| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
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| 3. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 5. |
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| 6. |
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| 7. |
- Aamodt, K., et al.
(författare)
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The ALICE experiment at the CERN LHC
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08002
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Forskningsöversikt (refereegranskat)abstract
- ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries, Its overall dimensions are 16 x 16 x 26 m(3) with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This paper describes in detail the detector components as installed for the first data taking in the summer of 2008.
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| 8. |
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| 9. |
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| 10. |
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| 11. |
- Clark, DW, et al.
(författare)
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Associations of autozygosity with a broad range of human phenotypes
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
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Tidskriftsartikel (refereegranskat)abstract
- In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Abele, H., et al.
(författare)
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Particle physics at the European Spallation Source
- 2023
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Ingår i: Physics reports. - : Elsevier. - 0370-1573 .- 1873-6270. ; 1023, s. 1-84
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Forskningsöversikt (refereegranskat)abstract
- Presently under construction in Lund, Sweden, the European Spallation Source (ESS) will be the world’s brightest neutron source. As such, it has the potential for a particle physics program with a unique reach and which is complementary to that available at other facilities. This paper describes proposed particle physics activities for the ESS. These encompass the exploitation of both the neutrons and neutrinos produced at the ESS for high precision (sensitivity) measurements (searches).
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| 16. |
- Winkler, TW, et al.
(författare)
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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
- 2022
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1, s. 580-
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Tidskriftsartikel (refereegranskat)abstract
- Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
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| 17. |
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| 18. |
- van de Vegte, Yordi, et al.
(författare)
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Genetic insights into resting heart rate and its role in cardiovascular disease
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke. Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do not find evidence for a linear or non-linear genetic association between resting heart rate and all-cause mortality in contrast to our previous Mendelian randomization study. Systematic alteration of key differences between the current and previous Mendelian randomization study indicates that the most likely cause of the discrepancy between these studies arises from false positive findings in previous one-sample MR analyses caused by weak-instrument bias at lower P-value thresholds. The results extend our understanding of resting heart rate biology and give additional insights in its role in cardiovascular disease development.
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| 19. |
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| 20. |
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| 21. |
- Enfors, Sven-Olof, et al.
(författare)
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Physiological responses to mixing in large scale bioreactors
- 2001
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Ingår i: Journal of Biotechnology. - 0168-1656 .- 1873-4863. ; 85:2, s. 175-185
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Tidskriftsartikel (refereegranskat)abstract
- Escherichia coli fed-batch cultivations at 22 m(3) scale were compared to corresponding laboratory scale processes and cultivations using a scale-down reactor furnished with a high-glucose concentration zone to mimic the conditions in a feed zone of the large bioreactor. Formate accumulated in the large reactor, indicating the existence of oxygen limitation zones. It is suggested that the reduced biomass yield at large scale partly is due to repeated production/reassimilation of acetate from overflow metabolism and mixed acid fermentation products due to local moving zones with oxygen limitation. The conditions that generated mixed-acid fermentation in the scale-down reactor also induced a number of stress responses, monitored by analysis of mRNA of selected stress induced genes. The stress responses were relaxed when the cells returned to the substrate limited and oxygen sufficient compartment of the reactor. Corresponding analysis in the large reactor showed that the concentration of mRNA of four stress induced genes was lowest at the sampling port most distant from the feed zone. It is assumed that repeated induction/relaxation of stress responses in a large bioreactor may contribute to altered physiological properties of the cells grown in large-scale bioreactor. Flow cytometric analysis revealed reduced damage with respect to cytoplasmic membrane potential and integrity in cells grown in the dynamic environments of the large scale reactor and the scale-down reactor.
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| 22. |
- Perez-Nadales, Elena, et al.
(författare)
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Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales : The impact of cytomegalovirus disease and lymphopenia
- 2020
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Ingår i: American Journal of Transplantation. - : WILEY. - 1600-6135 .- 1600-6143. ; 20:6, s. 1629-1641
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Tidskriftsartikel (refereegranskat)abstract
- Treatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase-producing Enterobacterales bloodstream infections. A multinational, retrospective (2004-2016) cohort study (INCREMENT-SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30-day all-cause mortality. The INCREMENT-SOT-CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the following variables: INCREMENT-CPE mortality score >= 8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT-CPE score >= 8 and CMV disease (minus 7 points). This score showed an area under the receiver operating characteristic curve of 0.82 (95% confidence interval [CI] 0.76-0.88) and classified patients into 3 strata: 0-7 (low mortality), 8-11 (high mortality), and 12-17 (very-high mortality). We performed a stratified analysis of the effect of monotherapy vs combination therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very-high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13-7.06, P = .03) and high (HR 9.93, 95% CI 2.08-47.40, P = .004) mortality risk strata. A score-based algorithm is provided for therapy guidance.
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| 23. |
- Altheimer, A., et al.
(författare)
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Boosted objects and jet substructure at the LHC. Report of BOOST2012, held at IFIC Valencia, 23rd-27th of July 2012
- 2014
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 74:3
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Tidskriftsartikel (refereegranskat)abstract
- This report of the BOOST2012 workshop presents the results of four working groups that studied key aspects of jet substructure. We discuss the potential of first-principle QCD calculations to yield a precise description of the substructure of jets and study the accuracy of state-of-the-art Monte Carlo tools. Limitations of the experiments' ability to resolve substructure are evaluated, with a focus on the impact of additional (pile-up) proton proton collisions on jet substructure performance in future LHC operating scenarios. A final section summarizes the lessons learnt from jet substructure analyses in searches for new physics in the production of boosted top quarks.
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| 24. |
- Addazi, A., et al.
(författare)
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New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spallation Source
- 2021
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Ingår i: Journal of Physics G. - : Institute of Physics Publishing (IOPP). - 0954-3899 .- 1361-6471. ; 48:7
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Tidskriftsartikel (refereegranskat)abstract
- The violation of baryon number, , is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the Universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron–antineutron oscillation () via mixing, neutron–antineutron oscillation via regeneration from a sterile neutron state (), and neutron disappearance (n → n'); the effective process of neutron regeneration () is also possible. The program can be used to discover and characterize mixing in the neutron, antineutron and sterile neutron sectors. The experiment addresses topical open questions such as the origins of baryogenesis and the nature of dark matter, and is sensitive to scales of new physics substantially in excess of those available at colliders. A goal of the program is to open a discovery window to neutron conversion probabilities (sensitivities) by up to three orders of magnitude compared with previous searches. The opportunity to make such a leap in sensitivity tests should not be squandered. The experiment pulls together a diverse international team of physicists from the particle (collider and low energy) and nuclear physics communities, while also including specialists in neutronics and magnetics.
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| 25. |
- Da Ronch, A., et al.
(författare)
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Benchmarking ceasiom software to predict flight control and flying qualities of the B-747
- 2010
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Ingår i: 27th Congress of the International Council of the Aeronautical Sciences 2010, ICAS 2010. - 9781617820496 ; , s. 2906-2912
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Konferensbidrag (refereegranskat)abstract
- CEASIOM, the Computerized Environment for Aircraft Synthesis and Integrated Optimization Methods, is a framework that integrates discipline-specific tools for conceptual design. At this early stage of the design it is very useful to be able to predict the flying and handling qualities of the aircraft. In order to do this for the configuration being studied, the aerodynamic database needs to be computed and coupled to the stability and control tools to carry out the analysis. This paper describes how the adaptivefidelity CFD module of CEASIOM computes the aerodynamic database of an aircraft configuration, and how that data is analyzed by the FCSDT module to determine the flying qualities and the control laws of the aircraft. The paper compares the predicted flying qualities with the flight-test data of the Boeing B747 aircraft in order to verify the goodness of the overall approach.
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| 26. |
- Gorski, Mathias, et al.
(författare)
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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
- 2022
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Ingår i: Kidney International. - : Elsevier. - 0085-2538 .- 1523-1755. ; 102:3, s. 624-639
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Tidskriftsartikel (refereegranskat)abstract
- Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genomewide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR- baseline (11 novel, one known for this phenotype), including nine variants robustly associated across models were identified. All loci for eGFR-decline were known for cross-sectional eGFR and thus distinguished a subgroup of eGFR loci. Seven of the nine variants showed variant- by-age interaction on eGFR cross section (further about 350,000 individuals), which linked genetic associations for eGFR-decline with agedependency of genetic cross- section associations. Clinically important were two to four-fold greater genetic effects on eGFR-decline in high-risk subgroups. Five variants associated also with chronic kidney disease progression mapped to genes with functional in- silico evidence (UMOD, SPATA7, GALNTL5, TPPP). An unfavorable versus favorable nine-variant genetic profile showed increased risk odds ratios of 1.35 for kidney failure (95% confidence intervals 1.03- 1.77) and 1.27 for acute kidney injury (95% confidence intervals 1.08-1.50) in over 2000 cases each, with matched controls). Thus, we provide a large data resource, genetic loci, and prioritized genes for kidney function decline, which help inform drug development pipelines revealing important insights into the age-dependency of kidney function genetics.
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| 27. |
- Oppo, C. I., et al.
(författare)
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Polarity dependent strongly inhomogeneous In-incorporation in GaN nanocolumns
- 2016
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Ingår i: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 27:35
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Tidskriftsartikel (refereegranskat)abstract
- In this work, GaN/InGaN/GaN nanocolumns (NCs) have been grown by molecular beam epitaxy. Selective area growth (SAG) and self-organized growth (SOG) were performed simultaneously in patterned and unpatterned regions of the same substrate, respectively. The resulting structures show different tip morphologies and structural properties due to the different polarity along the growth direction, namely Ga-polar with r-plane faceted tips for the SAG NCs and N-polar with c-plane top facet for the SOG ones. When growing Ga-polar GaN/InGaN NCs, no indium is incorporated at a substrate temperature of °C. Rather, indium incorporation takes place under the same growth conditions on the N-polar NCs. The In-incorporation is investigated by means of nano x-ray fluorescence and diffraction, high-angle annular dark-field scanning transmission electron microscopy and high-resolution transmission electron microscopy.
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| 28. |
- Rizzi, Maria C, et al.
(författare)
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The potential of different countermeasures to prevent injuries with high risk of health loss among bicyclists in Sweden
- 2020
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Ingår i: Traffic Injury Prevention. - : Informa UK Limited. - 1538-9588 .- 1538-957X. ; 21:3, s. 215-221
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: As bicyclists account for the largest share of serious injuries in Sweden, focus to improve safety for bicyclists is needed. While knowledge about fatal bicycle crashes is rather extensive, the number of studies that have investigated non-fatal injuries is still rather limited. The aim of this study was to estimate the potential of different countermeasures to reduce crashes resulting in injuries with high risk of health-loss among cyclists in Sweden. A further aim was to describe the residual—that is, crashes that were not considered to be addressed by the analyzed countermeasures. Methods: A sample of individuals with specific injury diagnoses was drawn from the Swedish national crash database Strada. A survey form was used to collect additional information about the crash and the health-related outcomes. The potential of countermeasures currently included in the Swedish Safety Performance Indicators, as well as of countermeasures that could be described as “existing but not fully implemented” was assessed. The overall potential of all countermeasures assessed was calculated, giving a grand total without double counting. Cases that were considered not to be addressed by any of the countermeasures included (i.e., the residual crashes) were described in more detail. Results: The current Swedish Safety Performance Indicators that relate to safe cycling addressed 22% of crashes. Improved maintenance by deicing and removal of snow from bicycle infrastructure was found to have the highest potential (8%), followed by improved crashworthiness of passenger cars (5%) and safer bicycle crossings (4%). The potential for existing but not fully implemented safety improvements was 56%. The greatest potential was found for Autonomous Emergency Braking with cyclist detection for passenger cars (12%), followed by studded winter tyres for bicycles (12%), and improved maintenance on non-bicycle infrastructure (11%). In total, taking double counting into consideration, all safety improvements could address 64% of all crashes. Among the residual crashes, the majority (69%) were single bicycle crashes of which most were related to wheel locking during braking and losing balance at low speed or stationary. Conclusions: Compared with fatal crashes that involve a majority of bicycle-car crashes, the crashes leading to health-loss are mostly single bicycle crashes. Therefore, innovation and development of additional countermeasures to improve safety for bicyclists should focus on single bicycle crashes.
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| 29. |
- Santoro, V., et al.
(författare)
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DEVELOPMENT OF A HIGH INTENSITY NEUTRON SOURCE AT THE EUROPEAN SPALLATION SOURCE : THE HIGHNESS PROJECT
- 2022
-
Ingår i: Proceedings of the 14th International Topical Meeting on Nuclear Applications of Accelerators, AccApp 2021, Embedded with the 2021 ANS Winter Meeting. - 9780894487842 ; , s. 11-20
-
Konferensbidrag (refereegranskat)abstract
- The European Spallation Source (ESS), presently under construction in Lund, Sweden, is a multidisciplinary international laboratory that will operate the world’s most powerful pulsed neutron source. Supported by a 3M Euro Research and Innovation Action within the EU Horizon 2020 program, a design study (HighNESS) is now underway to develop a second neutron source below the spallation target. Compared to the first source, located above the spallation target and designed for high cold and thermal brightness, the new source will provide higher intensity, and a shift to longer wavelengths in the spectral regions of cold (2-20 Å), very cold (VCN, 10-120 Å), and ultra cold (UCN, > 500 Å) neutrons. The core of the second source will consist of a large liquid deuterium moderator to deliver a high flux of cold neutrons and to serve secondary VCN and UCN sources, for which different options are under study. The features of these new sources will boost several areas of condensed matter research and will provide unique opportunities in fundamental physics. Part of the HighNESS project is also dedicated to the development of future instruments that will make use of the new source and will complement the initial suite of instruments in construction at ESS. The HighNESS project started in October 2020. In this paper, the ongoing developments and the results obtained in the first year are described.
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| 30. |
- Santoro, V., et al.
(författare)
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HighNESS conceptual design report: Volume I
- 2024
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Ingår i: Journal of Neutron Research. - 1023-8166 .- 1477-2655. ; 25:3-4, s. 85-314
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Tidskriftsartikel (refereegranskat)abstract
- The European Spallation Source, currently under construction in Lund, Sweden, is a multidisciplinary international laboratory. Once completed to full specifications, it will operate the world’s most powerful pulsed neutron source. Supported by a 3 million Euro Research and Innovation Action within the EU Horizon 2020 program, a design study (HighNESS) has been completed to develop a second neutron source located below the spallation target. Compared to the first source, designed for high cold and thermal brightness, the new source has been optimized to deliver higher intensity, and a shift to longer wavelengths in the spectral regions of cold (CN, 2–20 Å), very cold (VCN, 10–120 Å), and ultracold (UCN, >500 Å) neutrons. The second source comprises a large liquid deuterium moderator designed to produce CN and support secondary VCN and UCN sources. Various options have been explored in the proposed designs, aiming for world-leading performance in neutronics. These designs will enable the development of several new instrument concepts and facilitate the implementation of a high-sensitivity neutron-antineutron oscillation experiment (NNBAR). This document serves as the Conceptual Design Report for the HighNESS project, representing its final deliverable.
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| 31. |
- Santoro, V., et al.
(författare)
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HighNESS conceptual design report: Volume II. the NNBAR experiment.
- 2024
-
Ingår i: Journal of Neutron Research. - 1023-8166 .- 1477-2655. ; 25:3-4, s. 315-406
-
Tidskriftsartikel (refereegranskat)abstract
- A key aim of the HighNESS project for the European Spallation Source is to enable cutting-edge particle physics experiments. This volume presents a conceptual design report for the NNBAR experiment. NNBAR would exploit a new cold lower moderator to make the first search in over thirty years for free neutrons converting to anti-neutrons. The observation of such a baryon-number-violating signature would be of fundamental significance and tackle open questions in modern physics, including the origin of the matter-antimatter asymmetry. This report shows the design of the beamline, supermirror focusing system, magnetic and radiation shielding, and anti-neutron detector necessary for the experiment. A range of simulation programs are employed to quantify the performance of the experiment and show how background can be suppressed. For a search with full background suppression, a sensitivity improvement of three orders of magnitude is expected, as compared with the previous search. Civil engineering studies for the NNBAR beamline are also shown, as is a costing model for the experiment.
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| 32. |
- Santoro, V., et al.
(författare)
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The HighNESS Project at the European Spallation Source : Current Status and Future Perspectives
- 2024
-
Ingår i: Nuclear science and engineering. - 0029-5639 .- 1943-748X. ; 198:1, s. 31-63
-
Tidskriftsartikel (refereegranskat)abstract
- The European Spallation Source (ESS), presently under construction in Lund, Sweden, is a multidisciplinary international laboratory that, once completed at full specifications, will operate the world's most powerful pulsed neutron source. Supported by a 3 M Euro Research and Innovation Action within the European Union Horizon 2020 program, a design study (HighNESS) is now underway to develop a second neutron source located below the spallation target. Compared to the first source, which is located above the spallation target and designed for high cold and thermal brightness, the new source is being optimized to deliver higher intensity and a shift to longer wavelengths in the spectral regions of cold neutrons (CNs) (2 to 20 & Aring;), very cold neutrons (VCNs) (10 to 120 & Aring;), and ultracold neutrons (UCNs) (> 500 & Aring;). The second source consists of a large liquid deuterium moderator to deliver CNs and serve secondary VCN and UCN sources, for which different options are under study. These new sources will boost several areas of condensed matter research and will provide unique opportunities in fundamental physics. The HighNESS project is now entering its last year, and we are working toward the Conceptual Design Report of the ESS upgrade. In this paper, results obtained in the first 2 years, ongoing developments, and future perspectives are described.
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| 33. |
- Verhaaren, C. B., et al.
(författare)
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Searches for Long-Lived Particles at the Future FCC-ee
- 2022
-
Ingår i: Frontiers in Physics. - : Frontiers Media S.A.. - 2296-424X. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- The electron-positron stage of the Future Circular Collider, FCC-ee, is a frontier factory for Higgs, top, electroweak, and flavour physics. It is designed to operate in a 100 km circular tunnel built at CERN, and will serve as the first step towards ≥100 TeV proton-proton collisions. In addition to an essential and unique Higgs program, it offers powerful opportunities to discover direct or indirect evidence of physics beyond the Standard Model. Direct searches for long-lived particles at FCC-ee could be particularly fertile in the high-luminosity Z run, where 5 × 1012 Z bosons are anticipated to be produced for the configuration with two interaction points. The high statistics of Higgs bosons, W bosons and top quarks in very clean experimental conditions could offer additional opportunities at other collision energies. Three physics cases producing long-lived signatures at FCC-ee are highlighted and studied in this paper: heavy neutral leptons (HNLs), axion-like particles (ALPs), and exotic decays of the Higgs boson. These searches motivate out-of-the-box optimization of experimental conditions and analysis techniques, which could lead to improvements in other physics searches.
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| 34. |
- Wuttke, Matthias, et al.
(författare)
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A catalog of genetic loci associated with kidney function from analyses of a million individuals
- 2019
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Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
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| 35. |
- Algurén, Beatrix, 1977, et al.
(författare)
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In-depth understanding of single bicycle crashes in Sweden : Crash characteristics, injury types and health outcomes differentiated by gender and age-groups
- 2022
-
Ingår i: Journal of Transport & Health. - : Elsevier. - 2214-1405 .- 2214-1413. ; 24
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: To study in-depth characteristics of single bicycle crashes and type of injuries considering gender and age differences. Methods: Hospital reported bicycle crashes identified in the Swedish national database STRADA were combined with self-reported detailed information regarding crash circumstances and injury outcomes. Gender and age-group differences were investigated using univariate statistics and Pearson Chi- Square test. Results: A total of 616 cyclists injured in single bicycle crashes between 2013 and 2017 were included. Participants (49% women) had a mean age of 58 years (ranged 15–89 years), most rode a comfort bike (54%) and cycled several times a week (81%). The most common crash type was skidding on ice or snow (26%). This crash type was significantly more common among women than men (30% versus 21%). Women more than twice as often lost balance at low or no speed (13% versus 5%). While men's injuries were located more than twice as often at shoulder and upper arm (28% versus 11%), women injured more than four times as often the lower leg and ankle (30% versus 7%). Differences regarding age-groups could be observed as an exponential increase of hip and upper leg injuries with increased age (9, 19 and 38%). Older cyclists were more often injured while losing balance at no or low speed and while getting on or off the bicycle. Conclusions: Concrete countermeasures to prevent injuries in single bicycle crashes can be suggested and directed to different target groups, i.e. women or men or younger or elderly.
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| 36. |
- Algurén, Beatrix, 1977, et al.
(författare)
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In-depth understanding of single bicycle crashes in Sweden - Crash characteristics, injury types and health outcomes differentiated by gender and age-groups
- 2022
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Ingår i: Journal of Transport and Health. - : Elsevier BV. - 2214-1405. ; 24
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Tidskriftsartikel (refereegranskat)abstract
- To study in-depth characteristics of single bicycle crashes and type of injuries considering gender and age differences. Methods: Hospital reported bicycle crashes identified in the Swedish national database STRADA were combined with self-reported detailed information regarding crash circumstances and injury outcomes. Gender and age-group differences were investigated using univariate statistics and Pearson Chi- Square test. Results: A total of 616 cyclists injured in single bicycle crashes between 2013 and 2017 were included. Participants (49% women) had a mean age of 58 years (ranged 15–89 years), most rode a comfort bike (54%) and cycled several times a week (81%). The most common crash type was skidding on ice or snow (26%). This crash type was significantly more common among women than men (30% versus 21%). Women more than twice as often lost balance at low or no speed (13% versus 5%). While men's injuries were located more than twice as often at shoulder and upper arm (28% versus 11%), women injured more than four times as often the lower leg and ankle (30% versus 7%). Differences regarding age-groups could be observed as an exponential increase of hip and upper leg injuries with increased age (9, 19 and 38%). Older cyclists were more often injured while losing balance at no or low speed and while getting on or off the bicycle. Conclusions: Concrete countermeasures to prevent injuries in single bicycle crashes can be suggested and directed to different target groups, i.e. women or men or younger or elderly.
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| 37. |
- Backman, Filip, 1991-, et al.
(författare)
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The development of the NNBAR experiment
- 2022
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Ingår i: Journal of Instrumentation. - : Institute of Physics (IOP). - 1748-0221. ; 17:10
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Tidskriftsartikel (refereegranskat)abstract
- The NNBAR experiment for the European Spallation Source will search for free neutrons converting to antineutrons with a sensitivity improvement of three orders of magnitude compared to the last such search. This paper describes progress towards a conceptual design report for NNBAR. The design of a moderator, neutron reflector, beamline, shielding and annihilation detector is reported. The simulations used form part of a model which will be used for optimisation of the experiment design and quantification of its sensitivity.
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| 38. |
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| 39. |
- Bertoni, Marco, et al.
(författare)
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PLM paradigm : how to lead BPR within product development field
- 2009
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Ingår i: Computers in industry (Print). - : Elsevier BV. - 0166-3615 .- 1872-6194. ; 60:7, s. 476-484
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Tidskriftsartikel (refereegranskat)abstract
- The design and implementation of a PLM solution in a cross-company environment is a complex and labour intensive operation, which is often coupled with a Business Process Re-engineering (BPR) project to better deploy technologies as well as methodologies and to target the system implementation on the real company needs. Enterprise Modelling (EM) languages are typically used to collect and share process knowledge among the BPR participants. Plenty of techniques are actually available at this scope and it is not always easy to understand how to select and use them in the different steps of re-engineering. The main purpose of this paper is to perform a qualitative analysis of three well known EM languages (IDEF, UML and ARIS) and to propose a new methodology, based on their integrated use, supporting BPR efforts in the Product Development domain.
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| 40. |
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| 41. |
- Eriksson, Jenny, 1975-, et al.
(författare)
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Oskyddade trafikanters inblandning i olyckor och deras skadeutfall : en jämförande studie mellan fotgängare, cyklister, mopedister och motorcyklister
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I tidigare arbete för säker gång-, cykel- och mopedtrafik har faktaunderlag tagits fram för olyckor och skador. Det finns en stor efterfrågan på uppdaterade analyser samt att utvidga innehållet till mopedister och motorcyklister. Syftet är dels att se över klassificeringsmetoden, dels att öka kunskapen om oskyddade trafikanters inblandning i olyckor och deras skador. Olycksunderlaget är hämtat från olycksdatabasen Strada, främst från sjukvården, för åren 2014–2019. Resvanedata är hämtade från den nationella resvaneundersökningen RVU Sverige 2011–2016. Måttet allvarligt skadad används och med det menas att personen bedöms få en framtida medicinsk invaliditet på minst en procent. Under aktuell sexårsperiod blev 19 042 fotgängare, 11 195 cyklister, 1 325 mopedister och 1 393 motorcyklister allvarligt skadade. En majoritet av dessa var singelolyckor. Fotgängare bestod av en övervägande del kvinnor i åldern 45 år och äldre. För cyklister var det något fler män som skadades allvarligt och åldersgruppen 10–14 år hade högst andel allvarligt skadade. De allvarligt skadade mopedisterna bestod av en övervägande del män och över hälften var i åldern 15–17 år. Nio av tio allvarligt skadade motorcyklister var män och de flesta var i åldern 25–64 år. Oavsett trafikantgrupp var det vanligaste ärendet fritid vid skadetillfället. Halka var bland den vanligaste uppgivna orsaken, mellan 30–60 procent, där snö/is var vanligast för fotgängare, snö/is och löst grus för cyklister och löst grus för mopedister och motorcyklister. Ojämnt/hål och gropar var också något som var vanligt, mellan 9 och 17 procent beroende på trafikantkategori. För cyklister, mopedister och motorcyklister var följande angivna orsak vanlig för singelolyckor utöver halka: • Väjt för annan trafikant, mellan 6–11 procent, • inbromsning 6–22 procent, • svängt/kurva 9–30 procent. Risken att skadas allvarligt per resa är högst bland motorcyklister och per en miljon kilometer var det mopedister.
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| 42. |
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| 43. |
- Lackner, Christian, et al.
(författare)
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Tram to Pedestrian Collisions—Priorities and Potentials
- 2022
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Ingår i: Frontiers in Future Transportation. - : Frontiers Media SA. - 2673-5210. ; 3
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Tidskriftsartikel (refereegranskat)abstract
- To improve mobility in cities in line with environmental goals, in urban traffic, trams represent an increasingly important means of transport. Due to the close interaction with other road users, this makes collisions with trams fairly frequent. This study has investigated accidents between trams and vulnerable road users resulting in personal injury, aimed at identifying priorities for simulating collisions between trams and pedestrians to assess passive safety measures. Tram accident data collection established throughout Europe from multiple sources and with varying degree of details, have been combined and analysed. These analyses comprise risk assessments per km-driven and general tram accident partner and site type evaluations, with more detailed analyses on accident site distance to the closest tram stop and injured body regions, respectively. In total, 7,535 tram-pedestrian accident resulting in 8,802 pedestrian injuries, collected in the year 2000–2021, was analysed. Accident risk ranges from 0.934 accidents per number of tram (million) km-driven, for slight injuries to 0.063 for fatal injuries. Pedestrians represent a large proportion of tram accident collision partners, especially for severe and fatal accidents. In accidents between trams and pedestrians, 3% of reported injuries are fatal, 23% severe and 74% minor. Generally, low-speed accidents close to tram stops often leading to minor injuries were observed to be of significant importance (<20m to the GPS location of a stop). Analysis of accidents was done bases on gender of the pedestrian showing overall similar involvements in accident with slight difference for various age groups and sites. Regardless of injury severity, the most frequently injured body region in accidents involving a tram is the head. Likewise, injuries sustained to the thorax, especially for higher injury severities are of high relevance, followed by injuries to the lower extremities. Based on this study, recommendations for developing reasonable tram-pedestrian accident scenarios for virtual testing can be derived for further optimisation of pedestrian safety of trams.
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| 44. |
- Leo, Christoph, et al.
(författare)
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Are There Any Significant Differences in Terms of Age and Sex in Pedestrian and Cyclist Accidents?
- 2021
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Ingår i: Frontiers in Bioengineering and Biotechnology. - : Frontiers Media SA. - 2296-4185. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- This study has analyzed sex-specific differences in pedestrian and cyclist accidents involving passenger cars. The most frequently injured body regions, types of injuries, which show sex-specific differences and the general accident parameters of females and males were compared. Accident data from three different European countries (Austria, Netherlands, Sweden) were analyzed. The current analysis shows that for both, females and males, pedestrian and cyclist injuries are sustained mainly to the body regions head, thorax, upper extremities and lower extremities. The results show that the odds for sustaining skeletal injuries to the lower extremities (incl. pelvis) in females are significantly higher. It was observed in all datasets, that the odds of females being involved in a rural accident or an accident at night are lower than for males. Elderly pedestrian and cyclist (≥60YO) tend to sustain more severe injuries (AIS2+ and AIS3+) than younger pedestrian and cyclists (
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| 45. |
- Linder, Astrid, 1959, et al.
(författare)
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VIRTUAL - a European approach to foster the uptake of virtual testing in vehicle safety assessment
- 2020
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Ingår i: Proceedings of 8th Transport Research Arena TRA 2020.
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Konferensbidrag (refereegranskat)abstract
- In the assessment of road user and vehicle occupant safety, physical testing is limited to a few scenarios. To advance transport safety it is vital to include more relevant scenarios. Virtual Testing offers an opportunity to introduce additional test scenarios. The objectives of the VIRTUAL project, described in this paper, include: Identifying impact scenarios relevant for the future, providing tools such as models, guidelines, and a corresponding platform to foster the uptake of virtual testing. The safety of standing passengers on public transport has been reviewed, scenarios for Vulnerable Road User testing have been identified and new seated positions for future vehicles have been described. In addition, a virtual testing platform has been established on which human body models are provided. The platform follows the open access approach, complements other approaches and does not just provide the models, but also guidelines on how to implement new scenarios in test procedures.
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| 46. |
- Mendenhall, M.R., et al.
(författare)
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Comparing and benchmarking engineering methods for the prediction of X-31 aerodynamics
- 2012
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Ingår i: Aerospace Science and Technology. - : Elsevier BV. - 1270-9638 .- 1626-3219. ; 20:1, s. 12-20
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Tidskriftsartikel (refereegranskat)abstract
- A number of useful engineering methods are available for fast and economic estimates of the aerodynamic characteristics of complex flight vehicles. This article investigates the application of three specific engineering methods to the X-31 fighter configuration, and CFD, wind tunnel, and flight test data are used for comparison and evaluation purposes. The emphasis is on static longitudinal stability aspects up to high angles of attack; however, selected asymmetric and unsteady effects are considered. Results from the engineering methods are in good agreement with experiment and CFD for angles of attack up to 15° for most cases and higher angles for some cases. Results for pitching moment are in good agreement with CFD, but many of the nonlinear characteristics of the airplane are not predicted by the engineering methods. The quality of the longitudinal stability results is discussed in terms of the prediction of the center of pressure on the vehicle. The results provide improved understanding of the continued usefulness of engineering methods as an analysis tool during the design phase and into the flight test diagnostic phase of a new aircraft.
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| 47. |
- Osterborg, Anders, et al.
(författare)
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Ofatumumab retreatment and maintenance in fludarabine-refractory chronic lymphocytic leukaemia patients
- 2015
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 170:1, s. 40-49
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Tidskriftsartikel (refereegranskat)abstract
- There are limited data on retreatment with monoclonal antibodies (mAb) in patients with chronic lymphocytic leukaemia (CLL). In a pivotal study, ofatumumab (human anti-CD20 mAb) monotherapy demonstrated a 47% objective response rate (ORR) in fludarabine refractory CLL patients. From this study, a subset of 29 patients who had at least stable disease and then progressed were retreated with eight weekly ofatumumab infusions (induction treatment period), followed by monthly infusions for up to 2years (maintenance treatment period). The ORR after 8weeks of induction retreatment was 45% and 24% had continued disease control after maintenance at 52weeks. Efficacy and safety of the retreated patients were compared with their initial results in the pivotal study. Response duration was 241months vs. 68months; time to next therapy was 148months vs. 123months; and progression-free survival was 74months vs. 79months (medians). Upon retreatment, 72% had infusion reactions, mostly Grade 1-2. Three patients had fatal infections. In summary, ofatumumab retreatment and maintenance therapy was feasible in patients with heavily pretreated CLL and appeared to result in more durable disease control than initial ofatumumab treatment in this subset of patients who may have a more favourable disease profile.
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| 48. |
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| 49. |
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| 50. |
- Pierrotti, Ligia C., et al.
(författare)
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Efficacy of beta-lactam/beta-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project)
- 2021
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Ingår i: Transplant Infectious Disease. - : John Wiley & Sons. - 1398-2273 .- 1399-3062. ; 23:3
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Tidskriftsartikel (refereegranskat)abstract
- Background Whether active therapy with beta-lactam/beta-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney transplant recipients (KTRs) remains unclear. Methods We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively. Results Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count <= 500 cells/mu L at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%, mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes. Conclusions Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be excluded (ClinicalTrials.gov identifier: NCT02852902).
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