| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
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| 3. |
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| 4. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 5. |
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| 6. |
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| 7. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 8. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 9. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 10. |
- Mishra, A., et al.
(författare)
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Stroke genetics informs drug discovery and risk prediction across ancestries
- 2022
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 611, s. 115-123
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Tidskriftsartikel (refereegranskat)abstract
- Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
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| 11. |
- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 12. |
- Aaltonen, T., et al.
(författare)
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Combination of CDF and D0 measurements of the W boson helicity in top quark decays
- 2012
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 85:7, s. 071106-
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Tidskriftsartikel (refereegranskat)abstract
- We report the combination of recent measurements of the helicity of the W boson from top quark decay by the CDF and D0 collaborations, based on data samples corresponding to integrated luminosities of 2.7-5.4 fb(-1) of p (p) over bar collisions collected during Run II of the Fermilab Tevatron collider. Combining measurements that simultaneously determine the fractions of W bosons with longitudinal (f(0)) and right-handed (f(+)) helicities, we find f(0) = 0.722 +/- 0.081[+/- 0.062(stat) +/- 0.052(syst)] and f(+) = -0.033 +/- 0.046[+/- 0.034(stat) +/- 0.031(syst)]. Combining measurements where one of the helicity fractions is fixed to the value expected in the standard model, we find f(0) = 0.682 +/- 0.057[+/- 0.035(stat) +/- 0.046(syst)] for fixed f(+) and f(+) = -0.015 +/- 0.035[+/- 0.018(stat) +/- 0.030(syst)] for fixed f(0). The results are consistent with standard model expectations.
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| 13. |
- Aaltonen, T., et al.
(författare)
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Evidence for a Particle Produced in Association with Weak Bosons and Decaying to a Bottom-Antibottom Quark Pair in Higgs Boson Searches at the Tevatron
- 2012
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 109:7, s. 071804-
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Tidskriftsartikel (refereegranskat)abstract
- We combine searches by the CDF and D0 Collaborations for the associated production of a Higgs boson with a W or Z boson and subsequent decay of the Higgs boson to a bottom-antibottom quark pair. The data, originating from Fermilab Tevatron p (p) over bar collisions at root s = 1.96 TeV, correspond to integrated luminosities of up to 9.7 fb(-1). The searches are conducted for a Higgs boson with mass in the range 100-150 GeV/c(2). We observe an excess of events in the data compared with the background predictions, which is most significant in the mass range between 120 and 135 GeV/c(2). The largest local significance is 3.3 standard deviations, corresponding to a global significance of 3.1 standard deviations. We interpret this as evidence for the presence of a new particle consistent with the standard model Higgs boson, which is produced in association with a weak vector boson and decays to a bottom-antibottom quark pair.
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| 14. |
- Aaltonen, T., et al.
(författare)
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Combination of CDF and D0 W-Boson mass measurements
- 2013
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:5, s. 052018-
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Tidskriftsartikel (refereegranskat)abstract
- We summarize and combine direct measurements of the mass of the W boson in root s = 1.96 TeV proton-antiproton collision data collected by CDF and D0 experiments at the Fermilab Tevatron Collider. Earlier measurements from CDF and D0 are combined with the two latest, more precise measurements: a CDF measurement in the electron and muon channels using data corresponding to 2.2 fb(-1) of integrated luminosity, and a D0 measurement in the electron channel using data corresponding to 4.3 fb(-1) of integrated luminosity. The resulting Tevatron average for the mass of the W boson is M-W = 80387 +/- 16 MeV. Including measurements obtained in electron-positron collisions at LEP yields the most precise value of M-W = 80385 +/- 15 MeV.
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| 15. |
- Aaltonen, T., et al.
(författare)
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Combination of measurements of the top-quark pair production cross section from the Tevatron Collider
- 2014
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:7
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Tidskriftsartikel (refereegranskat)abstract
- We combine six measurements of the inclusive top-quark pair (t(sic)) production cross section (sigma(t)(sic)) from data collected with the CDF and D0 detectors at the Fermilab Tevatron with proton-antiproton collisions at root s = 1.96 TeV. The data correspond to integrated luminosities of up to 8.8 fb(-1). We obtain a value of sigma tt = 7.60 +/- 0.41 pb for a top-quark mass of m(t) = 172.5 GeV. The contributions to the uncertainty are 0.20 pb from statistical sources, 0.29 pb from systematic sources, and 0.21 pb from the uncertainty on the integrated luminosity. The result is in good agreement with the standard model expectation of 7.35(-0.33)(+0.28) pb at next-to-next-to-leading order and next-to-next-to leading logarithms in perturbative QCD.
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| 16. |
- Aaltonen, T., et al.
(författare)
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Observation of s-Channel Production of Single Top Quarks at the Tevatron
- 2014
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 112:23
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Tidskriftsartikel (refereegranskat)abstract
- We report the first observation of single-top-quark production in the s channel through the combination of the CDF and D0 measurements of the cross section in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV. The data correspond to total integrated luminosities of up to 9.7 fb(-1) per experiment. The measured cross section is sigma(s) = 1.29(-0.24)(+0.26) pb. The probability of observing a statistical fluctuation of the background to a cross section of the observed size or larger is 1.8 x 10(-10), corresponding to a significance of 6.3 standard deviations for the presence of an s-channel contribution to the production of single-top quarks.
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| 17. |
- Aaltonen, T., et al.
(författare)
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Tevatron Combination of Single-Top-Quark Cross Sections and Determination of the Magnitude of the Cabibbo-Kobayashi-Maskawa Matrix Element V-tb
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:15
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Tidskriftsartikel (refereegranskat)abstract
- We present the final combination of CDF and D0 measurements of cross sections for single-top-quark production in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV. The data correspond to total integrated luminosities of up to 9.7 fb(-1) per experiment. The t-channel cross section is measured to be sigma(t) = 2.25(-0.31)(+0.29) pb. We also present the combinations of the two-dimensional measurements of the s- vs t-channel cross section. In addition, we give the combination of the s + t channel cross section measurement resulting in sigma(s+t) = 3.30(-0.40)(+0.52) pb, without assuming the standard model value for the ratio sigma(s)/sigma(t). The resulting value of the magnitude of the top-to-bottom quark coupling is vertical bar V-tb vertical bar = 1.02(-0.05)(+0.06), corresponding to vertical bar V-tb vertical bar > 0.92 at the 95% C. L.
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| 18. |
- Aaltonen, T., et al.
(författare)
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Tevatron Constraints on Models of the Higgs Boson with Exotic Spin and Parity Using Decays to Bottom-Antibottom Quark Pairs
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:15
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Tidskriftsartikel (refereegranskat)abstract
- Combined constraints from the CDF and D0 Collaborations on models of the Higgs boson with exotic spin J and parity P are presented and compared with results obtained assuming the standard model value J(P) = 0(+). Both collaborations analyzed approximately 10 fb(-1) of proton-antiproton collisions with a center-of-mass energy of 1.96 TeV collected at the Fermilab Tevatron. Two models predicting exotic Higgs bosons with J(P) = 0(-) and J(P) = 2(+) are tested. The kinematic properties of exotic Higgs boson production in association with a vector boson differ from those predicted for the standard model Higgs boson. Upper limits at the 95% credibility level on the production rates of the exotic Higgs bosons, expressed as fractions of the standard model Higgs boson production rate, are set at 0.36 for both the J(P) = 0(-) hypothesis and the J(P) = 2(+) hypothesis. If the production rate times the branching ratio to a bottom-antibottom pair is the same as that predicted for the standard model Higgs boson, then the exotic bosons are excluded with significances of 5.0 standard deviations and 4.9 standard deviations for the J(P) = 0(-) and J(P) = 2(+) hypotheses, respectively.
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| 19. |
- Aaltonen, T., et al.
(författare)
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Tevatron Run II combination of the effective leptonic electroweak mixing angle
- 2018
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:11
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Tidskriftsartikel (refereegranskat)abstract
- Drell-Yan lepton pairs produced in the process p (p) over bar -> l(+)l(-) + X through an intermediate gamma*/Z boson have an asymmetry in their angular distribution related to the spontaneous symmetry breaking of the electroweak force and the associated mixing of its neutral gauge bosons. The CDF and D0 experiments have measured the effective-leptonic electroweak mixing parameter sin(2) theta(lept)(eff) using electron and muon pairs selected from the full Tevatron proton-antiproton data sets collected in 2001-2011, corresponding to 9-10 fb(-1) of integrated luminosity. The combination of these measurements yields the most precise result from hadron colliders, sin(2)theta(lept)(eff) = 0.23148 +/- 0.00033. This result is consistent with, and approaches in precision, the best measurements from electron-positron colliders. The standard model inference of the on-shell electroweak mixing parameter sin(2) theta(W), or equivalently the W-boson mass M-W, using the ZFITTER software package yields sin(2) theta(W) = 0.22324 +/- 0.00033 or equivalently, M-W = 80.367 +/- 0.017 GeV/c(2).
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| 20. |
- Aaltonen, T., et al.
(författare)
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Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron
- 2018
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Ingår i: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 120:4
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Tidskriftsartikel (refereegranskat)abstract
- The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of root s = 1.96 TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A(FB)(t (t) over bar) = 0.128 +/- 0.025. The combined inclusive and differential asymmetries are consistent with recent standard model predictions.
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| 21. |
- Aaltonen, T., et al.
(författare)
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Higgs boson studies at the Tevatron
- 2013
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:5, s. 052014-
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Tidskriftsartikel (refereegranskat)abstract
- We combine searches by the CDF and D0 Collaborations for the standard model Higgs boson with mass in the range 90-200 GeV/c(2) produced in the gluon-gluon fusion, WH, ZH, t (t) over barH, and vector boson fusion processes, and decaying in the H -> b (b) over bar, H -> W+W-, H -> ZZ, H -> tau(+)tau(-), and H -> gamma gamma modes. The data correspond to integrated luminosities of up to 10 fb(-1) and were collected at the Fermilab Tevatron in p (p) over bar collisions at root s = 1.96 TeV. The searches are also interpreted in the context of fermiophobic and fourth generation models. We observe a significant excess of events in the mass range between 115 and 140 GeV/c(2). The local significance corresponds to 3.0 standard deviations at m(H) = 125 GeV/c(2), consistent with the mass of the Higgs boson observed at the LHC, and we expect a local significance of 1.9 standard deviations. We separately combine searches for H -> b (b) over bar, H -> W+W-, H -> tau(+)tau(-), and H -> gamma gamma. The observed signal strengths in all channels are consistent with the presence of a standard model Higgs boson with a mass of 125 GeV/c(2).
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| 22. |
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| 23. |
- Khatri, C, et al.
(författare)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 24. |
- Bousquet, Jean, et al.
(författare)
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- 2019
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:3, s. 864-879
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Tidskriftsartikel (refereegranskat)abstract
- Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
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| 25. |
- Buchanan, E. M., et al.
(författare)
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The Psychological Science Accelerator's COVID-19 rapid-response dataset
- 2023
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Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data.
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| 26. |
- Menditto, Enrica, et al.
(författare)
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Adherence to treatment in allergic rhinitis using mobile technology : The MASK Study
- 2019
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Ingår i: Clinical and Experimental Allergy. - : WILEY. - 0954-7894 .- 1365-2222. ; 49:4, s. 442-460
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Tidskriftsartikel (refereegranskat)abstract
- Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.
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| 27. |
- Abazov, V. M., et al.
(författare)
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Measurement of the differential cross section d sigma/dt in elastic p(p)over-bar scattering at root s=1.96 TeV
- 2012
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 86:1, s. 012009-
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the elastic differential cross section dσ(pp̅ →pp̅ )/dt as a function of the four-momentum-transfer squared t. The data sample corresponds to an integrated luminosity of ≈31 nb-1 collected with the D0 detector using dedicated Tevatron pp̅ Collider operating conditions at √s=1.96 TeV and covers the range 0.26<|t|<1.2 GeV2. For |t|<0.6 GeV2, dσ/dt is described by an exponential function of the form Ae-b|t| with a slope parameter b=16.86±0.10(stat)±0.20(syst) GeV-2. A change in slope is observed at |t|≈0.6 GeV2, followed by a more gradual |t| dependence with increasing values of |t|.
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| 28. |
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| 29. |
- Figlioli, G, et al.
(författare)
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- 2019
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Ingår i: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 5, s. 38-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.
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| 30. |
- Abazov, V. M., et al.
(författare)
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Combination of searches for anomalous top quark couplings with 5.4 fb(-1) of p(p)over-bar collisions
- 2012
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 713:3, s. 165-171
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of the tWb coupling form factors using information from electroweak single top quark production and from the helicity of W bosons from top quark decays in t (t) over bar events. We set upper limits on anomalous tWb coupling form factors using data collected with the DO detector at the Tevatron p (p) over bar collider corresponding to an integrated luminosity of 5.4 fb(-1).
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| 31. |
- Abazov, V. M., et al.
(författare)
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Measurement of the Lambda(0)(b) lifetime in the exclusive decay Lambda(0)(b) -> J/psi Lambda(0) in p(p)over-bar collisions at root s=1.96 TeV
- 2012
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 85:11, s. 112003-
-
Tidskriftsartikel (refereegranskat)abstract
- We measure the Lambda(0)(b) lifetime in the fully reconstructed decay Lambda(0)(b) -> J/psi Lambda(0) using 10.4 fb(-1) of p (p) over bar collisions collected with the D0 detector at root s = 1.96 TeV. The lifetime of the topologically similar decay channel B-0 -> J/psi K-S(0) is also measured. We obtain tau(Lambda(0)(b)) = 1.303 +/- 0.075(stat) +/- 0.035(syst) ps and tau(B-0) = 1.508 +/- 0.025(stat) +/- 0.043(syst) ps. Using these measurements, we determine the lifetime ratio of tau(Lambda(0)(b))/tau(B-0) = 0.864 +/- 0.052(stat) +/- 0.033(syst).
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| 32. |
- Abazov, V. M., et al.
(författare)
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Measurement of the photon plus b-jet production differential cross section in p(p)over-bar) collisions at root s=1.96 TeV
- 2012
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 714:1, s. 32-39
-
Tidskriftsartikel (refereegranskat)abstract
- We present measurements of the differential cross section d sigma/dp(T)(gamma) for the inclusive production of a photon in association with a b-quark jet for photons with rapidities vertical bar y(gamma)vertical bar < 1.0 and 30 < p(T)(gamma) < 300 GeV, as well as for photons with 1.5 < vertical bar y(gamma)vertical bar < 2.5 and 30 < p(T)(gamma) < 200 GeV, where p(T)(gamma) is the photon transverse momentum. The b-quark jets are required to have p(T) > 15 GeV and rapidity vertical bar Y-jet vertical bar < 1.5. The results are based on data corresponding to an integrated luminosity of 8.7 fb(-1), recorded with the DO detector at the Fermilab Tevatron p<(p)over bar>) Collider at root s = 1.96 TeV. The measured cross sections are compared with next-to-leading order perturbative QCD calculations using different sets of parton distribution functions as well as to predictions based on the k(T)-factorization QCD approach, and those from the SHERPA and PYTHIA Monte Carlo event generators.
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| 33. |
- Abazov, V. M., et al.
(författare)
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Observation of a narrow mass state decaying into Y(1S)+gamma in p(p)over-bar collisions at root s=1.96 TeV
- 2012
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 86:3, s. 031103-
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Tidskriftsartikel (refereegranskat)abstract
- Using data corresponding to an integrated luminosity of 1.3 fb(-1), we observe a narrow mass state decaying into Gamma(1S) + gamma, where the Gamma(1S) meson is detected by its decay into a pair of oppositely charged muons, and the photon is identified through its conversion into an electron-positron pair. The significance of this observation is 5.6 standard deviations. The mass of the state is centered at 10.551 +/- 0.014(stat) +/- 0.017(syst) GeV/c(2), which is consistent with that of the state recently observed by the ATLAS Collaboration.
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| 34. |
- Abazov, V. M., et al.
(författare)
-
Search for the standard model Higgs boson in tau lepton final states D0 Collaboration
- 2012
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 714:2-5, s. 237-245
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for the standard model Higgs boson in final states with an electron or muon and a hadronically decaying tau lepton in association with zero, one, or two or more jets using data corresponding to an integrated luminosity of up to 7.3 fb(-1) collected with the D0 detector at the Fermilab Tevatron collider. The analysis is sensitive to Higgs boson production via gluon-gluon fusion, associated vector boson production, and vector boson fusion, and to Higgs boson decays to tau tau, WW, ZZ and b (b) over bar pairs. Observed (expected) limits are set on the ratio of 95% C.L. upper limits on the cross section times branching ratio, relative to those predicted by the Standard Model, of 22 (14) at a Higgs boson mass of 115 GeV and 6.8 (7.7) at 165 GeV.
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| 35. |
- Abazov, V. M., et al.
(författare)
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Search for Violation of Lorentz Invariance in Top Quark Pair Production and Decay
- 2012
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 108:26, s. 261603-
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Tidskriftsartikel (refereegranskat)abstract
- Using data collected with the D0 detector at the Fermilab Tevatron Collider, corresponding to 5: 3 fb(-1) of integrated luminosity, we search for violation of Lorentz invariance by examining the t (t) over bar production cross section in lepton + jets final states. We quantify this violation using the standard-model extension framework, which predicts a dependence of the t (t) over bar production cross section on sidereal time as the orientation of the detector changes with the rotation of the Earth. Within this framework, we measure components of the matrices (c(Q))(mu nu 33) and (c(U))(mu nu 33) containing coefficients used to parametrize violation of Lorentz invariance in the top quark sector. Within uncertainties, these coefficients are found to be consistent with zero.
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| 36. |
- Abazov, V. M., et al.
(författare)
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Search for Z gamma events with large missing transverse energy in p(p)over-bar collisions at root s = 1.96 TeV
- 2012
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 86:7, s. 071701-
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Tidskriftsartikel (refereegranskat)abstract
- We present the first search for new phenomena in Z gamma final states with large missing transverse energy using data corresponding to an integrated luminosity of 6.2 fb(-1) collected with the D0 experiment in p (p) over bar collisions at root s 1.96 TeV. This signature is predicted in gauge-mediated supersymmetry-breaking models, where the lightest neutralino (chi) over tilde (0)(1) is the next-to-lightest supersymmetric particle and is produced in pairs, possibly through decay from heavier supersymmetric particles. The (chi) over tilde (0)(1) can decay either to a Z boson or a photon and an associated gravitino that escapes detection. We exclude this model at the 95% C.L. for supersymmetry-breaking scales of Lambda < 87 TeV.
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| 37. |
- Abazov, V. M., et al.
(författare)
-
Study of the decay Bs0→J/ψf2′(1525) in μ +μ -K +K - final states
- 2012
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 86:9, s. 092011-
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the decay Bs0→J/ψK +K - for invariant masses of the K +K - pair in the range 1.35<M(K +K -)<2GeV. The data sample corresponds to an integrated luminosity of 10.4fb -1 of pp̄ collisions at √s=1.96TeV accumulated with the D0 detector at the Fermilab Tevatron collider. From the study of the invariant mass and spin of the K +K - system, we find evidence for the two-body decay Bs0→J/ψf2′(1525) and measure the relative branching fraction of the decays Bs0→J/ψf2′(1525) and Bs0→J/ψ to be R f2′/=0.19±0.05(stat)±0.04(syst).
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| 38. |
- Abazov, V. M., et al.
(författare)
-
B-s(0) lifetime measurement in the CP-odd decay channel B-s(0) -> J/Psi f(0)(980)
- 2016
-
Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 94:1
-
Tidskriftsartikel (refereegranskat)abstract
- The lifetime of the B-s(0) meson is measured in the decay channel B-s(0) -> J/Psi pi(+)pi(-) with 880 <= M pi+pi- <= 1080 MeV/c(2), which is mainly a CP-odd state and dominated by the f(0)(980) resonance. In 10.4 fb(-1) of data collected with the D0 detector in Run II of the Tevatron, the lifetime of the B-s(0) meson is measured to be tau(B-s(0)) = 1.70 +/- 0.14(stat) +/- 0.05(syst) ps. Neglecting CP violation in B-s(0)/(B) over bar (0)(s) mixing, the measurement can be translated into the width of the heavy mass eigenstate of the B-s(0), Gamma(H) = 0.59 +/- 0.05(stat) +/- 0.02(syst) ps(-1).
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| 39. |
- Abazov, V. M., et al.
(författare)
-
Combination of D0 measurements of the top quark mass
- 2017
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 95:11
-
Tidskriftsartikel (refereegranskat)abstract
- We present a combination of measurements of the top quark mass by the D0 experiment in the lepton + jets and dilepton channels. We use all the data collected in Run I (1992-1996) at root s = 1.8 TeV and Run II (2001-2011) at root s = 1.96 TeV of the Tevatron p (p) over bar collider, corresponding to integrated luminosities of 0.1 fb(-1) and 9.7 fb(-1), respectively. The combined result is: m(t) = 174.95 +/- 0.40(stat)+/- 0.64(syst) GeV = 174.95 +/- 0.75 GeV.
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| 40. |
- Abazov, V. M., et al.
(författare)
-
Combined search for the Higgs boson with the D0 experiment
- 2013
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:5, s. 052011-
-
Tidskriftsartikel (refereegranskat)abstract
- We perform a combination of searches for standard model Higgs boson production in p (p) over bar collisions recorded by the D0 detector at the Fermilab Tevatron Collider at a center of mass energy of root s = 1.96 TeV. The different production and decay channels have been analyzed separately, with integrated luminosities of up to 9.7 fb(-1) and for Higgs boson masses 90 <= M-H <= 200 GeV. We combine these final states to achieve optimal sensitivity to the production of the Higgs boson. We also interpret the combination in terms of models with a fourth generation of fermions, and models with suppressed Higgs boson couplings to fermions. The result excludes a standard model Higgs boson at 95% C.L. in the ranges 90 < M-H < 101 GeV and 157 < M-H < 178 GeV, with an expected exclusion of 155 < M-H < 175 GeV. In the range 120 < M-H < 145 GeV, the data exhibit an excess over the expected background of up to 2 standard deviations, consistent with the presence of a standard model Higgs boson of mass 125 GeV.
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| 41. |
- Abazov, V. M., et al.
(författare)
-
Combined Search for the Standard Model Higgs Boson Decaying to b(b)over-bar Using the D0 Run II Data Set
- 2012
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 109:12, s. 121802-
-
Tidskriftsartikel (refereegranskat)abstract
- We present the results of the combination of searches for the standard model Higgs boson produced in association with a W or Z boson and decaying into b (b) over bar using the data sample collected with the D0 detector in p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron Collider. We derive 95% C.L. upper limits on the Higgs boson cross section relative to the standard model prediction in the mass range 100 GeV <= M-H <= 150 GeV, and we exclude Higgs bosons with masses smaller than 102 GeV at the 95% C.L. In the mass range 120 GeV <= M-H <= 145 GeV, the data exhibit an excess above the background prediction with a global significance of 1.5 standard deviations, consistent with the expectation in the presence of a standard model Higgs boson.
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| 42. |
- Abazov, V. M., et al.
(författare)
-
Constraints on Models for the Higgs Boson with Exotic Spin and Parity in VH -> Vb(b)over-bar Final States
- 2014
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 113:16, s. 161802-
-
Tidskriftsartikel (refereegranskat)abstract
- We present constraints on models containing non-standard-model values for the spin J and parity P of the Higgs boson H in up to 9.7 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV collected with the D0 detector at the Fermilab Tevatron Collider. These are the first studies of Higgs boson J(P) with fermions in the final state. In the ZH -> llb (b) over bar, WH -> l nu b (b) over barb, and ZH -> nu nu b (b) over bar final states, we compare the standard model (SM) Higgs boson prediction, J(P) = 0(+), with two alternative hypotheses, J(P) = 0(-) and J(P) = 2(+). We use a likelihood ratio to quantify the degree to which our data are incompatible with non-SM J(P) predictions for a range of possible production rates. Assuming that the production rate in the signal models considered is equal to the SM prediction, we reject the J(P) = 0(-) and J(P) = 2(+) hypotheses at the 97.6% CL and at the 99.0% CL, respectively. The expected exclusion sensitivity for a J(P) = 0(-)(J(P) = 2(+)) state is at the 99.86% (99.94%) CL. Under the hypothesis that our data are the result of a combination of the SM-like Higgs boson and either a J(P) = 0(-) or a J(P) = 2(+) signal, we exclude a J(P) = 0(-) fraction above 0.80 and a JP = 2(+) fraction above 0.67 at the 95% CL. The expected exclusion covers J(P) = 0(-)(J(P) = 2(+)) fractions above 0.54 (0.47).
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| 43. |
- Abazov, V. M., et al.
(författare)
-
Double parton interactions in gamma+3 jet and gamma plus b/c jet+2 jet events in p(p)over-bar collisions at root s=1.96 TeV
- 2014
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:7, s. 072006-
-
Tidskriftsartikel (refereegranskat)abstract
- We determine the fraction of events with double parton (DP) Scattering in a single p (p) over bar collisions at root s = 1.96 TeV in gamma + 3 jet and gamma + b/c jet + 2 jet events collected with the D0 detector and corresponding to an integrated luminosity of about 8.7 fb(-1). The DP fractions and effective cross sections (sigma(eff)) are measured for both event samples using the same kinematic selections. The measured DP fractions range from 0.21 to 0.17, with effective cross sections in the gamma + 3 jet and gamma + b/cjet + 2 jet samples of sigma(incl)(eff) = 12.7 +/- 0.2(stat) +/- 1.3(syst) mb and sigma(HF)(eff) = 14.6 +/- 0.6(stat) +/- 3.2(syst) mb, respectively.
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| 44. |
- Abazov, V. M., et al.
(författare)
-
Electron and photon identification in the Do experiment
- 2014
-
Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 750, s. 78-95
-
Tidskriftsartikel (refereegranskat)abstract
- The electron and photon reconstruction and identification algorithms used by the DO Collaboration at the Fermilab Tevatron collider are described. The determination of the electron energy scale and resolution is presented. Studies of the performance of the electron and photon reconstruction and identification are summarized. The results are based on measurements of Z boson decay events of Z ee and Z gamma ll(i=e mu) collected in pp(over bar) collisions at a center- of- mass energy of 1.96 TeV using an integrated luminosity of up to10 fb(-1.)
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| 45. |
- Abazov, V. M., et al.
(författare)
-
Evidence for a B-s(0)pi(+/-) State
- 2016
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 117:2
-
Tidskriftsartikel (refereegranskat)abstract
- We report evidence for a narrow structure, X(5568), in the decay sequence X(5568) -> B-s(0)pi(+/-), B-s(0) -> J/psi phi, J/psi -> mu(+)mu(-), phi -> K+K-. This is evidence for the first instance of a hadronic state with valence quarks of four different flavors. The mass and natural width of this state are measured to be m = 5567.8 +/- 2.9(stat)(-1.9)(+0.9) (syst) MeV/c(2) and Gamma = 21.9 +/- 6.4(stat)(-2.5)(+5.0) (syst) MeV/c(2). If the decay is X(5568) -> B-s*pi(+/-). B-s(0)gamma pi(+/-) with an unseen gamma, m(X(5568)) will be shifted up by m(B-s*) - m(B-s(0)) similar to 49 MeV/c(2). This measurement is based on 10.4 fb(-1) of p (p) over bar collision data at root s = 1.96 TeV collected by the D0 experiment at the Fermilab Tevatron collider.
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| 46. |
- Abazov, V. M., et al.
(författare)
-
Evidence for s-channel single top quark production in p(p)over-bar collisions at root s=1.96 TeV
- 2013
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 726:4-5, s. 656-664
-
Tidskriftsartikel (refereegranskat)abstract
- We present measurements of the cross sections for the two main production modes of single top quarks in p (p) over bar collisions at root s = 1.96 TeV in the Run II data collected with the DO detector at the Fermilab Tevatron Collider, corresponding to an integrated luminosity of 9.7 fb(-1). The s-channel cross section is measured to be sigma(p (p) over bar -> tb + X) = 1.10(-0.31)(+0.33) pb with no assumptions on the value of the t-channel cross section. Similarly, the t-channel cross section is measured to be sigma(p (p) over bar -> tqb + X) = 3.07(-0.49)(+0.54) pb. We also measure the s + t combined cross section as sigma(p (p) over bar -> tb + X, tqb + X) = 4.11(-0.55)(+0.60) ph and set a lower limit on the CKM matrix element vertical bar V-tb vertical bar> 0.92 at 95% C.L., assuming mt = 172.5 GeV. The probability to measure a cross section for the s channel at the observed value or higher in the absence of signal is 1.0 x 10(-4), corresponding to a significance of 3.7 standard deviations.
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| 47. |
- Abazov, V. M., et al.
(författare)
-
Evidence for Simultaneous Production of J/psi and Upsilon Mesons
- 2016
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 116:8
-
Tidskriftsartikel (refereegranskat)abstract
- We report evidence for the simultaneous production of J/psi and Upsilon mesons in 8.1 fb(-1) of data collected at root s = 1.96 TeV by the D0 experiment at the Fermilab p (p) over bar Tevatron Collider. Events with these characteristics are expected to be produced predominantly by gluon-gluon interactions. In this analysis, we extract the effective cross section characterizing the initial parton spatial distribution, sigma(eff) = 2.2 +/- 0.7(stat) +/- 0.9(syst) mb.
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| 48. |
- Abazov, V. M., et al.
(författare)
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Evidence for Z(c)(+/-)(3900) in semi-inclusive decays of b-flavored hadrons
- 2018
-
Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 98:5
-
Tidskriftsartikel (refereegranskat)abstract
- We present evidence for the exotic charged charmoniumlike state Z(c)(+/-)(3900) decaying to J/psi pi(+/-) in semi-inclusive weak decays of b-flavored hadrons. The signal is correlated with a parent J/psi pi(+)pi(-) system in the invariant-mass range 4.2-4.7 GeV that would include the exotic structure Y(4260). The study is based on 10.4 fb(-1) of p (p) over bar collision data collected by the D0 experiment at the Fermilab Tevatron collider.
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| 49. |
- Abazov, V. M., et al.
(författare)
-
Improved b quark jet identification at the D0 experiment
- 2014
-
Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 763, s. 290-303
-
Tidskriftsartikel (refereegranskat)abstract
- The ability to identify jets which originated from b quarks is an important tool of the physics program of the D0 experiment at the Fermilab Tevatron p (p) over bar collider. This paper describes a new algorithm designed to select jets originating from b quarks while suppressing the contamination caused by jets from other quark flavors and gluons. Additionally, a new technique, the SystemN method, for determining the misidentification rate directly from data is presented. (C) 2014 Elsevier B.V. All rights reserved.
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| 50. |
- Abazov, V. M., et al.
(författare)
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Inclusive Production of the X(4140) State in p(p)over-bar Collisions at D0
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:23
-
Tidskriftsartikel (refereegranskat)abstract
- We present a study of the inclusive production of the X(4140) state with the decay to the J/psi phi final state in hadronic collisions. Based on 10.4 fb(-1) of p (p) over bar collision data collected by the D0 experiment at the Fermilab Tevatron collider, we report the first evidence for the prompt production of an X(4140) state and find the fraction of X(4140) events originating from b hadrons to be f(b) = 0.39 +/- 0.07 (stat) +/- 0.10 (syst). The ratio of the nonprompt X(4140) production rate to the B-s(0) yield in the same channel is R = 0.19 +/- 0.05 (stat) +/- 0.07 (syst). The values of the mass M = 4152.5 +/- 1.7 (stat)(-5.4)(+/- 6.2)(syst) MeV and width Gamma = 16.3 +/- 5.6 (stat) +/- 11.4 (syst) MeV are consistent with previous measurements.
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