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- Iseri, K, et al.
(författare)
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Incidence of Fractures Before and After Dialysis Initiation
- 2020
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Ingår i: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - : Wiley. - 1523-4681. ; 35:12, s. 2372-2380
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Tidskriftsartikel (refereegranskat)
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- Bargmann, Swantje, 1980, et al.
(författare)
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Modeling of polycrystals with gradient crystal plasticity: A comparison of strategies
- 2010
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Ingår i: Philosophical Magazine. - : Informa UK Limited. - 1478-6435 .- 1478-6443. ; 90:10, s. 1263-1288
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Tidskriftsartikel (refereegranskat)abstract
- This paper treats the computational modeling of size dependence in microstructure models of metals. Different gradient crystal plasticity strategies are analyzed and compared. For the numerical implementation, a dual-mixed finite element formulation which is suitable for parallelization is suggested. The paper ends with a representative numerical example for polycrystals.
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| 16. |
- Jeremic, B., et al.
(författare)
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Finite deformation analysis of geomaterials
- 2001
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Ingår i: International Journal for Numerical and Analytical Methods in Geomechanics. ; 25, s. 809-840
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Tidskriftsartikel (refereegranskat)
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| 17. |
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| 18. |
- Keimpema, Erik, et al.
(författare)
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GABAergic Terminals Are a Source of Galanin to Modulate Cholinergic Neuron Development in the Neonatal Forebrain
- 2014
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Ingår i: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 24:12, s. 3277-3288
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Tidskriftsartikel (refereegranskat)abstract
- The distribution and (patho-) physiological role of neuropeptides in the adult and aging brain have been extensively studied. Galanin is an inhibitory neuropeptide that can coexist with.-aminobutyric acid (GABA) in the adult forebrain. However, galanin's expression sites, mode of signaling, impact on neuronal morphology, and colocalization with amino acid neurotransmitters during brain development are less well understood. Here, we show that galaninergic innervation of cholinergic projection neurons, which preferentially express galanin receptor 2 (GalR2) in the neonatal mouse basal forebrain, develops by birth. Nerve growth factor (NGF), known to modulate cholinergic morphogenesis, increases GalR2 expression. GalR2 antagonism (M871) in neonates reduces the in vivo expression and axonal targeting of the vesicular acetylcholine transporter (VAChT), indispensable for cholinergic neurotransmission. During cholinergic neuritogenesis in vitro, GalR2 can recruit Rho-family GTPases to induce the extension of a VAChT-containing primary neurite, the prospective axon. In doing so, GalR2 signaling dose-dependently modulates directional filopodial growth and antagonizes NGF-induced growth cone differentiation. Galanin accumulates in GABA-containing nerve terminals in the neonatal basal forebrain, suggesting its contribution to activity-driven cholinergic development during the perinatal period. Overall, our data define the cellular specificity and molecular complexity of galanin action in the developing basal forebrain.
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| 19. |
- Runesson, Ulla, 1952, et al.
(författare)
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The space of learning
- 2004
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Ingår i: Marton, F. & Tsui, A. (eds). Classroom discourse and the space of learning. - Mahwah, N.J. : Lawrence Erlbaum. - 0805840087 - 0805840095
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 20. |
- Webling, Kristin E. B., et al.
(författare)
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Galanin receptors and ligands
- 2012
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Ingår i: Frontiers in Endocrinology. - : Frontiers Media SA. - 1664-2392. ; 3:146, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- The neuropeptide galanin was first discovered 30 years ago. Today, the galanin family consists of galanin, galanin-like peptide (GALP), galanin-message associated peptide (GMAP), and alarin and this family has been shown to be involved in a wide variety of biological and pathological functions. The effect is mediated through three GPCR subtypes, GalR1-3. The limited number of specific ligands to the galanin receptor subtypes has hindered the understanding of the individual effects of each receptor subtype. This review aims to summarize the current data of the importance of the galanin receptor subtypes and receptor subtype specific agonists and antagonists and their involvement in different biological and pathological functions.
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