| 1. |
- Ablikim, M., et al.
(författare)
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First measurement of e(+)e(-) -> pK(S)(0)(n)over-barK(-) + c.c. above open charm threshold
- 2018
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Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 98:3
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Tidskriftsartikel (refereegranskat)abstract
- The process e(+)e(-) -> pK(S)(0)(n) over barK(-) + c.c. and its intermediate processes are studied for the first time, using data samples collected with the BESIII detector at BEPCII at center-of-mass energies of 3.773, 4.008, 4.226, 4.258, 4.358, 4.416, and 4.600 GeV, with a total integrated luminosity of 7.4 fb(-1). The Born cross section of e(+)e(-) -> pK(S)(0)(n) over barK(-) + c.c. is measured at each center-of-mass energy, but no significant resonant structure in the measured cross-section line shape between 3.773 and 4.600 GeV is observed. No evident structure is detected in the pK(-), nK(S)(0), pK(S)(0), nK(+), p (n) over bar, or (KSK-)-K-0 invariant mass distributions except for Lambda(1520). The Born cross sections of e(+)e(-) -> Lambda(1520)(n) over barK(S)(0) + c.c. and e(+)e(-) -> Lambda(1520)(p) over barK(+) + c.c. are measured, and the 90% confidence level upper limits on the Born cross sections of e(+)e(-) -> Lambda(1520)(Lambda) over bar (1520) are determined at the seven center-of-mass energies. There is an evident difference in line shape and magnitude of the measured cross sections between e(+)e(-) -> Lambda(1520)(-> pK(-))(n) over barK(S)(0) and e(+)e(-) -> pK-(Lambda) over bar (1520)(-> (n) over barK(S)(0)).
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| 2. |
- Ablikim, M., et al.
(författare)
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Search for invisible decays of omega and phi with J/psi data at BESIII
- 2018
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 98:3
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Tidskriftsartikel (refereegranskat)abstract
- Using a data sample of (1310.6 +/- 7.0) x 10(6) J/psi events collected with the BESIII detector operating at the BEPCII collider, we perform the first experimental search for invisible decays of a light vector meson (V = omega, phi) via J/psi -> V-eta decays. The decay of eta -> pi(+)pi(-)pi(0) is utilized to tag the V meson decaying into the invisible final state. No evidence for a significant invisible signal is observed, and the upper limits on the ratio of branching fractions at the 90% confidence level are determined to be B(omega -> invisible)/B(omega -> pi(+)pi(-)pi(0)) < 8.1 x 10(-5) and B(phi -> invisible)/B(phi -> K+K-) < 3.4 x 10(-4). By using the world average values of B(omega -> pi(+)pi(-)pi(0) and B(phi -> K+K-,) the upper limits on the decay branching fractions at the 90% confidence level are set as B(omega -> invisible) < 7.3 x 10(-5) and B(phi -> invisible) < 1.7 x 10(-4), respectively.
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| 3. |
- Ablikim, M., et al.
(författare)
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Search for the rare decays D -> h(h((')))e(+) e(-)
- 2018
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:7
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Tidskriftsartikel (refereegranskat)abstract
- We search for rare decays of D mesons to hadrons accompanied by an electron-positron pair (h(h((')))e(+)e(- )),using an e(+)e(-) collision sample corresponding to an integrated luminosity of 2.93 fb(-1) collected with the BESIII detector at root s = 3.773 GeV. No significant signals are observed, and the corresponding upper limits on the branching fractions at the 90% confidence level are determined. The sensitivities of the results are at the level of 10(-5)-10(-6), providing a large improvement over previous searches.
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| 4. |
- Ablikim, M., et al.
(författare)
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Observation of the Semileptonic Decay D-0 -> a(0)(980)(-)e(+)nu(e) and Evidence for D+ -> a(0)(980)(0)e(+)nu(e)
- 2018
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Ingår i: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 121:8
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Tidskriftsartikel (refereegranskat)abstract
- Using an e(+)e(-) collision data sample of 2.93 fb(-1) collected at a center-of-mass energy of 3.773 GeV by the BESIII detector at BEPCII, we report the observation of D-0 -> a(0)(980)(-)e(+)nu(e) and evidence for D+ -> a(0)(980)(0)e(+)nu(e) with significances of 6.4 sigma and 2.9 sigma, respectively. The absolute branching fractions are determined to be B(D-0 -> a(0)(980)(-)e(+)nu(e)) x B(a(0)(980)(-) -> eta pi(-)) = [1.33(-0.29)(+0.33)(stat) +/- 0.09(syst)] x 10(-4) and B(D+ -> a(0)(980)(0)e(+)nu(e)) x B(a(0)(980)(0) -> eta pi(0)) = [1.66(-0.66)(+0.81)(stat) +/- 0.11(syst) x 10(-4). This is the first time the a(0)(980) meson has been measured in a D-0 semileptonic decay, which would open one more interesting page in the investigation of the nature of the puzzling a(0)(980) states.
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| 5. |
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| 6. |
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| 7. |
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| 8. |
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| 9. |
- Wang, Q., et al.
(författare)
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Color-tunable single-fluorophore supramolecular system with assembly-encoded emission
- 2020
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Ingår i: Nature Communications. - : Nature Research. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Regulating the fluorescent properties of organic small molecules in a controlled and dynamic manner has been a fundamental research goal. Although several strategies have been exploited, realizing multi-color molecular emission from a single fluorophore remains challenging. Herein, we demonstrate an emissive system by combining pyrene fluorophore and acylhydrazone units, which can generate multi-color switchable fluorescent emissions at different assembled states. Two kinds of supramolecular tools, amphiphilic self-assembly and γ-cyclodextrin mediated host-guest recognition, are used to manipulate the intermolecular aromatic stacking distances, resulting in the tunable fluorescent emission ranging from blue to yellow, including a pure white-light emission. Moreover, an external chemical signal, amylase, is introduced to control the assembly states of the system on a time scale, generating a distinct dynamic emission system. The dynamic properties of this multi-color fluorescent system can be also enabled in a hydrogel network, exhibiting a promising potential for intelligent fluorescent materials.
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| 10. |
- Qu, CM, et al.
(författare)
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A Radiomics Model Based on Gd-EOB-DTPA-Enhanced MRI for the Prediction of Microvascular Invasion in Solitary Hepatocellular Carcinoma ≤ 5 cm
- 2022
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Ingår i: Frontiers in oncology. - : Frontiers Media SA. - 2234-943X. ; 12, s. 831795-
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study is to establish and validate a radiomics-based model using preoperative Gd-EOB-DTPA-enhanced MRI to predict microvascular invasion (MVI) in patients with hepatocellular carcinoma ≤ 5 cm.MethodsClinicopathologic and MRI data of 178 patients with solitary hepatocellular carcinoma (HCC) (≤5 cm) were retrospectively collected from a single medical center between May 2017 and November 2020. Patients were randomly assigned into training and test subsets by a ratio of 7:3. Imaging features were extracted from the segmented tumor volume of interest with 1-cm expansion on arterial phase (AP) and hepatobiliary phase (HBP) images. Different models based on the significant clinical risk factors and/or selected imaging features were established and the predictive performance of the models was evaluated.ResultsThree radiomics models, the AP_model, the HBP_model, and the AP+HBP_model, were constructed for MVI prediction. Among them, the AP+HBP_model outperformed the other two. When it was combined with a clinical model, consisting of tumor size and alpha-fetoprotein (AFP), the combined model (AP+HBP+Clin_model) showed an area under the curve of 0.90 and 0.70 in the training and test subsets, respectively. Its sensitivity and specificity were 0.91 and 0.76 in the training subset and 0.60 and 0.79 in the test subset, respectively. The calibration curve illustrated that the combined model possessed a good agreement between the predicted and the actual probabilities.ConclusionsThe radiomics-based model combining imaging features from the arterial and hepatobiliary phases of Gd-EOB-DTPA-enhanced MRI and clinical risk factors provides an effective and reliable tool for the preoperative prediction of MVI in patients with HCC ≤ 5 cm.
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| 11. |
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| 12. |
- Yin, X., et al.
(författare)
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Vertical Sandwich Gate-All-Around Field-Effect Transistors with Self-Aligned High-k Metal Gates and Small Effective-Gate-Length Variation
- 2020
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Ingår i: IEEE Electron Device Letters. - : Institute of Electrical and Electronics Engineers Inc.. - 0741-3106 .- 1558-0563. ; 41:1, s. 8-11
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Tidskriftsartikel (refereegranskat)abstract
- A new type of vertical nanowire (NW)/nanosheet (NS) field-effect transistors (FETs), termed vertical sandwich gate-all-around (GAA) FETs (VSAFETs), is presented in this work. Moreover, an integration flow that is compatible with processes used in the mainstream industry is proposed for the VSAFETs. Si/SiGe epitaxy, isotropic quasi-atomic-layer etching (qALE), and gate replacement were used to fabricate pVSAFETs for the first time. Vertical GAA FETs with self-aligned high-k metal gates and a small effective-gate-length variation were obtained. Isotropic qALE, including Si-selective etching of SiGe, was developed to control the diameter/thickness of the NW/NS channels. NWs with a diameter of 10 nm and NSs with a thickness of 20 nm were successfully fabricated, and good device characteristics were obtained. Finally, the device performance was investigated and is discussed in this work. © 2019 IEEE.
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| 13. |
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| 14. |
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| 15. |
- Gong, H., et al.
(författare)
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Photothermal Switching Based on Silicon Mach-Zehnder Interferometer Integrated with Light Absorber
- 2016
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Ingår i: IEEE Photonics Journal. - : Institute of Electrical and Electronics Engineers (IEEE). - 1943-0655. ; 8:2
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Tidskriftsartikel (refereegranskat)abstract
- We present an all-optical switch based on photothermal effects in a silicon Mach-Zehnder interferometer (MZI) integrated with a light absorber. The metal-insulator-metal light absorber located near the longer arm of the asymmetric MZI efficiently converts infrared light to heat. Pumped by a continuous-wave 1064-nm laser, the spectral transmittance of the fully etched strip waveguide (half-etched rib waveguide) MZI can be tuned with an efficiency of 38 pm/mW (98.5 pm/mW). Dynamic switching experiments show that the rise/fall time constant of the output probe light is 11.45/10.98 μs (8.25/7.13 μs) for the fully etched (half-etched) MZI.
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| 16. |
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| 17. |
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| 18. |
- Guo, Y., et al.
(författare)
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Hypercomplex Low Rank Reconstruction for NMR Spectroscopy
- 2023
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Ingår i: Signal Processing. - : Elsevier BV. - 0165-1684. ; 203
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Tidskriftsartikel (refereegranskat)abstract
- Nuclear magnetic resonance (NMR) spectroscopy serves as an important tool to analyze chemicals and proteins in bioengineering. Multi-dimensional NMR offers a major improvement in resolution with multi-dimensional spectrum, but significantly increases data acquisition time and produces hypercomplex data that is difficult to be handled. To reduce this time, non-uniformly sampling can be applied to obtain undersampled data and using a reconstruction approach, such as the state-of-the-art low rank method, to remove the spectral artifacts introduced by undersampling. However, only complex format of signal, including the real and imaginary parts, is considered in previous low rank approach, which is less efficient when dealing with hypercomplex data that has multiple components. To solve this problem, a hypercomplex low rank model is proposed by introducing an adjoint matrix operation and then solved with a fast matrix factorization algorithm. This method explores redundant information among all the components of hypercomplex signal. Using simulated data and real protein data, we demonstrate that the proposed method provides a fast and high-fidelity reconstruction of hypercomplex spectroscopy in fast NMR. © 2022 Elsevier B.V.
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| 19. |
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| 20. |
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| 21. |
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| 22. |
- Liu, B. Y., et al.
(författare)
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Explosive radiation and spatial expansion across the cold environments of the Old World in an avian family
- 2017
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Ingår i: Ecology and Evolution. - : Wiley. - 2045-7758. ; 7:16, s. 6346-6357
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Tidskriftsartikel (refereegranskat)abstract
- Our objective was to elucidate the biogeography and speciation patterns in an entire avian family, which shows a complex pattern of overlapping and nonoverlapping geographical distributions, and much variation in plumage, but less in size and structure. We estimated the phylogeny and divergence times for all of the world's species of Prunella based on multiple genetic loci, and analyzed morphometric divergence and biogeographical history. The common ancestor of Prunella was present in the Sino-Himalayan Mountains or these mountains and Central Asia-Mongolia more than 9 million years ago (mya), but a burst of speciations took place during the mid-Pliocene to early Pleistocene. The relationships among the six primary lineages resulting from that differentiation are unresolved, probably because of the rapid radiation. A general increase in sympatry with increasing time since divergence is evident. With one exception, species in clades younger than c. 3.7 my are allopatric. Species that are widely sympatric, including the most recently diverged (2.4 mya) sympatric sisters, are generally more divergent in size/structure than allo-/parapatric close relatives. The distributional pattern and inferred ages suggest divergence in allopatry and substantial waiting time until secondary contact, likely due to competitive exclusion. All sympatrically breeding species are ecologically segregated, as suggested by differences in size/structure and habitat. Colonizations of new areas were facilitated during glacialperiods, followed by fragmentation during interglacials-contrary to the usual view that glacial periods resulted mainly in fragmentations.
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| 23. |
- Liu, G.Q., et al.
(författare)
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Naphthenic acid corrosion characteristic and corrosion product film resistance of carbon steel and Cr5Mo low alloy steel in secondary vacuum gas oil
- 2016
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Ingår i: Corrosion Engineering, Science and Technology. - 1478-422X .- 1743-2782. ; 51:6, s. 445-454
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Tidskriftsartikel (refereegranskat)abstract
- Although naphthenic acid corrosion (NAC) has been studied for many years, the mechanism of NAC is not fully understood. The objective of this paper is to study high-temperature NAC in secondary vacuum gas oil of an industrial crude oil vacuum distillation tower. A high-temperature autoclave was applied to conduct high-temperature corrosion test to investigate NAC behaviour of carbon steel and Cr5Mo low alloy steel at different sulphur contents and total acid numbers (TAN). The result shows that the corrosion rate of carbon steel and low alloy steel is high at low TAN and high TAN while it keeps at a low value at medium TAN. Corrosion product film on Cr5Mo low alloy steel surface is denser and more compact than that of carbon steel at high TAN. The chromium present in Cr5Mo low alloy steel plays an important role in NAC resistance by the formation of Cr7S8 film in the inner layer of the scale. Corrosion rates of the two steels in secondary vacuum gas oil are high at low TAN and high TAN, but low at medium TAN which are strange and different from previous experimental results conducted in non-industrial oil solution. A tentative explanation for this new phenomenon is also put forward.
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| 24. |
- Ma, Xiao, et al.
(författare)
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Decision Tree Based Rules Redistribution algorithm for IP monitoring of lawful interception on IPv4 networks
- 2012
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Ingår i: Advanced Materials Research. - 9783037854389 ; , s. 1384-1388
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Konferensbidrag (refereegranskat)abstract
- IP networks were growing rapidly over past decades. Perhaps more significant is the impact that it is also provide a medium to the illicit activities. Therefore, IP monitoring of lawful interception of IPv4 Networks was proposed to combat against those illicit activities over IP Networks. The Law Enforcement Agencies (LEA) can monitor the IP packets as well as capture them for analysis or providing forensics. In order to assist IP Monitoring of lawful interception from technical perspective, we propose a scheme named Decision Tree Based Rules Redistribution Algorithm (DTBRRA) which can be fast applied on IP networks. © (2012) Trans Tech Publications, Switzerland.
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| 25. |
- Nie, Duxian, et al.
(författare)
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Improved augmented Lagrangian coordination for optimizing supply chain configuration with multiple sharing elements in industrial cluster
- 2019
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Ingår i: Industrial management & data systems. - : EMERALD GROUP PUBLISHING LTD. - 0263-5577 .- 1758-5783. ; 119:4, s. 743-773
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Tidskriftsartikel (refereegranskat)abstract
- Purpose The purpose of this paper is to study various combination forms of the three basic sharing elements (i.e. orders sharing, manufacturers capacity sharing and suppliers capacity sharing) in the cluster supply chain (CSC), formulate a distributed model to protect enterprises decision privacy and seek to develop an effective method for solving the distributed complex model. Design/methodology/approach A distributed assembly cluster supply chain configuration (ACSCC) model is formulated. An improved augmented Lagrangian coordination (ALC) is proposed and used to solve the ACSCC model. A series of experiments are conducted to validate the improved ALC and the model. Findings Two major findings are obtained. First, the market orders quantity change and the sales price of the product have a great impact on both the optimal results of the ACSCC and the cooperative strategy, especially, when the market order increases sharply, enterprises have to adopt multiple cooperative strategies to complete the order; meanwhile, the lower sales price of the product helps independent suppliers to get more orders. Second, the efficiency and computational accuracy of the improved ALC method are validated as compared to the centralized ALC and Lingo11. Research limitations/implications This paper formulated the single-period ACSCC model under certain assumptions, yet a multi-period ACSCC model is to be developed, a more comprehensive investigation of the relationships among combination forms is to be extended further and a rigid proof of the improved ALC is necessary. Practical implications Enterprises in the industrial cluster should adopt different cooperative strategies in terms of the market orders quantity change and the sales price of the product. Social implications The proposed various combination forms of sharing elements and the formulated ACSCC model provide guidance to managers in the industrial cluster to choose the proper policy. Originality/value This research studies various combination forms of the three basic sharing elements in the CSC. A distributed ACSCC model has been established considering simultaneously multiple sharing elements. An improved ALC is presented and applied to the ACSCC problem.
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| 26. |
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| 27. |
- Qu, C. L., et al.
(författare)
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Activation of mu-opioid receptors in the ventrolateral orbital cortex inhibits the GABAergic miniature inhibitory postsynaptic currents in rats
- 2015
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Ingår i: Neuroscience Letters. - : Elsevier BV. - 0304-3940. ; 592, s. 64-69
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have indicated that mu-opioid receptors in the ventrolateral orbital cortex (VLO) are involved in antinociception in tail flick tests and GABAergic neurons or terminals express mu-opioid receptors in the VLO. The current study examined the effect of selective mu-opioid receptor agonist DAMGO on the GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in the VLO in rats using the whole-cell patch clamp. The results demonstrated that 5 mu M DAMGO application into the rat VLO slices significantly reduced the GABAergic mIPSCs frequency, without any effect on its amplitude, and this effect of DAMGO was reversed by pretreatment with selective mu-opioid receptor antagonist I i.M CTOP. Importantly, application of CTOP alone into the VLO slices did not produce any effect on the frequency and amplitude of GABAergic mIPSCs. These results indicate a presynaptic effect of mu-opioid receptor activation on the GABAergic neurons in the VLO. The current data suggests that a presynaptic inhibition of the GABA release may contribute to the mu-opioid receptor mediated effects in the VLO and provides novel electrophysiological evidence for the underlying mechanisms of mu-opioid receptors in the VLO. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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| 28. |
- Qu, M., et al.
(författare)
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Carbon Black Nanoparticle/Polydopamine-Coated Core-Spun Yarns for Flexible Strain Sensors
- 2022
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Ingår i: ACS Applied Nano Materials. - : American Chemical Society (ACS). - 2574-0970. ; 5:11, s. 16996-17003
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Tidskriftsartikel (refereegranskat)abstract
- A smart and flexible textile strain sensor was developed based on a commercial core-spun yarn coated with carbon black (CB) nanoparticles and polydopamine (PDA). The morphology of the textile was studied using scanning electron microscopy (SEM), and the distribution of CB and self-polymerized PDA was observed. Thermogravimetric analysis (TGA) revealed the applicable temperature range of the strain sensor. The smart textile showed an outstanding strain sensor response range up to 450%, and its mechanical properties were only slightly reduced as compared to the original textile. The cyclic strain sensor behavior of the smart textile was investigated by stretching the textile 100% for 100 cycles, yielding a stable and durable output electrical signal. Application tests for various human motions were also performed. Finally, two mathematical equations based on tunneling theory were proposed to accurately predict the electrical signal during stretching and to reveal the fundamental properties of the textile. Our findings clearly expand the current knowledge of strain sensors.
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| 29. |
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| 30. |
- Rosengren, Johan, et al.
(författare)
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Structural and functional characterization of the conserved salt bridge in mammalian Paneth cell alpha-defensins - Solution structures of mouse cryptdin-4 AND (E15D)-cryptdin-4
- 2006
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 281:38, s. 28068-28078
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Tidskriftsartikel (refereegranskat)abstract
- alpha-Defensins are mediators of mammalian innate immunity, and knowledge of their structure-function relationships is essential for understanding their mechanisms of action. We report here the NMR solution structures of the mouse Paneth cell alpha-defensin cryptdin-4 (Crp4) and a mutant (E15D)-Crp4 peptide, in which a conserved Glu(15) residue was replaced by Asp. Structural analysis of the two peptides confirms the involvement of this Glu in a conserved salt bridge that is removed in the mutant because of the shortened side chain. Despite disruption of this structural feature, the peptide variant retains a well defined native fold because of a rearrangement of side chains, which result in compensating favorable interactions. Furthermore, salt bridge-deficient Crp4 mutants were tested for bactericidal effects and resistance to proteolytic degradation, and all of the variants had similar bactericidal activities and stability to proteolysis. These findings support the conclusion that the function of the conserved salt bridge in Crp4 is not linked to bactericidal activity or proteolytic stability of the mature peptide.
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| 31. |
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| 32. |
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| 33. |
- Thomas, M, et al.
(författare)
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Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity
- 2023
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Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expanded PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS were 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1,681-3,651 cases and 8,696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They were significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values<0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
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| 34. |
- Wang, Y, et al.
(författare)
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Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
- 2022
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Ingår i: Cell death and differentiation. - : Springer Science and Business Media LLC. - 1476-5403 .- 1350-9047. ; 29:11, s. 2190-2202
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Tidskriftsartikel (refereegranskat)abstract
- The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance. Ferroptosis is a form of regulated cell death, induced by an iron-dependent accumulation of lipid peroxides during chemotherapy. However, whether the Wnt/beta-catenin signaling directly controls resistance to cell death, remains unclear. Here, we show that the activation of the Wnt/beta-catenin signaling attenuates cellular lipid ROS production and subsequently inhibits ferroptosis in GC cells. The beta-catenin/TCF4 transcription complex directly binds to the promoter region of GPX4 and induces its expression, resulting in the suppression of ferroptotic cell death. Concordantly, TCF4 deficiency promotes cisplatin-induced ferroptosis in vitro and in vivo. Thus, we demonstrate that the aberrant activation of the Wnt/beta-catenin signaling confers ferroptosis resistance and suggests a potential therapeutic strategy to enhance chemo-sensitivity for advanced GC patients.
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| 35. |
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| 36. |
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| 38. |
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| 39. |
- Zhang, Kai, et al.
(författare)
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Digital twin-based opti-state control method for a synchronized production operation system
- 2020
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Ingår i: Robotics and Computer-Integrated Manufacturing. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0736-5845 .- 1879-2537. ; 63
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Tidskriftsartikel (refereegranskat)abstract
- The intelligent manufacturing strategy and customer demand have mutually promoted each other. Also, the production mode is shifting towards customized production, and more rental resources or services are introduced to the production system, therefore, the systems are becoming more complex. Compared with traditional production systems, such systems have some new features, this work calls this type of system as a synchronized production operation system (SPOS). Under such circumstances, production systems are influenced by more frequent uncertainties, and the planning-based production decision and control approach is no longer applicable. The opti-state control (OsC) method is proposed to help SPOS keep in an optimal state when uncertainties affect the system. Besides, a digital twin-based control framework (DTCF) is designed for getting the full element information needed for decision making. Based on the comprehensive information of the production system obtained by the DTCF, the OsC method is introduced to the virtual control layer to formulate the optimal target guiding the path of the system in real time through the dynamic matching mechanism (qualitative perspective). Then multi-stage synchronized control with analysis target cascading (ATC) method is used to get the local optimal state decisions (quantitative perspective). From both qualitative and quantitative aspects to ensure the system is under an optimal target path for optimal operation procedure. At last, a case study in a large-size paint making company in China is used to validate the effectiveness of the approach.
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| 40. |
- Zhang, Kai, et al.
(författare)
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IoT-enabled dynamic lean control mechanism for typical production systems
- 2019
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Ingår i: Journal of Ambient Intelligence and Humanized Computing. - : SPRINGER HEIDELBERG. - 1868-5137 .- 1868-5145. ; 10:3, s. 1009-1023
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Tidskriftsartikel (refereegranskat)abstract
- The emergence and subsequent popularization of lean has been one of the most significant developments in the history of operations management. However, there is a lack of systematic theory on the control framework underlying lean production. It is therefore difficult to conduct more in-depth research on Lean theory, specifically in the context of emerging technologies as smart manufacturing or Industry 4.0. In this study, process control theory is used to re-define several major lean methods and tools. Then a Lean-Oriented Optimum-State Control Theory (L-OSCT) is proposed that integrates these lean methods and tools into optimum-state control theory. On the level of method and mechanism, we adopt a recently emerged synchronization approach to obtain global-wide leanness of a large-scale system. L-OSCT provides dynamic process control in industrial networking systems. At last, a case study in a large-size paint making company in China is used to validate the effectiveness of the approach.
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| 41. |
- Zhu, RJ, et al.
(författare)
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Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms
- 2021
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Ingår i: Cell research. - : Springer Science and Business Media LLC. - 1748-7838 .- 1001-0602. ; 31:12, s. 1244-1262
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Tidskriftsartikel (refereegranskat)abstract
- The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms, but the underlying mechanism remains unclear. We conducted a randomized, single-blind, placebo-controlled (29 patients/group) phase II clinical trial to validate previous findings and explore the potential mechanisms. Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay (P = 0.0198) and less time required for symptoms remission (P = 0.0194) than those who received placebo. Based on chest images, both severe and critical patients treated with MSCs showed improvement by day 7 (P = 0.0099) and day 21 (P = 0.0084). MSC-treated patients had fewer adverse events. MSC infusion reduced the levels of C-reactive protein, proinflammatory cytokines, and neutrophil extracellular traps (NETs) and promoted the maintenance of SARS-CoV-2-specific antibodies. To explore how MSCs modulate the immune system, we employed single-cell RNA sequencing analysis on peripheral blood. Our analysis identified a novel subpopulation of VNN2+ hematopoietic stem/progenitor-like (HSPC-like) cells expressing CSF3R and PTPRE that were mobilized following MSC infusion. Genes encoding chemotaxis factors — CX3CR1 and L-selectin — were upregulated in various immune cells. MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro. In addition, an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling. Together, our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis.
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