| 1. |
- Fenstermacher, M.E., et al.
(author)
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DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
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In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
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Journal article (peer-reviewed)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
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| 2. |
- Zouganelis, I., et al.
(author)
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The Solar Orbiter Science Activity Plan : Translating solar and heliospheric physics questions into action
- 2020
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In: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 642
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Journal article (peer-reviewed)abstract
- Solar Orbiter is the first space mission observing the solar plasma both in situ and remotely, from a close distance, in and out of the ecliptic. The ultimate goal is to understand how the Sun produces and controls the heliosphere, filling the Solar System and driving the planetary environments. With six remote-sensing and four in-situ instrument suites, the coordination and planning of the operations are essential to address the following four top-level science questions: (1) What drives the solar wind and where does the coronal magnetic field originate?; (2) How do solar transients drive heliospheric variability?; (3) How do solar eruptions produce energetic particle radiation that fills the heliosphere?; (4) How does the solar dynamo work and drive connections between the Sun and the heliosphere? Maximising the mission's science return requires considering the characteristics of each orbit, including the relative position of the spacecraft to Earth (affecting downlink rates), trajectory events (such as gravitational assist manoeuvres), and the phase of the solar activity cycle. Furthermore, since each orbit's science telemetry will be downloaded over the course of the following orbit, science operations must be planned at mission level, rather than at the level of individual orbits. It is important to explore the way in which those science questions are translated into an actual plan of observations that fits into the mission, thus ensuring that no opportunities are missed. First, the overarching goals are broken down into specific, answerable questions along with the required observations and the so-called Science Activity Plan (SAP) is developed to achieve this. The SAP groups objectives that require similar observations into Solar Orbiter Observing Plans, resulting in a strategic, top-level view of the optimal opportunities for science observations during the mission lifetime. This allows for all four mission goals to be addressed. In this paper, we introduce Solar Orbiter's SAP through a series of examples and the strategy being followed.
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| 3. |
- Orsini, S., et al.
(author)
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Inner southern magnetosphere observation of Mercury via SERENA ion sensors in BepiColombo mission
- 2022
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In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 13:1
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Journal article (peer-reviewed)abstract
- Mercury’s southern inner magnetosphere is an unexplored region as it was not observed by earlier space missions. In October 2021, BepiColombo mission has passed through this region during its first Mercury flyby. Here, we describe the observations of SERENA ion sensors nearby and inside Mercury’s magnetosphere. An intermittent high-energy signal, possibly due to an interplanetary magnetic flux rope, has been observed downstream Mercury, together with low energy solar wind. Low energy ions, possibly due to satellite outgassing, were detected outside the magnetosphere. The dayside magnetopause and bow-shock crossing were much closer to the planet than expected, signature of a highly eroded magnetosphere. Different ion populations have been observed inside the magnetosphere, like low latitude boundary layer at magnetopause inbound and partial ring current at dawn close to the planet. These observations are important for understanding the weak magnetosphere behavior so close to the Sun, revealing details never reached before.
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| 4. |
- Milillo, A., et al.
(author)
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Investigating Mercury's Environment with the Two-Spacecraft BepiColombo Mission
- 2020
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In: Space Science Reviews. - : Springer Science and Business Media LLC. - 0038-6308 .- 1572-9672. ; 216:5
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Research review (peer-reviewed)abstract
- The ESA-JAXA BepiColombo mission will provide simultaneous measurements from two spacecraft, offering an unprecedented opportunity to investigate magnetospheric and exospheric dynamics at Mercury as well as their interactions with the solar wind, radiation, and interplanetary dust. Many scientific instruments onboard the two spacecraft will be completely, or partially devoted to study the near-space environment of Mercury as well as the complex processes that govern it. Many issues remain unsolved even after the MESSENGER mission that ended in 2015. The specific orbits of the two spacecraft, MPO and Mio, and the comprehensive scientific payload allow a wider range of scientific questions to be addressed than those that could be achieved by the individual instruments acting alone, or by previous missions. These joint observations are of key importance because many phenomena in Mercury's environment are highly temporally and spatially variable. Examples of possible coordinated observations are described in this article, analysing the required geometrical conditions, pointing, resolutions and operation timing of different BepiColombo instruments sensors.
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| 5. |
- Shi, Z., et al.
(author)
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An Eastward Current Encircling Mercury
- 2022
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In: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 49:10
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Journal article (peer-reviewed)abstract
- Mercury has a terrestrial-like magnetosphere which is usually taken as a scaled-down-version of Earth's magnetosphere with a similar current system. We examine Mercury's magnetospheric current system based on a survey of Mercury's magnetic field measured by the Mercury Surface, Space Environment, Geochemistry, and Ranging spacecraft as well as computer simulations. We show that there is no significant Earth-like ring current flowing westward around Mercury, instead, we find, for the first time, an eastward current (EC) encircling the planet near the night-side magnetic equator with an altitude of ∼500–1,000 km. The EC is closed with the dayside magnetopause current and could be driven by the gradient of plasma pressure as a diamagnetic current. Thus, Mercury's magnetosphere is not a scaled-down Earth magnetosphere, but a unique natural space plasma laboratory. Our findings offer fresh insights to analyze data from the BepiColombo mission, which is expected to orbit Mercury in 2025.
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| 6. |
- Sun, W. J., et al.
(author)
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A Comparative Study of the Proton Properties of Magnetospheric Substorms at Earth and Mercury in the Near Magnetotail
- 2018
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In: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 45:16, s. 7933-7941
-
Journal article (peer-reviewed)abstract
- The variations of plasma sheet proton properties during magnetospheric substorms at Earth and Mercury are comparatively studied. This study utilizes kappa distributions to interpret proton properties at both planets. Proton number densities are found to be around an order of magnitude higher, temperatures several times smaller, and kappa values broader at Mercury than at Earth. Protons become denser and cooler during the growth phase, and are depleted and heated after the dipolarizations in both magnetospheres. The changes of kappa at Earth are generally small (<20%), indicating that spectrum-preserving processes, like adiabatic betatron acceleration, play an important role there, while variations of kappa at Mercury are large (>60%), indicating the importance of spectrum-altering processes there, such as acceleration due to nonadiabatic cross-tail particle motions and wave-particle interactions. This comparative study reveals important intrinsic properties on the energization of protons in both magnetospheres. Plain Language Summary Earth and Mercury are the only two planets possessing global intrinsic magnetic fields among the four inner planets, which are Mercury, Venus, Earth, and Mars, within the solar system. The interactions between the intrinsic magnetic fields and the continual flow of high-speed solar wind from the Sun form similar magnetospheres at the two planets, although the scale of the magnetosphere is much smaller at Mercury than at Earth. Magnetospheric substorms, a result of solar wind-magnetosphere coupling, occur in both magnetospheres. Comparative study of a similar process between different planets is meaningful as it can help us in understanding the specific process further as well as help us in understanding the intrinsic properties of the magnetospheres. This research paper characterizes the proton properties of magnetospheric substorms of both planets, revealing that different mechanisms control the behavior of protons during the magnetospheric substorms of the two planets.
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| 7. |
- Wurz, P., et al.
(author)
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Particles and Photons as Drivers for Particle Release from the Surfaces of the Moon and Mercury
- 2022
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In: Space Science Reviews. - : Springer. - 0038-6308 .- 1572-9672. ; 218:3
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Research review (peer-reviewed)abstract
- The Moon and Mercury are airless bodies, thus they are directly exposed to the ambient plasma (ions and electrons), to photons mostly from the Sun from infrared range all the way to X-rays, and to meteoroid fluxes. Direct exposure to these exogenic sources has important consequences for the formation and evolution of planetary surfaces, including altering their chemical makeup and optical properties, and generating neutral gas exosphere. The formation of a thin atmosphere, more specifically a surface bound exosphere, the relevant physical processes for the particle release, particle loss, and the drivers behind these processes are discussed in this review.
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| 8. |
- Hadid, L. Z., et al.
(author)
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BepiColombo's Cruise Phase : Unique Opportunity for Synergistic Observations
- 2021
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In: Frontiers in Astronomy and Space Sciences. - : Frontiers Media S.A.. - 2296-987X. ; 8
-
Journal article (peer-reviewed)abstract
- The investigation of multi-spacecraft coordinated observations during the cruise phase of BepiColombo (ESA/JAXA) are reported, with a particular emphasis on the recently launched missions, Solar Orbiter (ESA/NASA) and Parker Solar Probe (NASA). Despite some payload constraints, many instruments onboard BepiColombo are operating during its cruise phase simultaneously covering a wide range of heliocentric distances (0.28 AU-0.5 AU). Hence, the various spacecraft configurations and the combined in-situ and remote sensing measurements from the different spacecraft, offer unique opportunities for BepiColombo to be part of these unprecedented multipoint synergistic observations and for potential scientific studies in the inner heliosphere, even before its orbit insertion around Mercury in December 2025. The main goal of this report is to present the coordinated observation opportunities during the cruise phase of BepiColombo (excluding the planetary flybys). We summarize the identified science topics, the operational instruments, the method we have used to identify the windows of opportunity and discuss the planning of joint observations in the future.
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| 9. |
- Louarn, P., et al.
(author)
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Multiscale views of an Alfvenic slow solar wind : 3D velocity distribution functions observed by the Proton-Alpha Sensor of Solar Orbiter
- 2021
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 656
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Journal article (peer-reviewed)abstract
- Context. The Alfvenic slow solar wind is of particular interest, as it is often characterized by intense magnetic turbulence, complex proton 3D velocity distribution functions (VDF), and an ensuing richness of kinetic and dynamic processes.Aims. We take advantage of the fast time cadence of measurements taken by the Proton-Alpha Sensor (PAS) on board Solar Orbiter to analyze the kinetic properties of the proton population, the variability of their VDFs, and the possible link with propagating magnetic structures. We also study the magnetic (B) and velocity (V) correlation that characterizes this type of wind down to the ion gyroperiod.Methods. We analyzed the VDFs measured by PAS, a novelty that take advantages of the capability of 3D measurements at a 4 Hz cadence. In addition, we considered MAG observations.Results. We first show that there is a remarkable correlation between the B and V components observed down to timescales approaching the ion gyrofrequency. This concerns a wide variety of fluctuations, such as waves, isolated peaks, and discontinuities. The great variability of the proton VDFs is also documented. The juxtaposition of a core and a field-aligned beam is the norm but the relative density of the beam, drift speed, and temperatures can considerably change on scales as short as as a few seconds. The characteristics of the core are comparatively more stable. These variations in the beam characteristics mostly explain the variations in the total parallel temperature and, therefore, in the total anisotropy of the proton VDFs. Two magnetic structures that are associated with significant changes in the shape of VDFs, one corresponding to relaxation of total anisotropy and the other to its strong increase, are analyzed here. Our statistical analysis shows a clear link between total anisotropy (and, thus, beam characteristics) and the direction of B with respect to the Parker spiral. In the present case, flux tubes aligned with Parker spiral contain an average proton VDF with a much more developed beam (thus, with larger total anisotropy) than those that are inclined, perpendicular, or even reverse with regard to the outward direction.Conclusions. These observations document the variability of the proton VDF shape in relation to the propagation of magnetic structures. This is a key area of interest for understanding of the effect of turbulence on solar wind dynamics.
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| 10. |
- Perrone, D., et al.
(author)
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Evolution of coronal hole solar wind in the inner heliosphere : Combined observations by Solar Orbiter and Parker Solar Probe
- 2022
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 668
-
Journal article (peer-reviewed)abstract
- We study the radial evolution, from 0.1 AU to the Earth, of a homogeneous recurrent fast wind, coming from the same source on the Sun, by means of new measurements by both Solar Orbiter and Parker Solar Probe. With respect to previous radial studies, we extend, for the first time, the analysis of a recurrent fast stream at distances never reached prior to the Parker Solar Probe mission. Confirming previous findings, the observations show: (i) a decrease in the radial trend of the proton density that is slower than the one expected for a radially expanding plasma, due to the possible presence of a secondary beam in the velocity distribution function; (ii) a deviation for the magnetic field from the Parker prediction, supported by the strong Alfvenicity of the stream at all distances; and (iii) a slower decrease in the proton temperature with respect to the adiabatic prediction, suggesting the local presence of external heating mechanisms. Focusing on the radial evolution of the turbulence, from the inertial to the kinetic range along the turbulent cascade, we find that the slopes, in both frequency ranges, strongly depend on the different turbulence observed by the two spacecraft, namely a mostly parallel turbulence in the Parker Solar Probe data and a mostly perpendicular turbulence in the Solar Orbiter intervals. Moreover, we observe a decrease in the level of intermittency for the magnetic field during the expansion of the stream. Furthermore, we perform, for the first time, a statistical analysis of coherent structures around proton scales at 0.1 AU and we study how some of their statistical properties change from the Sun to the Earth. As expected, we find a higher occurrence of events in the Parker Solar Probe measurements than in the Solar Orbiter data, considering the ratio between the intervals length and the proton characteristic scales at the two radial distances. Finally, we complement this statistical analysis with two case studies of current sheets and vortex-like structures detected at the two radial distances, and we find that structures that belong to the same family have similar characteristics at different radial distances. This work provides an insight into the radial evolution of the turbulent character of solar wind plasma coming from coronal holes.
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| 11. |
- Chen, Y., et al.
(author)
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Studying Dawn-Dusk Asymmetries of Mercury's Magnetotail Using MHD-EPIC Simulations
- 2019
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In: Journal of Geophysical Research - Space Physics. - : Blackwell Publishing Ltd. - 2169-9380 .- 2169-9402. ; 124:11, s. 8954-8973
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Journal article (peer-reviewed)abstract
- MESSENGER has observed a lot of dawn-dusk asymmetries in Mercury's magnetotail, such as the asymmetries of the cross-tail current sheet thickness and the occurrence of flux ropes, dipolarization events, and energetic electron injections. In order to obtain a global pictures of Mercury's magnetotail dynamics and the relationship between these asymmetries, we perform global simulations with the magnetohydrodynamics with embedded particle-in-cell (MHD-EPIC) model, where Mercury's magnetotail region is covered by a PIC code. Our simulations show that the dawnside current sheet is thicker, the plasma density is larger, and the electron pressure is higher than the duskside. Under a strong interplanetary magnetic field driver, the simulated reconnection sites prefer the dawnside. We also found the dipolarization events and the planetward electron jets are moving dawnward while they are moving toward the planet, so that almost all dipolarization events and high-speed plasma flows concentrate in the dawn sector. The simulation results are consistent with MESSENGER observations.
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| 12. |
- Liljeblad, Elisabet, 1986-, et al.
(author)
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MESSENGER observations of the dayside low-latitude boundary layer in Mercury's magnetosphere
- 2015
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In: Journal of Geophysical Research - Space Physics. - : Blackwell Publishing. - 2169-9380 .- 2169-9402. ; 120:10
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Journal article (peer-reviewed)abstract
- Observations from MESSENGER's MAG and FIPS instruments during the first orbital year have resulted in the identification of 25 magnetopause crossings in Mercury's magnetosphere with significant low-latitude boundary layers (LLBLs). Of these crossings 72% are observed dawnside, and 65% for northward interplanetary magnetic field.The estimated LLBL thickness is 450 ± 56 km, and increases with distance to noon. The Na+-group ion is sporadically present in 14 of the boundary layers, with an observed average number density of 22 ± 11% of the proton density. Furthermore, the average Na+-group gyroradii in the layers is 220 ± 34 km, the same order of magnitude as the LLBL thickness.Magnetic shear, plasma β and reconnection rates have been estimated for the LLBL crossings, and compared to those of a control group (non-LLBL) of 61 distinct magnetopause crossings which show signs of nearly no plasma inside the magnetopause. The results indicate that reconnection is significantly slower, or even suppressed, for the LLBL crossings compared to the non-LLBL cases.Possible processes that form or impact the LLBL are discussed. Protons injected through the cusp or flank may be important for the formation of the LLBL. Furthermore, the opposite asymmetry in the Kelvin-Helmholtz instability (KHI) as compared to the LLBL, rules out the KHI as a dominant formation mechanism. However, the KHI and LLBL could be related to each other, either by the impact of sodium ions gyrating across the magnetopause, or by the LLBL preventing the growth of KH waves on the dawnside.
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| 13. |
- Hughes, Jonathan D., et al.
(author)
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More anterior placement of femoral tunnel position in ACL-R is associated with postoperative meniscus tears
- 2023
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In: Journal of Experimental Orthopaedics. - 2197-1153. ; 10:1
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Journal article (peer-reviewed)abstract
- PurposeThe purpose of this study was to investigate the relationship between tunnel position in ACL reconstruction (ACL-R) and postoperative meniscus tears.MethodsThis was a single institution, case-control study of 170 patients status-post ACL-R (2010-2019) separated into two matched groups (sex, age, BMI, graft type). Group 1-symptomatic, operative meniscus tears (both de novo and recurrent) after ACL-R. Group 2-no postoperative meniscus tears. Femoral and tibial tunnel positions were measured by 2 authors via lateral knee radiographs that were used to measure two ratios (a/t and b/h). Ratio a/t was defined as distance from the tunnel center to dorsal most subchondral contour of the lateral femoral condyle (a) divided by total sagittal diameter of the lateral condyle along Blumensaat's line (t). The ratio b/h was defined as distance between the tunnel and Blumensaat's line (b) divided by maximum intercondylar notch height (h). Wilcoxon sign-ranks paired test was used to compare measurements between groups (alpha set at p < 0.05).ResultsGroup 1 had average follow up of 45 months and Group 2 had average follow up of 22 months. There were no significant demographic differences between Groups 1 and 2. Group 1-a/t was 32.0% (& PLUSMN; 10.2), which was significantly more anterior than group 2, 29.3% (& PLUSMN; 7.3; p < 0.05). There was no difference in average femoral tunnel ratio b/h or tibial tunnel placement between groups.ConclusionsA relationship exists between more anterior/less anatomic femoral tunnel position and the presence of recurrent or de novo, operative meniscus tears after ACL-R. Surgeons performing ACL-R should strive for recreation of native anatomy via proper tunnel placement to maximize postoperative outcomes.
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| 14. |
- Kozaki, Koichi, et al.
(author)
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Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice.
- 2002
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In: The American journal of pathology. - 0002-9440. ; 161:4, s. 1395-407
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Journal article (peer-reviewed)abstract
- Platelet-derived growth factor (PDGF) is a potent stimulant of smooth muscle cell migration and proliferation in culture. To test the role of PDGF in the accumulation of smooth muscle cells in vivo, we evaluated ApoE -/- mice that develop complex lesions of atherosclerosis. Fetal liver cells from PDGF-B-deficient embryos were used to replace the circulating cells of lethally irradiated ApoE -/- mice. One month after transplant, all monocytes in PDGF-B -/- chimeras are of donor origin (lack PDGF), and no PDGF-BB is detected in circulating platelets, primary sources of PDGF in lesions. Although lesion volumes are comparable in the PDGF-B +/+ and -/- chimeras at 35 weeks, lesions in PDGF-B -/- chimeras contain mostly macrophages, appear less mature, and have a reduced frequency of fibrous cap formation as compared with PDGF-B +/+ chimeras. However, after 45 weeks, smooth muscle cell accumulation in fibrous caps is indistinguishable in the two groups. Comparison of elicited peritoneal macrophages by RNase protection assay shows an altered cytokine and cytokine receptor profile in PDGF-B -/- chimeras. ApoE -/- mice were also treated for up to 50 weeks with a PDGF receptor antagonist that blocks all three PDGF receptor dimers. Blockade of the PDGF receptors similarly delays, but does not prevent, accumulation of smooth muscle and fibrous cap formation. Thus, elimination of PDGF-B from circulating cells or blockade of PDGF receptors does not appear sufficient to prevent smooth muscle accumulation in advanced lesions of atherosclerosis.
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| 15. |
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| 16. |
- Sánchez-Cano, Beatriz, et al.
(author)
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Solar Energetic Particle Events Detected in the Housekeeping Data of the European Space Agency's Spacecraft Flotilla in the Solar System
- 2023
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In: Space Weather. - : American Geophysical Union (AGU). - 1542-7390. ; 21:8
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Journal article (peer-reviewed)abstract
- Despite the growing importance of planetary Space Weather forecasting and radiation protection for science and robotic exploration and the need for accurate Space Weather monitoring and predictions, only a limited number of spacecraft have dedicated instrumentation for this purpose. However, every spacecraft (planetary or astronomical) has hundreds of housekeeping sensors distributed across the spacecraft, some of which can be useful to detect radiation hazards produced by solar particle events. In particular, energetic particles that impact detectors and subsystems on a spacecraft can be identified by certain housekeeping sensors, such as the Error Detection and Correction (EDAC) memory counters, and their effects can be assessed. These counters typically have a sudden large increase in a short time in their error counts that generally match the arrival of energetic particles to the spacecraft. We investigate these engineering datasets for scientific purposes and perform a feasibility study of solar energetic particle event detections using EDAC counters from seven European Space Agency Solar System missions: Venus Express, Mars Express, ExoMars-Trace Gas Orbiter, Rosetta, BepiColombo, Solar Orbiter, and Gaia. Six cases studies, in which the same event was observed by different missions at different locations in the inner Solar System are analyzed. The results of this study show how engineering sensors, for example, EDAC counters, can be used to infer information about the solar particle environment at each spacecraft location. Therefore, we demonstrate the potential of the various EDAC to provide a network of solar particle detections at locations where no scientific observations of this kind are available.
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| 17. |
- Tang, Jingjing, et al.
(author)
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The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice.
- 2005
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In: The American journal of pathology. - 0002-9440. ; 167:3, s. 901-12
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Journal article (peer-reviewed)abstract
- Both innate and adaptive immunity contribute to the progression of inflammatory-fibrotic lesions of atherosclerosis. Although platelet-derived growth factor (PDGF)-B has been investigated as a stimulant of smooth muscle cells in vascular diseases, its effects on the immune response during disease have not been evaluated in vivo. We used hematopoietic chimeras generated after lethal irradiation of ApoE-/- recipients to test the role of PDGF in atherosclerosis. Monocyte accumulation in early atherosclerotic lesions increased 1.9-fold in ApoE-/-/PDGF-B-/- chimeras. Lymphocytes from null chimeras showed a 1.6- to 2.0-fold increase in the number of activated CD4(+) T cells and a 2.5-fold elevation of interferon-gamma-secreting CD4(+) T cells on ex vivo challenge with modified low-density lipoprotein. Splenocyte transcript levels were also altered with a twofold decrease in interleukin-10 and 1.7- and 3.0-fold increases in interleukin-18 and CCR 5, respectively. These cellular and molecular changes were consistent with a shift to a proinflammatory phenotype in null chimeras. Our data also demonstrated for the first time the presence of a recently discovered family of negative regulators of innate and adaptive immunity, the suppressors of cytokine signaling (SOCS), in developing atherosclerotic lesions. Thus, our studies identify two independent negative immune regulatory pathways-PDGF-B and SOCS-that may help limit lesion expansion.
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