| 1. |
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| 2. |
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| 3. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 4. |
- Perez, P., et al.
(författare)
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The GBAR antimatter gravity experiment
- 2015
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Ingår i: Hyperfine Interactions. - : Springer Science and Business Media LLC. - 0304-3843 .- 1572-9540. ; , s. 21-27
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Konferensbidrag (refereegranskat)abstract
- The GBAR project (Gravitational Behaviour of Anti hydrogen at Rest) at CERN, aims to measure the free fall acceleration of ultracold neutral anti hydrogen atoms in the terrestrial gravitational field. The experiment consists preparing anti hydrogen ions (one antiproton and two positrons) and sympathetically cooling them with Be (+) ions to less than 10 mu K. The ultracold ions will then be photo-ionized just above threshold, and the free fall time over a known distance measured. We will describe the project, the accuracy that can be reached by standard techniques, and discuss a possible improvement to reduce the vertical velocity spread.
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| 5. |
- Eiroa, C., et al.
(författare)
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Cold DUst around NEarby Stars (DUNES). First results A resolved exo-Kuiper belt around the solar-like star zeta(2) Ret
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L131-
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Tidskriftsartikel (refereegranskat)abstract
- We present the first far-IR observations of the solar-type stars delta Pav, HR 8501, 51 Peg and zeta(2) Ret, taken within the context of the DUNES Herschel open time key programme (OTKP). This project uses the PACS and SPIRE instruments with the objective of studying infrared excesses due to exo-Kuiper belts around nearby solar-type stars. The observed 100 mu m fluxes from delta Pav, HR 8501, and 51 Peg agree with the predicted photospheric fluxes, excluding debris disks brighter than L-dust/L-star similar to 5 x 10(-7) (1 sigma level) around those stars. A flattened, disk-like structure with a semi-major axis of similar to 100 AU in size is detected around zeta(2) Ret. The resolved structure suggests the presence of an eccentric dust ring, which we interpret as an exo-Kuiper belt with L-dust/L-star approximate to 10(-5).
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| 6. |
- Eiroa, C., et al.
(författare)
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DUst around NEarby Stars. The survey observational results
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 555, s. A11-
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Tidskriftsartikel (refereegranskat)abstract
- Context. Debris discs are a consequence of the planet formation process and constitute the fingerprints of planetesimal systems. Their solar system counterparts are the asteroid and Edgeworth-Kuiper belts. Aims. The DUNES survey aims at detecting extra-solar analogues to the Edgeworth-Kuiper belt around solar-type stars, putting in this way the solar system into context. The survey allows us to address some questions related to the prevalence and properties of planetesimal systems. Methods. We used Herschel/PACS to observe a sample of nearby FGK stars. Data at 100 and 160 mu m were obtained, complemented in some cases with observations at 70 mu m, and at 250, 350 and 500 mu m using SPIRE. The observing strategy was to integrate as deep as possible at 100 mu m to detect the stellar photosphere. Results. Debris discs have been detected at a fractional luminosity level down to several times that of the Edgeworth-Kuiper belt. The incidence rate of discs around the DUNES stars is increased from a rate of similar to 12.1% +/- 5% before Herschel to similar to 20.2% +/- 2%. A significant fraction (similar to 52%) of the discs are resolved, which represents an enormous step ahead from the previously known resolved discs. Some stars are associated with faint far-IR excesses attributed to a new class of cold discs. Although it cannot be excluded that these excesses are produced by coincidental alignment of background galaxies, statistical arguments suggest that at least some of them are true debris discs. Some discs display peculiar SEDs with spectral indexes in the 70-160 mu m range steeper than the Rayleigh-Jeans one. An analysis of the debris disc parameters suggests that a decrease might exist of the mean black body radius from the F-type to the K-type stars. In addition, a weak trend is suggested for a correlation of disc sizes and an anticorrelation of disc temperatures with the stellar age.
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| 7. |
- Eiroa, C., et al.
(författare)
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Exocomet signatures around the A-shell star φ Leonis?
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 594
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Tidskriftsartikel (refereegranskat)abstract
- We present an intensive monitoring of high-resolution spectra of the Ca ii K line in the A7IV shell star φ Leo at very short (minutes, hours), short (night to night), and medium (weeks, months) timescales. The spectra show remarkable variable absorptions on timescales of hours, days, and months. The characteristics of these sporadic events are very similar to most that are observed toward the debris disk host star β Pic, which are commonly interpreted as signs of the evaporation of solid, comet-like bodies grazing or falling onto the star. Therefore, our results suggest the presence of solid bodies around φ Leo. To our knowledge, with the exception of β Pic, our monitoring has the best time resolution at the mentioned timescales for a star with events attributed to exocomets. Assuming the cometary scenario and considering the timescales of our monitoring, our results indicate that φ Leo presents the richest environment with comet-like events known to date, second only to β Pic.
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| 8. |
- Dent, W. R. F., et al.
(författare)
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GASPS-A Herschel Survey of Gas and Dust in Protoplanetary Disks: Summary and Initial Statistics
- 2013
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Ingår i: Publications of the Astronomical Society of the Pacific. - : IOP Publishing. - 0004-6280 .- 1538-3873. ; 125:927, s. 477-505
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Tidskriftsartikel (refereegranskat)abstract
- We describe a large-scale far-infrared line and continuum survey of protoplanetary disk through to young debris disk systems carried out using the ACS instrument on the Herschel Space Observatory. This Open Time Key program, known as GASPS (Gas Survey of Protoplanetary Systems), targeted similar to 250 young stars in narrow wavelength regions covering the [OI] fine structure line at 63 mu m the brightest far-infrared line in such objects. A subset of the brightest targets were also surveyed in [OI]145 mu m, [CII] at 157 mu m, as well as several transitions of H2O and high-excitation CO lines at selected wavelengths between 78 and 180 mu m. Additionally, GASPS included continuum photometry at 70, 100 and 160 mu m, around the peak of the dust emission. The targets were SED Class II-III T Tauri stars and debris disks from seven nearby young associations, along with a comparable sample of isolated Herbig AeBe stars. The aim was to study the global gas and dust content in a wide sample of circumstellar disks, combining the results with models in a systematic way. In this overview paper we review the scientific aims, target selection and observing strategy of the program. We summarise some of the initial results, showing line identifications, listing the detections, and giving a first statistical study of line detectability. The [OI] line at 63 mu m was the brightest line seen in almost all objects, by a factor of similar to 10. Overall [OI]63 mu m detection rates were 49%, with 100% of HAeBe stars and 43% of T Tauri stars detected. A comparison with published disk dust masses (derived mainly from sub-mm continuum, assuming standard values of the mm mass opacity) shows a dust mass threshold for [OI] 63 mu m detection of similar to 10(-5) M-circle dot. Normalising to a distance of 140 pc, 84% of objects with dust masses >= 10(-5) M-circle dot can be detected in this line in the present survey; 32% of those of mass 10(-6)-10(-5) M-circle dot, and only a very small number of unusual objects with lower masses can be detected. This is consistent with models with a moderate UV excess and disk flaring. For a given disk mass, [OI] detectability is lower for M stars compared with earlier spectral types. Both the continuum and line emission was, in most systems, spatially and spectrally unresolved and centred on the star, suggesting that emission in most cases was from the disk. Approximately 10 objects showed resolved emission, most likely from outflows. In the GASPS sample, [OI] detection rates in T Tauri associations in the 0.3-4 Myr age range were similar to 50%. For each association in the 5-20 Myr age range, similar to 2 stars remain detectable in [OI]63 mu m, and no systems were detected in associations with age >20 Myr. Comparing with the total number of young stars in each association, and assuming a ISM-like gas/dust ratio, this indicates that similar to 18% of stars retain a gas-rich disk of total mass similar to 1 M-Jupiter for 1-4 Myr, 1-7% keep such disks for 5-10 Myr, but none are detected beyond 10-20 Myr. The brightest [OI] objects from GASPS were also observed in [OI]145 mu m, [CII]157 mu m and CO J = 18 - 17, with detection rates of 20-40%. Detection of the [CII] line was not correlated with disk mass, suggesting it arises more commonly from a compact remnant envelope.
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| 9. |
- Eiroa, C., et al.
(författare)
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Herschel discovery of a new class of cold, faint debris discs
- 2011
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 536
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Tidskriftsartikel (refereegranskat)abstract
- We present Herschel PACS 100 and 160 mu m observations of the solar-type stars alpha Men, HD 88230 and HD 210277, which form part of the FGK stars sample of the Herschel open time key programme (OTKP) DUNES (DUst around NEarby S tars). Our observations show small infrared excesses at 160 mu m for all three stars. HD 210277 also shows a small excess at 100 mu m, while the 100 mu m fluxes of alpha Men and HD 88230 agree with the stellar photospheric predictions. We attribute these infrared excesses to a new class of cold, faint debris discs. Both alpha Men and HD 88230 are spatially resolved in the PACS 160 mu m images, while HD 210277 is point-like at that wavelength. The projected linear sizes of the extended emission lie in the range from similar to 115 to
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| 10. |
- Krivov, A., et al.
(författare)
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HERSCHEL's "COLD DEBRIS DISKS": BACKGROUND GALAXIES OR QUIESCENT RIMS OF PLANETARY SYSTEMS?
- 2013
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 772:1
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Tidskriftsartikel (refereegranskat)abstract
- Infrared excesses associated with debris disk host stars detected so far peak at wavelengths around similar to 100 mu m or shorter. However, 6 out of 31 excess sources studied in the Herschel Open Time Key Programme, DUNES, have been seen to show significant-and in some cases extended-excess emission at 160 mu m, which is larger than the 100 mu m excess. This excess emission has been attributed to circumstellar dust and has been suggested to stem from debris disks colder than those known previously. Since the excess emission of the cold disk candidates is extremely weak, challenging even the unrivaled sensitivity of Herschel, it is prudent to carefully consider whether some or even all of them may represent unrelated galactic or extragalactic emission, or even instrumental noise. We re-address these issues using several distinct methods and conclude that it is highly unlikely that none of the candidates represents a true circumstellar disk. For true disks, both the dust temperatures inferred from the spectral energy distributions and the disk radii estimated from the images suggest that the dust is nearly as cold as a blackbody. This requires the grains to be larger than similar to 100 mu m, even if they are rich in ices or are composed of any other material with a low absorption in the visible. The dearth of small grains is puzzling, since collisional models of debris disks predict that grains of all sizes down to several times the radiation pressure blowout limit should be present. We explore several conceivable scenarios: transport-dominated disks, disks of low dynamical excitation, and disks of unstirred primordial macroscopic grains. Our qualitative analysis and collisional simulations rule out the first two of these scenarios, but show the feasibility of the third one. We show that such disks can indeed survive for gigayears, largely preserving the primordial size distribution. They should be composed of macroscopic solids larger than millimeters, but smaller than a few kilometers in size. If larger planetesimals were present, then they would stir the disk, triggering a collisional cascade and thus causing production of small debris, which is not seen. Thus, planetesimal formation, at least in the outer regions of the systems, has stopped before "cometary" or "asteroidal" sizes were reached.
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| 11. |
- Liseau, René, 1949, et al.
(författare)
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Resolving the cold debris disc around a planet-hosting star. PACS photometric imaging observations of q1 Eridani (HD 10647, HR 506)
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L132
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Tidskriftsartikel (refereegranskat)abstract
- Context. About two dozen exo-solar debris systems have been spatially resolved. These debris discs commonly display a variety of structural features such as clumps, rings, belts, excentric distributions and spiral patterns. In most cases, these features are believed to be formed, shaped and maintained by the dynamical influence of planets orbiting the host stars. In very few cases has the presence of the dynamically important planet(s) been inferred from direct observation. Aims. The solar-type star q(1) Eri is known to be surrounded by debris, extended on scales of less than or similar to 30 ''. The star is also known to host at least one planet, albeit on an orbit far too small to make it responsible for structures at distances of tens to hundreds of AU. The aim of the present investigation is twofold: to determine the optical and material properties of the debris and to infer the spatial distribution of the dust, which may hint at the presence of additional planets. Methods. The Photodetector Array Camera and Spectrometer (PACS) aboard the Herschel Space Observatory allows imaging observations in the far infrared at unprecedented resolution, i.e. at better than 6 '' to 12 '' over the wavelength range of 60 mu m to 210 mu m. Together with the results from ground-based observations, these spatially resolved data can be modelled to determine the nature of the debris and its evolution more reliably than what would be possible from unresolved data alone. Results. For the first time has the q(1) Eri disc been resolved at far infrared wavelengths. The PACS observations at 70 mu m, 100 mu m and 160 mu m reveal an oval image showing a disc-like structure in all bands, the size of which increases with wavelength. Assuming a circular shape yields the inclination of its equatorial plane with respect to that of the sky, i > 53 degrees. The results of image de-convolution indicate that i likely is larger than 63 degrees, where 90 degrees corresponds to an edge-on disc. Conclusions. The observed emission is thermal and optically thin. The resolved data are consistent with debris at temperatures below 30 K at radii larger than 120 AU. From image de-convolution, we find that q(1) Eri is surrounded by an about 40 AU wide ring at the radial distance of similar to 85 AU. This is the first real Edgeworth-Kuiper Belt analogue ever observed.
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| 12. |
- Mathews, G. S., et al.
(författare)
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GAS in Protoplanetary Systems (GASPS) I. First results
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L127
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Tidskriftsartikel (refereegranskat)abstract
- Context. Circumstellar discs are ubiquitous around young stars, but rapidly dissipate their gas and dust on timescales of a few Myr. The Herschel Space Observatory allows for the study of the warm disc atmosphere, using far-infrared spectroscopy to measure gas content and excitation conditions, and far-IR photometry to constrain the dust distribution. Aims. We aim to detect and characterize the gas content of circumstellar discs in four targets as part of the Herschel science demonstration phase. Methods. We carried out sensitive medium resolution spectroscopy and high sensitivity photometry at gimel similar to 60-190 mu m using the Photodetector Array Camera and Spectrometer instrument on the Herschel Space Observatory. Results. We detect [OI] 63 mu m emission from the young stars HD 169142, TW Hydrae, and RECX 15, but not HD 181327. No other lines, including [CII] 158 and [OI] 145, are significantly detected. All four stars are detected in photometry at 70 and 160 mu m. Extensive models are presented in associated papers.
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| 13. |
- Meeus, G., et al.
(författare)
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Gas in the protoplanetary disc of HD 169142: Herschel's view
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L124
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Tidskriftsartikel (refereegranskat)abstract
- In an effort to simultaneously study the gas and dust components of the disc surrounding the young Herbig Ae star HD 169142, we present far-IR observations obtained with the PACS instrument onboard the Herschel Space Observatory. This work is part of the open time key program GASPS, which is aimed at studying the evolution of protoplanetary discs. To constrain the gas properties in the outer disc, we observed the star at several key gas-lines, including [OI] 63.2 and 145.5 mu m, [CII] 157.7 mu m, CO 72.8 and 90.2 mu m, and o-H2O 78.7 and 179.5 mu m. We only detect the [OI] 63.2 mu m line in our spectra, and derive upper limits for the other lines. We complement our data set with PACS photometry and (CO)-C-12/13 data obtained with the Submillimeter Array. Furthermore, we derive accurate stellar parameters from optical spectra and UV to mm photometry. We model the dust continuum with the 3D radiative transfer code MCFOST and use this model as an input to analyse the gas lines with the thermo-chemical code ProDIMo. Our dataset is consistent with a simple model in which the gas and dust are well-mixed in a disc with a continuous structure between 20 and 200 AU, but this is not a unique solution. Our modelling effort allows us to constrain the gas-to-dust mass ratio as well as the relative abundance of the PAHs in the disc by simultaneously fitting the lines of several species that originate in different regions. Our results are inconsistent with a gas-poor disc with a large UV excess; a gas mass of 5.0 +/- 2.0 x 10(-3) M-circle dot is still present in this disc, in agreement with earlier CO observations.
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| 14. |
- Pinte, C., et al.
(författare)
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The Herschel view of GAS in Protoplanetary Systems (GASPS) First comparisons with a large grid of models
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L126
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Tidskriftsartikel (refereegranskat)abstract
- The Herschel GASPS key program is a survey of the gas phase of protoplanetary discs, targeting 240 objects which cover a large range of ages, spectral types, and disc properties. To interpret this large quantity of data and initiate self-consistent analyses of the gas and dust properties of protoplanetary discs, we have combined the capabilities of the radiative transfer code MCFOST with the gas thermal balance and chemistry code ProDiMo to compute a grid of approximate to 300 000 disc models (DENT). We present a comparison of the first Herschel/GASPS line and continuum data with the predictions from the DENT grid of models. Our objective is to test some of the main trends already identified in the DENT grid, as well as to define better empirical diagnostics to estimate the total gas mass of protoplanetary discs. Photospheric UV radiation appears to be the dominant gas-heating mechanism for Herbig stars, whereas UV excess and/or X-rays emission dominates for T Tauri stars. The DENT grid reveals the complexity in the analysis of far-IR lines and the difficulty to invert these observations into physical quantities. The combination of Herschel line observations with continuum data and/or with rotational lines in the (sub-)millimetre regime, in particular CO lines, is required for a detailed characterisation of the physical and chemical properties of circumstellar discs.
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| 15. |
- Marshall, J. P., et al.
(författare)
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A Herschel resolved far-infrared dust ring around HD 207129
- 2011
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 529
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Tidskriftsartikel (refereegranskat)abstract
- Context. Dusty debris discs around main sequence stars are thought to be the result of continuous collisional grinding of planetesimals in the system. The majority of these systems are unresolved and analysis of the dust properties is limited by the lack of information regarding the dust location. Aims. The Herschel DUNES key program is observing 133 nearby, Sun-like stars (
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| 16. |
- Thi, W. F., et al.
(författare)
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Herschel-PACS observation of the 10 Myr old T Tauri disk TW Hya Constraining the disk gas mass
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L125
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Tidskriftsartikel (refereegranskat)abstract
- Planets are formed in disks around young stars. With an age of similar to 10 Myr, TW Hya is one of the nearest T Tauri stars that is still surrounded by a relatively massive disk. In addition a large number of molecules has been found in the TW Hya disk, making TW Hya the perfect test case in a large survey of disks with Herschel-PACS to directly study their gaseous component. We aim to constrain the gas and dust mass of the circumstellar disk around TW Hya. We observed the fine-structure lines of [OI] and [CII] as part of the open-time large program GASPS. We complement this with continuum data and ground-based (12) CO 3-2 and (CO)-C-13 3-2 observations. We simultaneously model the continuum and the line fluxes with the 3D Monte-Carlo code MCFOST and the thermo-chemical code ProDiMo to derive the gas and dust masses. We detect the [OI] line at 63 mu m. The other lines that were observed, [OI] at 145 mu m and [CII] at 157 mu m, are not detected. No extended emission has been found. Preliminary modeling of the photometric and line data assuming [(CO)-C-12]/[(CO)-C-13] = 69 suggests a dust mass for grains with radius
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| 17. |
- Wiegert, Joachim, 1985, et al.
(författare)
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How dusty is alpha Centauri? : Excess or non-excess over the infrared photospheres of main-sequence stars
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 563, s. A102-
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Tidskriftsartikel (refereegranskat)abstract
- Context. Debris discs around main-sequence stars indicate the presence of larger rocky bodies. The components of the nearby, solar-type binary alpha Centauri have metallicities that are higher than solar, which is thought to promote giant planet formation. Aims. We aim to determine the level of emission from debris around the stars in the alpha Cen system. This requires knowledge of their photospheres. Having already detected the temperature minimum, T-min, of alpha Cen A at far-infrared wavelengths, we here attempt to do the same for the more active companion alpha Cen B. Using the alpha Cen stars as templates, we study the possible effects that T-min may have on the detectability of unresolved dust discs around other stars. Methods. We used Herschel-PACS, Herschel-SPIRE, and APEX-LABOCA photometry to determine the stellar spectral energy distributions in the far infrared and submillimetre. In addition, we used APEX-SHeFI observations for spectral line mapping to study the complex background around alpha Cen seen in the photometric images. Models of stellar atmospheres and of particulate discs, based on particle simulations and in conjunction with radiative transfer calculations, were used to estimate the amount of debris around these stars. Results. For solar-type stars more distant than alpha Cen, a fractional dust luminosity f(d) equivalent to L-dust/L-star similar to 2 x 10(-7) could account for SEDs that do not exhibit the T-min effect. This is comparable to estimates of f(d) for the Edgeworth-Kuiper belt of the solar system. In contrast to the far infrared, slight excesses at the 2.5 sigma level are observed at 24 mu m for both alpha Cen A and B, which, if interpreted as due to zodiacal-type dust emission, would correspond to f(d) similar to (1-3) x 10(-5), i.e. some 10(2) times that of the local zodiacal cloud. Assuming simple power-law size distributions of the dust grains, dynamical disc modelling leads to rough mass estimates of the putative Zodi belts around the alpha Cen stars, viz. less than or similar to 4 x 10(-6) M-(sic) of 4 to 1000 mu m size grains, distributed according to n(a) proportional to a(-3.5). Similarly, for filled-in T-min emission, corresponding Edgeworth-Kuiper belts could account for similar to 10(-3) M-(sic) of dust. Conclusions. Our far-infrared observations lead to estimates of upper limits to the amount of circumstellar dust around the stars alpha Cen A and B. Light scattered and/or thermally emitted by exo-Zodi discs will have profound implications for future spectroscopic missions designed to search for biomarkers in the atmospheres of Earth-like planets. The far-infrared spectral energy distribution of alpha Cen B is marginally consistent with the presence of a minimum temperature region in the upper atmosphere of the star. We also show that an alpha Cen A-like temperature minimum may result in an erroneous apprehension about the presence of dust around other, more distant stars.
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| 18. |
- Liseau, René, 1949, et al.
(författare)
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alpha Centauri A in the far infrared - First measurement of the temperature minimum of a star other than the Sun
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 549
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Tidskriftsartikel (refereegranskat)abstract
- Context. Chromospheres and coronae are common phenomena on solar-type stars. Understanding the energy transfer to these heated atmospheric layers requires direct access to the relevant empirical data. Study of these structures has, by and large, been limited to the Sun thus far.Aims. The region of the temperature reversal can be directly observed only in the far infrared and submillimetre spectral regime. We aim at determining the characteristics of the atmosphere in the region of the temperature minimum of the solar sister star alpha Cen A. As a bonus this will also provide a detailed mapping of the spectral energy distribution, i.e. knowledge that is crucial when searching for faint, Kuiper belt-like dust emission around other stars.Methods. For the nearby binary system alpha Cen, stellar parameters are known with high accuracy from measurements. For the basic model parameters T-eff, log g and [Fe/H], we interpolate stellar model atmospheres in the grid of Gaia/PHOENIX and compute the corresponding model for the G2 V star alpha Cen A. Comparison with photometric measurements shows excellent agreement between observed photospheric data in the optical and infrared. For longer wavelengths, the modelled spectral energy distribution is compared to Spitzer-MIPS, Herschel-PACS, Herschel-SPIRE, and APEX-LABOCA photometry. A specifically tailored Uppsala model based on the MARCS code and extending further in wavelength is used to gauge the emission characteristics of alpha Cen A in the far infared.Results. Similar to the Sun, the far infrared (FIR) emission of alpha Cen A originates in the minimum temperature region above the stellar photosphere in the visible. However, in comparison with the solar case, the FIR photosphere of alpha Cen A appears marginally cooler, T-min similar to T-160 (mu m) = 3920 +/- 375 K. Beyond the minimum near 160 mu m, the brightness temperatures increase, and this radiation very likely originates in warmer regions of the chromosphere of alpha Cen A.Conclusions. To the best of our knowledge, this is the first time a temperature minimum has been directly measured on a main-sequence star other than the Sun.
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| 19. |
- Cataldi, Gianni, et al.
(författare)
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ALMA Resolves C i Emission from the β Pictoris Debris Disk
- 2018
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 861:1
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Tidskriftsartikel (refereegranskat)abstract
- The debris disk around β Pictoris is known to contain gas. Previous ALMA observations revealed a CO belt at ∼85 au with a distinct clump, interpreted as a location of enhanced gas production. Photodissociation converts CO into C and O within ∼50 a. We resolve C i emission at 492 GHz using ALMA and study its spatial distribution. C i shows the same clump as seen for CO. This is surprising, as C is expected to quickly spread in azimuth. We derive a low C mass (between 5 ×10-4and 3.1 ×10-3), indicating that gas production started only recently (within ∼5000 a). No evidence is seen for an atomic accretion disk inward of the CO belt, perhaps because the gas did not yet have time to spread radially. The fact that C and CO share the same asymmetry argues against a previously proposed scenario where the clump is due to an outward-migrating planet trapping planetesimals in a resonance, nor can the observations be explained by an eccentric planetesimal belt secularly forced by a planet. Instead, we suggest that the dust and gas disks should be eccentric. Such a configuration, we further speculate, might be produced by a recent tidal disruption event. Assuming that the disrupted body has had a CO mass fraction of 10%, its total mass would be 3 MMoon.
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| 20. |
- Ferraro, Gino B., et al.
(författare)
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Fatty acid synthesis is required for breast cancer brain metastasis
- 2021
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Ingår i: Nature Cancer. - : Springer Science and Business Media LLC. - 2662-1347. ; 2:4, s. 414-428
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Tidskriftsartikel (refereegranskat)abstract
- Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for brain metastatic breast cancer growth may introduce liabilities that can be exploited for therapy. Here we assessed how metabolism differs between breast tumors in brain versus extracranial sites and found that fatty acid synthesis is elevated in breast tumors growing in the brain. We determine that this phenotype is an adaptation to decreased lipid availability in the brain relative to other tissues, resulting in site-specific dependency on fatty acid synthesis for breast tumors growing at this site. Genetic or pharmacological inhibition of fatty acid synthase reduces human epidermal growth factor receptor 2-positive breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies.
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| 21. |
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| 22. |
- Cataldi, Gianni, et al.
(författare)
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Constraints on the gas content of the Fomalhaut debris belt Can gas-dust interactions explain the belt's morphology?
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 574
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Tidskriftsartikel (refereegranskat)abstract
- Context. The 440 Myr old main-sequence A-star Fomalhaut is surrounded by an eccentric debris belt with sharp edges. This sort of a morphology is usually attributed to planetary perturbations, but the orbit of the only planetary candidate detected so far, Fomalhaut b, is too eccentric to efficiently shape the belt. Alternative models that could account for the morphology without invoking a planet are stellar encounters and gas-dust interactions. Aims. We aim to test the possibility of gas-dust interactions as the origin of the observed morphology by putting upper limits on the total gas content of the Fomalhaut belt. Methods. We derive upper limits on the CII 158 mu m and 01 63 pint emission by using non detections from the Photocletector Array Camera and Spectrometer (PACS) onboard the Herschel Space Observatory. Line fluxes are converted into total gas mass using the non-local thermodynamic equilibrium (non-LTE) code RADEX. We consider two different cases for the elemental abundances of the gas: solar abundances and abundances similar to those observed for the gas in the beta Pictoris debris disc. Results. The gas mass is shown to be below the millimetre dust mass by a factor of at least similar to 3 (for solar abundances) respectively similar to 300 (for beta Pic-like abundances). Conclusions. The lack of gas co-spatial with the dust implies that gas-dust interactions cannot efficiently shape the Fomalhaut debris belt. The morphology is therefore more likely due to a yet unseen planet (Fomalhaut c) or stellar encounters.
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| 23. |
- Cataldi, Gianni, et al.
(författare)
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Primordial or Secondary? Testing Models of Debris Disk Gas with ALMA*
- 2023
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 951:2
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Tidskriftsartikel (refereegranskat)abstract
- The origin and evolution of gas in debris disks are still not well understood. Secondary gas production from cometary material or a primordial origin have been proposed. So far, observations have mostly concentrated on CO, with only a few C observations available. We overview the C and CO content of debris disk gas and test state-of-the-art models. We use new and archival Atacama Large Millimeter/submillimeter Array (ALMA) observations of CO and C i emission, complemented by C ii data from Herschel, for a sample of 14 debris disks. This expands the number of disks with ALMA measurements of both CO and C i by 10 disks. We present new detections of C i emission toward three disks: HD 21997, HD 121191, and HD 121617. We use a simple disk model to derive gas masses and column densities. We find that current state-of-the-art models of secondary gas production overpredict the C-0 content of debris disk gas. This does not rule out a secondary origin, but might indicate that the models require an additional C removal process. Alternatively, the gas might be produced in transient events rather than a steady-state collisional cascade. We also test a primordial gas origin by comparing our results to a simplified thermochemical model. This yields promising results, but more detailed work is required before a conclusion can be reached. Our work demonstrates that the combination of C and CO data is a powerful tool to advance our understanding of debris disk gas.
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| 24. |
- Cataldi, Gianni, et al.
(författare)
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The Surprisingly Low Carbon Mass in the Debris Disk around HD 32297
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 892:2
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Tidskriftsartikel (refereegranskat)abstract
- Gas has been detected in a number of debris disks. It is likely secondary, i.e., produced by colliding solids. Here, we report ALMA Band 8 observations of neutral carbon in the CO-rich debris disk around the 15-30 Myr old A-type star HD 32297. We find that C-0 is located in a ring at similar to 110 au with an FWHM of similar to 80 au and has a mass of (3.5 0.2) x 10(-3) M-circle plus. Naively, such a surprisingly small mass can be accumulated from CO photodissociation in a time as short as similar to 10(4) yr. We develop a simple model for gas production and destruction in this system, properly accounting for CO self-shielding and shielding by neutral carbon, and introducing a removal mechanism for carbon gas. We find that the most likely scenario to explain both C-0 and CO observations is one where the carbon gas is rapidly removed on a timescale of order a thousand years and the system maintains a very high CO production rate of similar to 15 M-circle plus Myr(-1), much higher than the rate of dust grind-down. We propose a possible scenario to meet these peculiar conditions: the capture of carbon onto dust grains, followed by rapid CO re-formation and rerelease. In steady state, CO would continuously be recycled, producing a CO-rich gas ring that shows no appreciable spreading over time. This picture might be extended to explain other gas-rich debris disks.
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| 25. |
- Youngblood, Allison, et al.
(författare)
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A Radiatively Driven Wind from the η Tel Debris Disk
- 2021
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Ingår i: Astronomical Journal. - : American Astronomical Society. - 0004-6256 .- 1538-3881. ; 162:6
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Tidskriftsartikel (refereegranskat)abstract
- We present far- and near-ultraviolet absorption spectroscopy of the ∼23 Myr edge-on debris disk surrounding the A0V star η Telescopii, obtained with the Hubble Space Telescope Space Telescope Imaging Spectrograph. We detect absorption lines from C i, C ii, O i, Mg ii, Al ii, Si ii, S ii, Mn ii, Fe ii, and marginally N i. The lines show two clear absorption components at −22.7 ± 0.5 km s−1 and −17.8 ± 0.7 km s−1, which we attribute to circumstellar (CS) and interstellar gas, respectively. CO absorption is not detected, and we find no evidence for star-grazing exocomets. The CS absorption components are blueshifted by −16.9 ± 2.6 km s−1 in the star's reference frame, indicating that they are outflowing in a radiatively driven disk wind. We find that the C/Fe ratio in the η Tel CS gas is significantly higher than the solar ratio, as is the case in the β Pic and 49 Cet debris disks. Unlike those disks, however, the measured C/O ratio in the η Tel CS gas is consistent with the solar value. Our analysis shows that because η Tel is an earlier type star than β Pic and 49 Cet, with more substantial radiation pressure at the dominant C ii transitions, this species cannot bind the CS gas disk to the star as it does for β Pic and 49 Cet, resulting in the disk wind.
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