| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
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| 3. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 4. |
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| 5. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 6. |
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| 7. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 8. |
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| 9. |
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| 10. |
- Mishra, A., et al.
(författare)
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Stroke genetics informs drug discovery and risk prediction across ancestries
- 2022
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 611, s. 115-123
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Tidskriftsartikel (refereegranskat)abstract
- Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
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| 11. |
- Khatri, C, et al.
(författare)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 12. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 13. |
- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 14. |
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| 15. |
- Aaltonen, T., et al.
(författare)
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Combination of CDF and D0 measurements of the W boson helicity in top quark decays
- 2012
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 85:7, s. 071106-
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Tidskriftsartikel (refereegranskat)abstract
- We report the combination of recent measurements of the helicity of the W boson from top quark decay by the CDF and D0 collaborations, based on data samples corresponding to integrated luminosities of 2.7-5.4 fb(-1) of p (p) over bar collisions collected during Run II of the Fermilab Tevatron collider. Combining measurements that simultaneously determine the fractions of W bosons with longitudinal (f(0)) and right-handed (f(+)) helicities, we find f(0) = 0.722 +/- 0.081[+/- 0.062(stat) +/- 0.052(syst)] and f(+) = -0.033 +/- 0.046[+/- 0.034(stat) +/- 0.031(syst)]. Combining measurements where one of the helicity fractions is fixed to the value expected in the standard model, we find f(0) = 0.682 +/- 0.057[+/- 0.035(stat) +/- 0.046(syst)] for fixed f(+) and f(+) = -0.015 +/- 0.035[+/- 0.018(stat) +/- 0.030(syst)] for fixed f(0). The results are consistent with standard model expectations.
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| 16. |
- Aaltonen, T., et al.
(författare)
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Evidence for a Particle Produced in Association with Weak Bosons and Decaying to a Bottom-Antibottom Quark Pair in Higgs Boson Searches at the Tevatron
- 2012
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 109:7, s. 071804-
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Tidskriftsartikel (refereegranskat)abstract
- We combine searches by the CDF and D0 Collaborations for the associated production of a Higgs boson with a W or Z boson and subsequent decay of the Higgs boson to a bottom-antibottom quark pair. The data, originating from Fermilab Tevatron p (p) over bar collisions at root s = 1.96 TeV, correspond to integrated luminosities of up to 9.7 fb(-1). The searches are conducted for a Higgs boson with mass in the range 100-150 GeV/c(2). We observe an excess of events in the data compared with the background predictions, which is most significant in the mass range between 120 and 135 GeV/c(2). The largest local significance is 3.3 standard deviations, corresponding to a global significance of 3.1 standard deviations. We interpret this as evidence for the presence of a new particle consistent with the standard model Higgs boson, which is produced in association with a weak vector boson and decays to a bottom-antibottom quark pair.
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| 17. |
- Aaltonen, T., et al.
(författare)
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Tevatron Run II combination of the effective leptonic electroweak mixing angle
- 2018
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:11
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Tidskriftsartikel (refereegranskat)abstract
- Drell-Yan lepton pairs produced in the process p (p) over bar -> l(+)l(-) + X through an intermediate gamma*/Z boson have an asymmetry in their angular distribution related to the spontaneous symmetry breaking of the electroweak force and the associated mixing of its neutral gauge bosons. The CDF and D0 experiments have measured the effective-leptonic electroweak mixing parameter sin(2) theta(lept)(eff) using electron and muon pairs selected from the full Tevatron proton-antiproton data sets collected in 2001-2011, corresponding to 9-10 fb(-1) of integrated luminosity. The combination of these measurements yields the most precise result from hadron colliders, sin(2)theta(lept)(eff) = 0.23148 +/- 0.00033. This result is consistent with, and approaches in precision, the best measurements from electron-positron colliders. The standard model inference of the on-shell electroweak mixing parameter sin(2) theta(W), or equivalently the W-boson mass M-W, using the ZFITTER software package yields sin(2) theta(W) = 0.22324 +/- 0.00033 or equivalently, M-W = 80.367 +/- 0.017 GeV/c(2).
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| 18. |
- Aaltonen, T., et al.
(författare)
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Combination of CDF and D0 W-Boson mass measurements
- 2013
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:5, s. 052018-
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Tidskriftsartikel (refereegranskat)abstract
- We summarize and combine direct measurements of the mass of the W boson in root s = 1.96 TeV proton-antiproton collision data collected by CDF and D0 experiments at the Fermilab Tevatron Collider. Earlier measurements from CDF and D0 are combined with the two latest, more precise measurements: a CDF measurement in the electron and muon channels using data corresponding to 2.2 fb(-1) of integrated luminosity, and a D0 measurement in the electron channel using data corresponding to 4.3 fb(-1) of integrated luminosity. The resulting Tevatron average for the mass of the W boson is M-W = 80387 +/- 16 MeV. Including measurements obtained in electron-positron collisions at LEP yields the most precise value of M-W = 80385 +/- 15 MeV.
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| 19. |
- Aaltonen, T., et al.
(författare)
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Combination of measurements of the top-quark pair production cross section from the Tevatron Collider
- 2014
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:7
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Tidskriftsartikel (refereegranskat)abstract
- We combine six measurements of the inclusive top-quark pair (t(sic)) production cross section (sigma(t)(sic)) from data collected with the CDF and D0 detectors at the Fermilab Tevatron with proton-antiproton collisions at root s = 1.96 TeV. The data correspond to integrated luminosities of up to 8.8 fb(-1). We obtain a value of sigma tt = 7.60 +/- 0.41 pb for a top-quark mass of m(t) = 172.5 GeV. The contributions to the uncertainty are 0.20 pb from statistical sources, 0.29 pb from systematic sources, and 0.21 pb from the uncertainty on the integrated luminosity. The result is in good agreement with the standard model expectation of 7.35(-0.33)(+0.28) pb at next-to-next-to-leading order and next-to-next-to leading logarithms in perturbative QCD.
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| 20. |
- Aaltonen, T., et al.
(författare)
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Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron
- 2018
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Ingår i: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 120:4
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Tidskriftsartikel (refereegranskat)abstract
- The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of root s = 1.96 TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A(FB)(t (t) over bar) = 0.128 +/- 0.025. The combined inclusive and differential asymmetries are consistent with recent standard model predictions.
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| 21. |
- Aaltonen, T., et al.
(författare)
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Observation of s-Channel Production of Single Top Quarks at the Tevatron
- 2014
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 112:23
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Tidskriftsartikel (refereegranskat)abstract
- We report the first observation of single-top-quark production in the s channel through the combination of the CDF and D0 measurements of the cross section in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV. The data correspond to total integrated luminosities of up to 9.7 fb(-1) per experiment. The measured cross section is sigma(s) = 1.29(-0.24)(+0.26) pb. The probability of observing a statistical fluctuation of the background to a cross section of the observed size or larger is 1.8 x 10(-10), corresponding to a significance of 6.3 standard deviations for the presence of an s-channel contribution to the production of single-top quarks.
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| 22. |
- Aaltonen, T., et al.
(författare)
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Tevatron Combination of Single-Top-Quark Cross Sections and Determination of the Magnitude of the Cabibbo-Kobayashi-Maskawa Matrix Element V-tb
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:15
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Tidskriftsartikel (refereegranskat)abstract
- We present the final combination of CDF and D0 measurements of cross sections for single-top-quark production in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV. The data correspond to total integrated luminosities of up to 9.7 fb(-1) per experiment. The t-channel cross section is measured to be sigma(t) = 2.25(-0.31)(+0.29) pb. We also present the combinations of the two-dimensional measurements of the s- vs t-channel cross section. In addition, we give the combination of the s + t channel cross section measurement resulting in sigma(s+t) = 3.30(-0.40)(+0.52) pb, without assuming the standard model value for the ratio sigma(s)/sigma(t). The resulting value of the magnitude of the top-to-bottom quark coupling is vertical bar V-tb vertical bar = 1.02(-0.05)(+0.06), corresponding to vertical bar V-tb vertical bar > 0.92 at the 95% C. L.
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| 23. |
- Aaltonen, T., et al.
(författare)
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Tevatron Constraints on Models of the Higgs Boson with Exotic Spin and Parity Using Decays to Bottom-Antibottom Quark Pairs
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:15
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Tidskriftsartikel (refereegranskat)abstract
- Combined constraints from the CDF and D0 Collaborations on models of the Higgs boson with exotic spin J and parity P are presented and compared with results obtained assuming the standard model value J(P) = 0(+). Both collaborations analyzed approximately 10 fb(-1) of proton-antiproton collisions with a center-of-mass energy of 1.96 TeV collected at the Fermilab Tevatron. Two models predicting exotic Higgs bosons with J(P) = 0(-) and J(P) = 2(+) are tested. The kinematic properties of exotic Higgs boson production in association with a vector boson differ from those predicted for the standard model Higgs boson. Upper limits at the 95% credibility level on the production rates of the exotic Higgs bosons, expressed as fractions of the standard model Higgs boson production rate, are set at 0.36 for both the J(P) = 0(-) hypothesis and the J(P) = 2(+) hypothesis. If the production rate times the branching ratio to a bottom-antibottom pair is the same as that predicted for the standard model Higgs boson, then the exotic bosons are excluded with significances of 5.0 standard deviations and 4.9 standard deviations for the J(P) = 0(-) and J(P) = 2(+) hypotheses, respectively.
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| 24. |
- Aaltonen, T., et al.
(författare)
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Higgs boson studies at the Tevatron
- 2013
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:5, s. 052014-
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Tidskriftsartikel (refereegranskat)abstract
- We combine searches by the CDF and D0 Collaborations for the standard model Higgs boson with mass in the range 90-200 GeV/c(2) produced in the gluon-gluon fusion, WH, ZH, t (t) over barH, and vector boson fusion processes, and decaying in the H -> b (b) over bar, H -> W+W-, H -> ZZ, H -> tau(+)tau(-), and H -> gamma gamma modes. The data correspond to integrated luminosities of up to 10 fb(-1) and were collected at the Fermilab Tevatron in p (p) over bar collisions at root s = 1.96 TeV. The searches are also interpreted in the context of fermiophobic and fourth generation models. We observe a significant excess of events in the mass range between 115 and 140 GeV/c(2). The local significance corresponds to 3.0 standard deviations at m(H) = 125 GeV/c(2), consistent with the mass of the Higgs boson observed at the LHC, and we expect a local significance of 1.9 standard deviations. We separately combine searches for H -> b (b) over bar, H -> W+W-, H -> tau(+)tau(-), and H -> gamma gamma. The observed signal strengths in all channels are consistent with the presence of a standard model Higgs boson with a mass of 125 GeV/c(2).
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| 25. |
- Buchanan, E. M., et al.
(författare)
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The Psychological Science Accelerator's COVID-19 rapid-response dataset
- 2023
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Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data.
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| 26. |
- Bousquet, Jean, et al.
(författare)
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- 2019
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:3, s. 864-879
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Tidskriftsartikel (refereegranskat)abstract
- Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
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| 27. |
- Abazov, V. M., et al.
(författare)
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Measurement of the differential cross section d sigma/dt in elastic p(p)over-bar scattering at root s=1.96 TeV
- 2012
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 86:1, s. 012009-
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the elastic differential cross section dσ(pp̅ →pp̅ )/dt as a function of the four-momentum-transfer squared t. The data sample corresponds to an integrated luminosity of ≈31 nb-1 collected with the D0 detector using dedicated Tevatron pp̅ Collider operating conditions at √s=1.96 TeV and covers the range 0.26<|t|<1.2 GeV2. For |t|<0.6 GeV2, dσ/dt is described by an exponential function of the form Ae-b|t| with a slope parameter b=16.86±0.10(stat)±0.20(syst) GeV-2. A change in slope is observed at |t|≈0.6 GeV2, followed by a more gradual |t| dependence with increasing values of |t|.
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| 28. |
- Delios, A., et al.
(författare)
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Examining the generalizability of research findings from archival data
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:30
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Tidskriftsartikel (refereegranskat)abstract
- This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability-for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples.
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| 29. |
- Figlioli, G, et al.
(författare)
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- 2019
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Ingår i: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 5, s. 38-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.
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| 30. |
- Menditto, Enrica, et al.
(författare)
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Adherence to treatment in allergic rhinitis using mobile technology : The MASK Study
- 2019
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Ingår i: Clinical and Experimental Allergy. - : WILEY. - 0954-7894 .- 1365-2222. ; 49:4, s. 442-460
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Tidskriftsartikel (refereegranskat)abstract
- Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.
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| 31. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 32. |
- Abazov, V. M., et al.
(författare)
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Combination of searches for anomalous top quark couplings with 5.4 fb(-1) of p(p)over-bar collisions
- 2012
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 713:3, s. 165-171
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of the tWb coupling form factors using information from electroweak single top quark production and from the helicity of W bosons from top quark decays in t (t) over bar events. We set upper limits on anomalous tWb coupling form factors using data collected with the DO detector at the Tevatron p (p) over bar collider corresponding to an integrated luminosity of 5.4 fb(-1).
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| 33. |
- Abazov, V. M., et al.
(författare)
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Determination of the pole and (MS)over-bar masses of the top quark from the t(t)over-bar cross section
- 2011
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 703:4, s. 422-427
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Tidskriftsartikel (refereegranskat)abstract
- We use higher-order quantum chromodynamics calculations to extract the mass of the top quark from the t (t) over bar cross section measured in the lepton + jets channel in p (p) over bar collisions at root s = 1.96 TeV using 5.3 fb(-1) of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. The extracted top quark pole mass and (MS) over bar mass are compared to the current Tevatron average top quark mass obtained from direct measurements.
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| 34. |
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| 35. |
- Abazov, V. M., et al.
(författare)
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Measurement of Spin Correlation in t(t)over-bar Production Using a Matrix Element Approach
- 2011
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 107:3, s. 032001-
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Tidskriftsartikel (refereegranskat)abstract
- We determine the fraction of t (t) over bar events with spin correlation, assuming that the spin of the top quark is either correlated with the spin of the top antiquark as predicted by the standard model or is uncorrelated. For the first time we use a matrix-element-based approach to study t (t) over bar spin correlation. We use t (t) over bar -> W(+)bW(-)(b) over bar -> l(+)nu bl(-)(nu) over bar(b) over bar final states produced in p (p) over bar collisions at a center- of- mass energy root s = 1: 96 TeV, where l denotes an electron or a muon. The data correspond to an integrated luminosity of 5: 4 fb(-1) and were collected with the D0 detector at the Fermilab Tevatron collider. The result agrees with the standard model prediction. We exclude the hypothesis that the spins of the t (t) over bar are uncorrelated at the 97.7% C.L.
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| 36. |
- Abazov, V. M., et al.
(författare)
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Measurement of spin correlation in t(t)over-bar production using dilepton final states
- 2011
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 702:1, s. 16-23
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Tidskriftsartikel (refereegranskat)abstract
- We measure the correlation between the spin of the top quark and the spin of the anti-top quark in t (t) over bar -> W(+)bW(-)(b) over bar -> l(+)vbl(-) (v) over bar(b) over bar final states produced in p (p) over bar collisions at a center of mass energy root s = 1.96 TeV, where l is an electron or muon. The data correspond to an integrated luminosity of 5.4 fb(-1) and were collected with the D0 detector at the Fermilab Tevatron collider. The correlation is extracted from the angles of the two leptons in the t and (t) over bar rest frames, yielding a correlation strength C = 0.10(-0.45)(+0.45). in agreement with the NLO QCD prediction within two standard deviations, but also in agreement with the no correlation hypothesis.
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| 37. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the Lambda(0)(b) lifetime in the exclusive decay Lambda(0)(b) -> J/psi Lambda(0) in p(p)over-bar collisions at root s=1.96 TeV
- 2012
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 85:11, s. 112003-
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Tidskriftsartikel (refereegranskat)abstract
- We measure the Lambda(0)(b) lifetime in the fully reconstructed decay Lambda(0)(b) -> J/psi Lambda(0) using 10.4 fb(-1) of p (p) over bar collisions collected with the D0 detector at root s = 1.96 TeV. The lifetime of the topologically similar decay channel B-0 -> J/psi K-S(0) is also measured. We obtain tau(Lambda(0)(b)) = 1.303 +/- 0.075(stat) +/- 0.035(syst) ps and tau(B-0) = 1.508 +/- 0.025(stat) +/- 0.043(syst) ps. Using these measurements, we determine the lifetime ratio of tau(Lambda(0)(b))/tau(B-0) = 0.864 +/- 0.052(stat) +/- 0.033(syst).
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| 38. |
- Abazov, V. M., et al.
(författare)
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Measurement of the photon plus b-jet production differential cross section in p(p)over-bar) collisions at root s=1.96 TeV
- 2012
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 714:1, s. 32-39
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of the differential cross section d sigma/dp(T)(gamma) for the inclusive production of a photon in association with a b-quark jet for photons with rapidities vertical bar y(gamma)vertical bar < 1.0 and 30 < p(T)(gamma) < 300 GeV, as well as for photons with 1.5 < vertical bar y(gamma)vertical bar < 2.5 and 30 < p(T)(gamma) < 200 GeV, where p(T)(gamma) is the photon transverse momentum. The b-quark jets are required to have p(T) > 15 GeV and rapidity vertical bar Y-jet vertical bar < 1.5. The results are based on data corresponding to an integrated luminosity of 8.7 fb(-1), recorded with the DO detector at the Fermilab Tevatron p<(p)over bar>) Collider at root s = 1.96 TeV. The measured cross sections are compared with next-to-leading order perturbative QCD calculations using different sets of parton distribution functions as well as to predictions based on the k(T)-factorization QCD approach, and those from the SHERPA and PYTHIA Monte Carlo event generators.
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| 39. |
- Abazov, V. M., et al.
(författare)
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Measurement of the production fraction times branching fraction f(b -> Lambda(b)) . B(Lambda(b) -> J/psi Lambda)
- 2011
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 84:3, s. 031102-
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Tidskriftsartikel (refereegranskat)abstract
- The Lambda(b)(udb) baryon is observed in the decay Lambda(b) -> J/psi Lambda using 6.1fb(-1) of p (p) over bar collisions collected with the D0 detector at root s = 1/96 TeV. The production fraction multiplied by the branching fraction for this decay relative to that for the decay B(0) -> J/psi K(s)(0) is measured to be 0.345 +/- 0.034(stat) +/- 0.033(syst) +/- 0.003(PDG). Using the world average value of f(b -> B(0)) . B(B(0) -> J/psi K(s)(0) = (1.74 +/- 0.08) x 10(-5), we obtain f(b -> Lambda(b)) . B(Lambda(b) -> J/psi Lambda) = (6.01 +/- 0.60(stat) +/- 0.58(syst) +/- 0.28(PDG)) x 10(-5). This measurement represents an improvement in precision by about a factor of 3 with respect to the current world average.
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| 40. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the t(t)over-bar production cross section using dilepton events in p(p)over-bar collisions
- 2011
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 704:5, s. 403-410
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the a production cross section sigma((u) over bar) in p (p) over bar collisions at root s = 1.96 TeV using 5.4 fb(-1) of integrated luminosity collected with the D0 detector. We consider final states with at least two jets and two leptons (ee, e mu, mu mu), and events with one jet for the e mu final state as well. The measured cross section is sigma((u) over bar) = 7.36(-0.79)(+0.90)(stat + syst) pb. This result combined with the cross section measurement in the lepton + jets final state yields sigma((u) over bar) = 7.56(-0.56)(+0.63)(stat + syst) pb, which agrees with the standard model expectation. The relative precision of 8% of this measurement is comparable to the precision of the latest theoretical calculations. (C) 2011 Elsevier B.V. All rights reserved.
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| 41. |
- Abazov, V. M., et al.
(författare)
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Measurement of the W Boson Mass with the D0 Detector
- 2012
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 108:15, s. 151804-
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the W boson mass using data corresponding to 4: 3 fb(-1) of integrated luminosity collected with the D0 detector during Run II at the Fermilab Tevatron p (p) over tilde collider. With a sample of 1 677 394 W -> e nu candidate events, we measure M-W = 80.367 +/- 0.026 GeV. This result is combined with an earlier D0 result determined using an independent Run II data sample, corresponding to 1 fb(-1) of integrated luminosity, to yield MW 80.375 +/- 0.023 GeV.
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| 42. |
- Abazov, V. M., et al.
(författare)
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Measurement of the ZZ production cross section in p(p)over-bar collisions at root s=1.96 TeV
- 2011
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 84:1, s. 011103-
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Tidskriftsartikel (refereegranskat)abstract
- We present a new measurement of the production cross section sigma(p (p) over bar -> ZZ) at a center-of-mass energy root s = 1.96 TeV, obtained from the analysis of the four charged lepton final state l(+)l(-)l'(+)l'-(l,l' = e or mu). We observe ten candidate events with an expected background of 0: 37 +/- 0: 13 events. The measured cross section sigma(p (p) over bar -> ZZ) = 1.26(-0.37)(+0.47)(stat) +/- 0.14(syst) pb is in agreement with NLO QCD predictions. This result is combined with a previous result from the ZZ -> l(+)l(-)v (v) over bar channel resulting in a combined cross section of sigma(p (p) over bar -> ZZ) = 1.40(-0.37)(+0.43)(stat) +/- 0.14(syst) pb.
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| 43. |
- Abazov, V. M., et al.
(författare)
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Measurement of three-jet differential cross sections d sigma(3jet)/dM(3jet) in p(p)over-bar collisions at root s=1.96 TeV
- 2011
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 704:5, s. 434-441
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Tidskriftsartikel (refereegranskat)abstract
- We present the first measurement of the inclusive three-jet differential cross section as a function of the invariant mass of the three jets with the largest transverse momenta in an event in p (p) over bar collisions at root s = 1.96 TeV. The measurement is made in different rapidity regions and for different jet transverse momentum requirements and is based on a data set corresponding to an integrated luminosity of 0.7 fb(-1) collected with the DO detector at the Fermilab Tevatron Collider. The results are used to test the three-jet matrix elements in perturbative QCD calculations at next-to-leading order in the strong coupling constant. The data allow discrimination between parametrizations of the parton distribution functions of the proton. (C) 2011 Elsevier B.V. All rights reserved.
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| 44. |
- Abazov, V. M., et al.
(författare)
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Model-independent measurement of t-channel single top quark production in p(p)over-bar collisions at,root s=1.96 TeV
- 2011
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 705:4, s. 313-319
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Tidskriftsartikel (refereegranskat)abstract
- We present a model-independent measurement of t-channel electroweak production of single top quarks in p collisions at root s = 1.96 TeV. Using 5.4 fb(-1) of integrated luminosity collected by the DO detector at the Fermilab Tevatron Collider, and selecting events containing an isolated electron or muon, missing transverse energy and one or two jets originating from the fragmentation of b quarks, we measure a cross section sigma (p (p) over bar -> tqb + X) = 2.90 +/- 0.59 (stat + syst) pb for a top quark mass of 172.5 GeV. The probability of the background to fluctuate and produce a signal as large as the one observed is 1.6 x 10(-8), corresponding to a significance of 5.5 standard deviations. (C) 2011 Elsevier B.V. All rights reserved.
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| 45. |
- Abazov, V. M., et al.
(författare)
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Observation of a narrow mass state decaying into Y(1S)+gamma in p(p)over-bar collisions at root s=1.96 TeV
- 2012
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 86:3, s. 031103-
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Tidskriftsartikel (refereegranskat)abstract
- Using data corresponding to an integrated luminosity of 1.3 fb(-1), we observe a narrow mass state decaying into Gamma(1S) + gamma, where the Gamma(1S) meson is detected by its decay into a pair of oppositely charged muons, and the photon is identified through its conversion into an electron-positron pair. The significance of this observation is 5.6 standard deviations. The mass of the state is centered at 10.551 +/- 0.014(stat) +/- 0.017(syst) GeV/c(2), which is consistent with that of the state recently observed by the ATLAS Collaboration.
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| 46. |
- Abazov, V. M., et al.
(författare)
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Precise measurement of the top-quark mass from lepton plus jets events at D0
- 2011
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 84:3, s. 032004-
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Tidskriftsartikel (refereegranskat)abstract
- We report a measurement of the mass of the top quark in lepton + jets final states of p (p) over bar -> t (t) over bar data corresponding to 2.6 fb(-1) of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron Collider. A matrix-element method is developed that combines an in situ jet energy calibration with our standard jet energy scale derived from studies of gamma + jet and dijet events. We then implement a flavor-dependent jet-response correction through a novel approach. This method is used to measure a top-quark mass of m(t) = 176.01 +/- 1.64 GeV. Combining this result with our previous result obtained on an independent data set, we measure a top-quark mass of m(t) = 174.94 +/- 1.49 GeV for a total integrated luminosity of 3.6 fb(-1).
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| 47. |
- Abazov, V. M., et al.
(författare)
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Precise Measurement of the Top Quark Mass in the Dilepton Channel at D0
- 2011
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 107:8, s. 082004-
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Tidskriftsartikel (refereegranskat)abstract
- We measure the top quark mass (m(t)) in p (p) over bar collisions at a center of mass energy root s = 1.96 TeV using dilepton t (t) over bar -> W(+)bW(-)b(-) -> l(+)nu(l)bl(-)(nu) over bar (l)(b) over bar events, where l denotes an electron, a muon, or a tau that decays leptonically. The data correspond to an integrated luminosity of 5.4 fb(-1) collected with the D0 detector at the Fermilab Tevatron Collider. We obtain m(t) = 174.0 +/- 1.8(stat) +/- 2.4(syst) GeV, which is in agreement with the current world average m(t) = 173.3 +/- 1.1 GeV. This is currently the most precise measurement of mt in the dilepton channel.
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| 48. |
- Abazov, V. M., et al.
(författare)
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Search for a Fourth Generation t ' Quark in p(p)over-bar Collisions at root s=1.96 TeV
- 2011
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 107:8, s. 082001-
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for pair production of a fourth generation t' quark and its antiparticle, followed by their decays to a W boson and a jet, based on an integrated luminosity of 5: 3 fb(-1) of proton-antiproton collisions at root s = 1.96 TeV collected by the D0 Collaboration at the Fermilab Tevatron Collider. We set upper limits on the t'(t) over bar' production cross section that exclude at the 95% C. L. a t' quark that decays exclusively to W + jet with a mass below 285 GeV. We observe a small excess in the mu + jets channel which reduces the mass range excluded compared to the expected limit of 320 GeV in the absence of a signal.
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| 49. |
- Abazov, V. M., et al.
(författare)
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Search for flavor changing neutral currents in decays of top quarks
- 2011
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 701:3, s. 313-320
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for flavor changing neutral currents in decays of top quarks. The analysis is based on a search for (ℓ,ℓ′=e,μ) final states using 4.1 fb−1 of integrated luminosity of collisions at . We extract limits on the branching ratio B(t→Zq) (q=u,c quarks), assuming anomalous tuZ or tcZ couplings. We do not observe any sign of such anomalous coupling and set a limit of B<3.2% at 95% C.L.
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| 50. |
- Abazov, V. M., et al.
(författare)
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Search for the standard model Higgs boson in tau lepton final states D0 Collaboration
- 2012
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 714:2-5, s. 237-245
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Tidskriftsartikel (refereegranskat)abstract
- We present a search for the standard model Higgs boson in final states with an electron or muon and a hadronically decaying tau lepton in association with zero, one, or two or more jets using data corresponding to an integrated luminosity of up to 7.3 fb(-1) collected with the D0 detector at the Fermilab Tevatron collider. The analysis is sensitive to Higgs boson production via gluon-gluon fusion, associated vector boson production, and vector boson fusion, and to Higgs boson decays to tau tau, WW, ZZ and b (b) over bar pairs. Observed (expected) limits are set on the ratio of 95% C.L. upper limits on the cross section times branching ratio, relative to those predicted by the Standard Model, of 22 (14) at a Higgs boson mass of 115 GeV and 6.8 (7.7) at 165 GeV.
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