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1.
  • Haiman, Christopher A., et al. (author)
  • A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
  • 2011
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:12, s. 61-1210
  • Journal article (peer-reviewed)abstract
    • Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 x 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 x 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 x 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
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2.
  • Wang, Li-San, et al. (author)
  • Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.
  • 2015
  • In: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:2
  • Journal article (peer-reviewed)abstract
    • Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.
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3.
  • Razavi-Shearer, Devin M., et al. (author)
  • Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories
  • 2024
  • In: JOURNAL OF HEPATOLOGY. - 0168-8278 .- 1600-0641. ; 80:2, s. 232-242
  • Journal article (peer-reviewed)abstract
    • Background & Aims: Hepatitis delta virus (HDV) is a satellite RNA virus that requires the hepatitis B virus (HBV) for assembly and propagation. Individuals infected with HDV progress to advanced liver disease faster than HBV-monoinfected individuals. Recent studies have estimated the global prevalence of anti-HDV antibodies among the HBV-infected population to be 5-15%. This study aimed to better understand HDV prevalence at the population level in 25 countries/territories. Methods: We conducted a literature review to determine the prevalence of anti-HDV and HDV RNA in hepatitis B surface antigen (HBsAg)-positive individuals in 25 countries/territories. Virtual meetings were held with experts from each setting to discuss the findings and collect unpublished data. Data were weighted for patient segments and regional heterogeneity to estimate the prevalence in the HBV-infected population. The findings were then combined with The Polaris Observatory HBV data to estimate the anti-HDV and HDV RNA prevalence in each country/territory at the population level. Results: After adjusting for geographical distribution, disease stage and special populations, the anti-HDV prevalence among the HBsAg+ population changed from the literature estimate in 19 countries. The highest anti-HDV prevalence was 60.1% in Mongolia. Once adjusted for the size of the HBsAg+ population and HDV RNA positivity rate, China had the highest absolute number of HDV RNA+ cases. Conclusions: We found substantially lower HDV prevalence than previously reported, as prior meta-analyses primarily focused on studies conducted in groups/regions that have a higher probability of HBV infection: tertiary care centers, specific risk groups or geographical regions. There is large uncertainty in HDV prevalence estimates. The implementation of reflex testing would improve estimates, while also allowing earlier linkage to care for HDV RNA+ individuals. The logistical and economic burden of reflex testing on the health system would be limited, as only HBsAg+ cases would be screened.
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4.
  • Werren, John H, et al. (author)
  • Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.
  • 2010
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 327:5963, s. 343-8
  • Journal article (peer-reviewed)abstract
    • We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. Key findings include the identification of a functional DNA methylation tool kit; hymenopteran-specific genes including diverse venoms; lateral gene transfers among Pox viruses, Wolbachia, and Nasonia; and the rapid evolution of genes involved in nuclear-mitochondrial interactions that are implicated in speciation. Newly developed genome resources advance Nasonia for genetic research, accelerate mapping and cloning of quantitative trait loci, and will ultimately provide tools and knowledge for further increasing the utility of parasitoids as pest insect-control agents.
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5.
  • Baker, Michelle L, et al. (author)
  • Analysis of a set of Australian northern brown bandicoot expressed sequence tags with comparison to the genome sequence of the South American grey short tailed opossum
  • 2007
  • In: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 8, s. 50-
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: Expressed sequence tags (ESTs) have been used for rapid gene discovery in a variety of organisms and provide a valuable resource for whole genome annotation. Although the genome of one marsupial, the opossum Monodelphis domestica, has now been sequenced, no EST datasets have been reported from any marsupial species. In this study we describe an EST dataset from the bandicoot, Isoodon macrourus, providing information on the transcriptional profile of the bandicoot thymus and the opportunity for a genome wide comparison between the bandicoot and opossum, two distantly related marsupial species. RESULTS: A set of 1319 ESTs was generated from sequencing randomly chosen clones from a bandicoot thymus cDNA library. The nucleic acid and deduced amino acid sequences were compared with sequences both in GenBank and the recently completed whole genome sequence of M. domestica. This study provides information on the transcriptional profile of the bandicoot thymus with the identification of genes involved in a broad range of activities including protein metabolism (24%), transcription and/or nucleic acid metabolism (10%), metabolism/energy pathways (9%), immunity (5%), signal transduction (5%), cell growth and maintenance (3%), transport (3%), cell cycle (0.7%) and apoptosis (0.5%) and a proportion of genes whose function is unknown (5.8%). Thirty four percent of the bandicoot ESTs found no match with annotated sequences in any of the public databases. Clustering and assembly of the 1319 bandicoot ESTs resulted in a set of 949 unique sequences of which 375 were unannotated ESTs. Of these, seventy one unannotated ESTs aligned to non-coding regions in the opossum, human, or both genomes, and were identified as strong non-coding RNA candidates. Eighty-four percent of the 949 assembled ESTs aligned with the M. domestica genome sequence indicating a high level of conservation between these two distantly related marsupials. CONCLUSION: This study is among the first reported marsupial EST datasets with a significant inter-species genome comparison between marsupials, providing a valuable resource for transcriptional analyses in marsupials and for future annotation of marsupial whole genome sequences.
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7.
  • Bianchi, Matteo, et al. (author)
  • Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort
  • 2022
  • In: Arthritis & Rheumatology. - : John Wiley & Sons. - 2326-5191 .- 2326-5205. ; 74:2, s. 342-352
  • Journal article (peer-reviewed)abstract
    • Objective Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of complex autoimmune conditions characterized by inflammation in skeletal muscle and extramuscular compartments, and interferon (IFN) system activation. We undertook this study to examine the contribution of genetic variation to disease susceptibility and to identify novel avenues for research in IIMs.Methods Targeted DNA sequencing was used to mine coding and potentially regulatory single nucleotide variants from ~1,900 immune-related genes in a Scandinavian case–control cohort of 454 IIM patients and 1,024 healthy controls. Gene-based aggregate testing, together with rare variant– and gene-level enrichment analyses, was implemented to explore genotype–phenotype relations.Results Gene-based aggregate tests of all variants, including rare variants, identified IFI35 as a potential genetic risk locus for IIMs, suggesting a genetic signature of type I IFN pathway activation. Functional annotation of the IFI35 locus highlighted a regulatory network linked to the skeletal muscle–specific gene PTGES3L, as a potential candidate for IIM pathogenesis. Aggregate genetic associations with AGER and PSMB8 in the major histocompatibility complex locus were detected in the antisynthetase syndrome subgroup, which also showed a less marked genetic signature of the type I IFN pathway. Enrichment analyses indicated a burden of synonymous and noncoding rare variants in IIM patients, suggesting increased disease predisposition associated with these classes of rare variants.Conclusion Our study suggests the contribution of rare genetic variation to disease susceptibility in IIM and specific patient subgroups, and pinpoints genetic associations consistent with previous findings by gene expression profiling. These features highlight genetic profiles that are potentially relevant to disease pathogenesis.
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8.
  • Bosse, Yohan, et al. (author)
  • Transcriptome-wide association study reveals candidate causal genes for lung cancer
  • 2020
  • In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 146:7, s. 1862-1878
  • Journal article (peer-reviewed)abstract
    • We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large‐scale expression quantitative trait loci (eQTL) mapping study in human lung tissues (n = 1,038) to identify candidate causal genes for lung cancer. We performed transcriptome‐wide association study (TWAS) for lung cancer overall, by histology (adenocarcinoma, squamous cell carcinoma and small cell lung cancer) and smoking subgroups (never‐ and ever‐smokers). We performed replication analysis using lung data from the Genotype‐Tissue Expression (GTEx) project. DNA damage assays were performed in human lung fibroblasts for selected TWAS genes. As expected, the main TWAS signal for all histological subtypes and ever‐smokers was on chromosome 15q25. The gene most strongly associated with lung cancer at this locus using the TWAS approach was IREB2 (pTWAS = 1.09E−99), where lower predicted expression increased lung cancer risk. A new lung adenocarcinoma susceptibility locus was revealed on 9p13.3 and associated with higher predicted expression of AQP3 (pTWAS = 3.72E−6). Among the 45 previously described lung cancer GWAS loci, we mapped candidate target gene for 17 of them. The association AQP3‐adenocarcinoma on 9p13.3 was replicated using GTEx (pTWAS = 6.55E−5). Consistent with the effect of risk alleles on gene expression levels, IREB2 knockdown and AQP3 overproduction promote endogenous DNA damage. These findings indicate genes whose expression in lung tissue directly influences lung cancer risk.
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9.
  • Clarke, Robert, et al. (author)
  • Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials
  • 1998
  • In: British Medical Journal. - : BMJ. - 0959-8146. ; 316:7135, s. 894-898
  • Research review (peer-reviewed)abstract
    • Objective: To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. Design: Meta-analysis of randomised controlled trials that assessed the effects of folic acid based supplements on blood homocysteine concentration. Multivariate regression analysis was used to determine the effects on homocysteine concentrations of different doses of folic acid and of the addition of vitamin B-12 or B-6. Subjects: Individual data on 1114 people included in 12 trials. Findings: The proportional and absolute reductions in blood homocysteine produced by folic acid supplements were greater at higher pretreatment blood homocysteine concentrations (P < 0.001) and at lower pretreatment blood folate concentrations (P < 0.001). After standardisation to pretreatment blood concentrations of homocysteine of 12 μmol/l and of folate of 12 nmol/l (approximate average concentrations for Western populations), dietary folic acid reduced blood homocysteine concentrations by 25% (95% confidence interval 23% to 28%; P < 0.001), with similar effects in the range of 0.5-5 mg folic acid daily. Vitamin B-12 (mean 0.5 mg daily) produced an additional 7% (3% to 10%) reduction in blood homocysteine. Vitamin B-6 (mean 16.5 mg daily) did not have a significant additional effect. Conclusions: Typically in Western populations, daily supplementation with both 0.5-5 mg folic acid and about 0.5 mg vitamin B-12 would be expected to reduce blood homocysteine concentrations by about a quarter to a third (for example, from about 12 μmol/l to 8-9 μmol/l). Large scale randomised trials of such regimens in high risk populations are now needed to determine whether lowering blood homocysteine concentrations reduces the risk of vascular disease.
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10.
  • Cloninger, Kevin M., et al. (author)
  • A Randomized Controlled Pilot Study using Mind-Body Interventions among Refugees in Sweden
  • 2019
  • In: The International Journal of Person Centered Medicine. - : University of Buckingham Press. - 2043-7730 .- 2043-7749. ; 9:3, s. 19-34
  • Journal article (peer-reviewed)abstract
    • Background: Migration is one of the major challenges of the 21st century with many refugees being victims of torture and experiencing war and the collapse of their society. Sweden, for example, received about 169,520 refugees during 2015 and 20–30% of them were estimated to suffer from mental illness. Nevertheless, research shows that about 66.40% of refugees never reveal their traumatic experiences to a doctor and a majority refuse psychiatric help. Hence, we need innovative methods to promote the physical, mental, and social health of refugees. Objective: We examined the effects of Anthropedia’s Well-Being Coaching (i.e., a biopsychosocial approach to coaching) and Well-Being Spa (i.e., modern version of age-old Spa interventions) on the personality and health of a sample of refugees living in Sweden. Methodology: Participants were recruited as part of a health and employment project in Blekinge, Sweden. A total of 70 Syrian refugees were randomly assigned to a six-month intervention comprising either Well-Being Coaching, or Well-Being Spa, or both (i.e., Mind–Body). The participants reported personality (temperament and character), well-being (positive and negative affect, life satisfaction, and harmony in life), and ill-being (defeat and entrapment, and anxiety and depression) at the beginning and at the end of the six-month intervention period. Results: Participants assigned to the Well-Being Coaching intervention showed increases in self-directedness (Cohen’s d = 0.84), cooperativeness (Cohen’s d = 0.36), positive affect (Cohen’s d = 0.43), and life satisfaction (Cohen’s d = 0.56), and decreases in both negative affect (Cohen’s d = 0.38) and defeat (Cohen’s d = 0.89). Participants assigned to the Well-Being Spa intervention showed decreases in harm avoidance (Cohen’s d = 0.55), reward dependence (Cohen’s d = 0.69), negative affect (Cohen’s d = 0.82), anxiety (Cohen’s d = 0.53), defeat (Cohen’s d = 0.34), and external entrapment (Cohen’s d = 0.42). Participants assigned to the Mind–Body intervention showed significant decreases in harm avoidance (Cohen’s d = 0.47), anxiety (Cohen’s d = 0.61), depression (Cohen’s d = 0.34), defeat (Cohen’s d = 0.56), external entrapment (Cohen’s d = 0.44), and internal entrapment (Cohen’s d = 0.79) and increases in persistence (Cohen’s d = 0.27), self-directedness (Cohen’s d = 0.28), cooperativeness (Cohen’s d = 0.43), self-transcendence (Cohen’s d = 0.51), positive affect (Cohen’s d = 0.42), and harmony in life (Cohen’s d = 0.36). Conclusions: The results of the present study suggest that Well-Being Coaching strengthens refugees’ character, while the Well-Being Spa treatments reduced participants’ tendency to worry and anxiety. Finally, the combination of these two interventions seems to promote the development of health-related traits, reduce ill-health, and stress, and increase well-being in a wider biopsychosocial perspective.
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11.
  • Cloninger, Kevin M., et al. (author)
  • The Health Effects of Anthropedia’s Well-Being Coaching: A 6-Month Pilot Study Among Long-Term Unemployment Swedish Young Adults
  • 2019
  • In: 3rd Biennial International Convention of Psychological Science, Paris, France.
  • Conference paper (other academic/artistic)abstract
    • In recent years Sweden had an increased number of asylum seekers entering the country. Asylum seeking can affect the physical and mental health of individuals due to prolonged application processes and waiting times which can lead to inactivity. Physical inactivity is one of the leading risk factors leading to noncommunicable diseases and overall mortality. The Public Health Report Blekinge 2014 states that groups with low socioeconomic status are less likely to be physically active in comparison with groups with a high socioeconomic status. Physical activity contributes to physical and mental well-being, and increases the possibilities for creating social networks as well as being part of the society. The project “Health for Everybody” (Hälsa för Alla) offers physical and cultural activities to approximately 300 refugees who have been granted asylum in the Blekinge region. The activities are conducted with the help of physical trainers, testing staff and community workers. In its current format each group of 20 to 30 refugees is offered training once a week for a 10-week period. The participants’ physical and psychological health and lifestyle habits are measured before and after the program through bioimpedance, physical conditioning tests and self-reports of psychological aspects related to health and lifestyle. We examined the health effects of cultural activities and Well-Being Coaching among long-term unemployed Swedish young adults. While individuals receiving cultural activities only showed a slight decrease in anxiety, those receiving Well-Being Coaching showed significant increases in subjective well-being and decreases in depression, anxiety, and sense of defeat and entrapment.
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12.
  • Drake, TM, et al. (author)
  • Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
  • 2020
  • In: BMJ global health. - : BMJ. - 2059-7908. ; 5:12
  • Journal article (peer-reviewed)abstract
    • Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.MethodsA multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).ResultsOf 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.ConclusionThe odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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13.
  • Gadalla, Shahinaz M, et al. (author)
  • Outcomes of allogeneic hematopoietic cell transplant in patients with dyskeratosis congenita.
  • 2013
  • In: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. - : Elsevier BV. - 1523-6536. ; 19:8, s. 1238-1243
  • Journal article (peer-reviewed)abstract
    • We describe outcomes after allogeneic transplantation in 34 patients with dyskeratosis congenita transplanted between 1981 and 2009. The median age at transplantation was 13 years (range 2 - 35). Approximately 50% of transplants were from related donors. Bone marrow was the predominant source of stem cells (n=24/34). The day-28 probability of neutrophil recovery was 73% and the day-100 platelet recovery was 72%. The day-100 probability of grade II-IV acute GVHD and the 3-year probability of chronic GVHD were 24% and 37%, respectively. The 10-year probability of survival was 30%; 14 patients were alive at last follow-up. Ten deaths occurred within 4 months from transplantation due to graft failure (n=6) or other transplant-related complications; 9 of these patients had been transplanted from mismatched related or from unrelated donors. Another 10 deaths occurred after 4 months; 6 of them occurred more than 5 years from transplantation, 4 of these were attributed to pulmonary failure. Transplant-regimen intensity and transplants from mismatched related or unrelated donors were associated with early mortality. Transplantation of grafts from HLA-matched siblings with cyclophosphamide-containing non-radiation regimens was associated with early low toxicity. Late mortality was attributed mainly to pulmonary complications and likely related to the underlying disease.
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14.
  • Garcia, Danilo, 1973, et al. (author)
  • A Pilot Study on Newly Graduated Nurses' Personal Vulnerability for Burnout
  • 2019
  • In: 31st Association for Psychological Science Annual Convention. Washington, D.C., USA.
  • Conference paper (other academic/artistic)abstract
    • Nurses’ work is characterized by overload and hard decisions. Despite 80% of new ly graduated nurses being socially warm and dedicated, 72.97% lacked purpose and meaning and felt ineffective and disconnected from the rest of the world. Moreover, 51.70% had a personality profile with high risk for burnout and ill-being.
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15.
  • Garcia, Danilo, 1973, et al. (author)
  • A Pilot Study on Resilience (Harm Avoidance, Persistence, and Self-directedness) among Swedish Newly Graduated Nurses
  • 2019
  • In: 3rd Biennial International Convention of Psychological Science, Paris, France.
  • Conference paper (other academic/artistic)abstract
    • A Resilient profile is low in Harm Avoidance (i.e., relaxed, confident, and optimistic) and high in Persistence (i.e., industrious, perseverant, and hard-working) and Self-Directedness (i.e., responsible, reliable, self-acceptant, goal-oriented, and resourceful). We found that, compared to the general population, only 6.90% of Swedish newly graduated nurses had a resilient profile.
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  • Garcia, Danilo, 1973, et al. (author)
  • A Quantification of Agentic and Communal Values in Adolescents’ Life Narratives
  • 2014
  • In: 167th American Psychiatric Association Annual Meeting, New York, New York, USA..
  • Conference paper (other academic/artistic)abstract
    • Background Life stories emphasize the narrative and self-organizing aspects of human behaviors and complement personality traits in explaining human identity. In contrast to most research on narratives in which the analysis is restricted to the researcher’s subjective evaluations and interpretations, we used computational methods to quantitatively investigate the relationship between personality and narratives events. Meta-cognitive strategies and principles that guide agentic (self-directedness; e.g., being autonomous, responsible and having self-control), communal (cooperativeness; e.g., showing empathy, helping behavior, and social tolerance), and transcendental (self-transcendence; e.g., the sense of being part of the whole universe) behavior were of special interest. We also investigated which pronouns were most common in relation to personality constructs that were significantly related to the narratives. Method Personality was assessed among 79 adolescents at one point in time using the NEO Personality Inventory – Revised (NEO-PI-R) and the Temperament and Character Inventory (TCI). Six months later, adolescents were asked to write down the most positive or the most negative event that had happened to them in the last three months. Adolescents were explicitly instructed to answer the following questions within their narratives: What happened? Who were involved? Why do you think it happened? How did you feel when it happened? How do you think the involved persons felt? The descriptions were quantified using semantic spaces, a computational method in which the Latent Semantic Analysis algorithm generates a semantic representation of the narratives. This representation was used to study whether it predicted the personality measures. Results Only Self-directedness and Cooperativeness were predicted by the semantic representation of the narratives. High levels of Self-directedness and Cooperativeness were associated with plural pronouns (e.g., us), whereas low levels were associated with singular pronouns (e.g., one-self, mine). Conclusions Agentic and communal values are involved when adolescents describe positive and negative life experiences.
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  • Garcia, Danilo, 1973, et al. (author)
  • Affectivity in Bulgaria: Differences in Life Satisfaction, Temperament, and Character
  • 2023
  • In: The Affective Profiles Model - 20 Years of Research and Beyond. - Cham : Springer. ; , s. 127-143
  • Book chapter (peer-reviewed)abstract
    • Background: The affective profiles model allows the comparison between diametrically different individuals, but also the comparison within individuals who differ in one affectivity dimension but that are similar in the other. This line of research indicates that individuals with different affective profiles regulate their emotions in distinct ways in order to adapt their stress levels and achieve greater subjective well-being. Nevertheless, even if some studies among North Americans and Swedes suggest that personality may play a key role in this process, the mechanism behind self-regulation within each profile is still poorly understood. Aims: We investigated differences in life satisfaction and personality traits (temperament and character) between individuals with distinct affective profiles in a population of Bulgarian adults. Method: The sample (see Angelova, Psychol Thought 13:127–145, 2020; Garcia et al., PeerJ 10:e13956, 2022) consisted of 443 individuals from Bulgaria (68.70% females) with a mean age of 34 years (SD = 15.05). Participants self-reported affect (Positive Affect Negative Affect Schedule), personality (Temperament and Character Inventory), and life satisfaction (Satisfaction with Life Scale). Self-reported affect was used for affectivity profiling: self-fulfilling (high/low positive/negative affect), high affective (high/high positive/negative affect), low affective (low/low positive/negative affect), and self-destructive (low/high positive/negative affect). We conducted both variable-oriented (e.g., linear correlations, t-tests between diametrically different profiles) and person-oriented analysis (matched t-tests between profiles that differed in one affect dimension and were similar in the other). Results: Positive affect was positively related to Persistence, Self-Directedness, Cooperativeness, Self-Transcendence, and life satisfaction (r between 0.27 to 0.56), but negatively to Harm Avoidance (r = −0.40). Conversely, negative affect was negatively related to Self-Directedness, Cooperativeness, and life satisfaction (r between −0.25 to −0.47), but positive to Harm Avoidance (r = 0.42). The diametrical comparisons indicated that individuals with a self-fulfilling profile, compared to those with a self-destructive profile, reported lower scores in Harm Avoidance and higher scores in Reward Dependence, Persistence, Self-Directedness, Cooperativeness, Self-Transcendence, and life satisfaction. Additionally, individuals with a high affective profile, compared to individuals with a low affective profile, reported higher scores in Persistence, Self-Transcendence, and life satisfaction. The person-oriented analyses, however, showed that high positive affect was positively associated high Reward Dependence and Cooperativeness only when negative affect was high (high affective vs. self-destructive) and that high negative affect was negatively associated with Cooperativeness and positively associated with Self-Transcendence only when positive affect was low (self-destructive vs. low affective). Finally, life satisfaction was related to different personality traits for individuals with distinct profiles, the common denominator being high Self-Directedness. Conclusions: Besides replicating past studies regarding the relationship between personality and life satisfaction and affect, our study mapped the personality of individuals with different affective profiles throughout person-oriented analyses. This allowed us to understand more deeply the mechanisms behind self-regulation among individuals with distinct profiles. The development of some personality traits might influence a person’s affective profile only under certain conditions or only in conjunction with the development of character traits.
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19.
  • Garcia, Danilo, 1973, et al. (author)
  • Agentic, communal, and spiritual traits are related to the semantic representation of written narratives of positive and negative life events
  • 2015
  • In: Psychology of Well-Being. - : Springer Science and Business Media LLC. - 2211-1522. ; 5:8, s. 1-20
  • Journal article (peer-reviewed)abstract
    • Background: We used a computational method to quantitatively investigate the relationship between personality and written narratives of life events. Agentic (i.e., self- directedness), communal (i.e., cooperativeness), and spiritual (self-transcendence) traits were of special interest because they represent individual differences in intentional val- ues and goals, in contrast to temperament traits, which describe individual differences in automatic responses to emotional stimuli. We also investigated which pronouns were most common in relation to personality constructs that were significantly related to the narratives. Methods: Personality was assessed among 79 adolescents at one point in time using the NEO Personality Inventory—Revised (NEO-PI-R) and the temperament and char- acter inventory (TCI). Six months later, adolescents were asked to write down the most positive or the most negative event that had happened to them in the last 3 months. Adolescents were explicitly instructed to answer the following questions within their narratives: What happened? Who were involved? Why do you think it happened? How did you feel when it happened? How do you think the involved persons felt? The descriptions were quantified using a computational method in which the latent semantic analysis algorithm generates a semantic representation of the narratives. Results: Only self-directedness, cooperativeness, and self-transcendence were related to the semantic representation of the narratives. Moreover, cooperativeness and self- transcendence were associated with less frequent usage of singular pronouns (e.g., me respectively mine). Conclusions: Agentic, communal, and spiritual traits are involved when adolescents describe positive and negative life experiences. Moreover, high levels of communal and spiritual traits are related to less self-focused narratives.
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20.
  • Garcia, Danilo, 1973, et al. (author)
  • Self-transcendence
  • 2017
  • In: V. Zeigler-Hill & T. Shackelford (Eds.), Encyclopedia of Personality and Individual Differences.. - Cham : Springer. - 9783319280998
  • Book chapter (other academic/artistic)abstract
    • Self-transcendence (concept of our participation in the world as a whole) is one of the three aspects of human character in Cloninger’s biopsychosociospiritual model of personality (Cloninger, Svrakic & Przybeck, 1993). This character trait is a measure of how well people identify themselves as an integral part of the universe as a whole and their experience of something elevated that goes beyond ourselves, that is, self-forgetfulness, transpersonal identification, spiritual acceptance, contemplation, idealism (Cloninger, 2004).
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21.
  • Garcia, Danilo, 1973, et al. (author)
  • Synergetic Effects of Anthropedia’s Well-Being Coaching and Mind-Body Interventions on Refugees’ Health
  • 2020
  • In: 32nd Association for Psychological Science Annual Convention. Chicago, Illinois, USA..
  • Conference paper (other academic/artistic)abstract
    • We evaluated the effects of Anthropedia’s Well-Being Coaching and Mind-Body interventions (i.e., modern version of age-old Spa interventions) on health among a sample of refugees living in Sweden. While each intervention increased well-being and reduced ill-being respectively, the combination had a wider biopsychosocial effect on health.
  •  
22.
  • Granjard, Alexandre, et al. (author)
  • Personality Among Swedish Long-Term Unemployed
  • 2020
  • In: 32nd Association for Psychological Science Annual Convention. Chicago, Illinois, USA..
  • Conference paper (other academic/artistic)abstract
    • As expected, compared to the normal population, the unemployed population scored one standard deviation higher in Harm Avoidance and lower in Self-directedness. Additionally, the analyses of personality profiles showed that 84.70% were high in Harm Avoidance, 65.30% low in Self-directedness, 38.30% low in Cooperativeness, and 49.50% low in Self- transcendence.
  •  
23.
  • Granjard, Alexandre, et al. (author)
  • Resilience Personality Profiles among Swedish Long-Term Unemployed
  • 2021
  • In: PsyCh Journal. - : Wiley. - 2046-0252 .- 2046-0260. ; 10:4, s. 670-673
  • Journal article (peer-reviewed)abstract
    • Our aim was to investigate the prevalence of resilience personality profiles in a sample of Swedish long-term unemployed in relation to the general Swedish population. We found that only 1.50% (vs. 26% in the general population) in the long-term unemployed sample had a resilient personality profile, that is, low in harm avoidance (e.g., relaxed and optimistic), high in persistence (e.g., hardworking), and high in self-directedness (i.e., goal-oriented and resourceful).
  •  
24.
  • Granjard, Alexandre, et al. (author)
  • Resilience Profiles Among Swedish Long-Term Unemployed
  • 2020
  • In: 32nd Association for Psychological Science Annual Convention. Chicago, Illinois, USA.
  • Conference paper (other academic/artistic)abstract
    • A Resilient profile is low in Harm Avoidance (i.e., relaxed, confident, and optimistic) and high in Persistence (i.e., industrious, perseverant, and hard-working) and Self-Directedness (i.e., responsible, reliable, self-acceptant, goal- oriented, and resourceful). We found that, compared to the general population, only 1% of Swedish long-term unemployed had a resilient profile.
  •  
25.
  • Heatherington, Laurie, et al. (author)
  • Sustaining outcomes research in residential treatment : a 15-year study of the Gould Farm program
  • 2019
  • In: Psychological services. - : American Psychological Association (APA). - 1541-1559 .- 1939-148X. ; 6:4, s. 675-686
  • Journal article (peer-reviewed)abstract
    • We present findings from a study of outcomes of residential treatment for people who have mental illness, primarily schizophrenia-spectrum and bipolar disorders. The study assesses a range of individual variables before and after participation in the program, to examine clinical and personal recovery and facilitate program improvement. To our knowledge, it is the longest ongoing outcomes study (15+ years) of its kind. The program, Gould Farm, provides recovery-focused, milieu treatment on a 700-acre working farm. It integrates counseling and medication with a work program that provides opportunities for the development of daily living, social, and work skills as well as mental and physical health. Clients were interviewed in person at intake and at discharge. Also, since study year 10 when the follow-up arm began, former clients were interviewed at 6, 18, and 36 months postdischarge via phone. Interview protocols included standard measures of psychiatric symptoms and functioning, substance use, quality of life, and treatment satisfaction. Follow-up interview protocols also assessed individuals’ living, working, family, and social situations as well as their satisfaction in these areas of recovery. Statistically significant improvements on all measures were found at discharge, and were not moderated by key demographic or clinical factors. Preliminary follow-up data showed maintenance of treatment gains, and high treatment satisfaction. We discuss clinical implications of the findings as well as limitations, directions for future research, and recommendations for sustaining outcomes research in organized care settings.
  •  
26.
  • Hultin Rosenberg, Jonas, 1983- (author)
  • The All-Affected Principle and its Critics : A Study on Democratic Inclusion
  • 2016
  • Doctoral thesis (other academic/artistic)abstract
    • The problem of democratic inclusion, which concerns inclusion in and exclusion from the demos, has attracted significant scholarly attention in the last decade. The all-affected principle seeks to resolve this problem by maintaining that all those and only those who are affected should be included in the demos. But although this principle has often been regarded as a prima facie attractive solution, the literature also claims that it has been “proven” to be unreasonable. The present discussion examines this claim by undertaking a critical evaluation of the arguments upon which it is based – that the all-affected principle is incoherent, that it provides no solution because it presupposes that the problem has already been solved, that it is incompatible with political equality, that it renders a functioning democracy impossible because it either frequently changes the composition of the demos, or generates an overly inclusive demos, and that it challenges established practices of incompetence-based exclusion. Adherents of the all-affected principle must take these arguments seriously since they criticize the principle on its own terms. But insofar as the present study demonstrates that such arguments fail to reveal any generic flaw in the principle, they do not challenge the principle as such, but only certain versions of it. These include the most common version, which requires the inclusion of all those and only those who are both competent and better or worse off as an actual consequence of actual decisions taken by the democratic state. Also affected is the main alternative version, which requires the inclusion of all those and only those who are better or worse off as a possible consequence of a possible decision taken by the democratic state. In response, this thesis proposes a third version of the principle that requires the inclusion of all those and only those who are able to participate, and also better or worse off as a foreseeable consequence of a decision or non-decision that the democratic state has capacity and ability to take. This version avoids the arguments that have been brought against the all-affected principle without compromising that which makes it initially attractive.
  •  
27.
  • Illini, Oliver, et al. (author)
  • Real-world experience with capmatinib in MET exon 14-mutated non-small cell lung cancer (RECAP) : a retrospective analysis from an early access program
  • 2022
  • In: Therapeutic Advances in Medical Oncology. - : Sage Publications. - 1758-8340 .- 1758-8359. ; 14
  • Journal article (peer-reviewed)abstract
    • Background: Patients with non-small cell lung cancer (NSCLC) presenting with mesenchymal-epithelial transition (MET) exon 14 skipping mutation have an unfavorable prognosis with standard treatments. Capmatinib is a selective MET inhibitor, which showed promising efficacy in this patient population in early trials. Methods: We performed a retrospective, international, multicenter efficacy and safety analysis in patients with NSCLC treated with capmatinib in an early access program between March 2019 and December 2021. Results: Data from 81 patients with advanced MET exon 14 mutated NSCLC treated with capmatinib in first- or later-line therapy were analyzed. Median age was 77 years (range, 48-91), 56% were women, 86% had stage IV disease, and 27% had brain metastases. For all patients, the objective response rate (ORR) to capmatinib was 58% (95% CI, 47-69), whereas it was 68% (95% CI, 50-82) in treatment-naive and 50% (95% CI, 35-65) in pretreated patients. The median progression-free survival was 9.5 months (95% CI, 4.7-14.3), whereas it was 10.6 months (95% CI, 5.5-15.7) in first-line and 9.1 months (95% CI, 3.1-15.1) in pretreated patients. After a median follow-up of 11.0 months, the median overall survival was 18.2 months (95% CI, 13.2-23.1). In patients with measurable brain metastases (n = 11), the intracranial ORR was 46% (95% CI, 17-77). Capmatinib showed a manageable safety profile. Grade > 3 treatment-related adverse events included peripheral edema (13%), elevated creatinine (4%), and elevated liver enzymes (3%). Conclusion: In patients with MET exon 14 skipping mutation, capmatinib showed durable systemic and intracranial efficacy and a manageable safety profile. This analysis confirms previously reported phase II data in a real-world setting.
  •  
28.
  • Jacobson, Martin, 1994- (author)
  • Land & Liberty : On the Natural Monopoly of Violence
  • 2024
  • Doctoral thesis (other academic/artistic)abstract
    • This thesis explores the analytical relationship between geoism, also known as left-libertarianism, and libertarian anarchism. Geoists argue that private property in land is unjust since no one has created the land. Furthermore, they contend that such landownership is the root cause of many social problems, generating systematic inequality and poverty. Hence, geoists argue that the economic rent of land should be shared equally among all. Similarly, libertarian anarchists claim that states are inherently unjust and that state-created privileges are the root cause of many social pathologies. Accordingly, they reject state authority and argue that society should instead be organized via voluntary associations. While both geoism and anarchism can be interpreted as versions of libertarianism, they are rarely discussed in relationship with each other. In this thesis, I seek to address this research gap. I argue that we can understand the territorial authority of states as a form of landownership, thereby facilitating a dialogue between these traditions. As an implication of this, I argue that the anarchist rejection of states can be extended to a rejection of landownership, while the geoist rejection of landownership can be extended to a rejection of state authority. However, it is often assumed that states are necessary to bring about an equal distribution of rent, rendering geoism and anarchism incompatible. Thus, this thesis also seeks to address the question of whether these ideologies are compatible, exploring possible non-state mechanisms for achieving a geoist distribution of rent. Finally, the thesis also considers political strategies that activists could use to achieve a more equitable distribution of rent, independent of state policy. Thus, this thesis seeks to provide an original contribution to the libertarian literature. The “geo-anarchist” position I explore is barely mentioned in the current academic literature. Nonetheless, I strive to show that it is not only a logically coherent position but also that it seems to follow from many of the internal commitments of libertarian theory.
  •  
29.
  • Johansson, Lars Age, et al. (author)
  • Counting the dead and what they died of.
  • 2006
  • In: Bulletin of the World Health Organization. - 0042-9686 .- 1564-0604. ; 84:3, s. 254-
  • Journal article (peer-reviewed)
  •  
30.
  • Kitahara, Cari M., et al. (author)
  • Association between Class III Obesity (BMI of 40-59 kg/m(2)) and Mortality : A Pooled Analysis of 20 Prospective Studies
  • 2014
  • In: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 11:7
  • Journal article (peer-reviewed)abstract
    • Background: The prevalence of class III obesity (body mass index [BMI]>= 40 kg/m(2)) has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness and death. Using data from a large pooled study, we evaluated the risk of death, overall and due to a wide range of causes, and years of life expectancy lost associated with class III obesity. Methods and Findings: In a pooled analysis of 20 prospective studies from the United States, Sweden, and Australia, we estimated sex-and age-adjusted total and cause-specific mortality rates (deaths per 100,000 persons per year) and multivariable-adjusted hazard ratios for adults, aged 19-83 y at baseline, classified as obese class III (BMI 40.0-59.9 kg/m(2)) compared with those classified as normal weight (BMI 18.5-24.9 kg/m(2)). Participants reporting ever smoking cigarettes or a history of chronic disease (heart disease, cancer, stroke, or emphysema) on baseline questionnaires were excluded. Among 9,564 class III obesity participants, mortality rates were 856.0 in men and 663.0 in women during the study period (19762009). Among 304,011 normal-weight participants, rates were 346.7 and 280.5 in men and women, respectively. Deaths from heart disease contributed largely to the excess rates in the class III obesity group (rate differences = 238.9 and 132.8 in men and women, respectively), followed by deaths from cancer (rate differences = 36.7 and 62.3 in men and women, respectively) and diabetes (rate differences = 51.2 and 29.2 in men and women, respectively). Within the class III obesity range, multivariable-adjusted hazard ratios for total deaths and deaths due to heart disease, cancer, diabetes, nephritis/nephrotic syndrome/nephrosis, chronic lower respiratory disease, and influenza/pneumonia increased with increasing BMI. Compared with normal-weight BMI, a BMI of 40-44.9, 45-49.9, 50-54.9, and 55-59.9 kg/m(2) was associated with an estimated 6.5 (95% CI: 5.7-7.3), 8.9 (95% CI: 7.4-10.4), 9.8 (95% CI: 7.4-12.2), and 13.7 (95% CI: 10.5-16.9) y of life lost. A limitation was that BMI was mainly ascertained by self-report. Conclusions: Class III obesity is associated with substantially elevated rates of total mortality, with most of the excess deaths due to heart disease, cancer, and diabetes, and major reductions in life expectancy compared with normal weight.
  •  
31.
  • Lorentsson, Robert, 1969, et al. (author)
  • A 4-afc study comparing ultrasound machines using a greyscale phantom
  • 2015
  • In: IFMBE Proceedings. 16th Nordic-Baltic Conference on Biomedical Engineering. October 14-16, 2014, Gothenburg, Sweden. - Cham : Springer International Publishing. - 1680-0737. ; 48, s. 82-85
  • Conference paper (peer-reviewed)abstract
    • © Springer International Publishing Switzerland 2015. Two ultrasound machines, one high-end and one ordinary, were compared in terms of their ability to reproduce low-contrast objects using the same probe. Images containing 4 mm objects of four different contrasts were collected from a greyscale phantom at 35-42 mm depth. Six observers participated in a 4-alternative forced choice study based on 120 images. At this certain depth and object size the proportion of correct responses was higher (statistically significant) for the high-end machine at three of four contrast levels, indicating the possibility to discriminate between ultrasound machines using a limited number of images of a greyscale phantom. However, the number of images and number of observers needed are larger than usually used for constancy control.
  •  
32.
  • Lorentsson, Robert, 1969, et al. (author)
  • Comparison of the low-contrast detectability of two ultrasound systems using a grayscale phantom
  • 2016
  • In: Journal of Applied Clinical Medical Physics. - : Wiley. - 1526-9914. ; 17:6, s. 366-378
  • Journal article (peer-reviewed)abstract
    • The purpose of the present study was to use a commercially available grayscale phantom to compare two ultrasound systems regarding their ability to reproduce clinically relevant low-contrast objects at different sizes and depths, taking into account human observer variability and other methodological issues related to observer performance studies. One high-end and one general ultrasound scanner from the same manufacturer using the same probe were included. The study was intended to simulate the clinical situation where small low-contrast objects are embedded in relatively homogeneous organs. Images containing 4 and 6.4 mm objects of four different contrasts were acquired from the grayscale phantom at different depths. Six observers participated in a 4-alternative forced-choice study based on 960 images. Case sample and human observer variabilities were taken into account using bootstrapping. At four of sixteen depth/size/contrast combinations, the visual performance of the high-end scanner was significantly higher. Thus, it was possible to use a grayscale phantom to discriminate between the two evaluated ultrasound systems in terms of their ability to reproduce clinically relevant low-contrast objects. However, the number of images and number of observers were larger than those usually used for constancy control.
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33.
  • Lorentsson, Robert, 1969, et al. (author)
  • Method for automatic detection of defective ultrasound linear array transducers based on uniformity assessment of clinical images - A case study
  • 2018
  • In: Journal of Applied Clinical Medical Physics. - : Wiley. - 1526-9914. ; 19:2, s. 265-274
  • Journal article (peer-reviewed)abstract
    • The purpose of the present study was to test an idea of and describe a concept of a novel method of detecting defects related to horizontal nonuniformities in ultrasound equipment. The method is based on the analysis of ultrasound images collected directly from the clinical workflow. In total over 31000 images from three ultrasound scanners from two vendors were collected retrospectively from a database. An algorithm was developed and applied to the images, 150 at a time, for detection of systematic dark regions in the superficial part of the images. The result was compared with electrical measurements (FirstCall) of the transducers, performed at times when the transducers were known to be defective. The algorithm made similar detection of horizontal nonuniformities for images acquired at different time points over long periods of time. The results showed good subjective visual agreement with the available electrical measurements of the defective transducers, indicating a potential use of clinical images for early and automatic detection of defective transducers, as a complement to quality control.
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34.
  • Mark, Daniel B., et al. (author)
  • Comprehensive Quality-of-Life Outcomes With Invasive Versus Conservative Management of Chronic Coronary Disease in ISCHEMIA
  • 2022
  • In: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 0009-7322 .- 1524-4539. ; 145:17, s. 1294-1307
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) compared an initial invasive treatment strategy (INV) with an initial conservative strategy in 5179 participants with chronic coronary disease and moderate or severe ischemia. The ISCHEMIA research program included a comprehensive quality-of-life (QOL) substudy.METHODS: In 1819 participants (907 INV, 912 conservative strategy), we collected a battery of disease-specific and generic QOL instruments by structured interviews at baseline; at 3, 12, 24, and 36 months postrandomization; and at study closeout. Assessments included angina-related QOL (19-item Seattle Angina Questionnaire), generic health status (EQ-5D), depressive symptoms (Patient Health Questionnaire-8), and, for North American patients, cardiac functional status (Duke Activity Status Index).RESULTS: Median age was 67 years, 19.2% were female, and 15.9% were non-White. The estimated mean difference for the 19-item Seattle Angina Questionnaire Summary score favored INV (1.4 points [95% CI, 0.2-2.5] over all follow-up). No differences were observed in patients with rare/absent baseline angina (SAQ Angina Frequency score >80). Among patients with more frequent angina at baseline (SAQ Angina Frequency score <80, 744 patients, 41%), those randomly assigned to INV had a mean 3.7-point higher 19-item Seattle Angina Questionnaire Summary score than conservative strategy (95% CI, 1.6-5.8) with consistent effects across SAQ subscales: Physical Limitations 3.2 points (95% CI, 0.2-6.1), Angina Frequency 3.2 points (95% CI, 1.2-5.1), Quality of Life/Health Perceptions 5.3 points (95% CI, 2.8-7.8). For the Duke Activity Status Index, no difference was estimated overall by treatment, but in patients with baseline SAQ Angina Frequency scores <80, Duke Activity Status Index scores were higher for INV (3.2 points [95% CI, 0.6-5.7]), whereas patients with rare/absent baseline angina showed no treatment-related differences. Moderate to severe depression was infrequent at randomization (11.5%-12.8%) and was unaffected by treatment assignment.CONCLUSIONS: In the ISCHEMIA comprehensive QOL substudy, patients with more frequent baseline angina reported greater improvements in the symptom, physical functioning, and psychological well-being dimensions of QOL when treated with an invasive strategy, whereas patients who had rare/absent angina at baseline reported no consistent treatment-related QOL differences.
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35.
  • Maron, David J., et al. (author)
  • Initial Invasive or Conservative Strategy for Stable Coronary Disease
  • 2020
  • In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 382:15, s. 1395-1407
  • Journal article (peer-reviewed)abstract
    • Background: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain.Methods: We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction.Results: Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, -1.8 percentage points; 95% CI, -4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32).Conclusions: Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, .) Patients with stable coronary disease were randomly assigned to an initial invasive strategy with angiography and revascularization if appropriate or to medical therapy alone. At 3.2 years, there was no significant difference between the groups with respect to the estimated rate of ischemic events. The findings were sensitive to the definition of myocardial infarction.
  •  
36.
  • Mihailovic, Marko, et al. (author)
  • The personality of newly graduated and employed nurses : Temperament and character profiles of Swedish nurses
  • 2022
  • In: International Journal of Nursing Studies Advances. - : Elsevier BV. - 2666-142X. ; 4
  • Journal article (peer-reviewed)abstract
    • Background: One of the challenges of the 21st century is the high turnover rate in the nursing profession due to burnout and mental illness. From a biopsychosocial perspective, an individual's personality is an important vulnerability-resilience factor that comprises four temperament traits (i.e., a person's emotional reactions) and three character traits (i.e., self-regulation systems). Indeed, different personality profiles are associated to different coping strategies and health outcomes. Objective: We investigated and mapped the temperament and character of Swedish newly graduated and employed nurses’ in relation to the Swedish general population and an age-matched sub-sample. Design: In this cross-sectional study, nurses self-reported their personality (Temperament and Character Inventory) at the beginning of their employment. Setting: The data collection was conducted at a hospital in the South of Sweden. Participants: A total of 118 newly graduated and employed nurses (Mage = 25.95±5.58) and 1,564 individuals from the Swedish general population participated in the study. Methods: We calculated T-scores and percentiles for all seven personality dimensions using the Swedish norms (N = 1,564). The profiles were calculated by combining high/low percentiles scores in three temperament dimensions (Novelty Seeking: N/n, Harm Avoidance: H/h, and Reward Dependence: R/r) and in the three character dimensions (Self-Directedness: S/s, Cooperativeness: C/c and Self-Transcendence: T/t). Results: Regarding T-scores, the nurses reported moderately lower Novelty Seeking (> 0.5 SD), slightly higher Harm-Avoidance (about 0.5 SD), moderately higher Persistence (> 0.5 SD) and Reward Dependence (> 0.5 SD), and extremely lower Self-Directedness (> 1 SD). The prevalence of the most common temperament profiles among the nurses (Swedish general population in brackets) were: 39.80% [10.90%] Cautious (nHR), 21.20% [10.90] Reliable (nhR), and 15.30% [16.50%] Methodical (nHr). The prevalence of the most common character profiles among the nurses were: 31.40% [4.90%] Dependent (sCt), 25.40% [14.40%] Apathetic (sct), and 19.50% [8.80%] Moody (sCT). Conclusions: The analyses of the personality profiles showed that High Novelty Seeking (79%), high Harm Avoidance (65%) high Reward Dependence (80%), low Self-Directedness (95%), and low Self-Transcendence (60%) were more prevalent among the newly graduated and employed nurses. This may partially explain newly graduated nurses’ difficulties at work and high turnover rate. After all, a well-developed character is of special importance when working with patients with serious and terminal illness or under large global crises, such as the current pandemic. Hence, both education at universities and development at work need to be person-centered to reduce stress levels and promote positive self-regulation strategies.
  •  
37.
  • Miller, David T., et al. (author)
  • Consensus Statement : Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies
  • 2010
  • In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 86:5, s. 749-764
  • Journal article (peer-reviewed)abstract
    • Chromosomal microarray (CMA) is increasingly utilized for genetic testing of individuals with unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), or multiple congenital anomalies (MCA). Performing CMA and G-banded karyotyping on every patient substantially increases the total cost of genetic testing. The International Standard Cytogenomic Array (ISCA) Consortium held two international workshops and conducted a literature review of 33 studies, including 21,698 patients tested by CMA. We provide an evidence-based summary of clinical cytogenetic testing comparing CMA to G-banded karyotyping with respect to technical advantages and limitations, diagnostic yield for various types of chromosomal aberrations, and issues that affect test interpretation. CMA offers a much higher diagnostic yield (15%-20%) for genetic testing of individuals with unexplained DD/ID, ASD, or MCA than a G-banded karyotype (similar to 3%, excluding Down syndrome and other recognizable chromosomal syndromes), primarily because of its higher sensitivity for submicroscopic deletions and duplications. Truly balanced rearrangements and low-level mosaicism are generally not detectable by arrays, but these are relatively infrequent causes of abnormal phenotypes in this population (<1%). Available evidence strongly supports the use of CMA in place of G-banded karyotyping as the first-tier cytogenetic diagnostic test for patients with DD/ID, ASD, or MCA. G-banded karyotype analysis should be reserved for patients with obvious chromosomal syndromes (e.g., Down syndrome), a family history of chromosomal rearrangement, or a history of multiple miscarriages.
  •  
38.
  • Raffnsøe, Sverre, et al. (author)
  • Editorial
  • 2021
  • In: Foucault Studies. - Copenhagen : Copenhagen Business School Press. - 1832-5203. ; :30, s. i-iv
  • Journal article (other academic/artistic)abstract
    • Shortly after thepublicationin April 2021of thethemedspecial issueFoucault’s History ofSexuality Vol. 4, Confessions of the Flesh, theeditors ofFoucault Studiesareinordinatelypleasedto present thisnon-themed issue containingthree original articles.Thefirstofthesearticles,“Resistance: An Arendtian Reading of Solidarity and Friend-ship in Foucault,” by Liesbeth Schoonheim (KU Leuven, Belgium)compares the accountsof resistance in Arendt and Foucault.While recent scholarship has firmly established thesimilarities betweenthem, in particular with regard tothe diagnosis ofthe dangers of late-modern social processesleading to atomization,totalitarianismandbiological racism,there are alsosignificantdifferences.AlthoughFoucaulthas reflected more extensivelyand rigorously on the shapes and conditions of resistance,thepaper argues that Fou-cault’scomprehensive accountof resistanceomits the encounter with the other,whereasthis encounterwith theunique and unfathomableotherhas been putat the center of po-litical praxis andof acts of resistanceby Arendt.Developing the discussion of resistancein Arendtasshearticulatesitin response to the Shoah,the article claims thatshe providesa concept of solidarity and friendship thatcan bedrawnupon to extend Foucault’s anal-ysis of the transnational solidarity among the governed in fighting for their rights vis-à-vis their governments, as well as tore-articulate andadvancehisunderstandingof friendship.
  •  
39.
  • Rapp-Ricciardi, Max, 1964, et al. (author)
  • A Pilot Study on Character (Self-directedness, Cooperativeness, and Self-transcendence) among Swedish Newly Graduated Nurses
  • 2019
  • In: 3rd Biennial International Convention of Psychological Science, Paris, France.
  • Conference paper (other academic/artistic)abstract
    • Character or an individual’s relation to the self (Self-Directedness) and others (Cooperativeness) and her participation in the world as a whole (Self-Transcendence) are important ingredients for well-being. Here we found that, compared to the general population, about 73% of Swedish newly graduated nurses were low in both Self-Directedness and Self-Transcendence.
  •  
40.
  • Razavi, Homie A., et al. (author)
  • Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries
  • 2023
  • In: JOURNAL OF HEPATOLOGY. - : Elsevier. - 0168-8278 .- 1600-0641. ; 79:2, s. 576-580
  • Journal article (peer-reviewed)abstract
    • Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, and mortality compared to hepatitis B virus (HBV) monoinfection. Reliable estimates of the prevalence of HDV infection and disease burden are essential to formulate strategies to find coinfected individuals more effectively and efficiently. The global prevalence of HBV infections was estimated to be 262,240,000 in 2021. Only 1,994,000 of the HBV in-fections were newly diagnosed in 2021, with more than half of the new diagnoses made in China. Our initial estimates indicated a much lower prevalence of HDV antibody (anti-HDV) and HDV RNA positivity than previously reported in published studies. Ac-curate estimates of HDV prevalence are needed. The most effective method to generate estimates of the prevalence of anti-HDV and HDV RNA positivity and to find undiagnosed individuals at the national level is to implement double reflex testing. This re-quires anti-HDV testing of all hepatitis B surface antigen-positive individuals and HDV RNA testing of all anti-HDV-positive in-dividuals. This strategy is manageable for healthcare systems since the number of newly diagnosed HBV cases is low. At the global level, a comprehensive HDV screening strategy would require only 1,994,000 HDV antibody tests and less than 89,000 HDV PCR tests. Double reflex testing is the preferred strategy in countries with a low prevalence of HBV and those with a high prevalence of both HBV and HDV. For example, in the European Union and North America only 35,000 and 22,000 cases, respectively, will require anti-HDV testing annually.
  •  
41.
  • Reynolds, Harmony R., et al. (author)
  • Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease : Insights From the ISCHEMIA Trial
  • 2024
  • In: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 13:5
  • Journal article (peer-reviewed)abstract
    • BackgroundWomen with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline‐directed medical therapy, and outcomes among patients with chronic coronary disease with ischemia on stress testing, with and without invasive management.Methods and ResultsThe ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial randomized patients with moderate or severe ischemia to invasive management with angiography, revascularization, and guideline‐directed medical therapy, or initial conservative management with guideline‐directed medical therapy alone. We evaluated the primary outcome (cardiovascular death, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest) and other end points, by sex, in 1168 (22.6%) women and 4011 (77.4%) men. Invasive group catheterization rates were similar, with less revascularization among women (73.4% of invasive‐assigned women revascularized versus 81.2% of invasive‐assigned men; P<0.001). Women had less coronary artery disease: multivessel in 60.0% of invasive‐assigned women and 74.8% of invasive‐assigned men, and no ≥50% stenosis in 12.3% versus 4.5% (P<0.001). In the conservative group, 4‐year catheterization rates were 26.3% of women versus 25.6% of men (P=0.72). Guideline‐directed medical therapy use was lower among women with fewer risk factor goals attained. There were no sex differences in the primary outcome (adjusted hazard ratio [HR] for women versus men, 0.93 [95% CI, 0.77–1.13]; P=0.47) or the major secondary outcome of cardiovascular death/myocardial infarction (adjusted HR, 0.93 [95% CI, 0.76–1.14]; P=0.49), with no significant sex‐by‐treatment‐group interactions.ConclusionsWomen had less extensive coronary artery disease and, therefore, lower revascularization rates in the invasive group. Despite lower risk factor goal attainment, women with chronic coronary disease experienced similar risk‐adjusted outcomes to men in the ISCHEMIA trial.
  •  
42.
  • Salazar, Ramon, et al. (author)
  • Comparison of ColoPrint risk classification with clinical risk in the prospective PARSC trial
  • 2014
  • In: Journal of Clinical Oncology. - Inst Catala Oncol, Early Clin Res Unit, Lhospitalet Barcelona, Spain. Vall dHebron Univ Hosp, Barcelona, Spain. Kantonsspital Baden, Dept Surg, Baden, Switzerland. Akad Univ Hosp, Uppsala, Sweden. Westfries Gasthuis, Hoorn, Netherlands. Inst Canc Montpelier, Dept Pathol, Montpellier, France. Med Spectrum Twente, Enschede, Netherlands. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Med Ctr Alkmaar, Alkmaar, Netherlands. Med Univ Vienna, Vienna, Austria. Univ Oxford, Dept Oncol, Oxford, England. Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA. Matsuda Hosp, Hamamatsu, Shizuoka, Japan. Acad Teaching Hosp, Linz, Austria. South Orange Cty Surg Med Grp, Laguna Hills, CA USA. Norfolk & Norwich Univ Hosp NHS FT, Norwich, Norfolk, England. Univ Hong Kong, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China. Long Beach Mem Med Ctr, Long Beach, CA USA. Agendia, Amsterdam, Netherlands. Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA.. - 0732-183X .- 1527-7755. ; 32:15
  • Journal article (peer-reviewed)
  •  
43.
  • Schweinsberg, Martin, et al. (author)
  • Same data, different conclusions : Radical dispersion in empirical results when independent analysts operationalize and test the same hypothesis
  • 2021
  • In: Organizational Behavior and Human Decision Processes. - : Elsevier BV. - 0749-5978 .- 1095-9920. ; 165, s. 228-249
  • Journal article (peer-reviewed)abstract
    • In this crowdsourced initiative, independent analysts used the same dataset to test two hypotheses regarding the effects of scientists' gender and professional status on verbosity during group meetings. Not only the analytic approach but also the operationalizations of key variables were left unconstrained and up to individual analysts. For instance, analysts could choose to operationalize status as job title, institutional ranking, citation counts, or some combination. To maximize transparency regarding the process by which analytic choices are made, the analysts used a platform we developed called DataExplained to justify both preferred and rejected analytic paths in real time. Analyses lacking sufficient detail, reproducible code, or with statistical errors were excluded, resulting in 29 analyses in the final sample. Researchers reported radically different analyses and dispersed empirical outcomes, in a number of cases obtaining significant effects in opposite directions for the same research question. A Boba multiverse analysis demonstrates that decisions about how to operationalize variables explain variability in outcomes above and beyond statistical choices (e.g., covariates). Subjective researcher decisions play a critical role in driving the reported empirical results, underscoring the need for open data, systematic robustness checks, and transparency regarding both analytic paths taken and not taken. Implications for orga-nizations and leaders, whose decision making relies in part on scientific findings, consulting reports, and internal analyses by data scientists, are discussed.
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44.
  • Stevens, Kristen N, et al. (author)
  • 19p13.1 is a triple negative-specific breast cancer susceptibility locus
  • 2012
  • In: Cancer Research. - 0008-5472 .- 1538-7445. ; 72, s. 1795-
  • Journal article (peer-reviewed)abstract
    • The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 Odds Ratio (OR)=1.10, 95% Confidence Interval (CI) 1.05 - 1.15, p=3.49 x 10-5] and triple negative (TN) (ER, PR and HER2 negative) breast cancer [rs8170 OR=1.22, 95% CI 1.13 - 1.31, p=2.22 x 10-7]. However, rs8170 was no longer associated with ER-negative breast cancer risk when TN cases were excluded [OR=0.98, 95% CI 0.89 - 1.07, p=0.62]. In addition, a combined analysis of TN cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC) (n=3,566) identified a genome-wide significant association between rs8170 and TN breast cancer risk [OR=1.25, 95% CI 1.18 - 1.33, p=3.31 x 10-13]. Thus, 19p13.1 is the first triple negative-specific breast cancer risk locus and the first locus specific to a histological subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple negative tumors and other subtypes likely arise through distinct etiologic pathways.
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45.
  • Witjes, J. Alfred, et al. (author)
  • EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer – An International Collaborative Multistakeholder Effort : Under the Auspices of the EAU-ESMO Guidelines Committees
  • 2020
  • In: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 77:2, s. 223-250
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial.OBJECTIVE: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management.DESIGN: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts prior to voting during a consensus conference.SETTING: Online Delphi survey and consensus conference.PARTICIPANTS: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), and 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus).RESULTS AND LIMITATIONS: Overall, 116 statements were included in the Delphi survey. Of these statements, 33 (28%) achieved level 1 consensus and 49 (42%) achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease, and the evolving role of checkpoint inhibitor therapy in metastatic disease.CONCLUSIONS: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time when further evidence is available to guide our approach.PATIENT SUMMARY: This report summarises findings from an international, multistakeholder project organised by the EAU and ESMO. In this project, a steering committee identified areas of bladder cancer management where there is currently no good-quality evidence to guide treatment decisions. From this, they developed a series of proposed statements, 71 of which achieved consensus by a large group of experts in the field of bladder cancer. It is anticipated that these statements will provide further guidance to health care professionals and could help improve patient outcomes until a time when good-quality evidence is available.
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46.
  • Thomas, HS, et al. (author)
  • 2019
  • swepub:Mat__t
  •  
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