| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Price, T. Douglas, et al.
(författare)
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Human remains, context, and place of origin for the Salme, Estonia, boat burials
- 2020
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Ingår i: Journal of Anthropological Archaeology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0278-4165 .- 1090-2686. ; 58
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Tidskriftsartikel (refereegranskat)abstract
- Isotopic proveniencing of all individuals from the ship and boat burials at Salme, Estonia, is the subject of this study of the interred human remains from around AD 750, at the beginning of the Viking period. The isotopic results indicate that the majority of these individuals came from a region with higher strontium isotopic ratios than those found in Estonia. There were five individuals, buried in Salme II-the ship burial with 34 individuals-who exhibited lower strontium isotope ratios that might have come from the Swedish island of Gotland or several other possible places. The combination of isotopic signals and archaeological information suggests that the majority of buried individuals (those with higher strontium isotope ratios) came from the Malaren Valley in east-central Sweden.
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| 3. |
- Abou-Zeid, Nancy, et al.
(författare)
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Towards a cancer mission in Horizon Europe: recommendations
- 2020
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Ingår i: Molecular Oncology. - : Wiley Open Access. - 1878-0261 .- 1574-7891. ; 14:8, s. 1589-1615
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Tidskriftsartikel (refereegranskat)abstract
- A comprehensive translational cancer research approach focused on personalized and precision medicine, and covering the entire cancer research–care–prevention continuum has the potential to achieve in 2030 a 10-year cancer-specific survival for 75% of patients diagnosed in European Union (EU) member states with a well-developed healthcare system. Concerted actions across this continuum that spans from basic and preclinical research through clinical and prevention research to outcomes research, along with the establishment of interconnected high-quality infrastructures for translational research, clinical and prevention trials and outcomes research, will ensure that science-driven and social innovations benefit patients and individuals at risk across the EU. European infrastructures involving comprehensive cancer centres (CCCs) and CCC-like entities will provide researchers with access to the required critical mass of patients, biological materials and technological resources and can bridge research with healthcare systems. Here, we prioritize research areas to ensure a balanced research portfolio and provide recommendations for achieving key targets. Meeting these targets will require harmonization of EU and national priorities and policies, improved research coordination at the national, regional and EU level and increasingly efficient and flexible funding mechanisms. Long-term support by the EU and commitment of Member States to specialized schemes are also needed for the establishment and sustainability of trans-border infrastructures and networks. In addition to effectively engaging policymakers, all relevant stakeholders within the entire continuum should consensually inform policy through evidence-based advice.
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| 4. |
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| 6. |
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| 7. |
- Alkarp, Magnus, et al.
(författare)
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Tempel av guld eller kyrka av trä? : markradarundersökningar vid Gamla Uppsala kyrka
- 2006
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Ingår i: Fornvännen: meddelanden från K. Vitterhets, historie och antikvitets akademien. - 0015-7813. ; :1, s. 261-272
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Tidskriftsartikel (refereegranskat)abstract
- In 1164 the "archbishopric of Sweden" was established at "Gamla Uppsala", once the political centre of the "Svear kingdom" in the late Iron Age and a stronghold of pre-Christian cult. This highly symbolic decision was manifested through the construction of one of the largest churches in Scandinavia.The cathedral church at Gamla Uppsala was allegedly built on the same spot as the famous "pagan temple2 described by "Adam of Bremen" in the early 1070s. Excavations carried out there in 1926 revealed a highly complex stratigraphic sequence and a confusing set of postholes that were immediately interpreted as the remains of the temple. Though still maintained today in school textbooks and elsewhere, this conclusion is clearly erroneous as the postholes can be shown stratigraphically to belong to different phases of construction.The exact events of the period c. 1050-1150 in Gamla Uppsala have never been satisfactorily understood, but there is clear evidence to suggest that the cathedral was by no means the first church to have been built on the site. In an effort to elucidate this early history of the church plateau, in 2003-04 the authors examined the area with ground-penetrating radar. In this paper we discuss some of the more important results of these investigations.
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| 8. |
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| 9. |
- Beecham, Ashley H, et al.
(författare)
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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
- 2013
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:11, s. 1353-60
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Tidskriftsartikel (refereegranskat)abstract
- Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
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| 10. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 11. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 12. |
- Bergström, Liselotte, 1974-
(författare)
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Gräddat : Brödkultur under järnåldern i östra Mälardalen
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis examines the carbonised bread findings from sites and cremation graves dated to the first millennium AD occurring in the eastern Mälar Valley region. The finds have been analysed by various methods including cell-structure analysis, chemical analysis, experimental and reconstructive examination, 14C-dating and statistical comparison. An attempt is made to identify the different stages and actors in the bread-making process. The finds of different utensils and other equipment usually related to food preparation, bread-making and a vegetable diet are presented.Bread was introduced into central Sweden at the same time that a series of food-technical artefacts turn up in the north-Germanic cultural sphere. When bread first appears during the Late Roman Iron Age it most likely is as a sign of power applied to official occasions. The introduction of bread seems to be connected with the rotary quern which is strongly associated with defended settlements in Scandinavia where finds of utensils and activities indicate a specialization of food-production and related processes.Bread burial appears to have been reserved for specific individuals in society and this custom seems to have continued over several centuries in the same cemetery. Bread obviously served as a social marker in the burial ceremony, playing a role which was obvious to the participants but not meant to be visible to outsiders after the burial. This probably indicated a distinguishing quality of the deceased’s specific earthly status rather than a burial tradition of general use.
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| 13. |
- Cove-Smith, Laura, et al.
(författare)
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An integrated characterization of serological, pathological, and functional events in doxorubicin-induced cardiotoxicity
- 2014
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Ingår i: Toxicological Sciences. - : Oxford University Press (OUP). - 1096-0929 .- 1096-6080. ; 140:1, s. 3-15
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Tidskriftsartikel (refereegranskat)abstract
- Many efficacious cancer treatments cause significant cardiac morbidity, yet biomarkers or functional indices of early damage, which would allow monitoring and intervention, are lacking. In this study, we have utilized a rat model of progressive doxorubicin (DOX)-induced cardiomyopathy, applying multiple approaches, including cardiac magnetic resonance imaging (MRI), to provide the most comprehensive characterization to date of the timecourse of serological, pathological, and functional events underlying this toxicity. Hannover Wistar rats were dosed with 1.25 mg/kg DOX weekly for 8 weeks followed by a 4 week off-dosing "recovery" period. Electron microscopy of the myocardium revealed subcellular degeneration and marked mitochondrial changes after a single dose. Histopathological analysis revealed progressive cardiomyocyte degeneration, hypertrophy/cytomegaly, and extensive vacuolation after two doses. Extensive replacement fibrosis (quantified by Sirius red staining) developed during the off-dosing period. Functional indices assessed by cardiac MRI (including left ventricular ejection fraction (LVEF), cardiac output, and E/A ratio) declined progressively, reaching statistical significance after two doses and culminating in "clinical" LV dysfunction by 12 weeks. Significant increases in peak myocardial contrast enhancement and serological cardiac troponin I (cTnI) emerged after eight doses, importantly preceding the LVEF decline to
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| 14. |
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| 15. |
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| 16. |
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| 17. |
- Green, Jonathan M. H., et al.
(författare)
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Research priorities for managing the impacts and dependencies of business upon food, energy, water and the environment
- 2017
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Ingår i: Sustainability Science. - : Springer Science and Business Media LLC. - 1862-4065 .- 1862-4057. ; 12:2, s. 319-331
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Tidskriftsartikel (refereegranskat)abstract
- Delivering access to sufficient food, energy and water resources to ensure human wellbeing is a major concern for governments worldwide. However, it is crucial to account for the 'nexus' of interactions between these natural resources and the consequent implications for human wellbeing. The private sector has a critical role in driving positive change towards more sustainable nexus management and could reap considerable benefits from collaboration with researchers to devise solutions to some of the foremost sustainability challenges of today. Yet opportunities are missed because the private sector is rarely involved in the formulation of deliverable research priorities. We convened senior research scientists and influential business leaders to collaboratively identify the top forty questions that, if answered, would best help companies understand and manage their food-energy-water-environment nexus dependencies and impacts. Codification of the top order nexus themes highlighted research priorities around development of pragmatic yet credible tools that allow businesses to incorporate nexus interactions into their decision-making; demonstration of the business case for more sustainable nexus management; identification of the most effective levers for behaviour change; and understanding incentives or circumstances that allow individuals and businesses to take a leadership stance. Greater investment in the complex but productive relations between the private sector and research community will create deeper and more meaningful collaboration and cooperation.
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| 18. |
- Gräslund, Anne-Sofie, 1940-, et al.
(författare)
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Akademien granskar... : Arkeologi
- 2015
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Ingår i: Saga och Sed.. Kungl. Gustav Adolfs akademiens årsbok. - Uppsala. - 0586-5360. ; 2014, s. 137-154
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 19. |
- Gräslund, Bo, et al.
(författare)
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Twilight of the gods? : The 'dust veil event' of AD 536 in critical perspective
- 2012
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Ingår i: Antiquity. - 0003-598X .- 1745-1744. ; 86:332, s. 428-443
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Tidskriftsartikel (refereegranskat)abstract
- The popular notion of social collapse consequent on natural catastrophe is here elegantly disentangled in a study of the dark summer of AD 536 Leaving aside the question of its cause, the authors show there is good scientific evidence for a climatic downturn, contemporary with good archaeological evidence for widespread disruption of settlement and population displacement in the northern latitudes. They then navigate through the shifting shadows of myth, and emerge with a welcome prize: strong circumstantial reasons for recognising that this widespread horror, like so many others, did leave its imprint on Scandinavian poetry and sculpture.
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| 20. |
- Hedenstierna-Jonson, Charlotte, 1971-, et al.
(författare)
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A female Viking warrior confirmed by genomics
- 2017
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Ingår i: American Journal of Physical Anthropology. - : Wiley. - 0002-9483 .- 1096-8644. ; 164:4, s. 853-860
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesThe objective of this study has been to confirm the sex and the affinity of an individual buried in a well-furnished warrior grave (Bj 581) in the Viking Age town of Birka, Sweden. Previously, based on the material and historical records, the male sex has been associated with the gender of the warrior and such was the case with Bj 581. An earlier osteological classification of the individual as female was considered controversial in a historical and archaeological context. A genomic confirmation of the biological sex of the individual was considered necessary to solve the issue.Materials and methodsGenome-wide sequence data was generated in order to confirm the biological sex, to support skeletal integrity, and to investigate the genetic relationship of the individual to ancient individuals as well as modern-day groups. Additionally, a strontium isotope analysis was conducted to highlight the mobility of the individual.ResultsThe genomic results revealed the lack of a Y-chromosome and thus a female biological sex, and the mtDNA analyses support a single-individual origin of sampled elements. The genetic affinity is close to present-day North Europeans, and within Sweden to the southern and south-central region. Nevertheless, the Sr values are not conclusive as to whether she was of local or nonlocal origin.DiscussionThe identification of a female Viking warrior provides a unique insight into the Viking society, social constructions, and exceptions to the norm in the Viking time-period. The results call for caution against generalizations regarding social orders in past societies.
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| 21. |
- Hennius, Andreas
(författare)
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Outlanders? : Resource colonisation, raw material exploitation and networks in Middle Iron Age Sweden
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Middle Iron Age, around 300–650 CE, was characterised by extensive transformations across many aspects of society in the area of present-day Sweden. Within the central agricultural regions of the southern parts of the country, these changes are evident in a re-organisation of the settlements, renewed burial practices, the building of large-scale monuments, as well as increased militarisation, social stratification and an increase in imported objects. This thesis addresses an additional aspect of Middle Iron Age societal change, namely an increase in the utilisation of raw materials and resources from forested and coastal landscapes situated beyond the settled farm. These non-agrarian landscapes are commonly referred to as the outlands. In previous research, the increased utilisation of the outlands has in general been understood as part of a Viking Age expansion.The case studies of the thesis suggest that the outlands saw an intensified resource colonisation already during the Middle Iron Age, and that a similar explanatory model can be used to accommodate the parallel developments that appear in the agrarian landscapes as well as the in the outlands. The resource colonisation contributed to a surplus production that seems to have exceeded the needs of ordinary households, along with serially produced items, distributed along far-reaching trade networks in exchange of exotic commodities. The thesis argues that these networks should be interpreted as part of systems connecting distant regions, ranging from the Far East to Arctic Scandinavia. The discussions of the cases studies illustrate interplay between different groups of people – producers and consumers, hunters and farmers – in different parts of the landscape, and how they generated complex, social and economic relations and interdependencies. This in turn resulted in specific cultural patterns in the border area between the boreal forest in the north and the agrarian region in the south. The main contribution of the study is that it highlights how the main elements of outland exploitation, such as mass production and trade in valuable non-agrarian resources, can be dated earlier than has been previously thought. Moreover, the thesis argues that outland resource colonisation was an important driving force for the societal developments that took place during the Middle Iron Age, and is crucial for our understanding of later time periods.
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| 22. |
- Hering, Jenny, et al.
(författare)
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Exploring the Active Site of the Antibacterial Target MraY by Modified Tunicamycins.
- 2020
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Ingår i: ACS chemical biology. - : American Chemical Society (ACS). - 1554-8937 .- 1554-8929. ; 15:11, s. 2885-2895
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Tidskriftsartikel (refereegranskat)abstract
- The alarming growth of antibiotic resistance that is currently ongoing is a serious threat to human health. One of the most promising novel antibiotic targets is MraY (phospho-MurNAc-pentapeptide-transferase), an essential enzyme in bacterial cell wall synthesis. Through recent advances in biochemical research, there is now structural information available for MraY, and for its human homologue GPT (GlcNAc-1-P-transferase), that opens up exciting possibilities for structure-based drug design. The antibiotic compound tunicamycin is a natural product inhibitor of MraY that is also toxic to eukaryotes through its binding to GPT. In this work, we have used tunicamycin and modified versions of tunicamycin as tool compounds to explore the active site of MraY and to gain further insight into what determines inhibitor potency. We have investigated tunicamycin variants where the following motifs have been modified: the length and branching of the tunicamycin fatty acyl chain, the saturation of the fatty acyl chain, the 6″-hydroxyl group of the GlcNAc ring, and the ring structure of the uracil motif. The compounds are analyzed in terms of how potently they bind to MraY, inhibit the activity of the enzyme, and affect the protein thermal stability. Finally, we rationalize these results in the context of the protein structures of MraY and GPT.
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| 23. |
- Hillerdal, Charlotta, 1976-
(författare)
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People in Between : Ethncity and Material Identity, a New Approach to Deconstructed Concepts
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In questions concerning ethnicity and cultural identity in prehistory, there is a great divide between the conclusions maintained on a theoretical level of discussion and the interpretations given to material remains, when these theories are practiced on the archaeological material. Inherited scientific and political structures, usage and ideas contribute to our understanding of ethnicity and the everyday use of the concept, and influence archaeological interpretations. By illuminating these inherited preconceptions, they can be deconstructed, and a workable definition of the concepts found. A categorical approach to material culture needs to be abandoned, along with the hope of identifying ethnic groups in an archaeological material. Analyses should instead concentrate on the concept of ethnicity, as a relational, situational social identity created in the prehistoric present. The discussion is here approached through case studies set in different contextual situations, displaying great chronological, geographical and political variation, but also revealing some obvious points of contact. Scientific, materialistic, colonial and national perceptions of ethnic groups and ethnicity are penetrated in the case studies of the Varangians in 8th to 10th century Russia, the history of the Métis in Canada from the 18th century till today, and the Swedish speaking population on the island of Ruhnu outside Estonia at the turn of the 20th century. The Varangians are part of the Russian national myth of origin, and have been understood as a Scandinavian people, especially by Scandinavian researchers. Archaeological material of Scandinavian character dating to between the 8th and 11th centuries confirms intense interaction between Russia and Scandinavia in this time period. The Métis trace their roots back to the fur trade era and the encounter between Indian and European traders. Since 1982, they have been recognised as an indigenous people of Canada. The population of Runö was documented as Swedish speaking in the Middle Ages. They were discovered by Swedish ethnography in the 19th century, and interpreted as archaic Swedish. As a consequence of this narrative, the population was evacuated to Sweden in almost its entirety during the Second World War. In these cases, scientific, political and ideological aspects of social practice interface with the everyday practices in communities and influence the outward perception of that group’s identity, as well as the self-perception within the community. It can be concluded that the ideological setting is equally important to a historical development as are economic or geographical circumstances. The final chapter introduces an alternative interpretation to the early Scandinavian towns as a disappearing phenomenon towards the end of the 10th century, deduced from the conclusions made in the previous case studies.
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| 24. |
- Hårdh, Birgitta, et al.
(författare)
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Viking Age Uppåkra and Lund
- 2008
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Ingår i: The Viking World. - 9780415333153 ; , s. 145-149
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Bokkapitel (refereegranskat)
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| 25. |
- Kjellberg, Joakim, 1976-
(författare)
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Den medeltida stadens dynamik : – urbanitet, sociala praktiker och materiell kultur i Uppsala 1100–1550
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Avhandlingen utforskar arkeologiska källor till sociala praktiker och materiell kultur i det medeltida Uppsala. Ett stort antal föremål som insamlats vid tio av stadens större undersökningar mellan 1975 och 2000 har bearbetats i avhandlingen. Fyndmaterialet ger nya ingångar till förändringar i det urbana rummet och till invånarnas skiftande sociala identiteter. Den materiellakulturen ligger även till grund för en vidare diskussion om centralabegrepp och problem inom historisk arkeologi och stadsarkeologi.Genom ett föreslaget föremålsintegrerat och handlingsteoretiskt perspektivpå urbanisering, urbanism och urbanitet kan via den metod som presenterasi avhandlingen både nya och äldre undersökningsmaterial aktiveras. Därigenom kan också ett mer dynamiskt stadsarkeologiskt narrativ skapas om de medeltida städerna som särskilda rum, mötesplatser och livsmiljöer.
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| 26. |
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| 27. |
- Lindbom, Peter, 1959-
(författare)
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Vapnen i wreccornas tid, 150-500 e.Kr. : om de romerska auxiliarpilspetsarna och den västliga traditionens framväxt
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Lindbom, Peter. 2006. Weapons in the time of the Wreccas, 150-500 AD., Roman auxiliary arrow points and the development of the Western tradition, AUN 36, Uppsala, 290 pp., 70 figs., 19 maps, 37 tables. ISSN 0285-1347, ISBN 91-506-1869-5 Archaeologists agree that the different Germanic peoples were influenced by the Roman Empire and its well organised and effective army. A common assumption is that the German Barbarians were inferior and merely copied the superior Roman customs and material culture. In this thesis I argue that the Germanic peoples created a hybrid culture, where specific Roman concepts and innovations were borrowed and manipulated in order to fit into the context, of a new Germanic Warrior Society which gradually developed during the first half millennium AD. Using Post Colonial theory I show that these socio-cultural developments took an ambivalent form and were often manifested in sudden changes in material culture and as grave goods deposited according to local customs. Power struggles between old and new elite groups often resulted in armed conflict, with an opposition between the superior or dominant colonials and the subaltern indigenous peoples, a relation that is similar to imperialistic dominance by a colonial power elite.
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| 28. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 29. |
- Margaryan, Ashot, et al.
(författare)
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Population genomics of the Viking world
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 585:7825, s. 390-396
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Tidskriftsartikel (refereegranskat)abstract
- The maritime expansion of Scandinavian populations during the Viking Age (about ad750–1050) was a far-flung transformation in world history1,2. Here we sequenced the genomes of 442humans from archaeological sites across Europe and Greenland (to a median depth of about 1×) to understand the global influence of this expansion. We find the Viking period involved gene flow into Scandinavia from the south and east. We observe genetic structure within Scandinavia, with diversity hotspots in the south and restricted gene flow within Scandinavia. We find evidence for a major influx of Danish ancestry into England; a Swedish influx into the Baltic; and Norwegian influx into Ireland, Iceland and Greenland. Additionally, we see substantial ancestry from elsewhere in Europe entering Scandinavia during the Viking Age. Our ancient DNA analysis also revealed that a Viking expedition included close family members. By comparing with modern populations, we find that pigmentation-associated loci have undergone strong population differentiation during the past millennium, and trace positively selected loci—including the lactase-persistence allele of LCT and alleles of ANKA that are associated with the immune response—in detail. We conclude that the Viking diaspora was characterized by substantial transregional engagement: distinct populations influenced the genomic makeup of different regions of Europe, and Scandinavia experienced increased contact with the rest of the continent.
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| 30. |
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| 31. |
- McCulloch, Laura J, et al.
(författare)
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COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity.
- 2015
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Ingår i: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 156:1, s. 134-46
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Tidskriftsartikel (refereegranskat)abstract
- Fibrosis of adipose tissue (AT) increases AT rigidity, reduces its expandability and contributes to metabolic dysfunction. Collagen type VI, alpha3 (COL6A3) encodes one subunit of a fibrotic extracellular matrix (ECM) protein highly expressed in rodent AT. Knock-out of collagen VI in rodent AT led to a significant improvement in metabolic health in obese, diabetic (ob/ob) mice however, it is unknown whether this collagen has the same metabolic significance in human AT. We therefore aimed to undertake a comprehensive assessment of COL6A3 in relation to human AT and obesity. Characterisation of COL6A3 in human AT showed 5 fold higher expression in the stromalvascular fraction compared with adipocyte expression and significantly higher expression in subcutaneous than omental AT. In both depots COL6A3 expression appeared to be lowered in obesity, whilst diet and surgery-induced weight loss increased COL6A3 expression in subcutaneous AT. Leptin treatment caused a dose dependent decrease in COL6A3 expression although no effect was seen with insulin or glucose treatment and no difference observed in subjects with diabetes. In addition, we found that the collagen expression profile in humans differs significantly from rodents as COL6A3 does not appear to be the predominant collagen in adipose, muscle or liver. Our findings oppose those initially seen in rodent studies and most importantly, demonstrate a direct regulation of COL6A3 by leptin. This highlights the importance of a paracrine leptin signalling pathway in human AT and suggests an additional mechanism by which leptin can regulate ECM composition and with it AT expandability.
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| 32. |
- Miklowitz, David J., et al.
(författare)
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Facilitated Integrated Mood Management for adults with bipolar disorder
- 2012
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Ingår i: Bipolar Disorders. - : WILEY. - 1398-5647 .- 1399-5618. ; 14:2, s. 185-197
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Forskningsöversikt (refereegranskat)abstract
- Objectives: We describe the development of a five-session psychoeducational treatment, Facilitated Integrated Mood Management (FIMM), which contains many of the core elements of longer evidencebased psychosocial treatments for bipolar disorder. FIMM incorporated a novel mood monitoring program based on mobile phone technology. Methods: Adult patients with bipolar I and II disorders (N = 19) received six sessions (Pilot I: n = 14) or five sessions (Pilot II: n = 5) of FIMM with pharmacotherapy. Treatment facilitators were novice counselors who were trained in a three-day workshop and supervised for six months. FIMM sessions focused on identifying early signs of recurrence, maintaining regular daily and nightly routines, rehearsing mood management strategies, maintaining adherence to medications, and education about substance abuse. Patients sent daily text messages or e-mails containing ratings of their mood and sleep, and weekly messages containing self-ratings on the Quick Inventory of Depressive Symptomatology (QIDS) and the Altman Self Rating Mania Scale (ASRM). Patients also completed a weekly mood management strategies questionnaire. Results: Of the 19 patients, 17 (89.5%) completed FIMM in an average of 9.2 +/- 3.4 weeks (Pilot I) and 7.6 +/- 0.9 weeks (Pilot II). Patients reported stable moods on the QIDS and ASRM over a 120-day period, and on average responded to 81% of the daily message prompts and 88% of the weekly QIDS and ASRM prompts. Facilitators maintained high levels of fidelity to the FIMM manual. Patients +/- knowledge of mood management strategies increased significantly between the first and last weeks of treatment. Conclusions: Patients with bipolar disorder can be engaged in a short program of facilitated mood management. The effects of FIMM on the course of bipolar disorder await evaluation in randomized trials. The program may be a useful adjunct to pharmacotherapy in community centers that cannot routinely administer full courses of psychosocial treatment.
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| 33. |
- Moen, Marianne, et al.
(författare)
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Archaeological knowledge production : reading mortuary reconstructions
- 2023
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Ingår i: Antiquity. - : Cambridge University Press. - 0003-598X .- 1745-1744. ; 97:391, s. 231-240
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Research on archaeological knowledge production emphasises the contingent nature of understandings of the past. In practice, however, levels of uncertainty and conjecture can easily become less than obvious in interpretations, perhaps especially visual ones. The authors interrogate multiple textual and visual accounts of a Viking-Age burial to demonstrate how selection processes-what to portray or omit-highlight the contextual nature of the knowledge claims in these images. Arguing that the circulation of reconstructions shorn of textual nuance leads to misperceptions, the authors call for transparency in the creation of these images. Rather than definitive depictions of archaeological fact, these reconstructions offer tools for archaeologists and the public to think with.
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| 34. |
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| 35. |
- Olalde, I., et al.
(författare)
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The Beaker phenomenon and the genomic transformation of northwest Europe
- 2018
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 555:7695, s. 190-196
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Tidskriftsartikel (refereegranskat)abstract
- From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain's gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries.
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| 36. |
- Patterson, Nick, et al.
(författare)
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Large-scale migration into Britain during the Middle to Late Bronze Age
- 2022
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; , s. 588-594
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Tidskriftsartikel (refereegranskat)abstract
- Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age1. To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
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| 37. |
- Plomp, Kimberly A., et al.
(författare)
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The composition of the founding population of Iceland : A new perspective from 3D analyses of basicranial shape
- 2021
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:2
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Tidskriftsartikel (refereegranskat)abstract
- The settlement of Iceland in the Viking Age has been the focus of much research, but the composition of the founding population remains the subject of debate. Some lines of evidence suggest that almost all the founding population were Scandinavian, while others indicate a mix of Scandinavians and people of Scottish and Irish ancestry. To explore this issue further, we used three-dimensional techniques to compare the basicrania of skeletons from archaeological sites in Iceland, Scandinavia, and the British Isles. Our analyses yielded two main results. One was that the founding population likely consisted of roughly equal numbers of Scandinavians and people from the British Isles. The other was that the immigrants who originated from the British Isles included individuals of southern British ancestry as well as individuals of Scottish and Irish ancestry. The first of these findings is consistent with the results of recent analyses of modern and ancient DNA, while the second is novel. Our study, therefore, strengthens the idea that the founding population was a mix of Scandinavians and people from the British Isles, but also raises a new possibility regarding the regions from which the settlers originated.
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