| 1. |
|
|
| 2. |
- Reifarth, R., et al.
(författare)
-
The [sup 14]C(n,gamma) cross section between 10 keV and 1 MeV
- 2008
-
Ingår i: Physical Review C (Nuclear Physics). ; 77:1, s. 015804-
-
Tidskriftsartikel (refereegranskat)abstract
- The neutron capture cross section of 14C is of relevance for several nucleosynthesis scenarios such as inhomogeneous Big Bang models, neutron induced CNO cycles, and neutrino driven wind models for the r process. The 14C(n,gamma) reaction is also important for the validation of the Coulomb dissociation method, where the (n,gamma) cross section can be indirectly obtained via the time-reversed process. So far, the example of 14C is the only case with neutrons where both, direct measurement and indirect Coulomb dissociation, have been applied. Unfortunately, the interpretation is obscured by discrepancies between several experiments and theory. Therefore, we report on new direct measurements of the 14C(n,gamma) reaction with neutron energies ranging from 20 to 800 keV.
|
|
| 3. |
- Huning, I., et al.
(författare)
-
Exon 2 duplication of the MID1 gene in a patient with a mild phenotype of Opitz G/BBB syndrome
- 2013
-
Ingår i: European Journal of Medical Genetics. - : Elsevier BV. - 1769-7212. ; 56:4, s. 188-191
-
Tidskriftsartikel (refereegranskat)abstract
- The X-linked form of Opitz G/BBB syndrome is a congenital midline malformation syndrome caused by MID1 loss-of-function mutations, including point mutations and small-sized duplications, insertions, and deletions. Three patients with an Opitz G/BBB syndrome phenotype and relatively large duplications of part of the MID1 gene have been described up to date. Here we report a 2-months-old boy with a very mild phenotype including craniofacial dysmorphism, swallowing difficulties, and a normal psychomotor development. Molecular karyotyping revealed a 57-kb duplication involving exon 2 of the MID1 gene. The in-frame tandem duplication was confirmed by MID1 transcript analysis. This alteration results likely in a mutant MID1 protein which contains 32 duplicated amino acids in the first part of the coiled-coil domain. The mild phenotype of the patient with the microduplication suggests that MID1 mutations can be found in patients with hypertelorism with or without other clinical signs and MID1 alterations might be missed in individuals not fulfilling the minimal criteria for diagnosis of X-linked Opitz G/BBB syndrome. This report further emphasizes the genotype-first approach in medical genetics in general and patients with unspecific clinical features in particular. (C) 2013 Elsevier Masson SAS. All rights reserved.
|
|
| 4. |
|
|
| 5. |
- Rundberg Nilsson, Alexandra J.S., et al.
(författare)
-
IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance
- 2023
-
Ingår i: Science Advances. - 2375-2548. ; 9:43
-
Tidskriftsartikel (refereegranskat)abstract
- Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between blood cell production and self-renewal. While inflammation-related signaling is a critical regulator of HSC activity, the underlying mechanisms and the precise functions of specific factors under steady-state and stress conditions remain incompletely understood. We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings demonstrate that the loss of IRF1 from mouse HSCs significantly impairs self-renewal, increases stress-induced proliferation, and confers resistance to apoptosis. In addition, given the frequent abnormal expression of IRF1 in leukemia, we explored the potential of IRF1 expression level as a stratification marker for human acute myeloid leukemia. We show that IRF1-based stratification identifies distinct cancer-related signatures in patient subgroups. These findings establish IRF1 as a pivotal HSC controller and provide previously unknown insights into HSC regulation, with potential implications to IRF1 functions in the context of leukemia.
|
|
| 6. |
- Åkesson, Susanne, et al.
(författare)
-
Effects of magnetic manipulations on orientation: comparing diurnal and nocturnal passerine migrants on Capri, Italy in autumn.
- 2006
-
Ingår i: Ornis Svecica. - 1102-6812. ; 16:1-2, s. 55-61
-
Tidskriftsartikel (refereegranskat)abstract
- Orientation cage experiments were performed on Capri in Italy, with a diurnal passerine migrant (Tree Pipit Anthus trivialis), and a nocturnal passerine migrant (Garden Warbler Sylvia borin), to study the use of magnetic compass information during autumn passage migration. The experiments were performed outdoors at sunset in: (1) the local geomagnetic field under natural clear skies, (2) a shifted magnetic field (mN -90[degree]) under clear skies, and (3) a shifted magnetic field (mN -90[degree]) under simulated overcast skies. Day migrating Tree Pipits showed a clear shift in orientation compared to controls (i.e. local geomagnetic field and clear sky conditions) corresponding roughly with the magnetic shift (mN -90[degree]) under clear as well as overcast skies, while the Garden Warbler migrating at night, did not respond to the same magnetic manipulations by shifting their preferred directions in the cages. The mean orientation of Tree Pipits did not differ from the sun's position during experiments, while it was clearly different in Garden Warblers. Species-specific orientation responses to experimental manipulations in caged compared to free-flying migrants is discussed.
|
|
