SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Rodriguez Hector) "

Sökning: WFRF:(Rodriguez Hector)

  • Resultat 1-50 av 65
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Blanton, Michael R., et al. (författare)
  • Sloan Digital Sky Survey IV : Mapping the Milky Way, Nearby Galaxies, and the Distant Universe
  • 2017
  • Ingår i: Astronomical Journal. - : IOP Publishing Ltd. - 0004-6256 .- 1538-3881. ; 154:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and. high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z similar to 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z similar to 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs. and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the. Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.
  •  
2.
  • Forouzanfar, Mohammad H, et al. (författare)
  • Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.
  • 2015
  • Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 386:10010, s. 2287-2323
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.FINDINGS: All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.INTERPRETATION: Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.FUNDING: Bill & Melinda Gates Foundation.
  •  
3.
  • Naghavi, Mohsen, et al. (författare)
  • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
  • 2015
  • Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 385:9963, s. 117-171
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specifi c all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specifi c causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65.3 years (UI 65.0-65.6) in 1990, to 71.5 years (UI 71.0-71.9) in 2013, while the number of deaths increased from 47.5 million (UI 46.8-48.2) to 54.9 million (UI 53.6-56.3) over the same interval. Global progress masked variation by age and sex: for children, average absolute diff erences between countries decreased but relative diff erences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative diff erences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10.7%, from 4.3 million deaths in 1990 to 4.8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specifi c mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade.
  •  
4.
  • Abolfathi, Bela, et al. (författare)
  • The Fourteenth Data Release of the Sloan Digital Sky Survey : First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment
  • 2018
  • Ingår i: Astrophysical Journal Supplement Series. - : IOP Publishing Ltd. - 0067-0049 .- 1538-4365. ; 235:2
  • Tidskriftsartikel (refereegranskat)abstract
    • The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V.
  •  
5.
  • Bott, Lukas Thomas, et al. (författare)
  • Coulomb dissociation of O-16 into He-4 and C-12
  • 2023
  • Ingår i: NUCLEAR PHYSICS IN ASTROPHYSICS - X, NPA-X 2022. - : EDP Sciences. - 2100-014X. ; 279
  • Konferensbidrag (refereegranskat)abstract
    • We measured the Coulomb dissociation of O-16 into He-4 and C-12 within the FAIR Phase-0 program at GSI Helmholtzzentrum fur Schwerionenforschung Darmstadt, Germany. From this we will extract the photon dissociation cross section O-16(alpha,gamma)C-12, which is the time reversed reaction to C-12(alpha,gamma)O-16. With this indirect method, we aim to improve on the accuracy of the experimental data at lower energies than measured so far. The expected low cross section for the Coulomb dissociation reaction and close magnetic rigidity of beam and fragments demand a high precision measurement. Hence, new detector systems were built and radical changes to the (RB)-B-3 setup were necessary to cope with the high-intensity O-16 beam. All tracking detectors were designed to let the unreacted O-16 ions pass, while detecting the C-12 and He-4.
  •  
6.
  • Morales Salinas, Alberto, et al. (författare)
  • Clinical Perspective on Antihypertensive Drug Treatment in Adults With Grade 1 Hypertension and Low-to-Moderate Cardiovascular Risk : An International Expert Consultation
  • 2017
  • Ingår i: Current problems in cardiology. - : Elsevier. - 0146-2806 .- 1535-6280. ; 42:7, s. 198-225
  • Forskningsöversikt (refereegranskat)abstract
    • Hypertension is a leading risk factor for disease burden globally. An unresolved question is whether grade 1 hypertension (140-159/90-99 mm Hg) with low (cardiovascular mortality < 1% at 10 years) to moderate (cardiovascular mortality ≥ 1% and <5% at 10 years) absolute total cardiovascular risk (CVR) should be treated with antihypertensive agents. A virtual international consultation process was undertaken to summarize the opinions of select experts. After holistic analysis of all epidemiological, clinical, psychosocial, and public health elements, this consultation process reached the following consensus in hypertensive adults aged < 80 years: (1) The question of whether drug treatment in grade 1 should be preceded by a period of some weeks or months during which only lifestyle measures are recommended cannot be evidence based, but the consensus opinion is to have a period of lifestyle alone reserved only to patients with grade 1 "isolated" hypertension (grade 1 uncomplicated hypertension with low absolute total CVR, and without other major CVR factors and risk modifiers). (2) The initiation of antihypertensive drug therapy in grade 1 hypertension with moderate absolute total CVR should not be delayed. (3) Men ≥ 55 years and women ≥ 60 years with uncomplicated grade 1 hypertension should automatically be classified within the moderate absolute total CVR category, even in the absence of other major CVR factors and risk modifiers. (4) Statins should be considered along with blood-pressure lowering therapy, irrespective of cholesterol levels, in patients with grade 1 hypertensive with moderate CVR.
  •  
7.
  • Taiebi, Julien, et al. (författare)
  • Studies on Fission with Aladin
  • 2018
  • Ingår i: FISSION AND PROPERTIES OF NEUTRON-RICH NUCLEI. - 9789813229426 ; , s. 339-340
  • Konferensbidrag (refereegranskat)
  •  
8.
  • The Seventeenth Data Release of the Sloan Digital Sky Surveys : Complete Release of MaNGA, MaStar, and APOGEE-2 Data
  • 2022
  • Ingår i: Astrophysical Journal Supplement Series. - : Institute of Physics (IOP). - 0067-0049 .- 1538-4365. ; 259:2
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library accompanies this data, providing observations of almost 30,000 stars through the MaNGA instrument during bright time. DR17 also contains the complete release of the Apache Point Observatory Galactic Evolution Experiment 2 survey that publicly releases infrared spectra of over 650,000 stars. The main sample from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), as well as the subsurvey Time Domain Spectroscopic Survey data were fully released in DR16. New single-fiber optical spectroscopy released in DR17 is from the SPectroscipic IDentification of ERosita Survey subsurvey and the eBOSS-RM program. Along with the primary data sets, DR17 includes 25 new or updated value-added catalogs. This paper concludes the release of SDSS-IV survey data. SDSS continues into its fifth phase with observations already underway for the Milky Way Mapper, Local Volume Mapper, and Black Hole Mapper surveys.
  •  
9.
  • Vos, Theo, et al. (författare)
  • Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
  • 2015
  • Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
  •  
10.
  • Akiyama, Kazunori, et al. (författare)
  • The persistent shadow of the supermassive black hole of M 87: I. Observations, calibration, imaging, and analysis*
  • 2024
  • Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 681
  • Tidskriftsartikel (refereegranskat)abstract
    • In April 2019, the Event Horizon Telescope (EHT) Collaboration reported the first-ever event-horizon-scale images of a black hole, resolving the central compact radio source in the giant elliptical galaxy M 87. These images reveal a ring with a southerly brightness distribution and a diameter of ∼42 μas, consistent with the predicted size and shape of a shadow produced by the gravitationally lensed emission around a supermassive black hole. These results were obtained as part of the April 2017 EHT observation campaign, using a global very long baseline interferometric radio array operating at a wavelength of 1.3 mm. Here, we present results based on the second EHT observing campaign, taking place in April 2018 with an improved array, wider frequency coverage, and increased bandwidth. In particular, the additional baselines provided by the Greenland telescope improved the coverage of the array. Multiyear EHT observations provide independent snapshots of the horizon-scale emission, allowing us to confirm the persistence, size, and shape of the black hole shadow, and constrain the intrinsic structural variability of the accretion flow. We have confirmed the presence of an asymmetric ring structure, brighter in the southwest, with a median diameter of 43.3-3.1+1.5 μas. The diameter of the 2018 ring is remarkably consistent with the diameter obtained from the previous 2017 observations. On the other hand, the position angle of the brightness asymmetry in 2018 is shifted by about 30 relative to 2017. The perennial persistence of the ring and its diameter robustly support the interpretation that the ring is formed by lensed emission surrounding a Kerr black hole with a mass ∼6.5× 109M. The significant change in the ring brightness asymmetry implies a spin axis that is more consistent with the position angle of the large-scale jet.
  •  
11.
  • Apellániz-Ruiz, Maria, et al. (författare)
  • Targeted sequencing reveals low-frequency variants in EPHA genes as markers of paclitaxel-induced peripheral neuropathy.
  • 2017
  • Ingår i: Clinical Cancer Research. - : American Association of Cancer Research. - 1078-0432 .- 1557-3265. ; 23:5, s. 1227-1235
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: Neuropathy is the dose limiting toxicity of paclitaxel and a major cause for decreased quality of life. Genetic factors have been shown to contribute to paclitaxel neuropathy susceptibility; however, the major causes for inter-individual differences remain unexplained. In this study we identified genetic markers associated with paclitaxel-induced neuropathy through massive sequencing of candidate genes.EXPERIMENTAL DESIGN: We sequenced the coding region of 4 EPHA genes, 5 genes involved in paclitaxel pharmacokinetics and 30 Charcot-Marie-Tooth genes, in 228 cancer patients with no/low neuropathy or high grade neuropathy during paclitaxel treatment. An independent validation series included 202 paclitaxel-treated patients. Variation-/ gene-based analyses were used to compare variant frequencies among neuropathy groups and Cox regression models were used to analyze neuropathy evolution along treatment.RESULTS: Gene-based analysis identified EPHA6 as the gene most significantly associated with paclitaxel-induced neuropathy. Low frequency non-synonymous variants in EPHA6 were present exclusively in patients with high neuropathy and all affected the ligand binding domain. Accumulated dose analysis in the discovery series showed a significantly higher neuropathy risk for EPHA5/6/8 low-frequency non-synonymous variant carriers (HR=14.60, 95%CI=2.33-91.62, P=0.0042) and an independent cohort confirmed an increased neuropathy risk (HR=2.07, 95%CI=1.14-3.77, P=0.017). Combining the series gave an estimated 2.50-fold higher risk of neuropathy (95%CI=1.46-4.31; P=9.1x10(-4)).CONCLUSION: This first study sequencing EPHA genes revealed that low frequency variants in EPHA6, EPHA5 and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy. Furthermore, EPHAs neuronal injury repair function suggests that these genes might constitute important neuropathy markers for many neurotoxic drugs.
  •  
12.
  • Ballantyne, Kaye N., et al. (författare)
  • Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
  • 2014
  • Ingår i: Human Mutation. - : John Wiley & Sons. - 1059-7794 .- 1098-1004. ; 35:8, s. 1021-1032
  • Tidskriftsartikel (refereegranskat)abstract
    • Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, greater than99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database.
  •  
13.
  • Bellm, Eric C., et al. (författare)
  • The Zwicky Transient Facility : System Overview, Performance, and First Results
  • 2019
  • Ingår i: Publications of the Astronomical Society of the Pacific. - : IOP Publishing. - 0004-6280 .- 1538-3873. ; 131:995
  • Tidskriftsartikel (refereegranskat)abstract
    • The Zwicky Transient Facility (ZTF) is a new optical time-domain survey that uses the Palomar 48 inch Schmidt telescope. A custom-built wide-field camera provides a 47 deg(2) field of view and 8 s readout time, yielding more than an order of magnitude improvement in survey speed relative to its predecessor survey, the Palomar Transient Factory. We describe the design and implementation of the camera and observing system. The ZTF data system at the Infrared Processing and Analysis Center provides near-real-time reduction to identify moving and varying objects. We outline the analysis pipelines, data products, and associated archive. Finally, we present on-sky performance analysis and first scientific results from commissioning and the early survey. ZTF's public alert stream will serve as a useful precursor for that of the Large Synoptic Survey Telescope.
  •  
14.
  • Blanco-Tourinan, Noel, et al. (författare)
  • The primary root procambium contributes to lateral root formation through its impact on xylem connection
  • 2023
  • Ingår i: Current Biology. - : CELL PRESS. - 0960-9822 .- 1879-0445. ; 33:9, s. 1716-1727
  • Tidskriftsartikel (refereegranskat)abstract
    • The postembryonic formation of lateral roots (LRs) starts in internal root tissue, the pericycle. An important question of LR development is how the connection of the primary root vasculature with that of the emerging LR is established and whether the pericycle and/or other cell types direct this process. Here, using clonal analysis and time-lapse experiments, we show that both the procambium and pericycle of the primary root (PR) affect the LR vascular connectivity in a coordinated manner. We show that during LR formation, pro -cambial derivates switch their identity and become precursors of xylem cells. These cells, together with the pericycle-origin xylem, participate in the formation of what we call a "xylem bridge"(XB), which establishes the xylem connection between the PR and the nascent LR. If the parental protoxylem cell fails to differentiate, XB is still sometimes formed but via a connection with metaxylem cells, highlighting that this process has some plasticity. Using mutant analyses, we show that the early specification of XB cells is determined by CLASS III HOMEODOMAIN-LEUCINE ZIPPER (HD-ZIP III) transcription factors (TFs). Subsequent XB cell dif-ferentiation is marked by the deposition of secondary cell walls (SCWs) in spiral and reticulate/scalariform patterns, which is dependent on the VASCULAR-RELATED NAC-DOMAIN (VND) TFs. XB elements were also observed in Solanum lycopersicum, suggesting that this mechanism may be more widely conserved in plants. Together, our results suggest that plants maintain vascular procambium activity, which safeguards the functionality of newly established lateral organs by assuring the continuity of the xylem strands throughout the root system.
  •  
15.
  • Bolin, Bryce T., et al. (författare)
  • Characterization of the Nucleus, Morphology, and Activity of Interstellar Comet 2I/Borisov by Optical and Near-infrared GROWTH, Apache Point, IRTF, ZTF, and Keck Observations
  • 2020
  • Ingår i: Astronomical Journal. - : American Astronomical Society. - 0004-6256 .- 1538-3881. ; 160:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present visible and near-infrared (NIR) photometric and spectroscopic observations of interstellar object (ISO) 2I/Borisov taken from 2019 September 10 to 2019 December 20 using the GROWTH, the Apache Point Observatory Astrophysical Research Consortium 3.5 m, and the NASA Infrared Telescope Facility 3.0 m combined with pre- and postdiscovery observations of 2I obtained by the Zwicky Transient Facility from 2019 March 17 to 2019 May 5. Comparison with imaging of distant solar system comets shows an object very similar to mildly active solar system comets with an outgassing rate of similar to 10(27)mol s(-1). The photometry, taken in filters spanning the visible and NIR range, shows a gradual brightening trend of similar to 0.03 mag day(-1)since 2019 September 10 UTC for a reddish object becoming neutral in the NIR. The light curve from recent and prediscovery data reveals a brightness trend suggesting the recent onset of significant H2O sublimation with the comet being active with super volatiles such as CO at heliocentric distances >6 au consistent with its extended morphology. Using the advanced capability to significantly reduce the scattered light from the coma enabled by high-resolution NIR images from Keck adaptive optics taken on 2019 October 4, we estimate a diameter for 2I's nucleus of less than or similar to 1.4 km. We use the size estimates of 1I/'Oumuamua and 2I/Borisov to roughly estimate the slope of the ISO size distribution, resulting in a slope of similar to 3.4 1.2, similar to solar system comets and bodies produced from collisional equilibrium.
  •  
16.
  • Breeur, Marie, et al. (författare)
  • Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
  • 2022
  • Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 20:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.Methods: We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty.Results: Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk.Conclusions: These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types.
  •  
17.
  • Cea Soriano, Lucía, et al. (författare)
  • Predictors and time trends in clopidogrel and proton pump inhibitor coprescription with low-dose acetylsalicylic acid
  • 2012
  • Ingår i: Pharmacoepidemiology and Drug Safety. - : Wiley. - 1053-8569 .- 1099-1557. ; 21, s. 463-469
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: To determine trends and predictors of clopidogrel and proton pump inhibitor (PPI) coprescription with low-dose acetylsalicylic acid (ASA) prescribed for secondary cardiovascular or cerebrovascular disease (CVD) prevention in UK primary care. Methods: Patients aged 50-84years who received a first prescription for low-dose ASA for secondary CVD prevention in 2000-2001 (n=10 330) or 2006-2007 (n=8154) were identified in The Health Improvement Network UK primary care database. Clopidogrel or PPI coprescriptions received within 15days after the first low-dose ASA prescription were ascertained. Results: Clopidogrel coprescription with low-dose ASA increased from 1.6% to 25.2% between the two study periods; PPI coprescription increased from 11.6% to 28.3%. Low-dose ASA indications of myocardial infarction [odds ratio (OR) 11.7, 95% confidence interval (CI) 10.2 to 13.4] and unstable angina (OR 1.73, 95%CI 1.09 to 2.75) were positive predictors of clopidogrel coprescription in 2006-2007, relative to chronic ischaemic heart disease. Patients at high risk of upper gastrointestinal bleeding were more likely to receive a PPI than those at lower risk in 2006-2007 (OR 4.36, 95%CI 3.93 to 4.84). In this period, 65.5% of patients who required a clopidogrel coprescription according to guideline recommendations received one, and 44.3% of patients at high risk of upper gastrointestinal bleeding received a PPI. Conclusion: Clopidogrel and PPI coprescription with low-dose ASA increased markedly between 2000-2001 and 2006-2007; however, many patients on low-dose ASA did not receive the recommended coprescriptions at the end of the study period. © 2012 John Wiley & Sons, Ltd.
  •  
18.
  •  
19.
  •  
20.
  •  
21.
  • Garg, Scot, et al. (författare)
  • Prediction of 1-year clinical outcomes using the SYNTAX score in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention : a substudy of the STRATEGY (Single High-Dose Bolus Tirofiban and Sirolimus-Eluting Stent Versus Abciximab and Bare-Metal Stent in Acute Myocardial Infarction) and MULTISTRATEGY (Multicenter Evaluation of Single High-Dose Bolus Tirofiban Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study) trials
  • 2011
  • Ingår i: JACC: Cardiovascular interventions. - : Elsevier BV. - 1876-7605 .- 1936-8798. ; 4:1, s. 66-75
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectivesThis study sought to evaluate the impact of SYNTAX score (SXscore), and compare its performance in isolation and combination with the PAMI (The Primary Angioplasty in Myocardial Infarction Study) score, for the prediction of 1-year clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.BackgroundPatients with STEMI were excluded from the original SYNTAX score (SXscore) algorithm. Therefore, the utility of using the SXscore in this patient group remains undefined.MethodsSXscore was calculated retrospectively in 807 patients with STEMI enrolled in the randomized STRATEGY (Single High-Dose Bolus Tirofiban and Sirolimus-Eluting Stent Versus Abciximab and Bare-Metal Stent in Acute Myocardial Infarction) and MULTISTRATEGY (Multicenter Evaluation of Single High-Dose Bolus Tirofiban Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study) clinical trials. Clinical outcomes of all-cause death, reinfarction, and clinically driven target vessel revascularization were subsequently stratified according to SXscore tertiles: SXLOW ≤9 (n = 311), 9 < SXMID ≤16 (n = 234), SXHIGH >16 (n = 262).ResultsAt 1-year follow-up, all clinical outcomes including mortality, mortality/reinfarction, major adverse cardiac events (MACE) (a composite of all-cause death, reinfarction and target vessel revascularization), and definite, definite/probable, and any stent thrombosis were all significantly higher in patients in the highest SXscore tertile. SXscore was identified as an independent predictor of mortality, MACE, and stent thrombosis out to 1-year follow-up. The combination SYNTAX-PAMI score led to a net reclassification improvement of 15.7% and 4.6% for mortality and MACE, respectively. The C-statistics for the SXscore, PAMI score, and the combined SYNTAX-PAMI score were 0.65, 0.81, and 0.73 for 1-year mortality, and 0.68, 0.64, and 0.69 for 1-year MACE, respectively.ConclusionsSXscore does have a role in the risk stratification of patients with STEMI having primary percutaneous coronary intervention; however, this ability can be improved through a combination with clinical variables. (Multicentre 2×2 Factorial Randomised Study Comparing Tirofiban Versus Abciximab and SES Versus BMS in AMI; NCT00229515)
  •  
22.
  • Heydari, Rasool, et al. (författare)
  • Model-Free Predictive Control of Grid-Forming Inverters With LCL Filters
  • 2022
  • Ingår i: IEEE transactions on power electronics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0885-8993 .- 1941-0107. ; 37:8, s. 9200-9211
  • Tidskriftsartikel (refereegranskat)abstract
    • With the increasing penetration of distributed energy resources into islanded microgrids, a grid-forming inverter (GFI) has become the key element interfacing renewable energy sources. Usually, the GFI is employed with an output filter to minimize the harmonic content achieving high-quality output voltage regulation. To this end, model-predictive control (MPC) has been widely proposed to control the output voltage of GFI systems due to the high-quality performance, fast control response, and straightforward handling of constraints. However, an accurate model of the system is required for the conventional MPC to avoid a suboptimal performance under uncertainties. To overcome this known drawback, a novel model-free predictive control is proposed in this article. Consequently, the output voltage of an LC L-filtered GFI is regulated without the knowledge of the physical model.
  •  
23.
  • Horesh, Assaf, et al. (författare)
  • A Non-equipartition Shock Wave Traveling in a Dense Circumstellar Environment around SN 2020oi
  • 2020
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 903:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the discovery and panchromatic follow-up observations of the young Type Ic supernova (SN Ic) SN 2020oi in M100, a grand-design spiral galaxy at a mere distance of 14 Mpc. We followed up with observations at radio, X-ray, and optical wavelengths from only a few days to several months after explosion. The optical behavior of the supernova is similar to those of other normal SNe Ic. The event was not detected in the X-ray band but our radio observations revealed a bright mJy source (L-nu approximate to 1.2 x 10(27) erg s(-1) Hz(-1)). Given the relatively small number of stripped envelope SNe for which radio emission is detectable, we used this opportunity to perform a detailed analysis of the comprehensive radio data set we obtained. The radio-emitting electrons initially experience a phase of inverse Compton cooling, which leads to steepening of the spectral index of the radio emission. Our analysis of the cooling frequency points to a large deviation from equipartition at the level of epsilon(e)/epsilon(B) greater than or similar to 200, similar to a few other cases of stripped envelope SNe. Our modeling of the radio data suggests that the shock wave driven by the SN ejecta into the circumstellar matter (CSM) is moving at similar to 3 x 10(4) km s(-1). Assuming a constant mass loss from the stellar progenitor, we find that the mass-loss rate is (M)over dot approximate to 1.4 x 10(-4) M-circle dot yr(-1) for an assumed wind velocity of 1000 km s(-1). The temporal evolution of the radio emission suggests a radial CSM density structure steeper than the standard r(-2).
  •  
24.
  • Immanen, Juha, et al. (författare)
  • Characterization of cytokinin signaling and homeostasis gene families in two hardwood tree species : Populus trichocarpa and Prunus persica
  • 2013
  • Ingår i: BMC Genomics. - : BioMed Central. - 1471-2164. ; 14, s. 885-
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Through the diversity of cytokinin regulated processes, this phytohormone has a profound impact on plant growth and development. Cytokinin signaling is involved in the control of apical and lateral meristem activity, branching pattern of the shoot, and leaf senescence. These processes influence several traits, including the stem diameter, shoot architecture, and perennial life cycle, which define the development of woody plants. To facilitate research about the role of cytokinin in regulation of woody plant development, we have identified genes associated with cytokinin signaling and homeostasis pathways from two hardwood tree species. Results: Taking advantage of the sequenced black cottonwood (Populus trichocarpa) and peach (Prunus persica) genomes, we have compiled a comprehensive list of genes involved in these pathways. We identified genes belonging to the six families of cytokinin oxidases (CKXs), isopentenyl transferases (IPTs), LONELY GUY genes (LOGs), two-component receptors, histidine containing phosphotransmitters (HPts), and response regulators (RRs). All together 85 Populus and 45 Prunus genes were identified, and compared to their Arabidopsis orthologs through phylogenetic analyses. Conclusions: In general, when compared to Arabidopsis, differences in gene family structure were often seen in only one of the two tree species. However, one class of genes associated with cytokinin signal transduction, the CKI1-like family of two-component histidine kinases, was larger in both Populus and Prunus than in Arabidopsis.
  •  
25.
  • Louis, Rohan E., et al. (författare)
  • Small-scale magnetic flux emergence in a sunspot light bridge
  • 2015
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 584
  • Tidskriftsartikel (refereegranskat)abstract
    • Context: Light bridges are convective intrusions in sunspots that often show enhanced chromospheric activity.Aims: We seek to determine the nature of flux emergence in a light bridge and the processes related to its evolution in the solar atmosphere.Methods: We analyse a sequence of high-resolution spectropolarimetric observations of a sunspot taken at the Swedish 1-m Solar Telescope. The data consist of spectral scans of the photospheric Fe I line pair at 630 nm and the chromospheric Ca II 854.2 nm line. Bisectors were used to construct Dopplergrams from the Fe I 630.15 nm measurements. We employed LTE and non-LTE inversions to derive maps of physical parameters in the photosphere and chromosphere, respectively.Results: We observe the onset of blueshifts of about 2 km s(-1) near the entrance of a granular light bridge on the limbward side of the spot. The blueshifts lie immediately next to a strongly redshifted patch that appeared six minutes earlier. Both patches can be seen for 25 min until the end of the sequence. The blueshifts coincide with an elongated emerging granule, while the redshifts appear at the end of the granule. In the photosphere, the development of the blueshifts is accompanied by a simultaneous increase in field strength of about 400 G. The field inclination increases by some 25 degrees, becoming nearly horizontal. At the position of the redshifts, the magnetic field is equally horizontal but of opposite polarity. An intense brightening is seen in the Ca II filtergrams over the blueshifts and redshifts, about 17 min after their detection in the photosphere. The brightening is due to emission in the blue wing of the Ca II 854.2 nm line, close to its knee. Non-LTE inversions reveal that this kind of asymmetric emission is caused by a temperature enhancement of similar to 700 K between -5.0 <= log tau <= -3.0 and a blueshift of 3 km s(-1) at log tau = - 2.3 that decreases to zero at log tau = - 6.0Conclusions: The photospheric blueshifts and redshifts observed in a granular light bridge seem to be caused by the emergence of a small-scale, flat Omega-loop with highly inclined footpoints of opposite polarity that brings new magnetic field to the surface. The gas motions detected in the two footpoints are reminiscent of a siphon flow. The rising loop is probably confined to the lower atmosphere by the overlying sunspot magnetic field and the interaction between the two flux systems may be responsible for temperature enhancements in the upper photosphere/lower chromosphere. This is the first time that magnetic flux is observed to emerge in the strongly magnetised environment of sunspots, pushed upwards by the convective flows of a granular light bridge.
  •  
26.
  • Luis-Ravelo, Diego, et al. (författare)
  • Pramipexole reduces soluble mutant huntingtin and protects striatal neurons through dopamine D3 receptors in a genetic model of Huntington's disease
  • 2018
  • Ingår i: Experimental Neurology. - : Elsevier BV. - 0014-4886 .- 1090-2430. ; 299, s. 137-147
  • Tidskriftsartikel (refereegranskat)abstract
    • Huntington's disease (HD) is a neurodegenerative disorder caused by abnormal expansion of the polyglutamine tract in the huntingtin protein (HTT). The toxicity of mutant HTT (mHTT) is associated with intermediate mHTT soluble oligomers that subsequently form intranuclear inclusions. Thus, interventions promoting the clearance of soluble mHTT are regarded as neuroprotective. Striatal neurons are particularly vulnerable in HD. Their degeneration underlies motor symptoms and striatal atrophy, the anatomical hallmark of HD. Recent studies indicate that autophagy may be activated by dopamine D-2 and D-3 receptor (D2R/D3R) agonists. Since autophagy plays a central role in the degradation of misfolded proteins, and striatal neurons express D2R and D3R, D2R/D3R agonists may promote the clearance of mHTT in striatal neurons. Here, this hypothesis was tested by treating 8 week old R6/1 mice with the D2R/D3R agonist pramipexole for 4 weeks. Pramipexole reduced striatal levels of soluble mHTT and increased the size of intranuclear inclusions in R6/1 mice. Furthermore, striatal DARPP-32 levels and motor functions were recovered. These effects were accompanied by an increase in LC3-II and a decrease in p62 in the striatum. Tollip, a selective adaptor of ubiquitinated polyQ proteins to LC3, was also reduced in the striata of R6/lmice but not in their wild-type littermates. No changes were detected in the cerebral cortex where D3R expression is very low, and behavioral and biochemical effects in the striatum were prevented by a D3R antagonist. The findings indicate that PPX protects striatal neurons by promoting the clearance of soluble mHTT through a D3R-mediated mechanism. The evidence of autophagy markers suggests that autophagy is activated, although it is not efficient at removing all mHTT recruited by the autophagic machinery as indicated by the increase in the size of intranuclear inclusions.
  •  
27.
  • Martín, Juan Carlos, et al. (författare)
  • Determinants of airport cost flexibility in a context of economic recession
  • 2013
  • Ingår i: Transportation Research Part E. - : Elsevier. - 1366-5545 .- 1878-5794. ; 57, s. 70-84
  • Tidskriftsartikel (refereegranskat)abstract
    • The recent economic downturn led to a significant contraction in the global demand for air travel and cargo. In spite of that, airports’ operating costs did not mirror the traffic trends and kept increasing during the same period, showing evident signs of lack of flexibility. With this background, this paper aims at identifying the drivers of airport cost flexibility in a context of economic recession. This is done by estimating a short-run stochastic cost frontier over a balanced pool database of 194 airports worldwide between 2007 and 2009. Using the total change in cost efficiency during the sample period as a proxy for cost flexibility, the impact of variables such as ownership, outsourcing, airline dominance, low-cost traffic, and revenue diversification is tested in a second-stage regression. Contrary to the existing literature, a higher level of outsourcing is shown to reduce cost flexibility. Results also indicate that low-cost traffic, diversification, and corporatization increase the airports’ ability to control costs. The negative impact of airline dominance suggests the need for more stringent regulations on slot allocation at congested airports in order to ensure optimal infrastructure usage.
  •  
28.
  • Menger, K. E., et al. (författare)
  • Two type I topoisomerases maintain DNA topology in human mitochondria
  • 2022
  • Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 50:19, s. 11154-11174
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic processes require the activity of multiple topoisomerases, essential enzymes that remove topological tension and intermolecular linkages in DNA. We have investigated the subcellular localisation and activity of the six human topoisomerases with a view to understanding the topological maintenance of human mitochondrial DNA. Our results indicate that mitochondria contain two topoisomerases, TOP1MT and TOP3A. Using molecular, genomic and biochemical methods we find that both proteins contribute to mtDNA replication, in addition to the decatenation role of TOP3A, and that TOP1MT is stimulated by mtSSB. Loss of TOP3A or TOP1MT also dysregulates mitochondrial gene expression, and both proteins promote transcription elongation in vitro. We find no evidence for TOP2 localisation to mitochondria, and TOP2B knockout does not affect mtDNA maintenance or expression. Our results suggest a division of labour between TOP3A and TOP1MT in mtDNA topology control that is required for the proper maintenance and expression of human mtDNA.
  •  
29.
  • Muscarella, Robert, et al. (författare)
  • The global abundance of tree palms
  • 2020
  • Ingår i: Global Ecology and Biogeography. - : Wiley. - 1466-822X .- 1466-8238. ; 29:9, s. 1495-1514
  • Tidskriftsartikel (refereegranskat)abstract
    • AimPalms are an iconic, diverse and often abundant component of tropical ecosystems that provide many ecosystem services. Being monocots, tree palms are evolutionarily, morphologically and physiologically distinct from other trees, and these differences have important consequences for ecosystem services (e.g., carbon sequestration and storage) and in terms of responses to climate change. We quantified global patterns of tree palm relative abundance to help improve understanding of tropical forests and reduce uncertainty about these ecosystems under climate change.LocationTropical and subtropical moist forests.Time periodCurrent.Major taxa studiedPalms (Arecaceae).MethodsWe assembled a pantropical dataset of 2,548 forest plots (covering 1,191 ha) and quantified tree palm (i.e., ≥10 cm diameter at breast height) abundance relative to co‐occurring non‐palm trees. We compared the relative abundance of tree palms across biogeographical realms and tested for associations with palaeoclimate stability, current climate, edaphic conditions and metrics of forest structure.ResultsOn average, the relative abundance of tree palms was more than five times larger between Neotropical locations and other biogeographical realms. Tree palms were absent in most locations outside the Neotropics but present in >80% of Neotropical locations. The relative abundance of tree palms was more strongly associated with local conditions (e.g., higher mean annual precipitation, lower soil fertility, shallower water table and lower plot mean wood density) than metrics of long‐term climate stability. Life‐form diversity also influenced the patterns; palm assemblages outside the Neotropics comprise many non‐tree (e.g., climbing) palms. Finally, we show that tree palms can influence estimates of above‐ground biomass, but the magnitude and direction of the effect require additional work.ConclusionsTree palms are not only quintessentially tropical, but they are also overwhelmingly Neotropical. Future work to understand the contributions of tree palms to biomass estimates and carbon cycling will be particularly crucial in Neotropical forests.
  •  
30.
  • Nielsen, Kristin, 1986-, et al. (författare)
  • UKF Parameter Tuning for Local Variation Smoothing
  • 2021
  • Ingår i: Proceedings of the 2021 IEEE International Conference on Multisensor Fusion and Integration for Intelligent Systems (MFI). - : Institute of Electrical and Electronics Engineers (IEEE). - 9781665445214 - 9781665445221
  • Konferensbidrag (refereegranskat)abstract
    • The unscented Kalman filter (UKF) is a method to solve nonlinear dynamic filtering problems, which internally uses the unscented transform (UT). The behavior of the UT is controlled by design parameters, seldom changed from the values suggested in early UT/UKF publications. Despite the knowledge that the UKF can perform poorly when the parameters are improperly chosen, there exist no wide spread intuitive guidelines for how to tune them. With an application relevant example, this paper shows that standard parameter values can be far from optimal. By analyzing how each parameter affects the resulting UT estimate, guidelines for how the parameter values should be chosen are developed. The guidelines are verified both in simulations and on real data collected in an underground mine. A strategy to automatically tune the parameters in a state estimation setting is presented, resulting in parameter values inline with developed guidelines.
  •  
31.
  • Pham, Tuan, Professor, 1962-, et al. (författare)
  • Tensor decomposition of non-EEG physiological signals for visualization and recognition of human stress
  • 2019
  • Ingår i: ICBBT 2019: 2019 11TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL TECHNOLOGY. - New York : ACM Publications. - 9781450362313 ; , s. 132-136
  • Konferensbidrag (refereegranskat)abstract
    • Recognition of physical and mental responses to stress is important for the purpose of stress management to reduce its negative effects in health. Wearable technology, mainly using electroencephalogram (EEG), provides information such as tracking fitness activity, disease detection, and neurological states of individuals. However, the recording of EEG signals from a wearable device is inconvenient. This study introduces the application of tensor decomposition of non-EEG data for visualizing and tracking neurological status with implication to human stress recognition. Results obtained from testing the proposed method using a PhyioNet database show visualizations that can well separate four groups of neurological statuses obtained from twenty healthy subjects, and very high up to 100% classification of the neurological statuses. The investigation suggests the potential application of tensor decomposition for the analysis of physiological measurements collected from multiple sensors. The proposed study can significantly contribute to the advancement of wearable technology for human stress monitoring
  •  
32.
  • Purdum, Josiah N., et al. (författare)
  • Time-series and Phase-curve Photometry of the Episodically Active Asteroid (6478) Gault in a Quiescent State Using APO, GROWTH, P200, and ZTF
  • 2021
  • Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8205 .- 2041-8213. ; 911:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We observed the episodically active asteroid (6478) Gault in 2020 with multiple telescopes in Asia and North America and found that it is no longer active after its recent outbursts at the end of 2018 and the start of 2019. The inactivity during this apparition allowed us to measure the absolute magnitude of Gault of H ( r ) = 14.63 +/- 0.02, G ( r ) = 0.21 +/- 0.02 from our secular phase-curve observations. In addition, we were able to constrain Gault's rotation period using time-series photometric lightcurves taken over 17 hr on multiple days in 2020 August, September, and October. The photometric lightcurves have a repeating less than or similar to 0.05 mag feature suggesting that (6478) Gault has a rotation period of similar to 2.5 hr and may have a semispherical or top-like shape, much like the near-Earth asteroids Ryugu and Bennu. The rotation period of similar to 2.5 hr is near the expected critical rotation period for an asteroid with the physical properties of (6478) Gault, suggesting that its activity observed over multiple epochs is due to surface mass shedding from its fast rotation spin-up by the Yarkovsky-O'Keefe-Radzievskii-Paddack effect.
  •  
33.
  • Raghavan, Maanasa, et al. (författare)
  • Genomic evidence for the Pleistocene and recent population history of Native Americans
  • 2015
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 349:6250
  • Tidskriftsartikel (refereegranskat)abstract
    • Howand when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericues and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.
  •  
34.
  • Rodriguez Déniz, Héctor, et al. (författare)
  • A multilayered block network model to forecast large dynamic transportation graphs : An application to US air transport
  • 2022
  • Ingår i: Transportation Research Part C. - Oxford, United Kingdom : Elsevier. - 0968-090X .- 1879-2359. ; 137
  • Tidskriftsartikel (refereegranskat)abstract
    • Dynamic transportation networks have been analyzed for years by means of static graph-based indicators in order to study the temporal evolution of relevant network components, and to reveal complex dependencies that would not be easily detected by a direct inspection of the data. This paper presents a state-of-the-art probabilistic latent network model to forecast multilayer dynamic graphs that are increasingly common in transportation and proposes a community-based extension to reduce the computational burden. Flexible time series analysis is obtained by modeling the probability of edges between vertices through latent Gaussian processes. The models and Bayesian inference are illustrated on a sample of 10-year data from four major airlines within the US air transportation system. Results show how the estimated latent parameters from the models are related to the airlines’ connectivity dynamics, and their ability to project the multilayer graph into the future for out-of-sample full network forecasts, while stochastic blockmodeling allows for the identification of relevant communities. Reliable network predictions would allow policy-makers to better understand the dynamics of the transport system, and help in their planning on e.g. route development, or the deployment of new regulations.
  •  
35.
  • Rodriguez Déniz, Héctor, 1982- (författare)
  • Bayesian Models for Spatiotemporal Data from Transportation Networks
  • 2023
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Urbanization has caused a historical transformation at a global scale, and humanity is moving towards a fully connected society where cities will concentrate population, infrastructure and economic activity. A key element in the cities’ infrastructure is the transportation system, as it facilitates the mobility of people and goods. Transportation systems are constantly generating data from, e.g., GPS, sensors and cameras, and the statistical modeling is challenging due to the complex structure and dynamics of the system, and the inherent uncertainty. In this thesis, we develop Bayesian models with applications to transportation. We specifically focus on models that can be trained on spatiotemporal data coming from transport networks to make predictions on, e.g., bus delays or the actual network topology. Special attention has been given to model scalability issues and uncertainty quantification. We have used real-world data from transportation systems in every study to keep a balance between statistical rigor, novelty, and applicability. The thesis consists of four papers. The first study presents a state-of-the-art probabilistic latent network model to forecast multilayer dynamic graphs. The model uses stochastic blockmodeling to reduce the computational burden, and is illustrated on a sample of 10-year data from four major airlines within the US air transportation system. In the second paper, we develop a robust model for real-time bus travel time prediction that departs from Gaussian assumptions by using Student-t errors, and show how Bayesian inference naturally allows for predictive uncertainty quantification in a highly stochastic environment. Experiments are performed using data from high-frequency buses in Stockholm, Sweden. The third paper shows the potential of multi-output Gaussian processes to tackle network-wide travel time prediction in an urban area. We develop a responsive online model based on a coregionalized covariance and test its accuracy on real data from GPS-equipped taxis. Finally, we propose a novel regularization strategy for the vector autoregressive model that is based on a graphical spike-and-slab prior, and present a case study with real airline delay data to assess its predictive performance and analyze network patterns related to the propagation of delays across airports. 
  •  
36.
  • Rodriguez Déniz, Héctor, et al. (författare)
  • Classifying airports according to their hub dimensions: an application to the US domestic network
  • 2013
  • Ingår i: Journal of Transport Geography. - : Elsevier. - 0966-6923 .- 1873-1236. ; 33, s. 188-195
  • Tidskriftsartikel (refereegranskat)abstract
    • Government agencies classify airports for different purposes, including the allocation of public funding for capacity developments. In a context of hub classification, determining the contribution of each airport to the national network in terms of the two dimensions of hubbing -i.e., traffic generation and connectivity- is a key aspect. In this regard, the choice of an appropriate connectivity indicator is still an unresolved issue. This paper adapts the well-known flow centrality indicator to an air transport context and develops a novel measure of airport connectivity. An application to the US domestic network is provided, using quarterly data on passenger demand to perform a detailed time-series analysis of airport connectivity patterns between 1993 and 2012. The flow centrality indicator is then used to define an alternative airport classification method within the context of the Federal Aviation Administration’s National Plan of Integrated Airport Systems (NPIASs). Results show that there is potential for improving the existing airport typology by explicitly separating connectivity and traffic generation as classification criteria.
  •  
37.
  • Rodriguez Déniz, Héctor, et al. (författare)
  • Robust Real-Time Delay Predictions in a Network of High-Frequency Urban Buses
  • 2022
  • Ingår i: IEEE transactions on intelligent transportation systems (Print). - : Institute of Electrical and Electronics Engineers (IEEE). - 1524-9050 .- 1558-0016. ; 23:9, s. 16304-16317
  • Tidskriftsartikel (refereegranskat)abstract
    • Providing transport users and operators with accurate forecasts on travel times is challenging due to a highly stochastic traffic environment. Public transport users are particularly sensitive to unexpected waiting times, which negatively affect their perception on the system's reliability. In this paper we develop a robust model for real-time bus travel time prediction that departs from Gaussian assumptions by using Student-t errors. The proposed approach uses spatiotemporal characteristics from the route and previous bus trips to model short-term effects, and date/time variables and Gaussian processes for long-run forecasts. The model allows for flexible modeling of mean, variance and kurtosis spaces. We propose algorithms for Bayesian inference and for computing probabilistic forecast distributions. Experiments are performed using data from high-frequency buses in Stockholm, Sweden. Results show that Student-t models outperform Gaussian ones in terms of log-posterior predictive power to forecast bus delays at specific stops, which reveals the importance of accounting for predictive uncertainty in model selection. Estimated Student-t regressions capture typical temporal variability between within-day hours and different weekdays. Strong spatiotemporal effects are detected for incoming buses from immediately previous stops, which is in line with many recently developed models. We finally show how Bayesian inference naturally allows for predictive uncertainty quantification, e.g. by returning the predictive probability that the delay of an incoming bus exceeds a given threshold.
  •  
38.
  • Rodriguez-Deniz, Hector, et al. (författare)
  • Robust Real-Time Delay Predictions in a Network of High-Frequency Urban Buses
  • 2022
  • Ingår i: IEEE transactions on intelligent transportation systems (Print). - 1524-9050 .- 1558-0016. ; 23:9, s. 16304-16317
  • Tidskriftsartikel (refereegranskat)abstract
    • Providing transport users and operators with accurate forecasts on travel times is challenging due to a highly stochastic traffic environment. Public transport users are particularly sensitive to unexpected waiting times, which negatively affect their perception on the system's reliability. In this paper we develop a robust model for real-time bus travel time prediction that departs from Gaussian assumptions by using Student-t errors. The proposed approach uses spatiotemporal characteristics from the route and previous bus trips to model short-term effects, and date/time variables and Gaussian processes for long-run forecasts. The model allows for flexible modeling of mean, variance and kurtosis spaces. We propose algorithms for Bayesian inference and for computing probabilistic forecast distributions. Experiments are performed using data from high-frequency buses in Stockholm, Sweden. Results show that Student-t models outperform Gaussian ones in terms of log-posterior predictive power to forecast bus delays at specific stops, which reveals the importance of accounting for predictive uncertainty in model selection. Estimated Student-t regressions capture typical temporal variability between within-day hours and different weekdays. Strong spatiotemporal effects are detected for incoming buses from immediately previous stops, which is in line with many recently developed models. We finally show how Bayesian inference naturally allows for predictive uncertainty quantification, e.g. by returning the predictive probability that the delay of an incoming bus exceeds a given threshold.
  •  
39.
  • Rodriguez-Deniz, Hector, et al. (författare)
  • Urban Network Travel Time Prediction via Online Multi-Output Gaussian Process Regression
  • 2017
  • Ingår i: 2017 IEEE 20TH INTERNATIONAL CONFERENCE ON INTELLIGENT TRANSPORTATION SYSTEMS (ITSC). - : IEEE. - 9781538615263
  • Konferensbidrag (refereegranskat)abstract
    • The paper explores the potential of Multi-Output Gaussian Processes to tackle network-wide travel time prediction in an urban area. Forecasting in this context is challenging due to the complexity of the traffic network, noisy data and unexpected events. We build on recent methods to develop an online model that can be trained in seconds by relying on prior network dependences through a coregionalized covariance. The accuracy of the proposed model outperforms historical means and other simpler methods on a network of 47 streets in Stockholm, by using probe data from GPS-equipped taxis. Results show how traffic speeds are dependent on the historical correlations, and how prediction accuracy can be improved by relying on prior information while using a very limited amount of current-day observations, which allows for the development of models with low estimation times and high responsiveness.
  •  
40.
  • Rodriguez, Ivan D., et al. (författare)
  • FOND Planning with Explicit Fairness Assumptions
  • 2022
  • Ingår i: The journal of artificial intelligence research. - : AI Access Foundation ; AAAI Press. - 1076-9757 .- 1943-5037. ; 74, s. 887-916
  • Tidskriftsartikel (refereegranskat)abstract
    • We consider the problem of reaching a propositional goal condition in fully-observable non deterministic (FOND) planning under a general class of fairness assumptions that are given explicitly. The fairness assumptions are of the form A/B and say that state trajectories that contain infinite occurrences of an action a from A in a state s and finite occurrence of actions from B, must also contain infinite occurrences of action a in s followed by each one of its possible outcomes. The infinite trajectories that violate this condition are deemed as unfair, and the solutions are policies for which all the fair trajectories reach a goal state. We show that strong and strong-cyclic FOND planning, as well as QNP planning, a planning model introduced recently for generalized planning, are all special cases of FOND planning with fairness assumptions of this form which can also be combined. FOND+ planning, as this form of planning is called, combines the syntax of FOND planning with some of the versatility of LTL for expressing fairness constraints. A sound and complete FOND+ planner is implemented by reducing FOND+ planning to answer set programs, and its performance is evaluated in comparison with FOND and QNP planners, and LTL synthesis tools. Two other FOND+ planners are introduced as well which are more scalable but are not complete.
  •  
41.
  • Ruiz, Héctor A., et al. (författare)
  • Severity factor kinetic model as a strategic parameter of hydrothermal processing (steam explosion and liquid hot water) for biomass fractionation under biorefinery concept
  • 2021
  • Ingår i: Bioresource Technology. - : Elsevier BV. - 0960-8524. ; 342
  • Forskningsöversikt (refereegranskat)abstract
    • Hydrothermal processes are an attractive clean technology and cost-effective engineering platform for biorefineries based in the conversion of biomass to biofuels and high-value bioproducts under the basis of sustainability and circular bioeconomy. The deep and detailed knowledge of the structural changes by the severity of biomasses hydrothermal fractionation is scientifically and technological needed in order to improve processes effectiveness, reactors designs, and industrial application of the multi-scale target compounds obtained by steam explosion and liquid hot water systems. The concept of the severity factor [log10 (Ro)] established>30 years ago, continues to be a useful index that can provide a simple descriptor of the relationship between the operational conditions for biomass fractionation in second generation of biorefineries. This review develops a deep explanation of the hydrothermal severity factor based in lignocellulosic biomass fractionation with emphasis in research advances, pretreatment operations and the applications of severity factor kinetic model.
  •  
42.
  • Stanaway, Jeffrey D., et al. (författare)
  • Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
  • 2018
  • Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
  • Tidskriftsartikel (refereegranskat)abstract
    • Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
  •  
43.
  • Stein, Robert, et al. (författare)
  • A tidal disruption event coincident with a high-energy neutrino
  • 2021
  • Ingår i: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; :5, s. 510-518
  • Tidskriftsartikel (refereegranskat)abstract
    • Cosmic neutrinos provide a unique window into the otherwise hidden mechanism of particle acceleration in astrophysical objects. The IceCube Collaboration recently reported the likely association of one high-energy neutrino with a flare from the relativistic jet of an active galaxy pointed towards the Earth. However a combined analysis of many similar active galaxies revealed no excess from the broader population, leaving the vast majority of the cosmic neutrino flux unexplained. Here we present the likely association of a radio-emitting tidal disruption event, AT2019dsg, with a second high-energy neutrino. AT2019dsg was identified as part of our systematic search for optical counterparts to high-energy neutrinos with the Zwicky Transient Facility. The probability of finding any coincident radio-emitting tidal disruption event by chance is 0.5%, while the probability of finding one as bright in bolometric energy flux as AT2019dsg is 0.2%. Our electromagnetic observations can be explained through a multizone model, with radio analysis revealing a central engine, embedded in a UV photosphere, that powers an extended synchrotron-emitting outflow. This provides an ideal site for petaelectronvolt neutrino production. Assuming that the association is genuine, our observations suggest that tidal disruption events with mildly relativistic outflows contribute to the cosmic neutrino flux. The tidal disruption event AT2019dsg is probably associated with a high-energy neutrino, suggesting that such events can contribute to the cosmic neutrino flux. The electromagnetic emission is explained in terms of a central engine, a photosphere and an extended synchrotron-emitting outflow.
  •  
44.
  • Stein, Robert, et al. (författare)
  • Neutrino follow-up with the Zwicky transient facility : results from the first 24 campaigns
  • 2023
  • Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 521:4, s. 5046-5063
  • Tidskriftsartikel (refereegranskat)abstract
    • The Zwicky Transient Facility (ZTF) performs a systematic neutrino follow-up programme, searching for optical counterparts to high-energy neutrinos with dedicated Target-of-Opportunity (ToO) observations. Since first light in March 2018, ZTF has taken prompt observations for 24 high-quality neutrino alerts from the IceCube Neutrino Observatory, with a median latency of 12.2 h from initial neutrino detection. From two of these campaigns, we have already reported tidal disruption event (TDE) AT 2019dsg and likely TDE AT 2019fdr as probable counterparts, suggesting that TDEs contribute >7.8 per cent of the astrophysical neutrino flux. We here present the full results of our programme through to December 2021. No additional candidate neutrino sources were identified by our programme, allowing us to place the first constraints on the underlying optical luminosity function of astrophysical neutrino sources. Transients with optical absolutes magnitudes brighter that -21 can contribute no more than 87 per cent of the total, while transients brighter than -22 can contribute no more than 58 per cent of the total, neglecting the effect of extinction and assuming they follow the star formation rate. These are the first observational constraints on the neutrino emission of bright populations such as superluminous supernovae. None of the neutrinos were coincident with bright optical AGN flares comparable to that observed for TXS 0506+056/IC170922A, with such optical blazar flares producing no more than 26 per cent of the total neutrino flux. We highlight the outlook for electromagnetic neutrino follow-up programmes, including the expected potential for the Rubin Observatory.
  •  
45.
  • Sternby, Hanna, et al. (författare)
  • Determinants of Severity in Acute Pancreatitis : A Nation-wide Multicenter Prospective Cohort Study
  • 2019
  • Ingår i: Annals of Surgery. - 1528-1140. ; 270:2, s. 348-355
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: The aim of this study was to compare and validate the different classifications of severity in acute pancreatitis (AP) and to investigate which characteristics of the disease are associated with worse outcomes. SUMMARY OF BACKGROUND DATA: AP is a heterogeneous disease, ranging from uneventful cases to patients with considerable morbidity and high mortality rates. Severity classifications based on legitimate determinants of severity are important to correctly describe the course of disease. METHODS: A prospective multicenter cohort study involving patients with AP from 23 hospitals in Spain. The Atlanta Classification (AC), Revised Atlanta Classification (RAC), and Determinant-based Classification (DBC) were compared. Binary logistic multivariate analysis was performed to investigate independent determinants of severity. RESULTS: A total of 1655 patients were included; 70 patients (4.2%) died. RAC and DBC were equally superior to AC for describing the clinical course of AP. Although any kind of organ failure was associated with increased morbidity and mortality, persistent organ failure (POF) was the most significant determinant of severity. All local complications were associated with worse outcomes. Infected pancreatic necrosis correlated with high morbidity, but in the presence of POF, it was not associated to higher mortality when compared with sterile necrotizing pancreatitis. Exacerbation of previous comorbidity was associated with increased morbidity and mortality. CONCLUSION: The RAC and DBC both signify an advance in the description and differentiation of AP patients. Herein, we describe the complications of the disease independently associated to morbidity and mortality. Our findings are valuable not only when designing future studies on AP but also for the improvement of current classifications.
  •  
46.
  • Suau-Sanchez, P., et al. (författare)
  • An assessment of the potential for self-connectivity at European airports in holiday markets
  • 2017
  • Ingår i: Tourism Management. - : Elsevier Ltd. - 0261-5177 .- 1879-3193. ; 62, s. 54-64
  • Tidskriftsartikel (refereegranskat)abstract
    • In a context of intense airport and airline competition, a few European airports have recently started offering self-connection services to price-sensitive holiday passengers travelling with a combination of tickets where the airline/s involved do not handle the transfer themselves. This paper provides an exploratory analysis of the potential and implications of self-connectivity for European airports and airlines using a case study of air travel routes to holiday destinations in the Mediterranean. With the help of a forecasting model based on a zero-inflated Poisson regression, we identify the airports and airlines that have the highest potential to facilitate self-connections in the selected markets. The results also explore some implications of the widespread development of self-connection services in Europe.
  •  
47.
  • Suau-Sanchez, P., et al. (författare)
  • Benchmarking worldwide airport connectivity with demand data : Global hub competition, new players, and the hidden potential of self-connectivity
  • 2017
  • Ingår i: Volume 6 - The Economics of Airport Operations. - : Emerald Group Publishing Ltd.. - 9781787144989 ; , s. 387-423
  • Bokkapitel (refereegranskat)abstract
    • The connectivity provided by full-service network carriers under the umbrella of airline alliances is increasingly challenged by the services of Middle Eastern airlines via their own hubs, and the rise of new passenger strategies like self-connectivity. While these two developments can potentially benefit consumers with more services and lower fares, the rise of Middle East carriers has been met with opposition by EU and US airlines that call for increased protectionism. In addition, only a few airports in the world actively support self-connections. In this context, this study aims to investigate (1) the markets in which Middle East carriers exert a stronger dominance in terms of the number of passenger connections, (2) whether EU, US, or Asian hubs provide a competitive quality of connectivity in terms of travel time, and (3) whether a significant potential for self-connections is hidden at major airports worldwide. To that end, several datasets of passenger bookings (MIDT), airline schedules, and minimum connecting times between 2012 and 2015 are combined in a connections-building methodology that delivers six market-specific airport connectivity indicators for our benchmarking exercise. Our findings show that although European and some Asian hubs have lost traffic in global markets, they remain competitive from a quality perspective. US hubs have maintained their market share and competitive position. Finally, we identify the airports and airlines with the highest potential to provide self-connecting travel options, which can become an attractive new source of revenue for the parties involved.
  •  
48.
  • Suau-Sanchez, Pere, et al. (författare)
  • Benchmarking Worldwide Airport Connectivity with Demand Data: Global Hub Competition, New Players, and the Hidden Potential of Self-connectivity
  • 2017
  • Ingår i: The Economics of Airport Operations. - : Emerald Group Publishing Limited. - 9781787144989 - 9781787144972 ; , s. 387-423
  • Bokkapitel (refereegranskat)abstract
    • The connectivity provided by full-service network carriers under the umbrella of airline alliances is increasingly challenged by the services of Middle Eastern airlines via their own hubs, and the rise of new passenger strategies like self-connectivity. While these two developments can potentially benefit consumers with more services and lower fares, the rise of Middle East carriers has been met with opposition by EU and US airlines that call for increased protectionism. In addition, only a few airports in the world actively support self-connections. In this context, this study aims to investigate (1) the markets in which Middle East carriers exert a stronger dominance in terms of the number of passenger connections, (2) whether EU, US, or Asian hubs provide a competitive quality of connectivity in terms of travel time, and (3) whether a significant potential for self-connections is hidden at major airports worldwide. To that end, several datasets of passenger bookings (MIDT), airline schedules, and minimum connecting times between 2012 and 2015 are combined in a connections-building methodology that delivers six market-specific airport connectivity indicators for our benchmarking exercise. Our findings show that although European and some Asian hubs have lost traffic in global markets, they remain competitive from a quality perspective. US hubs have maintained their market share and competitive position. Finally, we identify the airports and airlines with the highest potential to provide self-connecting travel options, which can become an attractive new source of revenue for the parties involved.
  •  
49.
  • Suau-Sanchez, Pere, et al. (författare)
  • Measuring the potential for self-connectivity in global air transport markets: Implications for airports and airlines
  • 2016
  • Ingår i: JOURNAL OF TRANSPORT GEOGRAPHY. - : ELSEVIER SCI LTD. - 0966-6923. ; 57, s. 70-82
  • Tidskriftsartikel (refereegranskat)abstract
    • One of the strategies that air travellers employ to save money is self-connectivity, i.e. travelling with a combination of tickets where the airline/s involved do not handle the transfer themselves. Both airports and airlines, particularly low-cost carriers, have recently started catering to the needs of this type of passengers with the introduction of transfer fees or the development of self-connection platforms. The evidence provided by the existing literature, however, suggests that the degree of implementation of these strategies falls short of its true potential. In order to investigate how much self-connectivity could be observed in global air transport markets, this paper develops a forecasting model based on a zero-inflated Poisson regression on MIDT data. We identify the airports that have the highest potential to facilitate self-connections, as well as the factors that hinder or facilitate the necessary airline agreements at major locations. The results from this paper have many implications in regards to the widespread implementation of self-connection services and the future of the air travel industry. (C) 2016 Elsevier Ltd. All rights reserved.
  •  
50.
  • Suau-Sanchez, Pere, et al. (författare)
  • Regulatory airport classification in the US: The role of international markets
  • 2015
  • Ingår i: Transport Policy. - : Elsevier. - 0967-070X .- 1879-310X. ; 37, s. 157-166
  • Tidskriftsartikel (refereegranskat)abstract
    • In a context of debate over the future of the US Federal Aviation Administrations (FAA) funding model, this paper revisits the current system of airport classification used for the allocation of public funding for capacity developments. Previous papers have already addressed the limitations of the FAAs uni-dimensional method, and proposed new approaches that take into account the two dimensions of "hubbing" activity, i.e., traffic generation and connectivity. However, these studies are biased by the lack of detailed demand data on international connections. Using an MIDT dataset comprising a sample of domestic and international markets served by US airports during the first quarter of 2013, this paper aims at providing a full picture on the pitfalls of the existing FAA method, as well as addressing the impact of international connectivity in characterising the airports hubbing profiles. Hierarchical clustering is used to provide alternative criteria for hub classification within the context of US National Plan of Integrated Airport Systems (NPIAS). This new typology of primary US airports can help to optimize AIP funding by allowing for further differentiation in the FAA allocation criteria.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-50 av 65
Typ av publikation
tidskriftsartikel (52)
konferensbidrag (6)
forskningsöversikt (2)
bokkapitel (2)
annan publikation (1)
doktorsavhandling (1)
visa fler...
visa färre...
Typ av innehåll
refereegranskat (62)
övrigt vetenskapligt/konstnärligt (2)
Författare/redaktör
Yano, Yuichiro (7)
Prakash, Braham (7)
McKee, Martin (6)
Brenner, Hermann (6)
Badawi, Alaa (6)
Dandona, Lalit (6)
visa fler...
Dandona, Rakhi (6)
Esteghamati, Alireza (6)
Feigin, Valery L. (6)
Geleijnse, Johanna M ... (6)
Jonas, Jost B. (6)
Khang, Young-Ho (6)
Kokubo, Yoshihiro (6)
Lopez, Alan D. (6)
Lotufo, Paulo A. (6)
Lozano, Rafael (6)
Malekzadeh, Reza (6)
Miller, Ted R. (6)
Mokdad, Ali H. (6)
Naghavi, Mohsen (6)
Pereira, David M. (6)
Sepanlou, Sadaf G. (6)
Vollset, Stein Emil (6)
Vos, Theo (6)
Werdecker, Andrea (6)
Xu, Gelin (6)
Yonemoto, Naohiro (6)
Bennett, Derrick A. (6)
Hafezi-Nejad, Nima (6)
Kim, Daniel (6)
Kinfu, Yohannes (6)
Rafay, Anwar (6)
Salomon, Joshua A. (6)
Santos, Itamar S. (6)
Sawhney, Monika (6)
Singh, Jasvinder A. (6)
Tonelli, Marcello (6)
Westerman, Ronny (6)
Gupta, Rahul (6)
Prabhakaran, Doraira ... (6)
Masci, Frank J. (6)
Gupta, Rajeev (6)
Monasta, Lorenzo (6)
Ronfani, Luca (6)
Bell, Michelle L (6)
Jha, Vivekanand (6)
Norheim, Ole F (6)
Haro, Josep Maria (6)
Basu, Sanjay (6)
Fereshtehnejad, Seye ... (6)
visa färre...
Lärosäte
Linköpings universitet (20)
Stockholms universitet (12)
Lunds universitet (11)
Uppsala universitet (10)
Karolinska Institutet (8)
Luleå tekniska universitet (7)
visa fler...
Göteborgs universitet (6)
Kungliga Tekniska Högskolan (6)
Umeå universitet (5)
Chalmers tekniska högskola (5)
Högskolan Dalarna (5)
Malmö universitet (3)
Mittuniversitetet (3)
visa färre...
Språk
Engelska (65)
Forskningsämne (UKÄ/SCB)
Teknik (25)
Naturvetenskap (23)
Medicin och hälsovetenskap (16)
Samhällsvetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy