| 1. |
- Boudrie, Gustaf Anton, 1724-1788
(författare)
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Dissertatio academica, præcepta Horatii de arte poëtica expositura cujus particulam, consensu ordinis philosophici, in regio athenæo Upsaliensi, publice ventilandam sistunt, præses, Gustav. Ant. Boudrie ... atque respondens, alumnus regius, Olaus Söderlund, Medelpadus. In auditorio Carolino majori, die XXII. Junii, MDCCLXXII. H. a. m. s.
- 1772
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)
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| 2. |
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| 3. |
- Bergh, Jonas, et al.
(författare)
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Tailored fluorouracil, epirubicin, and cyclophosphamide compared with marrow-supported high-dose chemotherapy as adjuvant treatment for high-risk breast cancer : A randomised trial
- 2000
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 356:9239, s. 1384-1391
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Tidskriftsartikel (refereegranskat)abstract
- Background: Chemotherapy drug distribution varies greatly among individual patients. Therefore, we developed an individualised fluorouracil, epirubicin, cyclophosphamide (FEC) regimen to improve outcomes in patients with high-risk early breast cancer. We then did a randomised trial to compare this individually tailored FEC regimen with conventional adjuvant chemotherapy followed by consolidation with high-dose chemotherapy with stem-cell support. Methods: 525 women younger than 60 years of age with high-risk primary breast cancer were randomised after surgery to receive nine cycles of tailored FEC to haematological equitoxicity with granulocyte colony-stimulating factor (G-CSF) support (n=251), or three cycles of FEC at standard doses followed by high-dose chemotherapy with cyclophosphamide, thiotepa, and carboplatin (CTCb), and peripheral-blood stem-cell or bone-marrow support (n=274). Both groups received locoregional radiation therapy and tamoxifen for 5 years. The primary outcome measure was relapse-free survival, and analysis was by intention to treat. Findings: At a median follow-up of 34.3 months, there were 81 breast-cancer relapses in the tailored FEC group versus 113 in the CTCb group (double triangular method p=0.04). 60 deaths occurred in the tailored FEC group and 82 in the CTCb group (log-rank p=0.12). Patients in the CTCb group experienced more grade 3 or 4 acute toxicity compared with the tailored FEC group (p<0.0001). Two treatment-related deaths (0.7%) occurred in the CTCb group. Six patients in the tailored FEC group developed acute myeloid leukaemia and three developed myelodysplastic syndrome. Interpretation: Tailored FEC with G-CSF support resulted in a significantly improved relapse-free survival and fewer grade 3 and 4 toxicities compared with marrow-supported high-dose chemotherapy with CTCb as adjuvant therapy of women with high-risk primary breast cancer.
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| 4. |
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| 5. |
- Carlsson, Adrian, et al.
(författare)
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KAUDroid : A tool that will spy on applications and how they spy on their users
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Our mobile phone is today our most precious and condential partof us. In many cases we do not only share phone number with it, butalso our most private information. This information is to some extensionnaively shared and gathered without our knowledge. As the number ofadvanced and sophisticated services increase the more sensitive informa-tion we seem to throw at them. To prevent privacy intrusions Googles'soperation system Android uses something called permissions. Permis-sions are a decision to allow an Android application access to a resourceon a specic device. Once a permission is granted there is no possibil-ity for a user to verify that the application does not take advantage ofthe given trust. With granted permissions applications can collect a vastamount of information without any connection to the service it provides.To highlight this problem we present the KAUDroid platform, a two part,Android application surveillance system. KAUDroid consists of an An-droid application that collect permission usage on phones and a centralserver responsible for data storage. Information is presented to the publicthrough a web user interface using graphs to visualize data in a under-standable manner. With this tool we hope to raise the general awareness ofhow third-party applications tend to abuse their trust and to help peoplerecapture their unconsciously lost privacy.
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| 6. |
- Frygner Holm, Sara, et al.
(författare)
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Physical therapists' experiences of learning and delivering a complex behavioral medicine intervention to adolescents with pain
- 2021
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Ingår i: Physiotherapy Theory and Practice. - : TAYLOR & FRANCIS INC. - 0959-3985 .- 1532-5040. ; 37:5, s. 583-593
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Tidskriftsartikel (refereegranskat)abstract
- The objective was to study physical therapists' (PTs') experiences of learning and delivering a complex intervention, a tailored behavioral medicine treatment (BMT) targeting adolescents with pain in primary care. Method: An explorative study with qualitative approach, using content analysis. Three primary care PTs delivering the treatments in a randomized controlled study were interviewed regarding their views on the BMT. Results: The participating PTs considered learning about and delivering the BMT as challenging but rewarding. The biopsychosocial approach, tailoring of the treatment and dialogues with parents were identified as key aspects of the BMT program. The process of formulating a functional behavioral analysis was perceived as strenuous. The supervision of the PTs throughout the study was regarded as crucial and necessary for learning about and providing tailored BMT. Conclusion: Learning about and delivering BMT targeting adolescents with persistent pain is fruitful but laborious and demanding according to three PTs experienced with treatment of pediatric pain in primary care. Extensive education and long periods of supervision seem to be crucial for success and safe delivery according to protocol.
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| 8. |
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| 9. |
- Hellmer, Kahl, et al.
(författare)
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The eye of the retriever : Developing episodic memory mechanisms in preverbal infants assessed through pupil dilation
- 2018
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Ingår i: Developmental Science. - : Wiley. - 1363-755X .- 1467-7687. ; 21:2
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Tidskriftsartikel (refereegranskat)abstract
- Studying memory in infants can be challenging, as they cannot express their subjective recollection verbally. In this study we use a novel method with which we can assess episodic recognition memory through pupillometry, using identical procedures and stimuli for infants and adults. In three experiments of 4- and 7-month-old infants, and adults we show that the adult pupillary response is larger to previously seen than to never seen items (old/new effect). Pupil dilations index subjective memory experience in adults, producing distinct pupil dilations to items judged as remembered, familiar, and new, regardless of actual previous exposure (Experiment 1). Seven-month-old infants demonstrate a clear pupillary old/new effect, very similar to that of adults (Experiment 2), whereas 4-month-olds do not demonstrate such an effect (Experiment 3). Our findings suggest that the mnemonic mechanisms that serve infants' and adults' episodic recognition memory are more similar than previously asserted: they are not fully developed at 4 months of age but that there is contiguity in human episodic memory development from 7 months of age.
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| 10. |
- Holm, Sara
(författare)
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Children and Adolescents with Pain in Primary care : Biopsychosocial determinants and behavioral medicine treatment in a physical therapy framework
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Pain during childhood and adolescents is prevalent and longstanding pain can have severe consequences for children, their families and in the long run for the society. Persisting pain influences many aspects of life and pain-related disability is often associated with impairment, decreased health-related quality of life, school functioning, participation in social life, emotional well-being, and with increased healthcare utilization. The overall aim was to explore, with cross-sectional design, pain conditions, to identify biopsychosocial determinants and their association with pain-related disability, and to study the feasibility of applying a behavioral medicine treatment for adolescents experiencing musculoskeletal pain using randomized controlled design and multimethod approach. Samples of children and adolescents and their parents seeking primary care physical therapy for a pain condition, and a sample of treating physical therapists were included.The results showed that some children had profiles of biopsychosocial determinants that could increase the risk for long-term pain-related disability. Many had long pain duration and multiple pain locations. Girls reported higher levels of catastrophizing compared to boys, who in turn used more behavioral distraction generally regarded as a positive coping strategy.Behavioral medicine treatment, based on a biopsychosocial approach, targeting adolescents with pain was shown to be feasible for use in primary care, with promising outcomes. Tailoring of the treatment was suboptimal but the effect of behavioral medicine treatment in pain-related disability exceeded the effect of the control treatment. The satisfaction with treatment content and results were high for both the control- and experimental condition, significantly higher for the experimental condition as rated by participants. Learning and delivering the behavioral medicine intervention was perceived challenging but rewarding by the treating physical therapists. The biopsychosocial approach in tailoring the treatment, and dialogs with parents were identified as key aspects in the behavioral medicine treatment program.In conclusion, in children seeking primary care for pain, the factors associated with pain-related disability were complex and interrelated. The findings highlight the importance for primary care health care providers to apply a biopsychosocial approach in assessment and treatment, for improvement of activities and participation, and thereby helping children and adolescents regain health.
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| 11. |
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| 12. |
- Holm, Sara, et al.
(författare)
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How children and adolescents in primary care cope with pain and the biopsychosocial factors that correlate with pain-related disability
- 2013
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 102:10, s. 1021-1026
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To describe how children and adolescents cope with pain and to examine the biopsychosocial factors that correlate with pain-related disability (PRD) in a sample of primary care patients. Methods: This cross-sectional study included 133 patients, aged from eight to 16 years, who consulted primary care physiotherapy on a pain-related problem. Data were collected with the Functional Disability Inventory, the Pain Coping Questionnaire and a study-specific questionnaire. Linear multivariate regression analyses were applied to study the associations between PRD and (i) pain coping, (ii) individual-, pain-related and psychosocial variables. Results: Behavioural distraction, externalizing and catastrophizing explained 13% of the variance in PRD (regression model 1). In addition, pain intensity, worrying and the ability to reduce pain explained 21% of the variance in PRD (regression model 2). Conclusion: Variance in PRD was partly explained by pain intensity, worrying and ability to reduce pain and by behavioural distraction, externalizing and catastrophizing. Future prospective longitudinal studies are needed to identify possible additional variables explaining PRD, establish causality and the potential benefits of addressing these variables in interventions in primary care.
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| 13. |
- Holm, Sara, et al.
(författare)
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Pain in children and adolescents in primary care : chronic and recurrent pain is common
- 2012
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 101:12, s. 1246-1252
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of this study was to describe a paediatric primary care pain sample and examine associations between pain, health-related quality of life and disability.Methods: The study design is descriptive and cross-sectional. One hundred and fifty-four consecutive children and adolescents between the ages of 8 and 16 seeking care for a pain-related conditions participated in this study. Pain characteristics, health-related quality of life and disability were investigated.Results: Eighty-seven per cent of participants had a pain duration of 3 months or more, and almost half of the group studied had a pain duration of ≥ 12 months. The disability levels in the study group as a whole were low, with a mean FDI of 10.4 (SD 7.6). However, 35% of the study group had moderate disability levels and reported a mean FDI of 18.7 (SD 4.8). Single pain location was reported in 42%, whereas 58% had two or more pain locations. The children with multiple pain locations reported lower health-related quality of life and higher disability than children with single pain location.Conclusion: Paediatric pain patients in primary care consist partly of patients only slightly influenced by pain and partly of patients for whom pain has a great impact on their lives.
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| 14. |
- Holm, Sara, et al.
(författare)
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Treating youth in pain : Comparing tailored behavioural medicine treatment provided by physical therapists in primary care with physical exercises
- 2016
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Ingår i: European Journal of Pain. - : Wiley-Blackwell. - 1090-3801 .- 1532-2149. ; 20:4, s. 626-638
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To study the efficacy of tailored behavioural medicine treatment within a physical therapy framework.Methods: The study was a randomized controlled study (RCT): tailored behavioural medicine treatment (EXT) delivered by physical therapists (PTs) was compared with exercise-based treatment (CT). Thirty-two adolescents (mean age 14.3 years) with persistent pain participated. Data on pain-related disability and school attendance (primary outcomes), pain intensity, catastrophizing, fear of movement and self-efficacy were collected.Results: The pain-related disability measured by the Functional Disability Inventory (FDI) resulted in mean score change of EXT = -18 and CT = -11, respectively. A significant change within both groups was found (EXT p = 0.003, CT p = 0.001), and a large effect size for FDI between the conditions was demonstrated (AUC of 0.77). For school attendance post-treatment, no difference was found between conditions. For secondary outcomes, a significant improvement in pain intensity and pain catastrophizing was found for the EXT and self-efficacy for the CT groups but no statistically significant difference between the two conditions was detected. Caution should be given to the small sample size, as it may affect the interpretation and generalizability of the results.Conclusion: In this study, differences between tailored behavioural medicine treatment delivered by PTs and exercise-based treatment could not be demonstrated, although the effect size was large. Patients who received either treatment demonstrated significant changes over time in pain-related disability. The low number of participants and suboptimal tailoring of the psychological components may partly explain the failure to demonstrate differences between groups, and future studies are warranted.
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| 16. |
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| 17. |
- Schöier, Johan, et al.
(författare)
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Chlamydia (Chlamydophila) pneumoniae-induced cell death in human coronary artery endothelial cells is caspase-independent and accompanied by subcellular translocations of Bax and apoptosis-inducing factor.
- 2006
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Ingår i: FEMS Immunology and Medical Microbiology. - 0928-8244 .- 1574-695X. ; 47:2, s. 207-216
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Tidskriftsartikel (refereegranskat)abstract
- Atherosclerosis and coronary heart disease are causing high morbidity and mortality worldwide. Different risk factors have been demonstrated, but the exact mechanisms behind these diseases are still not fully understood. Recent studies have suggested Chlamydia pneumoniae to be involved in the pathogenesis, and increased apoptotic indexes in atherosclerotic plaques have been documented. In this study, we show that C. pneumoniae induces apoptosis and necrosis in populations of human coronary artery endothelial cells. Apoptosis was determined by TUNEL and flow cytometry after staining of cells with annexin V and propidium iodide, and defined as TUNEL-reactive or annexin V-positive, propidium iodide-negative cells. The apoptosis was induced within 2 h postinfection and increased with inoculation dose. The general caspase inhibitor z-VAD-fmk did not affect apoptotic frequencies. By immunochemistry and immunoblot, we demonstrated activation and subcellular translocation of the proapoptotic protein Bax, and translocation of apoptosis-inducing factor from the cytosol to the nucleus. These results indicate that C. pneumoniae-induced apoptosis in human coronary artery endothelial cells is caspase-independent and regulated by Bax and apoptosis-inducing factor.
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| 18. |
- Schöier, Johan, et al.
(författare)
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Chlamydia trachomatis -induced apoptosis occurs in uninfected McCoy cells late in the developmental cycle and is regulated by the intracellular redox state
- 2001
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Ingår i: Microbial Pathogenesis. - : Elsevier BV. - 0882-4010 .- 1096-1208. ; 31:4, s. 173-184
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Tidskriftsartikel (refereegranskat)abstract
- Infections with the obligate intracellular bacterium Chlamydia trachomatis are characterized by avoidance of fusion between chlamydia-containing endosomes and lysosomes, bacterial persistence and development of post-infectious sequelae. In this report we show that C. trachomatis induces apoptosis in McCoy and HeLa cells. Apoptosis was monitored by three different techniques; enzyme-linked immunoassay (EIA) of fragmented nucleosomes, terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) and flow cytometry of propidium iodide-stained cells. Apoptosis occurred in uninfected cells, was induced late in the chlamydial developmental cycle, beyond 24 h post-infection and was dependent on bacterial protein synthesis. Apoptosis was not significantly increased in infected, inclusion-containing cells. Treatment of cells with the antioxidants ascorbic acid (10 μM) and α-tocopherol (10 μM) reduced the degree of apoptosis. These results suggest that host cells infected with C. trachomatis generate proapoptotic stimuli that induce apoptosis in uninfected, neighbouring cells and that the redox state of the cell is a regulator in chlamydia-induced apoptosis.
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| 19. |
- Söderlund, Gustaf, et al.
(författare)
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A note on the diophantine equation CZ2 = X5 + Y5
- 2013
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Ingår i: Advances in Theoretical and Applied Mathematics (ATAM). - 0973-4554. ; 8:3, s. 173-176
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Tidskriftsartikel (refereegranskat)abstract
- In a previous paper we determined an infinite sequence of C for which the title equation has no coprime non-trivial solutions. In this work we extend these results to C- values {2F, 10} where F is a prime number 3, 7 mod 10.
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| 20. |
- Söderlund, Gustaf, et al.
(författare)
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On the Diophantine Equation CZ2 = X5 + Y5
- 2011
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Ingår i: Advances in Theoretical and Applied Mathematics (ATAM). - : Research India Publications. - 0973-4554. ; 7:1, s. 59-71
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Tidskriftsartikel (refereegranskat)abstract
- In this work we determine an infinit sequence of different values of C for which the diophantine equation Cz2 = x5 + y5 has no coprime non-trivial solutions.
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