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| 2. |
- Reichel, Martin, et al.
(författare)
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Recombination of Hot Ionized Nebulae: The Old Planetary Nebula around V4334 Sgr (Sakurai’s Star)* * This investigation makes use of ESO data from program IDs 077.D-0394, 079.D-0256, 381.D-0117, 383.D-0427, 385.D-0292, 087.D-0223, 089.D-0080, 091.D-0209, 093.D-0195, 095.D-0113, 097.D-0146, 099.D-0045, and 0109.D-0060.
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 939:2
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Tidskriftsartikel (refereegranskat)abstract
- After becoming ionized, low-density astrophysical plasmas will begin a process of slow recombination. Models for this still have significant uncertainties. Recombination cannot normally be observed in isolation, because the ionization follows the evolutionary timescale of the ionizing source. Laboratory experiments are unable to reach the appropriate conditions because of the very long required timescales. The extended nebula around the very late helium pulse (VLTP) star V4334 Sgr provides a unique laboratory for this kind of study. The sudden loss of the ionizing UV radiation after the VLTP event has allowed the nebula to recombine free from other influences. More than 290 long-slit spectra taken with FORS1/2 at ESO’s Very Large Telescope between 2007 and 2022 are used to follow the time evolution of the lines of H, He, N, S, O, and Ar. Hydrogen and helium lines, representing most of the ionized mass, do not show significant changes. A small increase is seen in [N ii] (+2.8% yr−1; 2.7σ significance), while we see a decrease in [O iii] (−1.96% yr−1; 2.0σ significance). The [S ii] lines show a change of +3.0% yr−1 (1.6σ significance). The lines of [S iii] and of [Ar iii] show no significant changes. For [S iii], the measurement differs from the predicted decrease by 4.5σ. A possible explanation is that the fractions of S3+ and higher are larger than expected. Such an effect could provide a potential solution for the sulfur anomaly in planetary nebulae.
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| 3. |
- Valiokas, R., et al.
(författare)
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Self-assembled monolayers containing terminal mono-, bis-, and tris-nitrilotriacetic acid groups : Characterization and application
- 2008
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 24:9, s. 4959-4967
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Tidskriftsartikel (refereegranskat)abstract
- We have undertaken a structural and functional study of self-assembled monolayers (SAMs) formed on gold from a series of alkylthiol compounds containing terminal multivalent chelators (MCHs) composed of mono-, bis-, and tris-nitrilotriacetic acid (NTA) moieties. SAMs were formed from single-component solutions of the mono-, bis-, and tris-NTA compounds, as well as from mixtures with a tri(ethylene glycol)-terminated alkylthiol (EG3). Contact angle goniometry, null ellipsometry, and infrared spectroscopy were used to explore the structural characteristics of the MCH SAMs. Ellipsometric measurements show that the amount of the MCH groups on surfaces increases with increasing mol % of the MCH thiols in the loading solution up to about 80 mol %. We also conclude that mixed SAMs, prepared in the solution composition regime 0-30 mol % of the MCH thiols, consist of a densely packed alkyl layer, an amorphous ethylene glycol layer, and an outermost layer of MCH groups exposed toward the ambient. Above 30 mol %, a significant degree of disorder is observed in the SAMs. Finally, functional evaluation of the three MCH SAMs prepared at 0-30 mol% reveals a consistent increase in binding strengdi with increasing multivalency. The tris-NTA SAM, in particular, is enabled for stable and functional immobilization of a His6-tagged extracellular receptor subunit, even at low chelator surface concentrations, which makes it suitable for applications when a low surface density of capturing sites is desirable, e.g., in kinetic analyses. © 2008 American Chemical Society.
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- Ben-Menachem, Elinor, 1945, et al.
(författare)
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Safety, tolerability, and efficacy of brivaracetam as adjunctive therapy in patients with focal seizures, generalized onset seizures, or Unverricht-Lundborg disease: An open-label, long-term follow-up trial
- 2021
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Ingår i: Epilepsy Research. - : Elsevier BV. - 0920-1211. ; 170
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Tidskriftsartikel (refereegranskat)abstract
- This long-term open-label extension (OLE) trial was conducted to evaluate the long-term safety and tolerability of brivaracetam (BRV) at individualized doses in patients with epilepsy and focal (partial-onset) or generalized onset seizures, or Unverricht-Lundborg disease (ULD). A secondary objective was to evaluate efficacy of BRV in the subgroups of patients with focal or generalized onset seizures. Patients with epilepsy were eligible to enroll in this OLE (N01125; NCT00175916) and were analyzed if they had completed a previous double-blind BRV trial (N01114 [NCT00175929], N01252 [NCT00490035], N01254 [NCT00504881], N01187 [NCT00357669], and N01236 [NCT00368251]), and were expected to obtain a reasonable benefit from long-term BRV treatment. Patients entered the OLE at the BRV dose recommended at the end of the previous trial, with dose adjustments of BRV and concomitant antiseizure medications permitted. Safety variables included treatment-emergent adverse events (TEAEs). Efficacy variables in patients with focal seizures were percent reduction in focal seizure frequency, 50 % responder rates, and 6- and 12-month seizure-freedom. Eight hundred and fifty-three patients (729 [85.5 %] with focal seizures, 30 [3.5 %] with generalized onset seizures, and 94 [11.0 %] with ULD) were enrolled and included in the Safety Set. Overall, 619 (72.6 %) patients discontinued the trial, mainly due to lack of efficacy (354 [41.5 %]), adverse events (100 [11.7 %]), and patient choice (98 [11.5 %]). During the OLE, 588 (68.9 %) patients received BRV for >= 12 months, 403 (47.2 %) for >= 36 months, and 223 (26.1 %) for >= 96 months. The most common modal dose of BRV was 150 mg/day (415 [48.7 %] patients). In the ULD subgroup, the most common modal BRV dose was 100 mg/day (44/94 [46.8 %] patients), and 37/94 (39.4 %) patients had >= 96 months of BRV exposure. Overall, 720/853 (84.4 %) patients reported TEAEs, 451 (52.9 %) had a drug-related TEAE, and 95 (11.1 %) discontinued BRV due to a TEAE. In the ULD subgroup, 87/94 (92.6 %) patients reported TEAEs, 60 (63.8 %) had a drug-related TEAE, and 16 (17.0 %) discontinued due to a TEAE. In patients with focal seizures, the median reduction in focal seizure frequency from Baseline was 43.1 % (n = 728), the 50 % responder rate was 43.6 % (n = 729), and 6-and 12-month seizure freedom rates were 22.2 % and 15.8 %, respectively (n = 595). Overall, BRV was well-tolerated as long-term adjunctive therapy in patients with focal seizures, generalized onset seizures, or Unverricht-Lundborg disease, with improvements in focal seizure frequency maintained over time.
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| 5. |
- Bessani, A., et al.
(författare)
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BiobankCloud : A platform for the secure storage, sharing, and processing of large biomedical data sets
- 2016
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Ingår i: 1st International Workshop on Data Management and Analytics for Medicine and Healthcare, DMAH 2015 and Workshop on Big-Graphs Online Querying, Big-O(Q) 2015 held in conjunction with 41st International Conference on Very Large Data Bases, VLDB 2015. - Cham : Springer. - 9783319415758 - 9783319415765 ; , s. 89-105
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Konferensbidrag (refereegranskat)abstract
- Biobanks store and catalog human biological material that is increasingly being digitized using next-generation sequencing (NGS). There is, however, a computational bottleneck, as existing software systems are not scalable and secure enough to store and process the incoming wave of genomic data from NGS machines. In the BiobankCloud project, we are building a Hadoop-based platform for the secure storage, sharing, and parallel processing of genomic data. We extended Hadoop to include support for multi-tenant studies, reduced storage requirements with erasure coding, and added support for extensible and consistent metadata. On top of Hadoop, we built a scalable scientific workflow engine featuring a proper workflow definition language focusing on simple integration and chaining of existing tools, adaptive scheduling on Apache Yarn, and support for iterative dataflows. Our platform also supports the secure sharing of data across different, distributed Hadoop clusters. The software is easily installed and comes with a user-friendly web interface for running, managing, and accessing data sets behind a secure 2-factor authentication. Initial tests have shown that the engine scales well to dozens of nodes. The entire system is open-source and includes pre-defined workflows for popular tasks in biomedical data analysis, such as variant identification, differential transcriptome analysis using RNA-Seq, and analysis of miRNA-Seq and ChIP-Seq data.
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| 6. |
- Calcluth, Cameron, 1997, et al.
(författare)
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Sufficient Condition for Universal Quantum Computation Using Bosonic Circuits
- 2024
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Ingår i: PRX Quantum. - 2691-3399. ; 5:2
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Tidskriftsartikel (refereegranskat)abstract
- Continuous-variable bosonic systems stand as prominent candidates for implementing quantum computational tasks. While various necessary criteria have been established to assess their resourcefulness, sufficient conditions have remained elusive. We address this gap by focusing on promoting circuits that are otherwise simulatable to computational universality. The class of simulatable, albeit non-Gaussian, circuits that we consider is composed of Gottesman-Kitaev-Preskill (GKP) states, Gaussian operations, and homodyne measurements. Based on these circuits, we first introduce a general framework for mapping a continuous-variable state into a qubit state. Subsequently, we cast existing maps into this framework, including the modular and stabilizer subsystem decompositions. By combining these findings with established results for discrete-variable systems, we formulate a sufficient condition for achieving universal quantum computation. Leveraging this, we evaluate the computational resourcefulness of a variety of states, including Gaussian states, finite-squeezing GKP states, and cat states. Furthermore, our framework reveals that both the stabilizer subsystem decomposition and the modular subsystem decomposition (of position-symmetric states) can be constructed in terms of simulatable operations. This establishes a robust resource-theoretical foundation for employing these techniques to evaluate the logical content of a generic continuous-variable state, which can be of independent interest.
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| 11. |
- Rakickas, T., et al.
(författare)
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Protein-Protein Interactions in Reversibly Assembled Nanopatterns
- 2008
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Ingår i: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 8:10, s. 3369-3375
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Tidskriftsartikel (refereegranskat)abstract
- We describe herein a platform to study protein-protein interactions and to form functional protein complexes in nanoscopic surface domains. For this purpose, we employed multivalent chelator (MCh) templates, which were fabricated in a stepwise procedure combining dip-pen nanolithography (DPN) and molecular recognition-directed assembly. First, we demonstrated that an atomic force microscope (AFM) tip inked with an oligo(ethylene glycol) (OEG) disulfide compound bearing terminal biotin groups can be used to generate biotin patterns on gold achieving line widths below 100 nm, a generic platform for fabrication of functional nanostructures via the highly specific biotin-streptavidin recognition. Subsequently, we converted such biotin/streptavidin patterns into functional MCh patterns for reversible assembly of histidine- tagged (His-tagged) proteins via the attachment of a tris-nitriloacetic acid (trisNTA) biotin derivative. Fluorescence microscopy confirmed reversible immobilization of the receptor subunit ifnar2-His10 and its interaction with interferon-a2 labeled with fluorescent quantum dots in a 7 × 7 dot array consisting of trisNTA spots with a diameter of ~230 nm. Moreover, we carried out characterization of the specificity, stability, and reversibility as well as quantitative real-time analysis of protein-protein interactions at the fabricated nanopatterns by imaging surface plasmon resonance. Our work offers a route for construction and analysis of functional protein-based nanoarchitectures. © 2008 American Chemical Society.
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