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Sökning: WFRF:(Reza Salim)

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1.
  • Ademuyiwa, Adesoji O., et al. (författare)
  • Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
  • 2016
  • Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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2.
  • An, Siwen, et al. (författare)
  • Signal-to-Noise Ratio Optimization in X-ray Fluorescence Spectrometry for Chromium Contamination Analysis
  • 2021
  • Ingår i: Talanta. - : Elsevier BV. - 0039-9140 .- 1873-3573. ; 230
  • Tidskriftsartikel (refereegranskat)abstract
    • In most cases, direct X-ray fluorescence (XRF) analysis of solutions entails technical difficulties due to a high X-ray scattering background resulting in a spectrum with a poor signal-to-noise ratio (SNR). Key factors that determine the sensitivity of the method are the energy resolution of the detector and the amount of scattered radiation in the energy range of interest. Limiting the width of the primary spectrum by the use of secondary targets, or filters, can greatly improve the sensitivity for specific portions of the spectrum. This paper demonstrates a potential method for SNR optimization in direct XRF analysis of chromium (Cr) contamination. The suggested method requires minimal sample preparation and achieves higher sensitivity compared to existing direct XRF analysis. Two states of samples, fly ash and leachate from municipal solid waste incineration, were investigated. The effects of filter material, its absorption edge and filter thickness were analyzed using the combination of Monte Carlo N-Particle (MCNP) code and energy-dispersive XRF spectrometry. The applied filter removes primary photons with energies interfering with fluorescence photons from the element of interest, thus results in lower background scattering in the spectrum. The SNR of Cr peak increases with filter thickness and reaches a saturation value when further increased thickness only increases the measurement time. Measurements and simulations show that a Cu filter with a thickness between 100 μm and 140 μm is optimal for detecting Cr by taking into account both the SNR and the exposure time. With direct XRF analysis for solutions, the limit of quantitation (LOQ) of the achieved system was 0.32 mg/L for Cr, which is well below the allowed standard limitation for landfills in Sweden. This work shows that XRF can gain enough sensitivity for direct monitoring to certify that the Cr content in leachate is below environmental limits.
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3.
  • Bhat, Shakeel Ahmad, et al. (författare)
  • Application of Biochar for Improving Physical, Chemical, and Hydrological Soil Properties: A Systematic Review
  • 2022
  • Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 14:17
  • Forskningsöversikt (refereegranskat)abstract
    • Biochar is a carbon-based substance made by the pyrolysis of organic waste. The amount of biochar produced is determined by the type of feedstock and pyrolysis conditions. Biochar is frequently added to the soil for various reasons, including carbon sequestration, greenhouse gas mitigation, improved crop production by boosting soil fertility, removing harmful contaminants, and drought mitigation. Biochar may also be used for waste management and wastewater treatment. Biochar’s various advantages make it a potentially appealing instrument material for current science and technology. Although biochar’s impacts on soil chemical qualities and fertility have been extensively researched, little is known about its impact on enhancing soil physical qualities. This review is intended to describe biochar’s influence on some crucial soil physical and hydrological properties, including bulk density of soil, water holding capacity, soil porosity, soil hydraulic conductivity, soil water retention, water repellence–available plant water, water infiltration, soil temperature, soil color, and surface albedo. Therefore, we propose that the application of biochar in soils has considerable advantages, and this is especially true for arable soils with low fertility.
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4.
  • Correa, J., et al. (författare)
  • Characterisation of a PERCIVAL monolithic active pixel prototype using synchrotron radiation
  • 2016
  • Ingår i: Journal of Instrumentation. - : IOP. - 1748-0221. ; 11:2
  • Tidskriftsartikel (refereegranskat)abstract
    • PERCIVAL ("Pixelated Energy Resolving CMOS Imager, Versatile And Large") is a monolithic active pixel sensor (MAPS) based on CMOS technology. Is being developed by DESY, RAL/STFC, Elettra, DLS, and PAL to address the various requirements of detectors at synchrotron radiation sources and Free Electron Lasers (FELs) in the soft X-ray regime. These requirements include high frame rates and FELs base-rate compatibility, large dynamic range, single-photon counting capability with low probability of false positives, high quantum efficiency (QE), and (multi-)megapixel arrangements with good spatial resolution. Small-scale back-side-illuminated (BSI) prototype systems are undergoing detailed testing with X-rays and optical photons, in preparation of submission of a larger sensor. A first BSI processed prototype was tested in 2014 and a preliminary result—first detection of 350eV photons with some pixel types of PERCIVAL—reported at this meeting a year ago. Subsequent more detailed analysis revealed a very low QE and pointed to contamination as a possible cause. In the past year, BSI-processed chips on two more wafers were tested and their response to soft X-ray evaluated. We report here the improved charge collection efficiency (CCE) of different PERCIVAL pixel types for 400eV soft X-rays together with Airy patterns, response to a flat field, and noise performance for such a newly BSI-processed prototype sensor.
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5.
  • Correa, J., et al. (författare)
  • On the Charge Collection Efficiency of the PERCIVAL Detector
  • 2016
  • Ingår i: Journal of Instrumentation. - : IOP. - 1748-0221. ; 11:12
  • Tidskriftsartikel (refereegranskat)abstract
    • The PERCIVAL soft X-ray imager is being developed by DESY, RAL, Elettra, DLS, and PAL to address the challenges at high brilliance Light Sources such as new-generation Synchrotrons and Free Electron Lasers. Typical requirements for detector systems at these sources are high frame rates, large dynamic range, single-photon counting capability with low probability of false positives, high quantum efficiency, and (multi)-mega-pixel arrangements. PERCIVAL is a monolithic active pixel sensor, based on CMOS technology. It is designed for the soft X-ray regime and, therefore, it is post-processed in order to achieve high quantum efficiency in its primary energy range (250 eV to 1 keV) . This work will report on the latest experimental results on charge collection efficiency obtained for multiple back-side-illuminated test sensors during two campaigns, at the P04 beam-line at PETRA III, and the CiPo beam-line at Elettra, spanning most of the primary energy range as well as testing the performance for photon-energies below 250 eV . In addition, XPS surface analysis was used to cross-check the obtained results.
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6.
  • Fröjdh, Christer, 1952-, et al. (författare)
  • Precision scan-imaging for paperboard quality inspection utilizing X-ray fluorescence
  • 2018
  • Ingår i: Journal of Instrumentation. - : Institute of Physics Publishing. - 1748-0221. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Paperboard is typically made up of a core of cellulose fibers [C6H10O5] and a coating layer of [CaCO3]. The uniformity of these layers is a critical parameter for the printing quality. Current quality control methods include chemistry based visual inspection methods as well as X-ray based methods to measure the coating thickness. In this work we combine the X-ray fluorescence signals from the Ca atoms (3.7 keV) in the coating and from a Cu target (8.0 keV) placed behind the paper to simultaneously measure both the coating and the fibers. Cu was selected as the target material since its fluorescence signal is well separated from the Ca signal while its fluorescence's still are absorbed sufficiently in the paper. A laboratory scale setup is built using stepper motors, a silicon drift detector based spectrometer and a collimated X-ray beam. The spectroscopic image is retrieved by scanning the paperboard surface and registering the fluorescence signals from Ca and Cu. The exposure time for this type of setups can be significantly improved by implementing spectroscopic imaging sensors. The material contents in the layers can then be retrieved from the absolute and relative intensities of these two signals.
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7.
  • Fröjdh, Christer, et al. (författare)
  • Spectral resolution in pixel detectors with single photon processing
  • 2013
  • Ingår i: Proceedings SPIE Optical Engineering + Applications, 2013. - : SPIE - International Society for Optical Engineering. - 9780819497024
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Pixel detectors based on photon counting or single photon processing readout are becoming popular for spectral X-ray imaging. The detector is based on deep submicron electronics with functions to determine the energy of each individual photon in every pixel. The system is virtually noiseless when it comes to the number of the detected photons. However noise and variations in system parameters affect the determination of the photon energy. Several factors affect the energy resolution in the system. In the readout electronics the most important factors are the threshold dispersion, the gain variation and the electronic noise. In the sensor contributions come from charge sharing, variations in the charge collection efficiency, leakage current and the statistical nature of the charge generation, as described by the Fano factor. The MEDIPIX technology offers a powerful tool for investigating these effects since energy spectra can be captured in each pixel. In addition the TIMEPIX chip, when operated in Time over Threshold mode, offers an opportunity to analyze individual photon interactions, thus addressing charge sharing and fluorescence. Effects of charge sharing and the properties of charge summing can be investigated using MEDIPIX3RX. Experiments are performed using both Si and CdTe detectors. In this paper we discuss the various contributions to the spectral noise and how they affect detector response. The statements are supported with experimental data from MEDIPIX-type detectors.
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8.
  • Gaižauskaitė, Inga, et al. (författare)
  • Researching Academic Integrity : Designing Research to Help Participants Give Genuine Responses Using Quantitative and Qualitative Methods
  • 2022. - 1
  • Ingår i: Academic Integrity: Broadening Practices, Technologies, and the Role of Students. - Cham : Springer International Publishing. - 9783031169762 - 9783031169755 ; , s. 47-65
  • Bokkapitel (refereegranskat)abstract
    • Whether attempting a qualitative or quantitative study, scientific research depends on the study design, identifying the target population, establishing the appropriate methodology, choosing data collection methods and analysis procedures that ensure the validity of the study and reliability of results. Flawed research methodologies result in measurement error, which is the difference between the actual value and what has been measured. Although it is difficult to avoid random errors, any systematic errors (e.g., invalid and/or unreliable instruments) should be designed out.
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9.
  • Khan, Zeenath Reza, et al. (författare)
  • Academic Integrity Outreach Efforts : Making Education Accessible and Inclusive
  • 2022. - 1
  • Ingår i: Academic Integrity: Broadening Practices, Technologies, and the Role of Students. - Cham : Springer Publishing Company. - 9783031169762 - 9783031169755 ; , s. 3-16
  • Bokkapitel (refereegranskat)abstract
    • Outreach is typically a word used for the corporate sector when looking at their social responsibility. However, when it comes to the academic sector, outreach becomes a compulsory part of everyone’s responsibility in order to successfully achieve United Nation’s sustainable Goal 4 – quality education. Quality of education comes from ensuring all the stakeholders understand integrity values and make every effort to uphold such values in all aspects of academia and research.
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10.
  • Khromova, A., et al. (författare)
  • Report on recent results of the PERCIVAL soft X-ray imager
  • 2016
  • Ingår i: Journal of Instrumentation. - : IOP. - 1748-0221. ; 11:November
  • Tidskriftsartikel (refereegranskat)abstract
    • The PERCIVAL (Pixelated Energy Resolving CMOS Imager, Versatile And Large) soft X-ray 2D imaging detector is based on stitched, wafer-scale sensors possessing a thick epi-layer, which together with back-thinning and back-side illumination yields elevated quantum efficiency in the photon energy range of 125–1000 eV. Main application fields of PERCIVAL are foreseen in photon science with FELs and synchrotron radiation. This requires high dynamic range up to 105 ph @ 250 eV paired with single photon sensitivity with high confidence at moderate frame rates in the range of 10–120 Hz. These figures imply the availability of dynamic gain switching on a pixel-by-pixel basis and a highly parallel, low noise analog and digital readout, which has been realized in the PERCIVAL sensor layout. Different aspects of the detector performance have been assessed using prototype sensors with different pixel and ADC types. This work will report on the recent test results performed on the newest chip prototypes with the improved pixel and ADC architecture. For the target frame rates in the 10–120 Hz range an average noise floor of 14e− has been determined, indicating the ability of detecting single photons with energies above 250 eV. Owing to the successfully implemented adaptive 3-stage multiple-gain switching, the integrated charge level exceeds 4 centerdot 106 e− or 57000 X-ray photons at 250 eV per frame at 120 Hz. For all gains the noise level remains below the Poisson limit also in high-flux conditions. Additionally, a short overview over the updates on an oncoming 2 Mpixel (P2M) detector system (expected at the end of 2016) will be reported.
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11.
  • Lagercrantz, Ulf, et al. (författare)
  • DE‐ETIOLATED1 has a role in the circadian clock of the liverwort Marchantia polymorpha
  • 2021
  • Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 232:2, s. 595-609
  • Tidskriftsartikel (refereegranskat)abstract
    • Previous studies of plant circadian clock evolution have often relied on clock models and genes defined in Arabidopsis. These studies identified homologues with seemingly conserved function, as well as frequent gene loss. In the present study, we aimed to identify candidate clock genes in the liverwort Marchantia polymorpha using a more unbiased approach.To identify genes with circadian rhythm we sequenced the transcriptomes of gemmalings in a time series in constant light conditions. Subsequently, we performed functional studies using loss-of-function mutants and gene expression reporters.Among the genes displaying circadian rhythm, a homologue to the transcriptional co-repressor Arabidopsis DE-ETIOLATED1 showed high amplitude and morning phase. Because AtDET1 is arrhythmic and associated with the morning gene function of AtCCA1/LHY, that lack a homologue in liverworts, we functionally studied DET1 in M. polymorpha.We found that the circadian rhythm of MpDET1 expression is disrupted in loss-of-function mutants of core clock genes and putative evening-complex genes. MpDET1 knock-down in turn results in altered circadian rhythm of nyctinastic thallus movement and clock gene expression. We could not detect any effect of MpDET1 knock-down on circadian response to light, suggesting that MpDET1 has a yet unknown function in the M. polymorpha circadian clock.
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12.
  • Marras, A., et al. (författare)
  • Experimental characterization of the PERCIVAL soft X-ray detector
  • 2016
  • Ingår i: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781467398626
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Considerable interest has been manifested for the use of high-brilliance X-ray synchrotron sources and X-ray Free-Electron Lasers for the investigation of samples.
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13.
  • Masoudzadeh, Nasrin, et al. (författare)
  • Molecular signatures of anthroponotic cutaneous leishmaniasis in the lesions of patients infected with Leishmania tropica.
  • 2020
  • Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Anthroponotic cutaneous leishmaniasis (CL) caused by Leishmania tropica (L. tropica) represents a public health challenge in several resource poor settings. We herein employed a systems analysis approach to study molecular signatures of CL caused by L. tropica in the skin lesions of ulcerative CL (UCL) and non-ulcerative CL (NUCL) patients. Results from RNA-seq analysis determined shared and unique functional transcriptional pathways in the lesions of the UCL and NUCL patients. Several transcriptional pathways involved in inflammatory response were positively enriched in the CL lesions. A multiplexed inflammatory protein analysis showed differential profiles of inflammatory cytokines and chemokines in the UCL and NUCL lesions. Transcriptional pathways for Fcγ receptor dependent phagocytosis were among shared enriched pathways. Using L. tropica specific antibody (Ab)-mediated phagocytosis assays, we could substantiate Ab-dependent cellular phagocytosis (ADCP) and Ab-dependent neutrophil phagocytosis (ADNP) activities in the lesions of the UCL and NUCL patients, which correlated with L. tropica specific IgG Abs. Interestingly, a negative correlation was observed between parasite load and L. tropica specific IgG/ADCP/ADNP in the skin lesions of CL patients. These results enhance our understanding of human skin response to CL caused by L. tropica.
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14.
  • Minina, Alyona, et al. (författare)
  • The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis
  • 2017
  • Ingår i: Journal of Cell Science. - : The Company of Biologists. - 0021-9533 .- 1477-9137. ; 130, s. 1051-1063
  • Tidskriftsartikel (refereegranskat)abstract
    • Factors regulating dynamics of chromatin structure have direct impact on expression of genetic information. Cohesin is a multi-subunit protein complex that is crucial for pairing sister chromatids during cell division, DNA repair and regulation of gene transcription and silencing. In non-plant species, cohesin is loaded on chromatin by the Scc2-Scc4 complex (also known as the NIBPL-MAU2 complex). Here, we identify the Arabidopsis homolog of Scc4, which we denote Arabidopsis thaliana (At) SCC4, and show that it forms a functional complex with AtSCC2, the homolog of Scc2. We demonstrate that AtSCC2 and AtSCC4 act in the same pathway, and that both proteins are indispensable for cell fate determination during early stages of embryo development. Mutant embryos lacking either of these proteins develop only up to the globular stage, and show the suspensor overproliferation phenotype preceded by ectopic auxin maxima distribution. We further establish a new assay to reveal the AtSCC4-dependent dynamics of cohesin loading on chromatin in vivo. Our findings define the Scc2-Scc4 complex as an evolutionary conserved machinery controlling cohesin loading and chromatin structure maintenance, and provide new insight into the plant-specific role of this complex in controlling cell fate during embryogenesis.
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15.
  • Moschou, Panagiotis Nikolaou, et al. (författare)
  • EXTRA SPINDLE POLES (Separase) controls anisotropic cell expansion in Norway spruce (Picea abies) embryos independently of its role in anaphase progression
  • 2016
  • Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 212, s. 232-243
  • Tidskriftsartikel (refereegranskat)abstract
    • The caspase-related protease separase (EXTRA SPINDLE POLES, ESP) plays a major role in chromatid disjunction and cell expansion in Arabidopsis thaliana. Whether the expansion phenotypes are linked to defects in cell division in Arabidopsis ESP mutants remains elusive. Here we present the identification, cloning and characterization of the gymnosperm Norway spruce (Picea abies, Pa) ESP. We used the P.abies somatic embryo system and a combination of reverse genetics and microscopy to explore the roles of Pa ESP during embryogenesis. Pa ESP was expressed in the proliferating embryonal mass, while it was absent in the suspensor cells. Pa ESP associated with kinetochore microtubules in metaphase and then with anaphase spindle midzone. During cytokinesis, it localized on the phragmoplast microtubules and on the cell plate. Pa ESP deficiency perturbed anisotropic expansion and reduced mitotic divisions in cotyledonary embryos. Furthermore, whilst Pa ESP can rescue the chromatid nondisjunction phenotype of Arabidopsis ESP mutants, it cannot rescue anisotropic cell expansion. Our data demonstrate that the roles of ESP in daughter chromatid separation and cellexpansion are conserved between gymnosperms and angiosperms. However, the mechanisms of ESP-mediated regulation of cell expansion seem to be lineage-specific.
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16.
  • Niskanen, Ilpo, et al. (författare)
  • Determination of nanoparticle size using Rayleigh approximation and Mie theory
  • 2019
  • Ingår i: Chemical Engineering Science. - : Elsevier. - 0009-2509 .- 1873-4405. ; 201, s. 222-229
  • Tidskriftsartikel (refereegranskat)abstract
    • Accurate determination of the size of nanoparticles has an important role in many different scientific and industrial purposes, such as in material, medical and environment sciences, colloidal chemistry and astrophysics. We describe an effective optical method to determine the size of nanoparticles by analysis of transmission and scattering of visible spectral range data from a designed UV-Vis multi-spectrophotometer. The size of the nanoparticles was calculated from the extinction cross section of the particles using Rayleigh approximation and Mie theory. We validated the method using polystyrene nanospheres, cellulose nanofibrils, and cellulose nanocrystals. A good agreement was achieved through graphical analysis between measured extinction cross section values and theoretical Rayleigh approximation and Mie theory predictions for the sizes of polystyrene nanospheres at wavelength range 450-750 nm. Provided that Rayleigh approximation's forward scattering (FS)/back scattering (BS) ratio was smaller than 1.3 and Mie theory's FS/BS ratio was smaller than 1.8. A good fit for the hydrodynamic diameter of nanocellulose was achieved using the Mie theory and Rayleigh approximation. However, due to the high aspect ratio of nanocellulose, the obtained results do not directly reflect the actual cross-sectional diameters of the nanocellulose. Overall, the method is a fast, relatively easy, and simple technique to determine the size of a particle by a spectrophotometer. Consequently, the method can be utilized for example in production and quality control purposes as well as for research and development applications.
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17.
  • Norlin, Börje, et al. (författare)
  • Readout cross-talk for alpha-particle measurements in a pixelated sensor system
  • 2015
  • Ingår i: Journal of Instrumentation. - : IOP. - 1748-0221. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • Simulations in Medici are performed to quantify crosstalk and charge sharing in a hybrid pixelated silicon detector. Crosstalk and charge sharing degrades the spatial and spectral resolution of single photon processing X-ray imaging systems. For typical medical X-ray imaging applications, the process is dominated by charge sharing between the pixels in the sensor. For heavier particles each impact generates a large amount of charge and the simulation seems to over predict the charge collection efficiency. This indicates that some type of non modelled degradation of the charge transport efficiency exists, like the plasma effect where the plasma might shield the generated charges from the electric field and hence distorts the charge transport process. Based on the simulations it can be reasoned that saturation of the amplifiers in the Timepix system might generate crosstalk that increases the charge spread measured from ion impact on the sensor.
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18.
  • Norlin, Börje, 1967-, et al. (författare)
  • X-ray fluorescence measurements of toxic metal content in ash from municipal solid waste incineration
  • 2017
  • Ingår i: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD). - : IEEE. - 9781509016426
  • Konferensbidrag (refereegranskat)abstract
    • The vision of this paper is development of an online X-ray fluorescence method for monitoring of metal content in ash from municipal solid waste (MSW) incineration. With such measurements directly on site it is possible to optimize an ash washing process in incineration plants, allowing the fly ash to be stored in a landfill for non-hazardous waste. The presented X-ray fluorescence measurement assures that the measurement accuracy is sufficient for metal content monitoring. The actual measurement process is also fast enough to be possible to implement as an online measurement method. The optimal measurement setup is different for different metals. Several different metals might need environmental monitoring, which metals might vary over time due to systematic variations in waist content. Detection of a wide range of metals will require an X-ray source with variable voltage and multiple detectors.
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19.
  • Olsen, Martin, 1971-, et al. (författare)
  • Schottky model for triboelectric temperature dependence
  • 2018
  • Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The triboelectric effect, charging by contact, is the working principle in a device called a triboelectric nanogenerator. They are used as efficient energy transducers in energy harvesting. In such generators the charging of surfaces at contact is followed by a separation of the surfaces increasing the electrical energy which can subsequently be used. Different materials have different triboelectric potentials leading to charging at contact. The temperature dependence of the charging has just recently been studied: the triboelectric effect is decreasing with temperature for a generator of Al-PTFE-Cu. Here, we suggest a mechanism to explain this effect assuming ion transfer using a two-level Schottky model where the two levels corresponds to the two surfaces. The difference in binding energy for ions on the two surfaces then enters the formula for charging. We fit the triboelectric power density as a function of temperature obtained from a two-level Schottky model to measured data for nanogenerators made of Al-PTFE-Cu found in three references. We obtain an average separation energy corresponding to a temperature of 365 K which is of the right magnitude for physically adsorbed atoms. We anticipate that this model could be used for many types of triboelectric nanogenerators.
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20.
  • Patel, Riyaz S., et al. (författare)
  • Subsequent Event Risk in Individuals With Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium
  • 2019
  • Ingår i: Circulation. - 2574-8300. ; 12:4
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
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21.
  • Reza, Salim (författare)
  • Advanced X-ray Detectors for Industrial and Environmental Applications
  • 2016
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The new generation of X-ray free electron laser sources arecapable of producing light beams with billion times higherpeak brilliance than that of the best conventional X-ray sources.This advancement motivates the scientific community to pushforward the detector technology to its limit, in order to de-sign photon detectors which can cope with the extreme fluxgenerated by the free electron laser sources. Sophisticated ex-periments like deciphering the atomic details of viruses, filmingchemical reactions or investigating the extreme states of matterrequire detectors with high frame rate, good spatial resolution,high dynamic range and large active sensor area. The PERCI-VAL monolithic active pixel sensor is being developed by aninternational group of scientists in collaboration to meet theaforementioned detector requirements within the energy rangeof 250 eV to 1 keV, with a quantum efficiency above 90%.In this doctoral researchwork, Monte Carlo algorithm basedGeant4 and finite element method based Synopsys SentaurusTCADtoolkits have been used to simulate, respectively, theX-rayenergy deposition and the charge sharing in PERCIVAL. Energydeposition per pixel and charge sharing between adjacent pixelsat different energies have been investigated and presented.Novel methods for industrial and environmental applica-tions of some commercially available X-ray detectors have beendemonstrated. Quality inspection of paperboards by resolv-ing the layer thicknesses and by investigating orientation ofthe cellulose fibres have been performed using spectroscopicand phase-contrast X-ray imaging. It was found that, usingphase-contrast imaging it is possible to set burn-out like qualityindex on paperboards non-destructively. X-ray fluoroscopicmeasurements have been conducted in order to detect Cr inwater. This method can be used to detect Cr and other toxicelements in leachate in landfills and other waste dumping sites.
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24.
  • Reza, Salim, 1985-, et al. (författare)
  • Detecting Cr Contamination In Water Using X-Ray Fluorescence
  • 2015
  • Ingår i: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781467398626
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • With the rapid growth in population and the overwhelming demand of industrial consumer products around the world, the amount of generated wastes is also increasing. Therefore, the optimal utilization of wastes and the waste management policies are very important in order to protect the environment[1]. The most common way of waste management is to dispose them into city dumps and landfills. These disposal sites may produce toxic and green house gases and also a substantial amount of leachate, which can affect the environment[2]. Leachate is liquid, which, while percolating through wastes in a landfill, extracts soluble and suspended solids. Leachate contains toxic and harmful substances, such as Chromium (Cr), Arsenic, Lead, Mercury, Benzene, Chloroform and Methylene Chloride, and can contaminate surface water and aquifers.
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26.
  • Reza, Salim Hossain, et al. (författare)
  • Transcriptome analysis of embryonic domains in Norway spruce reveals potential regulators of suspensor cell death
  • 2018
  • Ingår i: PLOS ONE. - San Francisco : Public Library of Science. - 1932-6203. ; 13:3
  • Tidskriftsartikel (refereegranskat)abstract
    • The terminal differentiation and elimination of the embryo-suspensor is the earliest manifestation of programmed cell death (PCD) during plant ontogenesis. Molecular regulation of suspensor PCD remains poorly understood. Norway spruce (Picea abies) embryos provide a powerful model for studying embryo development because of their large size, sequenced genome, and the possibility to obtain a large number of embryos at a specific developmental stage through somatic embryogenesis. Here, we have carried out global gene expression analysis of the Norway spruce embryo-suspensor versus embryonal mass (a gymnosperm analogue of embryo proper) using RNA sequencing. We have identified that suspensors have enhanced expression of the NAC domain-containing transcription factors, XND1 and ANAC075, previously shown to be involved in the initiation of developmental PCD in Arabidiopsis. The analysis has also revealed enhanced expression of Norway spruce homologues of the known executioners of both developmental and stress-induced cell deaths, such as metacaspase 9 (MC9), cysteine endopeptidase-1 (CEP1) and ribonuclease 3 (RNS3). Interestingly, a spruce homologue of bax inhibitor-1 (PaBI-1, for Picea abies BI-1), an evolutionarily conserved cell death suppressor, was likewise up-regulated in the embryosuspensor. Since Arabidopsis BI-1 so far has been implicated only in the endoplasmic reticulum (ER)-stress induced cell death, we investigated its role in embryogenesis and suspensor PCD using RNA interference (RNAi). We have found that PaBI-1-deficient lines formed a large number of abnormal embryos with suppressed suspensor elongation and disturbed polarity. Cytochemical staining of suspensor cells has revealed that PaBI-1 deficiency suppresses vacuolar cell death and induces necrotic type of cell death previously shown to compromise embryo development. This study demonstrates that a large number of cell-death components are conserved between angiosperms and gymnosperms and establishes a new role for BI-1 in the progression of vacuolar cell death.
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27.
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28.
  • Reza, Salim, 1985-, et al. (författare)
  • Investigation on the directional dark-field signals from paperboards using a grating interferometer
  • 2014
  • Ingår i: Journal of Instrumentation. - : IOP. - 1748-0221. ; 9, s. Art. no. C04032-
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent advancements in the grating interferometer based Phase Contrast X-ray Imag- ing (PCXI) technique enables high quality dark-field images to be obtained using conventional X-ray tubes. The dark-field images map the scattering inhomogeneities inside objects. Since, the dark-field image is constructed by considering only those photons which are scattered while pass- ing through the objects, it can reveal useful information about the object inner structures, such as, the fibre structures inside paperboards.The end-use performance of paperboards, such as the printing quality and the stiffness de-pends on the uniformity in the thickness and the structures of the coating layer of the paperboards. The uniformity in the coating layer is determined by the coating techniques, the coating materials and the topography of the base sheet. In this article, the dark-field signals from four paperboard samples with different quality indices are analysed. The isotropic and the anisotropic scattering coefficients for all of the samples have been calculated. Based on the correlation between the isotropic coefficients and the quality indices of the paperboards, a new method for paperboard quality measurement has been suggested.
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29.
  • Reza, Salim, 1985-, et al. (författare)
  • Non-Destructive Method to Resolve the Core and the Coating on Paperboard by Spectroscopic X-ray Imaging
  • 2013
  • Ingår i: Nordic Pulp & Paper Research Journal. - 0283-2631 .- 2000-0669. ; 28:3, s. 439-442
  • Tidskriftsartikel (refereegranskat)abstract
    • Quality control is an important issue in the paperboard industry. A typical sheet of paperboard contains a core of cellulose fibers [C6H10O5], coated on one or both sides with layers of calcium carbonate [CaCO3] or Kaolin [Al2Si2O5(OH)4]. One of the major properties of a good quality paperboard is the consistency of the expected ratio between the thickness of the core and the coating layers. A measurement system to obtain this ratio could assist the paperboard industry to monitor the quality of their products in an automatic manner. In this work, the thicknesses of the core and the coating layers on a paperboard with coating layer on only one side were measured using an X-ray imaging technique. However, the limited spectral and spatial resolution offered by the measurement system being used led to the measured thicknesses of the layers being lower than their actual thicknesses in the paperboard sample. Suggestions have been made in relation to overcoming these limitations and to enhance the performance of the method. A Monte Carlo N-particle code simulation has been used in order to verify the suggested method.
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30.
  • Reza, Salim, 1985- (författare)
  • Phase-Contrast and Spectroscopic X-ray Imaging for Paperboard Quality Assurance
  • 2014
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The end-use performance of a paperboard depends on its quality.The major properties of a good quality paperboard include consistencyin the expected ratio between the thickness of the core andthe coating layers, and the uniformity in the coating layer. Measurementsystems using X-rays to monitor these properties could assistthe paperboard industries to assure the quality of their products in anon-destructive and automatic manner. Phase Contrast X-ray Imaging (PCXI) has been used successfullyto look inside a wide range of objects using synchrotron radiationsources. Recent advancements in the grating interferometer basedPCXI technique enables high quality phase-contrast and dark-fieldimages to be obtained using conventional X-ray tubes. The darkfieldimages map the scattering inhomogeneities inside objects andis very sensitive to micro-structures, and thus, can reveal useful informationabout the object’s inner structures, such as, the fibre structuresinside paperboards. In this thesis, methods, using spectroscopic X-ray imaging andPCXI technique have been demonstrated to measure paperboard quality.The thicknesses of the core and the coating layers on a paperboardwith the coating layer on only one side can be measured usingspectroscopic X-ray imaging technique. However, the limitedspectral and spatial resolution offered by the measurement systembeing used led to the measured thicknesses of the layers being lowerthan their actual thicknesses in the paperboard sample. Suggestionshave been made in relation to overcoming these limitations and toenhance the performance of the method. The dark-field signals from paperboard samples with different qualityindices are analysed. The isotropic and the anisotropic scatteringcoefficients for all of the samples have been calculated. Basedon the correlation between the isotropic coefficients and the qualityindices of the paperboards, suggestions have been made for paperboardquality measurements.
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31.
  • Reza, Salim, 1985- (författare)
  • Report on Control/DAQ Software Design and Current State of Implementation for the Percival Detector
  • 2015
  • Ingår i: ICALEPCS2015 - Proceedings Melbourne, Australia. - 9783954501489
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • The Percival Collaboration is developing a high-speed,low X-ray energy detector capable of detecting single pho-tons while maintaining a large dynamic range of sensitivity.The increased brilliance of state-of-the-art Synchrotronradiation sources and Free Electron Lasers require imagingdetectors capable of taking advantage of these light sourcefacilities. The PERCIVAL ("Pixelated Energy ResolvingCMOS Imager, Versatile and Large") detector is being de-veloped in collaboration between DESY, Elettra SincrotroneTrieste, Diamond Light Source and Pohang Accelerator Lab-oratory.It is a CMOS detector targeting soft X-rays < 1 KeV, witha high resolution of up to 13 M pixels reading out at 120 Hz,producing a challenging data rate of 6 GiB/s.The controls and data acquisition system will include aSoftware Development Kit to allow integration with thirdparty control systems like Tango and DOOCS; an EPICS [1]areaDetector [2] driver will be included by default. It willmake use of parallel readout to keep pace with the datarate, distributing the data over multiple nodes to create asingle virtual dataset using the HDF5 file format for its speedadvantages in high volumes of regular data.This development project will culminate in a control andDAQ system capable of dealing with very high data rateswhile providing easy integration with site-specific controlsystems.This report presents the design of the control system soft-ware for the Percival detector, an update of the current stateof the implementation carried out by Diamond Light Source.
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32.
  • Reza, Salim, 1985-, et al. (författare)
  • Smart dosimetry by pattern recognition using a single photon counting detector system in time over threshold mode
  • 2012
  • Ingår i: Journal of Instrumentation. - 1748-0221. ; 7:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The function of a dosimeter is to determine the absorbed dose of radiation, for those cases in which, generally, the particular type of radiation is already known. Lately, a number of applications have emerged in which all kinds of radiation are absorbed and are sorted by pattern recognition, such as the Medipix2 application in [1]. This form of smart dosimetry enables measurements where not only the total dosage is measured, but also the contributions of different types of radiation impacting upon the detector surface. Furthermore, the use of a photon counting system, where the energy deposition can be measured in each individual pixel, ensures measurements with a high degree of accuracy in relation to the pattern recognition. In this article a Timepix [2] detector system has been used in the creation of a smart dosimeter for Alpha, Beta and Gamma radiation. When a radioactive particle hits the detector surface it generates charge clusters and those impacting upon the detector surface are read out and image processing algorithms are then used to classify each charge cluster. The individual clusters are calculated and as a result, the dosage for each type of radiation is given. In some cases, several particles can impact in roughly the same place, forming overlapping clusters. In order to handle this problem, a cluster separation method has been added to the pattern recognition algorithm. When the clusters have been separated, they are classified by shape and sorted into the correct type of radiation. The algorithms and methods used in this dosimeter have been developed so as to be simple and computationally effective, in order to enable implementation on a portable device. © 2012 IOP Publishing Ltd and SISSA.
  •  
33.
  • Reza, Salim, 1985- (författare)
  • Stressed in a small group or university? Think Big!
  • 2019
  • Ingår i: Universitetsläraren. - : Universitetsläraren, Sveriges universitetslärare och forskares (SULF) medlemstidning. - 0282-4973. ; :11-feb
  • Annan publikation (populärvet., debatt m.m.)
  •  
34.
  • Reza, Salim, 1985- (författare)
  • Students are stories – let us recognize them
  • 2018
  • Ingår i: Universitetsläraren. - : Universitetsläraren, Sveriges universitetslärare och forskares (SULF) medlemstidning. - 0282-4973. ; :12-feb
  • Annan publikation (populärvet., debatt m.m.)
  •  
35.
  • Reza, Salim, 1985- (författare)
  • Unacknowledged supervisors – superheroes without capes
  • 2018
  • Ingår i: Universitetsläraren. - : Universitetsläraren, Sveriges universitetslärare och forskares (SULF) medlemstidning. - 0282-4973. ; :24-sep
  • Annan publikation (populärvet., debatt m.m.)
  •  
36.
  •  
37.
  • Semiconductor Radiation Detectors : Technology and Applications
  • 2017
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
    • The aim of this book is to educate the reader on radiation detectors, from sensor to read-out electronics to application. Relatively new detector materials, such as CdZTe and Cr compensated GaAs, are introduced, along with emerging applications of radiation detectors. This X-ray technology has practical applications in medical, industrial, and security applications. It identifies materials based on their molecular composition, not densities as the traditional transmission equipment does. With chapters written by an international selection of authors from both academia and industry, the book covers a wide range of topics on radiation detectors, which will satisfy the needs of both beginners and experts in the field.
  •  
38.
  • Thim, Jan, et al. (författare)
  • Suitable Post Processing Algorithms for X-Ray Imaging using Oversampled Displaced Multiple Images
  • 2011
  • Ingår i: Journal of Instrumentation. - 1748-0221. ; 6:2
  • Tidskriftsartikel (refereegranskat)abstract
    • X-ray imaging systems such as photon counting pixel detectors have a limited spatial resolution of the pixels, based on the complexity and processing technology of the readout electronics. For X-ray imaging situations where the features of interest are smaller than the imaging system pixel size, and the pixel size cannot be made smaller in the hardware, alternative means of resolution enhancement require to be considered. Oversampling with the usage of multiple displaced images, where the pixels of all images are mapped to a final resolution enhanced image, has proven a viable method of reaching a sub-pixel resolution exceeding the original resolution. The effectiveness of the oversampling method declines with the number of images taken, the sub-pixel resolution increases, but relative to a real reduction of imaging pixel sizes yielding a full resolution image, the perceived resolution from the sub-pixel oversampled image is lower. This is because the oversampling method introduces blurring noise into the mapped final images, and the blurring relative to full resolution images increases with the oversampling factor. One way of increasing the performance of the oversampling method is by sharpening the images in post processing. This paper focus on characterizing the performance increase of the oversampling method after the use of some suitable post processing filters, for digital X-ray images specifically. The results show that spatial domain filters and frequency domain filters of the same type yield indistinguishable results, which is to be expected. The results also show that the effectiveness of applying sharpening filters to oversampled multiple images increase with the number of images used (oversampling factor), leaving 60-80% of the original blurring noise after filtering a 6 x 6 mapped image (36 images taken), where the percentage is depending on the type of filter. This means that the effectiveness of the oversampling itself increase by using sharpening filters, and more images taken can be considered worth the effort.
  •  
39.
  • Thim, Jan, et al. (författare)
  • X-ray imaging of high velocity moving objects by scanning summation using a single photon processing system
  • 2015
  • Ingår i: Journal of Instrumentation. - : IOP. - 1748-0221.
  • Tidskriftsartikel (refereegranskat)abstract
    • X-ray imaging has been used extensively in the manufacturing industry. In the paper and paperboard industry X-ray imaging has been used for measuring parameters such as coat weight, using mean values of X-ray absorption inline in the manufacturing machines. Recently, an interest has surfaced to image paperboard coating with pixel resolved images showing material distribution in the coating on the paperboard, and to do this inline in the paper machine. Naturally, imaging with pixel resolution in an application where the paperboard web travels with velocities in the order on 10 m/s sets harsh demands on the X-ray source and the detector system to be used. This paper presents a scanning imaging method for single photon imaging systems that lower the demands on the source flux by hundreds of times, enabling a system to be developed for high velocity industrial measurement applications. The paper presents the imaging method, a discussion of system limitations, simulations and real measurements in a laboratory environment with a moving test object of low velocity, all to verify the potential and limits of the proposed method.
  •  
40.
  • Thungström, Göran, et al. (författare)
  • Measurement of the sensitive profile in a solid state silicon detector, irradiated by X-rays
  • 2013
  • Ingår i: Journal of Instrumentation. - : IOP. - 1748-0221. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • A newly constructed solid state silicon dose profile detector is characterized concerning its sensitive profile. The use of the MEDIPIX2 sensor system displays an excellent method to align an image of an X-ray slit to a sample under test. The scanning from front to reverse side of the detector, show a decrease in sensitivity of 20%, which indicates a minority charge carrier lifetime of 0.18 ms and a diffusion length of 460 mu m. The influence of diced edges results in a volumetric efficiency of 59%, an active volume of 1.2 mm(2) of total 2.1 mm(2).
  •  
41.
  • Wunderer, C. B., et al. (författare)
  • Detector developments at DESY
  • 2016
  • Ingår i: Journal of Synchrotron Radiation. - 0909-0495 .- 1600-5775. ; 23, s. 111-117
  • Tidskriftsartikel (refereegranskat)abstract
    • With the increased brilliance of state-of-the-art synchrotron radiation sources and the advent of free-electron lasers (FELs) enabling revolutionary science with EUV to X-ray photons comes an urgent need for suitable photon imaging detectors. Requirements include high frame rates, very large dynamic range, single-photon sensitivity with low probability of false positives and (multi)-megapixels. At DESY, one ongoing development project-in collaboration with RAL/STFC, Elettra Sincrotrone Trieste, Diamond, and Pohang Accelerator Laboratory-is the CMOS-based soft X-ray imager PERCIVAL. PERCIVAL is a monolithic active-pixel sensor back-thinned to access its primary energy range of 250 eV to 1 keV with target efficiencies above 90%. According to preliminary specifications, the roughly 10 cm × 10 cm, 3.5k × 3.7k monolithic sensor will operate at frame rates up to 120 Hz (commensurate with most FELs) and use multiple gains within 27 μm pixels to measure 1 to ∼ 100000 (500 eV) simultaneously arriving photons. DESY is also leading the development of the AGIPD, a high-speed detector based on hybrid pixel technology intended for use at the European XFEL. This system is being developed in collaboration with PSI, University of Hamburg, and University of Bonn. The AGIPD allows singlepulse imaging at 4.5 MHz frame rate into a 352-frame buffer, with a dynamic range allowing single-photon detection and detection of more than 10000 photons at 12.4 keV in the same image. Modules of 65k pixels each are configured to make up (multi)megapixel cameras. This review describes the AGIPD and the PERCIVAL concepts and systems, including some recent results and a summary of their current status. It also gives a short overview over other FEL-relevant developments where the Photon Science Detector Group at DESY is involved. © 2016 International Union of Crystallography.
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