranskat)abstract
- On 12 February 2020, the latest four Galileo satellites had completed one full year of space operational service. The satellites were launched on 25 July 2018. The quartet increased the operational capacity of the Galileo constellation to 22 satellites. This study reports on three signal-in-space (SiS) performance indicators - status, availability, and ranging accuracy - from 11 February 2019 to 12 February 2020. In addition, the study looks also at how the on-board satellite clocks have performed. The data analysis shows 100% data validity and signal health status for three our of the four satellites, whereas NAPA (No Accuracy Prediction Available) events accounted for about 2% of the time. In addition, SiS availability was higher than 95% in the first operational year. Furthermore, the 95th percentile of the global average of the instantaneous signal in space error is found to vary between 0.17 to 0.33 m on monthly basis. Lastly, the precise satellite clock biases show high short-term performance with 0.1 ps/s (10-13 s/s) standard deviations during the first operational year. The numerical results indicate a robust performance and high reliability for the youngest Galileo satellites in the constellation. They increase the number of operational satellites in the constellation and thus contribute to the Galileo's increased popularity in the satellite-based positioning and navigation user community.
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| 4. |
- Brader, Lea, et al.
(författare)
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Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET)
- 2014
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Ingår i: European Journal of Nutrition. - : Springer Science and Business Media LLC. - 1436-6215 .- 1436-6207. ; 53:4, s. 1123-1134
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Tidskriftsartikel (refereegranskat)abstract
- At northern latitudes, vitamin D is not synthesized endogenously during winter, causing low plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Therefore, we evaluated the effects of a healthy Nordic diet based on Nordic nutrition recommendations (NNR) on plasma 25(OH)D and explored its dietary predictors. In a Nordic multi-centre trial, subjects (n = 213) with metabolic syndrome were randomized to a control or a healthy Nordic diet favouring fish (a parts per thousand yen300 g/week, including a parts per thousand yen200 g/week fatty fish), whole-grain products, berries, fruits, vegetables, rapeseed oil and low-fat dairy products. Plasma 25(OH)D and parathyroid hormone were analysed before and after 18- to 24-week intervention. At baseline, 45 % had vitamin D inadequacy (< 50 nmol/l), whereas 8 % had deficiency (< 25 nmol/l). Dietary vitamin D intake was increased by the healthy Nordic diet (P < 0.001). The healthy Nordic and the control diet reduced the prevalence of vitamin D inadequacy by 42 % (P < 0.001) and 19 % (P = 0.002), respectively, without between-group difference (P = 0.142). Compared with control, plasma 25(OH)D (P = 0.208) and parathyroid hormone (P = 0.207) were not altered by the healthy Nordic diet. Predictors for 25(OH)D were intake of vitamin D, eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA), vitamin D supplement, plasma EPA and plasma DHA. Nevertheless, only vitamin D intake and season predicted the 25(OH)D changes. Consuming a healthy Nordic diet based on NNR increased vitamin D intake but not plasma 25(OH)D concentration. The reason why fish consumption did not improve vitamin D status might be that many fish are farmed and might contain little vitamin D or that frying fish may result in vitamin D extraction. Additional ways to improve vitamin D status in Nordic countries may be needed.
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| 5. |
- Gruber, Thomas, et al.
(författare)
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Geodetic SAR for Baltic Height System Unification and Baltic Sea Level Research
- 2021
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Rapport (refereegranskat)abstract
- Traditionally, sea level is observed at tide gauge stations, which usually also serve as height reference stations for national levelling networks and therefore define a height system of a country. Thus, sea level research across countries is closely linked to height system unification and needs to be regarded jointly. The project aims to make use of a new observation technique, namely SAR positioning, which can help to connect the GNSS basic network of a country to tide gauge stations and as such to link the sea level records of tide gauge stations to the geometric network. By knowing the geoid heights at the tide gauge stations in a global height reference frame with high precision, one can finally obtain absolute sea level heights of the tide gauge stations in a common reference system and can link them together. By this method, on the one hand national height systems can be connected and on the other hand the absolute sea level at the tide gauge stations can be determined. By analysing time series of absolute sea level heights their changes can be determined in an absolute sense in a global reference frame and the impact of climate change on sea level can be quantified (e.g. by ice sheet and glacier melting, water inflow, global warming). The major scientific challenges to be addressed by this project then can be summarized as follows: (1) Connection of the tide gauge markers with the GNSS network geometrically in order to determine the relative vertical motion and to correct the tide gauge readings. For this the new technique of SAR positioning is applied. (2) Determination of a GOCE based high resolution geoid at tide gauge stations in order to deliver absolute heights of tide gauges with respect to a global equipotential surface as reference. (3) Joint analysis of geometrical and physical reference frames to make them compatible, and to determine corrections to be applied for combined analysis of geometric and physical heights.
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| 6. |
- Gruber, Thomas, et al.
(författare)
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Geodetic SAR for Height System Unification and Sea Level Research - Observation Concept and Preliminary Results in the Baltic Sea
- 2020
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Ingår i: Remote Sensing. - : MDPI AG. - 2072-4292. ; 12:22
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Tidskriftsartikel (refereegranskat)abstract
- Traditionally, sea level is observed at tide gauge stations, which usually also serve as height reference stations for national leveling networks and therefore define a height system of a country. One of the main deficiencies to use tide gauge data for geodetic sea level research and height systems unification is that only a few stations are connected to the geometric network of a country by operating permanent GNSS receivers next to the tide gauge. As a new observation technique, absolute positioning by SAR using active transponders on ground can fill this gap by systematically observing time series of geometric heights at tide gauge stations. By additionally knowing the tide gauge geoid heights in a global height reference frame, one can finally obtain absolute sea level heights at each tide gauge. With this information the impact of climate change on the sea level can be quantified in an absolute manner and height systems can be connected across the oceans. First results from applying this technique at selected tide gauges at the Baltic coasts are promising but also exhibit some problems related to the new technique. The paper presents the concept of using the new observation type in an integrated sea level observing system and provides some early results for SAR positioning in the Baltic sea area.
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| 7. |
- Gruber, Thomas, et al.
(författare)
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Geodetic SAR for Height System Unification and Sea Level Research - Observation Concept and Results in the Baltic Sea
- 2022
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Konferensbidrag (refereegranskat)abstract
- Traditionally, sea level is observed at tide gauge stations, which usually also serve as height reference stations for national leveling networks and therefore define a height system of a country. Thus, sea level research across countries is closely linked to height system unification and needs to be regarded jointly. One of the main deficiencies to use tide gauge data for geodetic sea level research and height systems unification is that only a few stations are connected to permanent GNSS receivers next to the tide gauge in order to systematically observe vertical land motion. As a new observation technique, absolute positioning by SAR using active transponders on ground can fill this gap by systematically observing time series of geometric heights at tide gauge stations. By additionally knowing the tide gauge geoid heights in a global height reference frame, one can finally obtain absolute sea level heights at each tide gauge. With this information the impact of climate change on the sea level can be quantified in an absolute manner and height systems can be connected across the oceans.The paper presents the results of a project, which was conducted in the years 2019 to 2021 in the frame of ESA´s Baltic+ initiative. Within this project a test network of electronic corner reflectors (ECR) as targets for Sentinel-1 was realized in the Baltic Sea area. The ECR locations were either co-located with tide gauges or with permanent GNSS stations in order to observe systematically the ellipsoidal heights of the tide gauges and possibly also any vertical land motion at the stations. Data for the year 2020 were collected at 10 stations in Estonia, Finland, Poland and Sweden and jointly analyzed with GNSS data, tide gauge records and regional geoid height estimates. The obtained results are promising, but also exhibit some problems related to the ECR´s and their performance. At co-located GNSS stations the estimated ellipsoidal heights agree in a range between about 2 and 50 cm between both observation systems. From the results it could be identified that most likely variable systematic electronic instrument delays of the ECR´s are the main reason for these differences and that each instrument needs to be calibrated individually. Nevertheless, the project provides a valuable data set, which offers the possibility to enhance methods and procedures in order to develop the geodetic SAR positioning technique towards operability. All data and reports are accessible at the following web site: https://www.asg.ed.tum.de/iapg/baltic/
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| 8. |
- Gruber, Thomas, et al.
(författare)
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Geodetic SAR for Height System Unification and Sea Level Research - Results in the Baltic Sea Test Network
- 2022
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Ingår i: Remote Sensing. - : MDPI. - 2072-4292. ; 14:14
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Tidskriftsartikel (refereegranskat)abstract
- Coastal sea level is observed at tide gauge stations, which usually also serve as height reference stations for national networks. One of the main issues with using tide gauge data for sea level research is that only a few stations are connected to permanent GNSS stations needed to correct for vertical land motion. As a new observation technique, absolute positioning by SAR using off the shelf active radar transponders can be installed instead. SAR data for the year 2020 are collected at 12 stations in the Baltic Sea area, which are co-located to tide gauges or permanent GNSS stations. From the SAR data, 3D coordinates are estimated and jointly analyzed with GNSS data, tide gauge records and regional geoid height estimates. The obtained results are promising but also exhibit some problems related to the electronic transponders and their performance. At co-located GNSS stations, the estimated ellipsoidal heights agree in a range between about 2 and 50 cm for both observation systems. From the results, it can be identified that, most likely, variable systematic electronic instrument delays are the main reason, and that each transponder instrument needs to be calibrated individually. Nevertheless, the project provides a valuable data set, which offers the possibility of enhancing methods and procedures in order to develop a geodetic SAR positioning technique towards operability.
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| 9. |
- Gürdeniz, Gözde, et al.
(författare)
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Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids
- 2021
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Ingår i: Clinical Nutrition. - : Elsevier. - 0261-5614 .- 1532-1983. ; 41:2, s. 441-451
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers.METHODS: During 18-24 weeks of intervention, 200 participants with metabolic syndrome were advised at six centres to eat either HND (e.g. whole-grain products, berries, rapeseed oil, fish and low-fat dairy) or CD while being weight stable. Of these 166/159 completers delivered blood/urine samples. Metabolic profiles of fasting plasma and 24 h pooled urine were analysed to identify characteristic diet-related patterns. Principal components analysis (PCA) scores (i.e. PC1 and PC2 scores) were used to test their combined effect on blood glucose response (primary endpoint), serum lipoproteins, triglycerides, and inflammatory markers.RESULTS: The profiles distinguished HND and CD with AUC of 0.96 ± 0.03 and 0.93 ± 0.02 for plasma and urine, respectively, with limited heterogeneity between centers, reflecting markers of key foods. Markers of fish, whole grain and polyunsaturated lipids characterized HND, while CD was reflected by lipids containing palmitoleic acid. The PC1 scores of plasma metabolites characterizing the intervention is associated with HDL (β = 0.05; 95% CI: 0.02, 0.08; P = 0.001) and triglycerides (β = -0.06; 95% CI: -0.09, -0.03; P < 0.001). PC2 scores were related with glucose metabolism (2 h Glucose, β = 0.1; 95% CI: 0.05, 0.15; P < 0.001), LDL (β = 0.06; 95% CI: 0.01, 0.1; P = 0.02) and triglycerides (β = 0.11; 95% CI: 0.06, 0.15; P < 0.001). For urine, the scores were related with LDL cholesterol.CONCLUSIONS: Plasma and urine metabolite profiles from SYSDIET reflected good compliance with dietary recommendations across the region. The scores of metabolites characterizing the diets associated with outcomes related with cardio-metabolic risk. Our analysis therefore offers a novel way to approach a per protocol analysis with a balanced compliance assessment in larger multicentre dietary trials. The study was registered at clinicaltrials.gov with NCT00992641.
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| 10. |
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| 11. |
- Harju, Jorma, et al.
(författare)
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Radio Interferometric Observation of an Asteroid Occultation
- 2018
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Ingår i: Astronomical Journal. - : University of Chicago Press. - 0004-6256 .- 1538-3881. ; 156:4, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- The occultation of the radio galaxy 0141+268 by the asteroid(372)Palma on 2017 May 15 was observed using sixantennas of the Very Long Baseline Array(VLBA). The shadow of Palma crossed the VLBA station at Brewster,Washington. Owing to the wavelength used, and the size and the distance of the asteroid, a diffraction pattern in theFraunhofer regime was observed. The measurement retrieves both the amplitude and the phase of the diffractedelectromagnetic wave. This is thefirst astronomical measurement of the phase shift caused by diffraction. Themaximum phase shift is sensitive to the effective diameter of the asteroid. The bright spot at the shadow’s center,the so called Arago–Poisson spot, is clearly detected in the amplitude time-series, and its strength is a goodindicator of the closest angular distance between the center of the asteroid and the radio source. A sample ofrandom shapes constructed using a Markov chain Monte Carlo algorithm suggests that the silhouette of Palmadeviates from a perfect circle by 26±13%. The best-fitting random shapes resemble each other, and we suggesttheir average approximates the shape of the silhouette at the time of the occultation. The effective diameterobtained for Palma, 192.1±4.8 km, is in excellent agreement with recent estimates from thermal modeling ofmid-infrared photometry. Finally, our computations show that because of the high positional accuracy, a singleradio interferometric occultation measurement can reduce the long-term ephemeris uncertainty by an order ofmagnitude.
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| 12. |
- Johansson, Jan, 1960, et al.
(författare)
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Continuous GPS measurements of postglacial adjustment in Fennoscandia - 1. Geodetic results
- 2002
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 107:B8
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Tidskriftsartikel (refereegranskat)abstract
- Project BIFROST (Baseline Inferences for Fennoscandian Rebound Observations, Sea-level, and Tectonics) combines networks of continuously operating GPS receivers in Sweden and Finland to measure ongoing crustal deformation due to glacial isostatic adjustment (GIA). We present an analysis of data collected between August 1993 and May 2000. We compare the GPS determinations of three-dimensional crustal motion to predictions calculated using the high-resolution Fennoscandian deglaciation model recently proposed by Lambeck et al. [1998a, 1998b]. We find that the maximum observed uplift rate (~10 mm/yr) and the maximum predicted uplift rate agree to better than 1 mm yr-1. The patterns of uplift also agree quite well, although significant systematic differences are evident. The root-mean-square residual rate for a linear error model yields estimates of rate accuracy of 0.4 mm/yr for east, 0.3 mm/yr for north, and 1.3 mm/yr for up; these figures incorporate model errors, however. We have also compared the values for the observed radial deformation rates to those based on sea level rates from Baltic tide gauges. The observational error for the vertical GPS rates required to give a reduced chi^2 of unity is 0.8 mm/yr. The time series do exhibit temporal variations at seasonal frequencies, as well as apparent low-frequency noise. An empirical orthogonal function analysis indicates that the temporal variations are highly correlated among the sites. The correlation appears to be regional and falls off only slightly with distance. Some of this correlated noise is associated with snow accumulation on the antennas or, for those antennas with radomes, on the radomes. This problem has caused us to modify the radomes used several times, leading to one of our more significant sources of uncertainty.
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| 13. |
- Kolehmainen, Marjukka, et al.
(författare)
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Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome.
- 2015
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 101:1, s. 228-239
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.OBJECTIVE: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects.DESIGN: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration <10 mg/L at the beginning and the end of the intervention, and baseline body mass index (in kg/m(2)) <38. SAT biopsy specimens were obtained before and after the intervention and subjected to global transcriptome analysis with Gene 1.1 ST Arrays (Affymetrix).RESULTS: Altogether, 128 genes were differentially expressed in SAT between the ND and CD (nominal P < 0.01; false discovery rate, 25%). These genes were overrepresented in pathways related to immune response (adjusted P = 0.0076), resulting mainly from slightly decreased expression in the ND and increased expression in the CD. Immune-related pathways included leukocyte trafficking and macrophage recruitment (e.g., interferon regulatory factor 1, CD97), adaptive immune response (interleukin32, interleukin 6 receptor), and reactive oxygen species (neutrophil cytosolic factor 1). Interestingly, the regulatory region of the 128 genes was overrepresented for binding sites for the nuclear transcription factor κB.CONCLUSION: A healthy Nordic diet reduces inflammatory gene expression in SAT compared with a control diet independently of body weight change in individuals with features of the metabolic syndrome. The study was registered at clinicaltrials.gov as NCT00992641.
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| 14. |
- Lankinen, Maria, et al.
(författare)
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A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention
- 2016
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Ingår i: Journal of Nutrition. - New York, USA : Oxford University Press. - 0022-3166 .- 1541-6100. ; 146:4, s. 662-672
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: A healthy Nordic diet is associated with improvements in cardiometabolic risk factors, but the effect on lipidomic profile is not known.OBJECTIVE: The aim was to investigate how a healthy Nordic diet affects the fasting plasma lipidomic profile in subjects with metabolic syndrome.METHODS: Men and women (n = 200) with features of metabolic syndrome [mean age: 55 y; body mass index (in kg/m(2)): 31.6] were randomly assigned to either a healthy Nordic (n = 104) or a control (n = 96) diet for 18 or 24 wk at 6 centers. Of the participants, 156 completed the study with plasma lipidomic measurements. The healthy Nordic diet consisted of whole grains, fruits, vegetables, berries, vegetable oils and margarines, fish, low-fat milk products, and low-fat meat. An average Nordic diet served as the control diet and included low-fiber cereal products, dairy fat-based spreads, regular-fat milk products, and a limited amount of fruits, vegetables, and berries. Lipidomic profiles were measured at baseline, week 12, and the end of the intervention (18 or 24 wk) by using ultraperformance liquid chromatography mass spectrometry. The effects of the diets on the lipid variables were analyzed with linear mixed-effects models. Data from centers with 18- or 24-wk duration were also analyzed separately.RESULTS: Changes in 21 plasma lipids differed significantly between the groups at week 12 (false discovery rate P < 0.05), including increases in plasmalogens and decreases in ceramides in the healthy Nordic diet group compared with the control group. At the end of the study, changes in lipidomic profiles did not differ between the groups. However, when the intervention lasted 24 wk, changes in 8 plasma lipids that had been identified at 12 wk, including plasmalogens, were sustained. There were no differences in changes in plasma lipids between groups with an intervention of 18 wk. By the dietary biomarker score, adherence to diet did not explain the difference in the results related to the duration of the study.CONCLUSIONS: A healthy Nordic diet transiently modified the plasma lipidomic profile, specifically by increasing the concentrations of antioxidative plasmalogens and decreasing insulin resistance-inducing ceramides. This trial was registered at clinicaltrials.gov as NCT00992641.
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| 15. |
- Leder, Lena, et al.
(författare)
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Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome : A SYSDIET sub-study
- 2016
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Ingår i: Genes & Nutrition. - : Springer Science and Business Media LLC. - 1555-8932 .- 1865-3499. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term healthy Nordic diet (ND) can modify the expression of inflammation and lipid metabolism-related genes in peripheral blood mononuclear cells (PBMCs) during a 2-h oral glucose tolerance test (OGTT) in individuals with MetS. Methods: A Nordic multicenter randomized dietary study included subjects (n = 213) with MetS, randomized to a ND group or a control diet (CD) group applying an isocaloric study protocol. In this sub-study, we included subjects (n = 89) from three Nordic centers: Kuopio (n =26), Lund (n = 30), and Oulu (n = 33) with a maximum weight change of ±4 kg, high-sensitivity C-reactive protein concentration ≤10 mg L-1, and baseline body mass index -2. PBMCs were isolated, and the mRNA gene expression analysis was measured by quantitative real-time polymerase chain reaction (qPCR). We analyzed the mRNA expression changes of 44 genes before and after a 2hOGTT at the beginning and the end of the intervention. Results: The healthy ND significantly down-regulated the expression of toll-like receptor 4 (TLR4), interleukin 18 (IL18), and thrombospondin receptor (CD36) mRNA transcripts and significantly up-regulated the expression of peroxisome proliferator-activated receptor delta (PPARD) mRNA transcript after the 2hOGTT compared to the CD. Conclusions: A healthy ND is able to modify the gene expression in PBMCs after a 2hOGTT. However, more studies are needed to clarify the biological and clinical relevance of these findings.
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| 16. |
- Magnusdottir, Ola Kally, et al.
(författare)
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Plasma Alkylresorcinols Reflect Important Whole-Grain Components of a Healthy Nordic Diet
- 2013
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Ingår i: Journal of Nutrition. - : Elsevier BV. - 0022-3166 .- 1541-6100. ; 143:9, s. 1383-1390
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Tidskriftsartikel (refereegranskat)abstract
- Biomarkers of dietary intake can be important tools in nutrition research. Our aim was to assess whether plasma alkylresorcinol (AR) and beta-carotene concentrations could be used as dietary biomarkers for whole-grain, fruits and vegetables in a healthy Nordic diet (ND). Participants (n = 166), 30-65 y with a body mass index of 27-40 kg/m(2) and two more features of metabolic syndrome (International Diabetes Federation definition, slightly modified), were recruited through six centers in the Nordic countries and randomly assigned to an ND or control diet for 18 or 24 wk, depending on study center. Plasma AR and beta-carotene were analyzed and nutrient intake calculated from 4-d food records. Median fiber intake increased in the ND group from 2.5 g/MJ at baseline to 4.1 g/MJ (P < 0.001) at end point (week 18 or 24), and median (IQR) fasting plasma total AR concentration increased from 73 (88) to 106 (108) nmol/L, or 45%, from baseline to end point (P < 0.001). The AR concentration was significantly higher in the ND group (P < 0.001) than in the control group at end point. beta-Carotene intake tended to increase in the ND group (P = 0.07), but the plasma beta-carotene concentration did not change significantly throughout the study and did not differ between the groups at follow-up. In conclusion, an ND resulted in higher dietary fiber intake and increased plasma total AR concentration compared with the control diet, showing that the total AR concentration might be a valid biomarker for an ND in which whole-grain wheat and rye are important components. No significant difference in plasma beta-carotene concentrations was observed between the ND and control groups, suggesting that beta-carotene may not be a sensitive enough biomarker of the ND.
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| 17. |
- Magnusdottir, Ola Kally, et al.
(författare)
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Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome - a randomized study.
- 2014
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:10
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Tidskriftsartikel (refereegranskat)abstract
- Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17∶0/C21∶0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations.
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| 18. |
- Marklund, Matti, et al.
(författare)
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A Dietary Biomarker Approach Captures Compliance and Cardiometabolic Effects of a Healthy Nordic Diet in Individuals with Metabolic Syndrome.
- 2014
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Ingår i: Journal of Nutrition. - : Elsevier BV. - 1541-6100 .- 0022-3166. ; 144:10, s. 1642-1649
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Tidskriftsartikel (refereegranskat)abstract
- Assessment of compliance with dietary interventions is necessary to understand the observed magnitude of the health effects of the diet per se. To avoid reporting bias, different dietary biomarkers (DBs) could be used instead of self-reported data. However, few studies investigated a combination of DBs to assess compliance and its influence on cardiometabolic risk factors. The objectives of this study were to use a combination of DBs to assess compliance and to investigate how a healthy Nordic diet (ND) influences cardiometabolic risk factors in participants with high apparent compliance compared with the whole study population. From a recently conducted isocaloric randomized trial, SYSDIET (Systems Biology in Controlled Dietary Interventions and Cohort Studies), in 166 individuals with metabolic syndrome, several DBs were assessed to reflect different key components of the ND: canola oil (serum phospholipid α-linolenic acid), fatty fish [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], vegetables (plasma β-carotene), and whole grains (plasma alkylresorcinols). High-fat dairy intake (expectedly low in the ND) was reflected by serum pentadecanoic acid. All participants with biomarker data (n = 154) were included in the analyses. Biomarkers were combined by using a biomarker rank score (DB score) and principal component analysis (PCA). The DB score was then used to assess compliance. During the intervention, median concentrations of alkylresorcinols, α-linolenic acid, EPA, and DHA were >25% higher in the ND individuals compared with the controls (P < 0.05), whereas median concentrations of pentadecanoic acid were 14% higher in controls (P < 0.05). Median DB score was 57% higher in the ND compared with controls (P < 0.001) during the intervention, and participants were ranked similarly by DB score and PCA score. Overall, estimates of group difference in cardiometabolic effects generally appeared to be greater among compliant participants than in the whole study population (e.g., estimates of treatment effects on blood pressure and lipoproteins were ∼1.5- to 2-fold greater in the most compliant participants), suggesting that poor compliance attenuated the dietary effects. With adequate consideration of their limitations, DB combinations (e.g., DB score) could be useful for assessing compliance in intervention studies investigating cardiometabolic effects of healthy dietary patterns. The study was registered at clinicaltrials.gov as NCT00992641.
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| 19. |
- Myhrstad, Mari C. W., et al.
(författare)
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Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET Sub-Study
- 2019
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Ingår i: Molecular Nutrition & Food Research. - : John Wiley & Sons. - 1613-4125 .- 1613-4133. ; 63:13
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Tidskriftsartikel (refereegranskat)abstract
- Scope To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-kappa B, are downregulated in the healthy Nordic diet group. Conclusion These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.
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| 20. |
- Poutanen, Markku, et al.
(författare)
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DynaQlim – Upper Mantle Dynamics and Quaternary Climate in Cratonic Areas
- 2010
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Ingår i: New Frontiers in Integrated Solid Earth Sciences. - Dordrecht : Springer. - 9789048127368 - 9789048127375 ; , s. 349-372
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The isostatic adjustment of the solid Earth to the glacial loading (GIA, Glacial Isostatic Adjustment) with its temporal signature offers a great opportunity to retrieve information of Earth’s upper mantle to the changing mass of glaciers and ice sheets, which in turn is driven by variations in Quaternary climate. DynaQlim (Upper Mantle Dynamics and Quaternary Climate in Cratonic Areas) has its focus to study the relations between upper mantle dynamics, its composition and physical properties, temperature, rheology, and Quaternary climate. Its regional focus lies on the cratonic areas of northern Canada and Scandinavia.Geodetic methods like repeated precise levelling, tide gauges, high-resolution observations of recent movements, gravity change and monitoring of postglacial faults have given information on the GIA process for more than 100 years. They are accompanied by more recent techniques like GPS observations and the GRACE and GOCE satellite missions which provide additional global and regional constraints on the gravity field. Combining geodetic observations with seismological investigations, studies of the postglacial faults and continuum mechanical modelling of GIA, DynaQlim offers new insights into properties of the lithosphere. Another step toward a better understanding of GIA has been the joint inversion of different types of observational data – preferentially connected with geological relative sea-level evidence of the Earth’s rebound during the last 10,000 years.Due to the changes in the lithospheric stress state large faults ruptured violently at the end of the last glaciation in large earthquakes, up to the magnitudes MW = 7–8. Whether the rebound stress is still able to trigger a significant fraction of intraplate seismic events in these regions is not completely understood due to the complexity and spatial heterogeneity of the regional stress field. Understanding of this mechanism is of societal importance.Glacial ice sheet dynamics are constrained by the coupled process of the deformation of the viscoelastic solid Earth, the ocean and climate variability. Exactly how the climate and oceans reorganize to sustain growth of ice sheets that ground to continents and shallow continental shelves is poorly understood. Incorporation of nonlinear feedback in modelling both ocean heat transport systems and atmospheric CO2 is a major challenge. Climate-related loading cycles and episodes are expected to be important, hence also more short-term features of palaeoclimate should be explicitly treated.Within this Chapter View ChapterIntroductionObservational BasisCurrent Models and Problems to be SolvedClimateChallenges with DynaQlimReferencesReferencesOther actionsExport citationsAbout this BookReprints and Permissions
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| 21. |
- Poutanen, Markku, et al.
(författare)
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The Nordic Geodetic Observing System (NGOS)
- 2007
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Ingår i: International Association of Geodesy Symposia, Dynamic Planet. ; , s. 749-756
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The Nordic Geodetic Observing System (NGOS) integrates fundamental geodetic techniques for the long-term observation of Earth system parameters. The Nordic Geodetic Commission (NKG) established a Task Force with the mission to prepare a document providing the definition and draft for the implementation of the NGOS.The regional system aligns with international efforts such as the Global Earth Observation System of Systems (GEOSS) and Global Observing Systems and adheres to the Integrated Global Observing Strategy (IGOS). Recent developments in the structure and function of the International Association of Geodesy cumulated in the establishment of the Global Geodetic Observing System, GGOS. NGOS is planned as a regional implementation and densification of the GGOS.The NGOS is proposed as a system that will serve a wide range of scientific and practical applications. For the Nordic countries, a main focus will be on crustal motion, dynamics of glaciated areas and sea level. NGOS aims to provide geodetic observations for the Nordic area that are of sufficient quantity and quality to serve most of the needs of global Earth observation as well as practical and scientific applications in the region. In particular, NGOS will contribute to the GGOS and other IAG Services; European activities such as EUREF, ECGN, EUVN, and ESEAS; provide the reference frames for the Nordic countries, as well as contribute to the global ones; support scientific projects related to the geodynamics of the Nordic area and provide ground-truth for satellite missions. In this paper we describe the plans and current status of the NGOS.
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| 22. |
- Tuomainen, Marjo, et al.
(författare)
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Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
- 2019
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Ingår i: American Journal of Clinical Nutrition. - : OXFORD UNIV PRESS. - 0002-9165 .- 1938-3207. ; 110:5, s. 1108-1118
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Tidskriftsartikel (refereegranskat)abstract
- Background: Recently, a group of betainized compounds have been suggested to play a role in health effects in relation to a whole-grain-rich diet.Objectives: The aims of this study were to develop a quantitative mass spectrometric method for selected betainized compounds in human plasma, and to investigate their association with nutrient intake and measures of metabolic health in participants of the SYSDIET study.Methods: The SYSDIET study was a controlled randomized intervention including individuals with metabolic syndrome, where the healthy Nordic diet (HND) group increased intakes of whole grains, canola oil, berries, and fish, whereas the control diet (CD) group consumed low-fiber cereal products, milk fat, and restricted amounts of fish and berries. A quantitative LC combined with triple quadrupole MS method for betainized compounds was developed and applied to fasting plasma samples from baseline (week 0) and the end of the intervention (week 18 or 24). Concentrations of betainized compounds were correlated with intakes of selected nutrients and fiber and measures of metabolic health.Results: Pipecolic acid betaine (PAB) concentrations were significantly higher in the HND group than in the CD group (P = 0.00032) at the end of the intervention and correlated directly (P < 0.0001) with intakes of dietary fiber (r = 0.376) and a biomarker related to whole-grain rye intake, namely the ratio of alkylresorcinol C17:0 to C21:0 (r = 0.442). PAB was associated inversely with fasting plasma insulin consistently at the beginning and at the end of the intervention (P < 0.001, r = -0.300; P < 0.01, r = -0.250, respectively), as well as IL-1 receptor antagonist (P < 0.01, r = -0.232 at the beginning; P < 0.01, r = -0.236 at the end) and serum LDL/HDL cholesterol (P < 0.01, r = -0.239 at the beginning; P < 0.01, r = -0.241 at the end).Conclusions: Among adults with the metabolic syndrome, PAB plasma concentrations were associated with fasting insulin, inflammation, and lipids and were significantly increased with adoption of the HND. Further studies are needed to clarify the biological functions of betainized compounds.
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| 23. |
- Ulven, Stine M., et al.
(författare)
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An isocaloric nordic diet modulates rela and tnfrsf1a gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome—a sysdiet sub-study
- 2019
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 11:12
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Tidskriftsartikel (refereegranskat)abstract
- A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.
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| 24. |
- Varbla, Sander, et al.
(författare)
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Treatment of Tide Gauge Time Series and Marine GNSS Measurements for Vertical Land Motion with Relevance to the Implementation of the Baltic Sea Chart Datum 2000
- 2022
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Ingår i: Remote Sensing. - : MDPI. - 2072-4292. ; 14:4
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Tidskriftsartikel (refereegranskat)abstract
- Tide gauge (TG) time series and GNSS measurements have become standard datasets for various scientific and practical applications. However, the TG and geodetic networks in the Baltic Sea region are deforming due to vertical land motion (VLM), the primary cause of which is the glacial isostatic adjustment. Consequently, a correction for VLM, either obtained from a suitable VLM model or by utilizing space-geodetic techniques, must be applied to ensure compatibility of various data sources. It is common to consider the VLM rate relative to an arbitrary reference epoch, but this also yields that the resulting datasets may not be directly comparable. The common height reference, Baltic Sea Chart Datum 2000 (BSCD2000), has been initiated to facilitate the effective use of GNSS methods for accurate navigation and offshore surveying. The BSCD2000 agrees with the current national height realizations of the Baltic Sea countries. As TGs managed by national authorities are rigorously connected to the national height systems, the TG data can also be used in a common system. Hence, this contribution aims to review the treatment of TG time series for VLM and outline potential error sources for utilizing TG data relative to a common reference. Similar consideration is given for marine GNSS measurements that likewise require VLM correction for some marine applications (such as validating marine geoid models). The described principles are illustrated by analyzing and discussing numerical examples. These include investigations of TG time series and validation of shipborne GNSS determined sea surface heights. The latter employs a high-resolution geoid model and hydrodynamic model-based dynamic topography, which is linked to the height reference using VLM corrected TG data. Validation of the presented VLM corrected marine GNSS measurements yields a 1.7 cm standard deviation and –2.7 cm mean residual. The estimates are 1.9 cm and –10.2 cm, respectively, by neglecting VLM correction. The inclusion of VLM correction thus demonstrates significant improvement toward data consistency. Although the focus is on the Baltic Sea region, the principles described here are also applicable elsewhere.
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