| 1. |
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| 2. |
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| 3. |
- Aaron, F. D., et al.
(författare)
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Multi-leptons with high transverse momentum at HERA
- 2009
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Ingår i: Journal of High Energy Physics. - : Springer Science and Business Media LLC. - 1029-8479. ; :10
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Tidskriftsartikel (refereegranskat)abstract
- Events with at least two high transverse momentum leptons (electrons or muons) are studied using the H1 and ZEUS detectors at HERA with an integrated luminosity of 0.94 fb(-1). The observed numbers of events are in general agreement with the Standard Model predictions. Seven di- and tri-lepton events are observed in e(+)p collision data with a scalar sum of the lepton transverse momenta above 100 GeV while 1.94 +/- 0.17 events are expected. Such events are not observed in e(-)p collisions for which 1.19 +/- 0.12 are predicted. Total visible and differential di-electron and di-muon photoproduction cross sections are extracted in a restricted phase space dominated by photon-photon collisions.
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| 4. |
- Aaron, F. D., et al.
(författare)
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A search for excited neutrinos in e(-) p collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 663:5, s. 382-389
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Tidskriftsartikel (refereegranskat)abstract
- A search for first generation excited neutrinos is performed using the full e(-) p data sample collected by the HI experiment at HERA at a centre-of-mass energy of 319 GeV, corresponding to a total luminosity of 184 pb(-1). The electroweak decays of excited neutrinos nu* -> nu gamma, v* -> nu Z and nu* -> eW with subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for excited neutrino production is found. Mass dependent exclusion limits on nu* production cross sections and on the ratio of the coupling to the compositeness scale f/boolean AND are derived within gauge mediated models. A limit on f/boolean AND A, independent of the relative couplings to the SU(2) and U(1) gauge bosons, is also determined. These limits extend the excluded region to higher masses than has been possible in previous excited neutrino searches. (c) 2008 Elsevier B.V. All rights reserved.
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| 5. |
- Aaron, F. D., et al.
(författare)
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Measurement of diffractive scattering of photons with large momentum transfer at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 672:3, s. 219-226
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Tidskriftsartikel (refereegranskat)abstract
- The first measurement of diffractive scattering of quasi-real photons with large momentum transfer gamma p -> gamma Y, where Y is the proton dissociative system, is made using the H1 detector at HERA. The measurement is performed for initial photon virtualities Q(2) < 0.01 GeV2. Single differential cross sections are Measured as a function of W, the incident photon-proton centre of mass energy, and t, the square of the four-momentum transferred at the proton vertex, in the range 175 < W < 247 GeV and 4 < |t| < 36 GeV2. The W dependence is well described by a model based on perturbative QCD using a leading logarithmic approximation of the BFKL evolution. The measured |t| dependence is harder than that predicted by the model and those observed in exclusive vector meson production. (C) 2009 Published by Elsevier B.V.
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| 6. |
- Aaron, F. D., et al.
(författare)
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Measurement of isolated photon production in deep-inelastic scattering at HERA
- 2008
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 54:3, s. 371-387
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Tidskriftsartikel (refereegranskat)abstract
- The production of isolated photons in deep-inelastic scattering ep -> e gamma X is measured with the H1 detector at HERA. The measurement is performed in the kinematic range of negative four-momentum transfer squared 4 < Q(2)< 150 GeV2 and a mass of the hadronic system W-X > 50 GeV. The analysis is based on a total integrated luminosity of 227 pb(-1). The production cross section of isolated photons with a transverse energy in the range 3 < E-T(gamma)< 10 GeV and pseudorapidity range -1.2
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| 7. |
- Aaron, F. D., et al.
(författare)
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Measurement of the proton structure function F-L(x, Q(2)) at low x
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 665:4, s. 139-146
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Tidskriftsartikel (refereegranskat)abstract
- A first measurement is reported of the longitudinal proton structure function FL(X, Q(2)) at the ep collider HERA. It is based on inclusive deep inelastic e(+)p scattering cross section measurements with a positron beam energy of 27.5 GeV and proton beam energies of 920, 575 and 460 GeV. Employing the energy dependence of the cross section, FL is measured in a range of squared four-momentum transfers 12 <= Q2 <=, 90 GeV2 and low Bjorken x 0.00024 <= x <= 0.0036. The F-L values agree with higher order QCD calculations based on parton densities obtained using cross section data previously measured at HERA. (C) 2008 Elsevier B.V. All rights reserved.
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| 8. |
- Aaron, F. D., et al.
(författare)
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Multi-lepton production at high transverse momenta in ep collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 668:4, s. 268-276
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Tidskriftsartikel (refereegranskat)abstract
- Processes leading to a final state with at least two high transverse momentum leptons (electrons or muons) are studied using the full e(+/-) p data sample collected by the H1 experiment at HERA. The data correspond to an integrated luminosity of 463 pb(-1). Di-lepton and tri-lepton event classes are investigated. Cross sections of the production of e(+)e(-) and mu(+)mu(-) pairs are derived in a restricted phase space dominated by photon-photon collisions. In general, good agreement is found with Standard Model predictions. Events are observed with a total scalar sum of lepton transverse momenta above 100 GeV where the Standard Model expectation is low. In this region, combining di-lepton and tri-lepton classes, five events are observed in e(+) p collisions, compared to a Standard Model expectation of 0.96 +/- 0.12, while no such event is observed in e(-) p data for 0.64 +/- 0.09 expected. (C) 2008 Elsevier B.V. All rights reserved.
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| 9. |
- Aaron, F. D., et al.
(författare)
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Search for excited electrons in ep collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 666:2, s. 131-139
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Tidskriftsartikel (refereegranskat)abstract
- A search for excited electrons is performed using the full e(+/-) p data sample collected by the HI experiment at HERA, corresponding to a total luminosity of 475 pb(-1). The electroweak decays of excited electrons e* -> e gamma, e* -> eZ and e* -> vW with subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for excited electron production is found. Mass dependent exclusion limits on e* production cross sections and on the ratio f/Lambda of the coupling to the compositeness scale are derived within gauge mediated models. These limits extend the excluded region compared to previous excited electron searches. The e* production via contact interactions is also addressed for the first time in ep collisions. (C) 2008 Elsevier B.V. All rights reserved.
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| 10. |
- Aaron, F. D., et al.
(författare)
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Strangeness production at low Q(2) in deep-inelastic ep scattering at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 61:2, s. 185-205
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Tidskriftsartikel (refereegranskat)abstract
- The production of neutral strange hadrons is investigated using deep-inelastic scattering events measured with the H1 detector at HERA. The measurements are made in the phase space defined by the negative four-momentum transfer squared of the photon 2 < Q(2) < 100 GeV2 and the inelasticity 0.1 < y < 0.6. The K-s(0) s and Lambda((Lambda) over bar) production cross sections and their ratios are determined. K-s(0) s production is compared to the production of charged particles in the same region of phase space. The Lambda-(Lambda) over bar asymmetry is also measured and found to be consistent with zero. Predictions of leading order Monte Carlo programs are compared to the data.
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| 11. |
- Aaron, F. D., et al.
(författare)
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Study of charm fragmentation into D (* +/-) mesons in deep-inelastic scattering at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 59:3, s. 589-606
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Tidskriftsartikel (refereegranskat)abstract
- The process of charm quark fragmentation is studied using D (* +/-) meson production in deep-inelastic scattering as measured by the H1 detector at HERA. The parameters of fragmentation functions are extracted for QCD models based on leading order matrix elements and DGLAP or CCFM evolution of partons together with string fragmentation and particle decays. Additionally, they are determined for a next-to-leading order QCD calculation in the fixed flavour number scheme using the independent fragmentation of charm quarks to D (* +/-) mesons. Two different regions of phase space are investigated defined by the presence or absence of a jet containing the D (* +/-) meson in the event. The fragmentation parameters extracted for the two phase space regions are found to be different.
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| 12. |
- Aaron, F. D., et al.
(författare)
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Three- and four-jet production at low x at HERA
- 2008
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 54:3, s. 389-409
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Tidskriftsartikel (refereegranskat)abstract
- Three- and four-jet production is measured in deep-inelastic ep scattering at low x and Q(2) with the H1 detector using an integrated luminosity of 44.2 pb(-1). Several phase space regions are selected for the three-jet analysis in order to study the underlying parton dynamics from global topologies to the more restrictive regions of forward jets close to the proton direction. The measurements of cross sections for events with at least three jets are compared to fixed order QCD predictions of O(alpha(2)(s)) and O(alpha(3)(s)) and with Monte Carlo simulation programs where higher order effects are approximated by parton showers. A good overall description is provided by the O(alpha(3)(s)) calculation. Too few events are predicted at the lowest x similar to 10(-4), especially for topologies with two forward jets. This hints to large contributions at low x from initial state radiation of gluons close to the proton direction and unordered in transverse momentum. The Monte Carlo program in which gluon radiation is generated by the colour dipole model gives a good description of both the three- and the four-jet data in absolute normalisation and shape.
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| 13. |
- Aktas, A., et al.
(författare)
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Measurement of inclusive jet production in deep-inelastic scattering at high Q(2) and determination of the strong coupling
- 2007
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 653:2-4, s. 134-144
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive jet production is studied in neutral current deep-inelastic positron-proton scattering at large four momentum transfer squared Q(2) > 150 GeV2 with the H1 detector at HERA. Single and double differential inclusive jet cross sections are measured as a function of Q(2) and of the transverse energy E-T of the jets in the Breit frame. The measurements are found to be well described by calculations at next-to-leading order in perturbative QCD. The running of the strong coupling is demonstrated and the value of alpha(s)(M-Z) is determined. The ratio of the inclusive jet cross section to the inclusive neutral current cross section is also measured and used to extract a precise value for ces (M-Z) = 0.1193 +/- 0.0014(exp.)(-0.0030)(+0.0047) (th.) +/- 0.0016(pdf). (c) 2007 Elsevier BX All rights reserved.
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| 14. |
- Aaron, F. D., et al.
(författare)
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A general search for new phenomena at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 674:4-5, s. 257-268
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Tidskriftsartikel (refereegranskat)abstract
- A model-independent search for deviations from the Standard Model prediction is performed using the full e(+/-) p data sample collected by the H1 experiment at HERA. All event topologies involving isolated electrons, photons, muons, neutrinos and jets with transverse momenta above 20 GeV are investigated in a single analysis. Events are assigned to exclusive classes according to their final state. A dedicated algorithm is used to search for deviations from the Standard Model in the distributions of the scalar sum of transverse momenta or the invariant mass of final state particles and to quantify their significance. Variables related to angular distributions and energy sharing between final state particles are also introduced to study the final state topologies. No significant deviation from the Standard Model expectation is observed in the phase space covered by this analysis. (C) 2009 Elsevier B.V. All rights reserved.
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| 15. |
- Aaron, F. D., et al.
(författare)
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A precision measurement of the inclusive ep scattering cross section at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 64:4, s. 561-587
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of the inclusive deep inelastic neutral current e(+) p scattering cross section is reported in the region of four-momentum transfer squared, 12GeV(2) <= Q(2) <= 150 GeV2, and Bjorken x, 2 x 10(-4) <= x <= 0.1. The results are based on data collected by the H1 Collaboration at the ep collider HERA at positron and proton beam energies of E-e = 27.6 GeV and E-p = 920 GeV, respectively. The data are combined with previously published data, taken at E-p = 820 GeV. The accuracy of the combined measurement is typically in the range of 1.3-2%. A QCD analysis at next-to-leading order is performed to determine the parton distributions in the proton based on H1 data.
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| 16. |
- Aaron, F. D., et al.
(författare)
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Events with isolated leptons and missing transverse momentum and measurement of W production at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 64:2, s. 251-271
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Tidskriftsartikel (refereegranskat)abstract
- Events with high energy isolated electrons, muons or tau leptons and missing transverse momentum are studied using the full e(+/-)p data sample collected by the H1 experiment at HERA, corresponding to an integrated luminosity of 474 pb(-1). Within the Standard Model, events with isolated leptons and missing transverse momentum mainly originate from the production of single W bosons. The total single W boson production cross section is measured as 1.14 +/- 0.25 (stat.) +/- 0.14 (sys.) pb, in agreement with the Standard Model expectation. The data are also used to establish limits on the WW gamma gauge couplings and for a measurement of the W boson polarisation.
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| 17. |
- Aaron, F. D., et al.
(författare)
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Inclusive photoproduction of rho(0), K*(0) and phi mesons at HERA H1 Collaboration
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 673:2, s. 119-126
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive non-diffractive photoproduction of rho(770)(0), K*(892)(0) and phi(1020) mesons is investigated with the H1 detector in ep collisions at HERA. The corresponding average gamma p centre-of-mass energy is 210 GeV. The mesons are measured in the transverse momentum range 0.5 < p(T) < 7 GeV and the rapidity range vertical bar y(lab)vertical bar < 1. Differential cross sections are presented as a function of transverse momentum and rapidity, and are compared to the predictions of hadroproduction models. (C) 2009 Elsevier B.V. All rights reserved.
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| 18. |
- Aaron, F. D., et al.
(författare)
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Jet production in ep collisions at high Q(2) and determination of alpha(s)
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 65:3-4, s. 363-383
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Tidskriftsartikel (refereegranskat)abstract
- The production of jets is studied in deep-inelastic e(+/-) p scattering at large negative four momentum transfer squared 150 < Q(2) < 15000 GeV2 using HERA data taken in 1999-2007, corresponding to an integrated luminosity of 395 pb(-1). Inclusive jet, 2-jet and 3-jet cross sections, normalised to the neutral current deep-inelastic scattering cross sections, are measured as functions of Q(2), jet transverse momentum and proton momentum fraction. The measurements are well described by perturbative QCD calculations at next-to-leading order corrected for hadronisation effects. The strong coupling as determined from these measurements
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| 19. |
- Aaron, F. D., et al.
(författare)
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Measurement of the inclusive ep scattering cross section at low Q (2) and x at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 63:4, s. 625-678
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of the inclusive ep scattering cross section is presented in the region of low momentum transfers, 0.2 GeV2 a parts per thousand currency signQ (2)a parts per thousand currency sign12 GeV2, and low Bjorken x, 5a <...10(-6)a parts per thousand currency signxa parts per thousand currency sign0.02. The result is based on two data sets collected in dedicated runs by the H1 Collaboration at HERA at beam energies of 27.6 GeV and 920 GeV for positrons and protons, respectively. A combination with data previously published by H1 leads to a cross section measurement of a few percent accuracy. A kinematic reconstruction method exploiting radiative ep events extends the measurement to lower Q (2) and larger x. The data are compared with theoretical models which apply to the transition region from photoproduction to deep inelastic scattering.
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| 20. |
- Aaron, F. D., et al.
(författare)
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Search for excited quarks in ep collisions at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 678:4, s. 335-343
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Tidskriftsartikel (refereegranskat)abstract
- A search for excited quarks is performed using the full e(+/-)p data sample collected by the HI experiment at HERA, corresponding to a total integrated luminosity of 475 pb(-1). The electroweak decays of excited quarks q* -> q gamma. q* -> qZ and q* - qW with Subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for first generation excited quark production is found. Mass dependent exclusion limits on q* production cross sections and on the ratio f/Lambda of the coupling to the compositeness scale are derived Within gauge mediated models. These limits extend the excluded region compared to previous excited quark searches. (C) 2009 Elsevier B.V. All rights reserved.
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| 21. |
- Aaron, F. D., et al.
(författare)
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Diffractive electroproduction of rho and phi mesons at HERA
- 2010
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2010:5, s. 1-111
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Tidskriftsartikel (refereegranskat)abstract
- Diffractive electroproduction of rho and phi mesons is measured at HERA with the H1 detector in the elastic and proton dissociative channels. The data correspond to an integrated luminosity of 51 pb(-1). About 10500 rho and 2000 phi events are analysed in the kinematic range of squared photon virtuality 2.5 <= Q(2) <= 60 GeV2, photon-proton centre of mass energy 35 <= W <= 180 GeV and squared four-momentum transfer to the proton vertical bar t vertical bar <= 3 GeV2. The total, longitudinal and transverse cross sections are measured as a function of Q(2), W and vertical bar t vertical bar. The measurements show a transition to a dominantly "hard" behaviour, typical of high gluon densities and small q (q) over bar dipoles, for Q(2) larger than 10 to 20 GeV2. They support flavour independence of the diffractive exchange, expressed in terms of the scaling variable (Q(2) + M-V(2))/4, and proton vertex factorisation. The spin density matrix elements are measured as a function of kinematic variables. The ratio of the longitudinal to transverse cross sections, the ratio of the helicity amplitudes and their relative phases are extracted. Several of these measurements have not been performed before and bring new information on the dynamics of diffraction in a QCD framework. The measurements are discussed in the context of models using generalised parton distributions or universal dipole cross sections.
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| 22. |
- Aaron, F. D., et al.
(författare)
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Measurement of the charm and beauty structure functions using the H1 vertex detector at HERA
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 65:1-2, s. 89-109
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive charm and beauty cross sections are measured in e (-) p and e (+) p neutral current collisions at HERA in the kinematic region of photon virtuality 5a parts per thousand currency signQ (2)a parts per thousand currency sign2000 GeV2 and Bjorken scaling variable 0.0002a parts per thousand currency signxa parts per thousand currency sign0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb(-1). The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions.
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| 23. |
- Aaron, F. D., et al.
(författare)
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Observation of the hadronic final state charge asymmetry in high Q(2) deep-inelastic scattering at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 681:2, s. 125-133
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Tidskriftsartikel (refereegranskat)abstract
- A first measurement is presented of the charge asymmetry in the hadronic final state from the hard interaction in deep-inelastic ep neutral current scattering at HERA. The measurement is performed in the range of negative squared four momentum transfer 100 < Q(2) < 8000 GeV2. The difference between the event normalised distributions of the scaled momentum, x(p), for positively and negatively charged particles, measured in the current region of the Breit frame, is studied together with its evolution as a function of Q. The results are compared to Monte Carlo models at the hadron and parton levels. (C) 2009 Elsevier B.V. All rights reserved.
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| 24. |
- Aaron, F. D., et al.
(författare)
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Search for single top quark production at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 678:5, s. 450-458
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Tidskriftsartikel (refereegranskat)abstract
- A search for single top quark production is performed in the full e(+/-)p data sample collected by the H1 experiment at HERA, corresponding to an integrated luminosity of 474 pb(-1). Decays of top quarks into a b quark and a W boson with Subsequent leptonic or hadronic decay of the W are investigated. A multivariate analysis is performed to discriminate top quark production from Standard Model background processes. An upper limit on the top quark production cross section via flavour changing neutral current processes sigma(ep -> et X) < 0.25 pb is established at 95% CL. Limits on the anomalous coupling K-tu gamma are derived. (C) 2009 Elsevier B.V. All rights reserved.
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| 25. |
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| 31. |
- Vogel, Jacob W., et al.
(författare)
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Four distinct trajectories of tau deposition identified in Alzheimer’s disease
- 2021
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:5, s. 871-881
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
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| 32. |
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| 33. |
- Cleland, J. G., et al.
(författare)
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The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis
- 2003
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Ingår i: European heart journal. - 0195-668X. ; 24:5, s. 442-63
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Forskningsöversikt (refereegranskat)abstract
- BACKGROUND: The European Society of Cardiology (ESC) has published guidelines for the investigation of patients with suspected heart failure and, if the diagnosis is proven, their subsequent management. Hospitalisation provides a key point of care at which time diagnosis and treatment may be refined to improve outcome for a group of patients with a high morbidity and mortality. However, little international data exists to describe the features and management of such patients. Accordingly, the EuroHeart Failure survey was conducted to ascertain if appropriate tests were being performed with which to confirm or refute a diagnosis of heart failure and how this influenced subsequent management. METHODS: The survey screened consecutive deaths and discharges during 2000-2001 predominantly from medical wards over a 6-week period in 115 hospitals from 24 countries belonging to the ESC, to identify patients with known or suspected heart failure. RESULTS: A total of 46788 deaths and discharges were screened from which 11327 (24%) patients were enrolled with suspected or confirmed heart failure. Forty-seven percent of those enrolled were women. Fifty-one percent of women and 30% of men were aged >75 years. Eighty-three percent of patients had a diagnosis of heart failure made on or prior to the index admission. Heart failure was the principal reason for admission in 40%. The great majority of patients (>90%) had had an ECG, chest X-ray, haemoglobin and electrolytes measured as recommended in ESC guidelines, but only 66% had ever had an echocardiogram. Left ventricular ejection fraction had been measured in 57% of men and 41% of women, usually by echocardiography (84%) and was <40% in 51% of men but only in 28% of women. Forty-five percent of women and 22% of men were reported to have normal left ventricular systolic function by qualitative echocardiographic assessment. A substantial proportion of patients had alternative explanations for heart failure other than left ventricular systolic or diastolic dysfunction, including valve disease. Within 12 weeks of discharge, 24% of patients had been readmitted. A total of 1408 of 10434 (13.5%) patients died between admission and 12 weeks follow-up. CONCLUSIONS: Known or suspected heart failure comprises a large proportion of admissions to medical wards and such patients are at high risk of early readmission and death. Many of the basic investigations recommended by the ESC were usually carried out, although it is not clear whether this was by design or part of a general routine for all patients being admitted regardless of diagnosis. The investigation most specific for patients with suspected heart failure (echocardiography) was performed less frequently, suggesting that the diagnosis of heart failure is still relatively neglected. Most men but a minority of women who underwent investigation of cardiac function had evidence of moderate or severe left ventricular dysfunction, the main target of current advances in the treatment of heart failure. Considerable diagnostic uncertainty remains for many patients with suspected heart failure, even after echocardiography, which must be resolved in order to target existing and new therapies and services effectively.
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| 34. |
- Gutman, Boris A, et al.
(författare)
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A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium
- 2022
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Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 352-372
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Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
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| 35. |
- Johnson, Mats, 1956, et al.
(författare)
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Paediatric acute-onset neuropsychiatric syndrome in children and adolescents: an observational cohort study.
- 2019
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Ingår i: The Lancet. Child & adolescent health. - 2352-4650. ; 3:3, s. 175-180
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Tidskriftsartikel (refereegranskat)abstract
- Paediatric acute-onset neuropsychiatric syndrome (PANS) is a newly defined symptom-based condition that mainly occurs in children and adolescents. Few studies have described the clinical characteristics of the syndrome.We clinically assessed and reviewed the medical histories of children and adolescents (aged 4-14 years) with suspected PANS who were referred to a specialist clinic in Gothenburg, Sweden, by local paediatricians and child psychiatrists. We scored severity of symptoms and impairment retrospectively for the timepoint with the most severe symptoms using the PANS scale.Of 41 patients (37 referred and four visited upon parents' request), 23 (ten girls and 13 boys) met PANS diagnostic criteria. Mean age at PANS onset was 8·5 years (SD 3·37). 11 (48%) patients had a family history of developmental or neuropsychiatric disorders in a first-degree relative and 11 (48%) had a family history of autoimmune or inflammatory diseases in a first-degree relative. 17 (74%) patients had been previously diagnosed with a developmental disorder (n=5) or had symptoms indicative of developmental problems (n=12). A verified or suspected infection was temporally related to PANS onset in all patients; the infection was bacterial in ten (43%) patients (eight had streptococcal infection and two an infection caused by other bacteria) and viral in 13 (57%) patients. All patients had a relapsing-remitting course of illness. The mean PANS scale symptom score was 46 (SD 3·67) and the mean impairment score was 45 (2·74). Antibiotic treatment was reported as beneficial by the parents of 12 (63%) of the 19 children who received antibiotics.Our PANS cohort had severe, acute-onset, complex neuropsychiatric symptoms, a relapsing-remitting symptom course, and possible infectious triggers. Further research into the cause of, and appropriate treatment for, PANS is warranted.Swedish Brain Foundation.
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| 36. |
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| 37. |
- Klementiev, K., et al.
(författare)
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High performance emission spectrometer at Balder/MAX IV beamline
- 2016
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 712:1
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Tidskriftsartikel (refereegranskat)abstract
- The emission spectrometer at Balder/MAX IV beamline is presented. Its unique features are described. Comparison is given with other types of curved crystals analyzers.
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| 38. |
- Komajda, M., et al.
(författare)
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The EuroHeart Failure Survey programme--a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment
- 2003
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Ingår i: European heart journal. - 0195-668X. ; 24:5, s. 464-74
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Forskningsöversikt (refereegranskat)abstract
- BACKGROUND: National surveys suggest that treatment of heart failure in daily practice differs from guidelines and is characterized by underuse of recommended medications. Accordingly, the Euro Heart Failure Survey was conducted to ascertain how patients hospitalized for heart failure are managed in Europe and if national variations occur in the treatment of this condition. METHODS: The survey screened discharge summaries of 11304 patients over a 6-week period in 115 hospitals from 24 countries belonging to the ESC to study their medical treatment. RESULTS: Diuretics (mainly loop diuretics) were prescribed in 86.9% followed by ACE inhibitors (61.8%), beta-blockers (36.9%), cardiac glycosides (35.7%), nitrates (32.1%), calcium channel blockers (21.2%) and spironolactone (20.5%). 44.6% of the population used four or more different drugs. Only 17.2% were under the combination of diuretic, ACE inhibitors and beta-blockers. Important local variations were found in the rate of prescription of ACE inhibitors and particularly beta-blockers. Daily dosage of ACE inhibitors and particularly of beta-blockers was on average below the recommended target dose. Modelling-analysis of the prescription of treatments indicated that the aetiology of heart failure, age, co-morbid factors and type of hospital ward influenced the rate of prescription. Age <70 years, male gender and ischaemic aetiology were associated with an increased odds ratio for receiving an ACE inhibitor. Prescription of ACE inhibitors was also greater in diabetic patients and in patients with low ejection fraction (<40%) and lower in patients with renal dysfunction. The odds ratio for receiving a beta-blocker was reduced in patients >70 years, in patients with respiratory disease and increased in cardiology wards, in ischaemic heart failure and in male subjects. Prescription of cardiac glycosides was significantly increased in patients with supraventricular tachycardia/atrial fibrillation. Finally, the rate of prescription of antithrombotic agents was increased in the presence of supraventricular arrhythmia, ischaemic heart disease, male subjects but was decreased in patients over 70. CONCLUSION: Our results suggest that the prescription of recommended medications including ACE inhibitors and beta-blockers remains limited and that the daily dosage remains low, particularly for beta-blockers. The survey also identifies several important factors including age, gender, type of hospital ward, co morbid factors which influence the prescription of heart failure medication at discharge.
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| 39. |
- Martel-Duguech, Luciana Maria, et al.
(författare)
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ESE audit on management of Adult Growth Hormone Deficiency in clinical practice.
- 2021
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Ingår i: European journal of endocrinology. - 1479-683X. ; 184:2, s. 323-334
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Tidskriftsartikel (refereegranskat)abstract
- Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform.1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of healthcare professionals about AGHD.On-line survey in endocrine centres throughout Europe.Endocrinologists voluntarily completed an electronic questionnaire regarding AGHD patients diagnosed or treated in 2017-2018.Twenty-eight centres from 17 European countries participated, including 2139 AGHD patients, 28% of childhood-onset GHD. Aetiology was most frequently non-functioning pituitary adenoma (26%), craniopharyngioma (13%) and genetic/congenital mid-line malformations (13%). Diagnosis of GHD was confirmed by a stimulation test in 52% (GHRH+arginine, 45%; insulin-tolerance, 42%, glucagon, 6%; GHRH alone and clonidine tests, 7%); in the remaining, ≥3 pituitary deficiencies and low serum IGF-I were diagnostic. Initial GH dose was lower in older patients, but only women <26 years were prescribed a higher dose than men; dose titration was based on normal serum IGF-I, tolerance and side-effects. In one country, AGHD treatment was not approved. Full public reimbursement was not available in four countries and only in childhood-onset GHD in another. AGHD awareness was low among non-endocrine professionals and healthcare administrators. Postgraduate AGHD curriculum training deserves being improved.Despite guideline recommendations, GH replacement in AGHD is still not available or reimbursed in all European countries. Knowledge among professionals and health administrators needs improvement to optimize care of adults with GHD.
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| 40. |
- Simonelli, L., et al.
(författare)
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The CLEAR X-ray emission spectrometer available at the CLAESS beamline of ALBA synchrotron
- 2023
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Ingår i: Journal of Synchrotron Radiation. - 0909-0495. ; 30, s. 235-241
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Tidskriftsartikel (refereegranskat)abstract
- The CLEAR X-ray emission spectrometer installed at the CLAESS beamline of the ALBA synchrotron is described. It is an energy-dispersive spectrometer based on Rowland circle geometry with 1 m-diameter circle. The energy dispersion is achieved by the combination of a diced analyzer crystal and a unidimensional detector. A single unconventional dynamically bent analyzer crystal (Si 111) permits a wide energy range to be covered, just by exploiting its different reflections (333, 444, 555, 777, 888): 6-22 keV, with a spectrometer efficiency that decreases above 11 keV because of the Si detector thickness (Mythen, 350 μm), while the relative scattering intensities for the Si 333, 444, 555, 777 and 888 reflections correspond to 36, 40, 21, 13 and 15, respectively. The provided energy resolution is typically below 1-2 eV and depends on the beam size, working Bragg angle and reflection exploited. In most cases the energy dispersion ranges from 10 to 20 eV and can be enlarged by working in the out-of-Rowland geometry up to 40 eV. The spectrometer works in full backscattering geometry with the beam passing through the two halves of the analyzer. The vacuum beam path and the particular geometry allow a typical average noise of only 0.5 counts per second per pixel. The spectrometer is mainly used for measuring emission lines and high-resolution absorption spectra, with a typical scanning time for highly concentrated systems of around half an hour, including several repeats. The intrinsic energy dispersion allows systematic collection of resonant X-ray emission maps by measuring high-resolution absorption spectra. Moreover, it allows spectra to be measured on a single-shot basis. Resonant inelastic X-ray scattering experiments to probe electronic excitations are feasible, although the spectrometer is not optimized for this purpose due to the limited energy resolution and scattering geometry provided. In that case, to minimize the quasi-elastic line, the spectrometer is able to rotate along the beam path. Advantages and disadvantages with respect to other existing spectrometers are highlighted.
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| 41. |
- Zhou, XP, et al.
(författare)
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Non-coding variability at the APOE locus contributes to the Alzheimer's risk
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 3310-
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk factor in the APOE locus, it does not fully explain the risk effect conferred by the locus. Here, we report the identification of AD causal variants in PVRL2 and APOC1 regions in proximity to APOE and define common risk haplotypes independent of APOE-ε4 coding change. These risk haplotypes are associated with changes of AD-related endophenotypes including cognitive performance, and altered expression of APOE and its nearby genes in the human brain and blood. High-throughput genome-wide chromosome conformation capture analysis further supports the roles of these risk haplotypes in modulating chromatin states and gene expression in the brain. Our findings provide compelling evidence for additional risk factors in the APOE locus that contribute to AD pathogenesis.
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