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| 3. |
- Louchart, C., et al.
(författare)
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Collective nature of low-lying excitations in Zn-70,Zn-72,Zn-74 from lifetime measurements using the AGATA spectrometer demonstrator
- 2013
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 87:5
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Tidskriftsartikel (refereegranskat)abstract
- Background: Neutron-rich nuclei with protons in the fp shell show an onset of collectivity around N=40. Spectroscopic information is required to understand the underlying mechanism and to determine the relevant terms of the nucleon-nucleon interaction that are responsible for the evolution of the shell structure in this mass region. Methods: We report on the lifetime measurement of the first 2(+) and 4(+) states in Zn-70,Zn-72 ,Zn-74 and the first 6(+) state in Zn-72 using the recoil distance Doppler shift method. The experiment was carried out at the INFN Laboratory of Legnaro with the AGATA demonstrator, first phase of the Advanced Gamma Tracking Array of highly segmented, high-purity germanium detectors coupled to the PRISMA magnetic spectrometer. The excited states of the nuclei of interest were populated in the deep inelastic scattering of a Ge-76 beam impinging on a U-238 target. Results: The maximum of collectivity along the chain of Zn isotopes is observed for Zn-72 at N=42. An unexpectedly long lifetime of 20(-5.2)(+1.8) ps was measured for the 4(+) state in Zn-74. Conclusions: Our results lead to small values of the B(E2;4(1)(+) -> 21(+))/B(E2;2(1)(+->)0(1)(+)) ratio for Zn-72,Zn-74, suggesting a significant noncollective contribution to these excitations. These experimental results are not reproduced by state-of-the-art microscopic models and call for lifetime measurements beyond the first 2(+) state in heavy zinc and nickel isotopes.
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| 4. |
- Saygi, B., et al.
(författare)
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Reduced transition probabilities along the yrast line in W-166
- 2017
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 96:2
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of excited states in the yrast band of the neutron-deficient nuclide W-166 have been measured utilizing the DPUNS plunger device at the target position of the JUROGAM II gamma-ray spectrometer in conjunction with the RITU gas-filled separator and the GREAT focal-plane spectrometer. Excited states in W-166 were populated in the Mo-92(Kr-78, 4p) reaction at a bombarding energy of 380 MeV. The measurements reveal a low value for the ratio of reduced transitions probabilities for the lowest-lying transitions B(E2; 4(+)-> 2(+)) / B(E2; 2(+)-> 0(+)) = 0.33(5), compared with the expected ratio for an axially deformed rotor (B-4/2 = 1.43).
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| 5. |
- Procter, M. G., et al.
(författare)
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Anomalous transition strength in the proton-unbound nucleus (109)(53)I56
- 2011
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 704:3, s. 118-122
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Tidskriftsartikel (refereegranskat)abstract
- A lifetime measurement has been made for the first excited 11/2(+) state in the proton-unbound nucleus (109)(53)I56 using the recoil-distance Doppler-shift method in conjunction with recoil-proton tagging. The experimental reduced transition probability is considerably smaller than the prediction of theoretical shell-model calculations using the CD-Bonn nucleon-nucleon potential. The discrepancy between the theoretical and experimental reduced transition strengths in this work most likely arises from the inability of the current shell-model calculations to accurately account for the behavior of the unbound nuclear states.
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| 6. |
- Procter, M. G., et al.
(författare)
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Lifetime measurement in the proton-unbound nucleus 109I
- 2011
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Ingår i: AIP Conf. Proc.. - : AIP. - 9780735409835 ; , s. 105-110
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Konferensbidrag (refereegranskat)abstract
- The Recoil-Distance Doppler-shift method has been combined with Recoil-Decay Tagging for the first time to measure a lifetime in the proton-unbound nucleus 109I. The lifetime value was determined using the Differential Decay-Curve method in singles mode. The result has been compared to theoretical shell-model calculations in order to better understand the nature of unbound valence nucleons at the proton drip line.
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| 7. |
- Hagen, T. W., et al.
(författare)
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Evolution of nuclear shapes in odd-mass yttrium and niobium isotopes from lifetime measurements following fission reactions
- 2017
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Ingår i: Physical Review C: covering nuclear physics. - 2469-9985. ; 95:3
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of excited states in Y99,Y101,Nb101,Nb103, and Nb105 were measured in an experiment using the recoil distance Doppler shift method at GANIL (Grand Accélérateur National d'Ions Lourds). The neutron-rich nuclei were produced in fission reactions between a U238 beam and a Be9 target. Prompt γ rays were measured with the EXOGAM array and correlated with fission fragments that were identified in mass and atomic number with the VAMOS++ spectrometer. The measured lifetimes, together with branching ratios, provide B(M1) and B(E2) values for the strongly coupled rotational bands built on the [422]5/2+ ground state in the Y and Nb nuclei with neutron number N≥60. The comparison of the experimental results with triaxial particle-rotor calculations provides information about the evolution of the nuclear shape in this mass region.
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| 9. |
- Bäck, Torbjörn, et al.
(författare)
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Lifetime measurement of the first excited 2(+) state in (108)Te
- 2011
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 84:4, s. 041306-
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Tidskriftsartikel (refereegranskat)abstract
- The lifetime of the first excited 2(+) state in the neutron deficient nuclide (108)Te has been measured for the first time, using a combined recoil decay tagging and recoil distance Doppler shift technique. The deduced reduced transition probability is B(E2;0(g.s.)(+) -> 2(+)) = 0.39(-0.04)(+0.05)e(2)b(2). Compared to previous experimental data on neutron deficient tellurium isotopes, the new data point constitutes a large step (six neutrons) toward the N = 50 shell closure. In contrast to what has earlier been reported for the light tin isotopes, our result for tellurium does not show any enhanced transition probability with respect to the theoretical predictions and the tellurium systematics including the new data is successfully reproduced by state-of-the-art shell model calculations.
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| 10. |
- Modamio, V., et al.
(författare)
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Lifetime measurements in neutron-rich Co-63,Co-65 isotopes using the AGATA demonstrator
- 2013
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 88:4, s. 044326-
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Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of the low-lying (11/2(-)) states in Co-63,Co-65 have been measured employing the recoil distance doppler shift method (RDDS) with the AGATA gamma-ray array and the PRISMA mass spectrometer. These nuclei were populated via a multinucleon transfer reaction by bombarding a U-238 target with a beam of Ni-64. The experimental B(E2) reduced transition probabilities for Co-63,Co-65 are well reproduced by large-scale shell-model calculations that predict a constant trend of the B(E2) values up to the N = 40 Co-67 isotope.
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| 11. |
- Sahin, E., et al.
(författare)
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Shell evolution beyond N=40 : Cu-69,Cu-71,Cu-73
- 2015
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 91:3
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Tidskriftsartikel (refereegranskat)abstract
- The level structure of the neutron-rich Cu-69, Cu-71, and Cu-73 isotopes has been investigated by means of multinucleon transfer reactions. The experiment was performed at Laboratori Nazionali di Legnaro using the AGATA Demonstrator array coupled to the PRISMA magnetic spectrometer. Lifetimes of excited states in Cu nuclei were measured with the recoil-distance Doppler-shift method. The resulting electromagnetic matrix elements for transitions from excited states in Cu-69,Cu-71,Cu-73 nuclei are used to assess the collective or single-particle character of these states. The results are compared with predictions of large-scale shell-model calculations, giving further insight into the evolution of the proton pf shell as neutrons fill the 1g(9/2) orbital.
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| 12. |
- Cruz, Jose Almeida, et al.
(författare)
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RNA-Puzzles : A CASP-like evaluation of RNA three-dimensional structure prediction
- 2012
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Ingår i: RNA. - : Cold Spring Harbor Laboratory. - 1355-8382 .- 1469-9001. ; 18:4, s. 610-625
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Tidskriftsartikel (refereegranskat)abstract
- We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.
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| 13. |
- Doncel, Maria, et al.
(författare)
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Lifetime Measurements in Neutron-rich Cu Isotopes
- 2013
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Ingår i: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 44:3, s. 505-510
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Tidskriftsartikel (refereegranskat)abstract
- The nuclear structure of neutron-rich nuclei close to the double-magic nucleus Ni-78 has been investigated by measuring the lifetime of excited states. In this contribution, it will be presented the lifetime of the J(pi) = 7/2(-) excited state at 981 keV of the Cu-71 isotope, measured using the AGATA Demonstrator coupled to the PRISMA spectrometer and the Koln plunger setup. This is the first time this combined setup has been used for a lifetime measurement.
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| 14. |
- Helfricht, A, et al.
(författare)
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Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome
- 2020
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 217:11
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Tidskriftsartikel (refereegranskat)abstract
- The autosomal recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a genetically heterogeneous disorder. Despite the identification of the underlying gene defects, it is unclear how mutations in any of the four known ICF genes cause a primary immunodeficiency. Here we demonstrate that loss of ZBTB24 in B cells from mice and ICF2 patients affects nonhomologous end-joining (NHEJ) during immunoglobulin class-switch recombination and consequently impairs immunoglobulin production and isotype balance. Mechanistically, we found that ZBTB24 associates with poly(ADP-ribose) polymerase 1 (PARP1) and stimulates its auto-poly(ADP-ribosyl)ation. The zinc-finger in ZBTB24 binds PARP1-associated poly(ADP-ribose) chains and mediates the PARP1-dependent recruitment of ZBTB24 to DNA breaks. Moreover, through its association with poly(ADP-ribose) chains, ZBTB24 protects them from degradation by poly(ADP-ribose) glycohydrolase (PARG). This facilitates the poly(ADP-ribose)-dependent assembly of the LIG4/XRCC4 complex at DNA breaks, thereby promoting error-free NHEJ. Thus, we uncover ZBTB24 as a regulator of PARP1-dependent NHEJ and class-switch recombination, providing a molecular basis for the immunodeficiency in ICF2 syndrome.
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| 16. |
- Önnestam, K., et al.
(författare)
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Safety, Tolerability, Pharmacokinetics and Quantitative Electroencephalography Assessment of ACD856, a Novel Positive Allosteric Modulator of Trk-Receptors Following Multiple Doses in Healthy Subjects
- 2023
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Ingår i: The Journal of Prevention of Alzheimer's Disease. - : Springer. - 2274-5807 .- 2426-0266. ; 10:4, s. 778-789
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundACD856 is a positive allosteric modulator of tropomyosin receptor kinase (Trk) receptors which has shown to have pro-cognitive and anti-depressant-like effects in various animal models. It is currently in clinical development for the treatment of Alzheimer’s disease and other disorders where cognition is impaired and is also considered for indications such as depression or other neuropsychiatric diseases. ACD856 has a novel mechanism of action modulating the activity of the Trk-receptors, resulting in increased stimulation of the neurotrophin signaling pathways. Previous studies applying single intravenous and oral doses of ACD856 indicate that ACD856 is safe and well-tolerated by healthy volunteer subjects, and that it has suitable safety and pharmacokinetic properties for further clinical development.ObjectivesTo investigate the safety and tolerability of 7 days of treatment with multiple ascending oral doses of ACD856 in healthy subjects, and to characterize its pharmacokinetic (PK) properties. In addition, pharmacodynamic effects of ACD856 using quantitative electroencephalography (qEEG) as an indicator for central target engagement were assessed.DesignThis was a prospective, phase I, double-blind, parallel-group, placebo-controlled, randomized study of the safety, tolerability, PK and pharmacodynamics of multiple ascending oral doses of ACD856 in healthy subjects. ACD856 or placebo were administered in 3 ascending dose cohorts of 8 subjects. Within each cohort, subjects were randomized to receive either ACD856 (n=6) or placebo (n=2).SettingThe study was conducted at a First-in-Human unit in Sweden.ParticipantsTwenty-four healthy male and female subjects.InterventionThe study medication was administered as an oral solution, with ACD856 or the same contents without the active ingredient (placebo). The dose levels ranged from 10 mg to 90 mg. ACD856 was administered once daily for 7 days, targeting steady state.MeasurementsSafety and tolerability assessments included adverse events, laboratory, vital signs, 12-lead electrocardiogram (ECG), physical examination, assessment of stool frequency and questionnaires to assess symptoms of anxiety, depression, as well as suicidal ideation and behavior. In addition, cardiodynamic ECGs were extracted to evaluate cardiac safety. PK parameters were calculated based on measured concentrations of ACD856 in plasma, urine, and cerebrospinal fluid (CSF) samples. Metabolite profiling, characterization and analysis was performed based on and urine samples. qEEG was recorded for patients in the two highest dose cohorts (30 and 90 mg/day) as a pharmacodynamic assessment to explore central target engagement.ResultsTreatment with ACD856 was well tolerated with no serious adverse events. No treatment emergent or dose related trends were observed for any of the safety assessments. ACD856 was rapidly absorbed and reached maximum plasma exposure at 30 to 45 minutes after administration. Steady state was reached before Day 6, with an elimination half-life at steady state of approximately 20 hours. At steady state, ACD856 exhibited accumulation ratios for Cmax and AUC of approximately 1.6 and 1.9 respectively. The exposure, Cmax and AUC0-24, increased proportionally with the dose. There was no unchanged ACD856 detected in urine. The metabolic pattern in urine and plasma was similar, and in alignment with the metabolites observed in preclinical toxicology studies. The level of ACD856 measured in CSF at steady state increased with dose, indicating Central Nervous System (CNS) exposure at relevant levels for pharmacodynamic effects. ACD856 demonstrated significant dose-dependent treatment-associated changes on qEEG parameters. Specifically, increase of the relative theta power and decrease of the fast alpha and beta power was observed, leading to an acceleration of the delta+theta centroid and an increase in the theta/beta ratio.ConclusionsACD856 was well tolerated at the tested dose levels (10–90 mg/daily for 7 days) in healthy subjects. The compound has a robust pharmacokinetic profile, with rapid absorption and dose-dependent exposure. ACD856 was shown to pass the blood-brain-barrier, reach relevant exposure in the CNS and to induce dose-dependent treatment-related changes on qEEG parameters, indicating central target engagement.
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| 22. |
- Vucko, Flavien, et al.
(författare)
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Combined corrosion and fatigue performance of joined materials for automotive applications
- 2016
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Ingår i: Materials and corrosion - Werkstoffe und Korrosion. - : Wiley-VCH Verlag. - 0947-5117 .- 1521-4176. ; 67:11, s. 1143-1151
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study is to evaluate fatigue performance of joined assemblies (spot weld and/or adhesive bonding) in corrosive environment. Various assemblies have been tested in alternated and simultaneous fatigue-corrosion modes. Adhesive joints are strongly affected by simultaneous fatigue-corrosion with a large drop of the fatigue life compared to results in air. By alternating fatigue and corrosion, the reduction of fatigue life is important. For spot welding, fatigue life is decreased at higher load amplitudes and increased at lower amplitudes. These results are strongly linked to the opening of the gap near the spot weld at high load amplitudes. At low amplitudes, corrosion might limit the local stress at the notch root of the weld.
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