| 1. |
- Harms, Laura, 1991, et al.
(författare)
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Grace: Low-Cost Time-Synchronized GPIO Tracing for IoT Testbeds
- 2022
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Ingår i: Proceedings - 18th Annual International Conference on Distributed Computing in Sensor Systems, DCOSS 2022. ; , s. 9-16
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Konferensbidrag (refereegranskat)abstract
- Testbeds have become a vital tool for evaluating and benchmarking applications and algorithms in the Internet of Things (IoT). Testbeds commonly consist of low-power IoT devices augmented with observer nodes providing control, logging, and often also power-profiling. Today, the research community operates numerous testbeds, sometimes with hundreds of IoT nodes, to allow for detailed and large-scale evaluation. Most testbeds, however, lack opportunities for tracing distributed program execution with high accuracy in time, for example, via minimally invasive, distributed GPIO tracing. And the ones that do, like Flocklab, are built from custom hardware, which is often too complex, inflexible, or expensive to use for other research groups.This paper closes this gap and introduces Grace, a low-cost, retrofittable, distributed, and time-synchronized GPIO tracing system built from off-the-shelf components, costing less than €20 per node. Grace extends observer nodes in a testbed with (1) time-synchronization via wireless sub-GHz transceivers and (2) logic analyzers for GPIO tracing and logging, enabling time-synchronized GPIO tracing at a frequency of up to 8 MHz. We deploy Grace in a testbed and show that it achieves an average time synchronization error between nodes of 1.53 µs.
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| 2. |
- Harms, Laura, 1991, et al.
(författare)
-
Grace: Low-cost time-synchronized GPIO tracing for IoT testbeds
- 2023
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Ingår i: Computer Networks. - : Elsevier BV. - 1389-1286. ; 228
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Tidskriftsartikel (refereegranskat)abstract
- Testbeds have become a vital tool for evaluating and benchmarking applications and algorithms in the Internet of Things (IoT). IoT testbeds commonly consist of low-power IoT devices augmented with observer nodes providing control, debugging, logging, and often also power-profiling capabilities. Today, the research community operates numerous testbeds, sometimes with hundreds of IoT nodes, to allow for detailed and large-scale evaluation. Most testbeds, however, lack opportunities for tracing distributed program execution with high accuracy in time, for example, via minimally invasive, distributed GPIO tracing. And the ones that do, like Flocklab, are built from custom hardware, which is often too complex, inflexible, or expensive to use for other research groups. This paper closes this gap and introduces Grace, a low-cost, retrofittable, distributed, and time-synchronized GPIO tracing system built from off-the-shelf components, costing less than €20 per node. Grace extends observer nodes in a testbed with (1) time-synchronization via wireless sub-GHz transceivers and (2) logic analyzers for GPIO tracing and logging, enabling time-synchronized GPIO tracing at a frequency of up to 8 MHz. We deploy Grace in a testbed and evaluate it, showing that it achieves an average time synchronization error between nodes of 1.53 μs using a single time source, and 15.3 μs between nodes using different time sources, sufficient for most IoT applications.
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| 3. |
- Toenjes, Anke, et al.
(författare)
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Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
- 2009
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 18:23, s. 4662-4668
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Tidskriftsartikel (refereegranskat)abstract
- Recently, associations of several common genetic variants with height have been reported in different populations. We attempted to identify further variants associated with adult height in a self-contained population (the Sorbs in Eastern Germany) as discovery set. We performed a genome wide association study (GWAS) (similar to 390 000 genetic polymorphisms, Affymetrix gene arrays) on adult height in 929 Sorbian individuals. Subsequently, the best SNPs (P < 0.001) were taken forward to a meta-analysis together with two independent cohorts [Diabetes Genetics Initiative, British 1958 Birth Cohort, (58BC, publicly available)]. Furthermore, we genotyped our best signal for replication in two additional German cohorts (Leipzig, n = 1044 and Berlin, n = 1728). In the primary Sorbian GWAS, we identified 5 loci with a P-value < 10(-5) and 455 SNPs with P-value < 0.001. In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually. Upon replication, the SNP rs1569019 showed significant effects on height in the Leipzig cohort (P = 0.004, beta = 1.166) and in 577 men of the Berlin cohort (P = 0.049, beta = 1.127) though not in women. The combined analysis of all five cohorts (n = 6,687) resulted in a P-value of 4.7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height.
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| 4. |
- Toppila-Salmi, Sanna, et al.
(författare)
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Multi-Disciplinary Expert Perspective on the Management of Type 2 Inflammation-Driven Severe CRSwNP : A Brief Overview of Pathophysiology and Recent Clinical Insights
- 2024
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Ingår i: Journal of Asthma and Allergy. - 1178-6965. ; 17, s. 431-439
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Tidskriftsartikel (refereegranskat)abstract
- Severe chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disabling airway disease that significantly impacts patients’ lives through the severity of symptoms, the need for long-term medical treatment and the high risk of recurrence post-surgery. Biological agents targeting type 2 immune responses underlying the pathogenesis of CRSwNP have shown effectiveness in reducing polyp size and eosinophilic infiltrate, and in decreasing the need for additional sinus surgeries. However, despite recent progress in understanding and treating the disease, type 2 inflammation-driven severe CRSwNP continues to pose challenges to clinical management due to several factors such as persistent inflammation, polyp recurrence, heterogeneity of disease, and comorbidities. This article presents the findings of a scientific discussion involving a panel of ear, nose and throat (ENT) specialists and pulmonologists across Sweden and Finland. The discussion aimed to explore current management practices for type 2 inflammation-driven severe CRSwNP in the Nordic region. The main topics examined encompassed screening and referral, measurements of disease control, treatment goals, and future perspectives. The experts emphasized the importance of a collaborative approach in the management of this challenging patient population. The discussion also revealed a need to broaden treatment options for patients with type 2 inflammation-driven CRSwNP and comorbid conditions with shared type 2 pathophysiology. In light of the supporting evidence, a shift in the disease model from the presence of polyps to that of type 2 inflammation may be warranted. Overall, this discussion provides valuable insights for the scientific community and can potentially guide the future management of CRSwNP.
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| 5. |
- Trunschke, Annette, et al.
(författare)
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Towards Experimental Handbooks in Catalysis
- 2020
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Ingår i: Topics in Catalysis. - : Springer Science and Business Media LLC. - 1572-9028 .- 1022-5528. ; 63:19-20, s. 1683-1699
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Tidskriftsartikel (refereegranskat)abstract
- The “Seven Pillars” of oxidation catalysis proposed by Robert K. Grasselli represent an early example of phenomenological descriptors in the field of heterogeneous catalysis. Major advances in the theoretical description of catalytic reactions have been achieved in recent years and new catalysts are predicted today by using computational methods. To tackle the immense complexity of high-performance systems in reactions where selectivity is a major issue, analysis of scientific data by artificial intelligence and data science provides new opportunities for achieving improved understanding. Modern data analytics require data of highest quality and sufficient diversity. Existing data, however, frequently do not comply with these constraints. Therefore, new concepts of data generation and management are needed. Herein we present a basic approach in defining best practice procedures of measuring consistent data sets in heterogeneous catalysis using “handbooks”. Selective oxidation of short-chain alkanes over mixed metal oxide catalysts was selected as an example.
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