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1.	Bosnic-Anticevich, S, et al. (author) ARIA pharmacy 2018 "Allergic rhinitis care pathways for community pharmacy" 2019 In: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 74:7, s. 1219-1236 Research review (peer-reviewed)abstract Pharmacists are trusted health professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact of allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The ARIA-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses) and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of AR. However, the ARIA-pharmacy ICP should be adapted to local health care environments/situations as regional (national) differences exist in pharmacy care.
2.	Wilking, N., et al. (author) Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy 2007 In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 18:4, s. 694-700 Journal article (peer-reviewed)abstract Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below theage of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorouracil, epirubicin, cyclophosphamide), (n = 251) or standard FEC followed by marrow-supported high-dose therapy with CTCb (cyclophosphamide, thiotepa, carboplatin) therapy (n = 274), followed by locoregional radiotherapy and tamoxifen for 5 years. Results: There were 104 breast cancer relapses in the tailored FEC group versus 139 in the CTCb group (double triangular method by Whitehead, P = 0.046), with a median follow-up of all included patients of 60.8 months. The event-free survival demonstrated 121 and 150 events in the tailored FEC- and CTCb group, respectively [P = 0.074, hazard ratio (HR) 0.804, 95% confidence interval (CI) 0.633-1.022]. Ten patients in the tailored FEC regimen developed acute myeloid leukaemia (AML)/myelodysplasia (MDS). One hundred deaths occurred in the tailored FEC group and 121 in the CTCb group (P = 0.287, HR 0.866, 95% CI 0.665-1.129). Conclusion: The update of this study shows an improved outcome linked to the tailored FEC treatment in relation to breast cancer relapse, but also an increased incidence of AML/MDS. © 2007 Oxford University Press.
3.	Hayes, A., et al. (author) A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts 2020 In: Journal of Medical Virology. - : Wiley. - 0146-6615 .- 1096-9071. ; 92:8, s. 1065-1074 Journal article (peer-reviewed)abstract Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in-house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV species (EV-A71, echovirus 30, coxsackie A virus 21, and EV-D68), HPeV3, and specificity controls. Reported results from 48 in-house and 15 commercial assays showed 98% detection frequencies of high copy (1000 RNA copies/5 µL) transcripts. In-house assays showed significantly greater detection frequencies of the low copy (10 copies/5 µL) EV and HPeV transcripts (81% and 86%, respectively) compared with commercial assays (56%, 50%; P = 7 × 10−5). EV-specific PCRs showed low cross-reactivity with human rhinovirus C (3 of 42 tests) and infrequent positivity in the negative control (2 of 63 tests). Most or all high copy EV and HPeV controls were successfully typed (88%, 100%) by reference laboratories, but showed reduced effectiveness for low copy controls (41%, 67%). Stabilized RNA transcripts provide an effective, logistically simple and inexpensive reagent for evaluation of diagnostic assay performance. The study provides reassurance of the performance of the many in-house assay formats used across Europe. However, it identified often substantially reduced sensitivities of commercial assays often used as point-of-care tests.
4.	Skoglund, Karin, et al. (author) In vivo CYP3A activity and pharmacokinetics of imatinib in relation to therapeutic outcome in chronic myeloid leukemia patients Other publication (other academic/artistic)abstract Introduction: The hepatic enzymes CYP3A4 and CYP3A5 metabolize the tyrosine kinase inhibitor imatinib into a large number of metabolites including the pharmacologically active N-desmethyl imatinib (CGP74588). Because the metabolic activity of CYP3A varies considerably between individuals and a previous pilot study suggested an inverse association between in vivo CYP3A metabolic activity and therapeutic outcome of imatinib, the primary aim of this study was to investigate the influence of CYP3A metabolic activity on the outcome of imatinib therapy in chronic myeloid leukemia patients.Methods: Fifty-five patients were included and CYP3A activity was estimated in vivo using quinine as a probe drug. Imatinib and CGP74588 trough concentrations in the plasma were determined at steady state in 34 patients. Cytogenetic and molecular responses after 12 months of first-line imatinib were retrospectively collected from patients’ medical records.Results: Patients with optimal response to imatinib (complete cytogenetic response (CCgR) or molecular response of BCR-ABL <1%) did not have different levels of CYP3A activity compared to non-optimal responders. Similar results were found when analyzing the molecular response and CCgR separately. Neither the imatinib trough concentration nor the CGP74588/imatinib ratio were significantly associated with CYP3A activity.Conclusion: CYP3A enzyme activity, as measured by quinine metabolic ratio, does not correlate with the plasma concentrations of imatinib or CGP74588 and is not predictive of imatinib therapeutic outcome. These results indicate that even though imatinib is metabolized by CYP3A enzymes, this activity is not the ratelimiting step in imatinib metabolism and excretion. Future studies should focus on other pharmacokinetic processes such as plasma protein binding or transport protein activity to look for the major contributor to patient variability in imatinib plasma concentration.
5.	Matikainen, N., et al. (author) Minor contribution of endogenous GLP-1 and GLP-2 to postprandial lipemia in obese men 2016 In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:1 Journal article (peer-reviewed)abstract Context. Glucose and lipids stimulate the gut-hormones glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP) but the effect of these on human postprandial lipid metabolism is not fully clarified. Objective. To explore the responses of GLP-1, GLP-2 and GIP after a fat-rich meal compared to the same responses after an oral glucose tolerance test (OGTT) and to investigate possible relationships between incretin response and triglyceride-rich lipoprotein (TRL) response to a fat-rich meal. Design. Glucose, insulin, GLP-1, GLP-2 and GIP were measured after an OGTT and after a fat-rich meal in 65 healthy obese (BMI 26.5-40.2 kg/m2) male subjects. Triglycerides (TG), apoB48 and apoB100 in TG-rich lipoproteins (chylomicrons, VLDL1 and VLDL2) were measured after the fat-rich meal. Main Outcome Measures. Postprandial responses (area under the curve, AUC) for glucose, insulin, GLP-1, GLP-2, GIP in plasma, and TG, apoB48 and apoB100 in plasma and TG-rich lipoproteins. Results. The GLP-1, GLP-2 and GIP responses after the fat-rich meal and after the OGTT correlated strongly (r = 0.73, p<0.0001; r = 0.46, p<0.001 and r = 0.69, p<0.001, respectively). Glucose and insulin AUCs were lower, but the AUCs for GLP-1, GLP-2 and GIP were significantly higher after the fat-rich meal than after the OGTT. The peak value for all hormones appeared at 120 minutes after the fat-rich meal, compared to 30 minutes after the OGTT. After the fat-rich meal, the AUCs for GLP-1, GLP-2 and GIP correlated significantly with plasma TG- and apoB48 AUCs but the contribution was very modest. Conclusions. In obese males, GLP-1, GLP-2 and GIP responses to a fat-rich meal are greater than following an OGTT. However, the most important explanatory variable for postprandial TG excursion was fasting triglycerides. The contribution of endogenous GLP-1, GLP-2 and GIP to explaining the variance in postprandial TG excursion was minor. Copyright © 2016 Matikainen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
6.	Salminen, J., et al. (author) Paleomagnetic and geochronological studies on Paleoproterozoic diabase dykes of Karelia, East Finland-Key for testing the Superia supercraton 2014 In: Precambrian Research. - : Elsevier BV. - 0301-9268. ; 244, s. 87-99 Journal article (peer-reviewed)abstract Paleomagnetic results are presented for two Paleoproterozoic mafic dykes in the Taivalkoski area in northern Karelia Province of the Fennoscandian shield where, based on K-Ar data, the crust has seen minimal effects of the otherwise pervasive 1.8-1.9 Ga Svecofennian orogeny. Within this study a new U-Pb baddeleyite age of 2339 +/- 18 Ma has been determined for one of the E-W trending dykes (dyke AD13). The paleomagnetic results show that a strong Svecofennian overprinting is pervasive in the area. Upon thermal or AF demagnetization four remanence directions were obtained. Most typical are the secondary Svecofennian remanence direction A (intermediate down to the NNW) and remanence direction B (intermediate down to the NNE). Component D (D = 115.4 degrees, 1=50.5 degrees, alpha(95) =2.6 degrees) yielding a virtual geomagnetic pole (VGP) D (Plat= -19.5 degrees N, Plon= 263.3 degrees, A95 = 3.1 degrees) is obtained from baked rocks for dyke WD, and based on a positive baked contact test is interpreted to represent the primary magnetization dating from about 2.4 Ga. Dyke AD13 carries only secondary A and B components, its unbaked host migmatites carry reversed A (A(R)) component, and the baked host rock carries a component D' (D = 134.5 degrees, 1= -7.3 degrees, alpha(95) = 8.8 degrees), which yields a VGP pole D' (Plat= -20.4 degrees N, Plon = 257.3 degrees, A(95) = 7.6 degrees), possibly representing magnetization at 2.3 Ga. The new paleomagnetic data from the Karelia Province compared to similar-aged paleomagnetic data from the Superior Province does not support the recently proposed Superia configuration, based upon dyke swarm trajectories. (c) 2013 Elsevier B.V. All rights reserved.
7.	Carlström, P.A., et al. (author) Adaptations in peak oxygen consumption and fat oxidation following hypertrophy-induced heavy resistance training 2012 Conference paper (other academic/artistic)
8.	Cramer, Bradley D., et al. (author) U-Pb (zircon) age constraints on the timing and duration of Wen lock (Silurian) paleocommunity collapse and recovery during the "Big Crisis" 2012 In: Geological Society of America Bulletin. - 0016-7606. ; 124:11-12, s. 1841-1857 Journal article (peer-reviewed)abstract High-precision isotope-dilution U-Pb (zircon) dating was conducted on three volcanic ash fall (bentonite) samples from the Swedish island of Gotland, and on a fourth bentonite from the West Midlands, England. Zircons from the Ireviken, Grotlingbo, Djupvik (Gotland), and Wren's Nest Hill-15 (West Midlands) bentonites yielded weighted mean Pb-206/U-238 ages of 431.83 +/- 0.23/0.67 Ma, 428.45 +/- 035/0.73 Ma, 428.06 +/- 0.2110.66 Ma, and 427.86 +/- 032/0.71 Ma, respectively (analytical/total uncertainties). These biostratigraphically well-controlled age dates effectively bracket the Wenlock Epoch of the Silurian Period and provide control for the duration of one of the major Paleozoic biotic events and associated perturbations to the global carbon cycle (the "Big Crisis" or lundgreni event- graptolites; the NIulde Event-conodonts; the Mulde excursion-carbon isotopes). These new data suggest an older and shorter duration for the recalibration of the Wenlock Series and demonstrate that the cascade of biological and chemical events that took place during the Big Crisis happened on time scales of tens to hundreds of thousands of years.
9.	Fraenkel, C. J., et al. (author) Risk factors for hospital norovirus outbreaks : impact of vomiting, genotype, and multi-occupancy rooms 2018 In: Journal of Hospital Infection. - : Elsevier BV. - 0195-6701. ; 98:4, s. 398-403 Journal article (peer-reviewed)abstract Background: Norovirus is frequently introduced to the hospital and is a frequent cause of hospital outbreaks. Recognition of the factors that facilitate or impede norovirus transmission is an important step to effectively prevent hospital outbreaks. Aim: To investigate risk factors for norovirus outbreaks in hospital settings. Methods: Clinical data, ward setting, and norovirus genotype were collected from all 65 norovirus-positive index cases in outbreaks and all 186 sporadic norovirus cases at 192 wards in southern Sweden during 2010–2012 in a nested case–control study. Uni- and multivariate statistical analyses were conducted. Findings: Outbreak was independently associated with the number of patients sharing a room with the norovirus case (odds ratio (OR): 1.9 per additional patient in the room; P < 0.01), vomiting (OR: 2.6; P = 0.04), age >80 years (OR: 3.2; P < 0.01), comorbidity (OR: 2.3; P = 0.05), and onset of symptoms after admission to the ward (OR: 3.5; P < 0.01) in the multivariate analysis. Infection with genotype GII.4 was found to be strongly associated with outbreak in the univariate analysis (OR: 5.7; P < 0.01). Moreover, associations between GII.4 and vomiting (OR: 2.5; P = 0.01) and old age (OR: 4.3: P < 0.01) were found. Conclusion: This is the first study to investigate clinical, ward and genotype risk factors for norovirus hospital outbreaks. Recognition of these factors may help direct and prioritize infection control actions based on the outbreak risk. The results also suggest that the outbreak association with GII.4 partly may be explained by an enhanced ability to induce vomiting.
10.	Gaytán, Álvaro, 1988-, et al. (author) Changes in the foliar fungal community between oak leaf flushes along a latitudinal gradient in Europe 2022 In: Journal of Biogeography. - : Wiley. - 0305-0270 .- 1365-2699. ; 49:12, s. 2269-2280 Journal article (peer-reviewed)abstract Aim: Leaves support a large diversity of fungi, which are known to cause plant diseases, induce plant defences or influence leaf senescence and decomposition. To advance our understanding of how foliar fungal communities are structured and assembled, we assessed to what extent leaf flush and latitude can explain the within- and among-tree variation in foliar fungal communities.Location: A latitudinal gradient spanning c. 20 degrees in latitude in Europe.Taxa: The foliar fungal community associated with a foundation tree species, the pedunculate oak Quercus robur.Methods: We examined the main and interactive effects of leaf flush and latitude on the foliar fungal community by sampling 20 populations of the pedunculate oak Quercus robur across the tree's range. We used the ITS region as a target for characterization of fungal communities using DNA metabarcoding.Results: Species composition, but not species richness, differed between leaf flushes. Across the latitudinal gradient, species richness was highest in the central part of the oak's distributional range, and foliar fungal community composition shifted along the latitudinal gradient. Among fungal guilds, the relative abundance of plant pathogens and mycoparasites was lower on the first leaf flush, and the relative abundance of plant pathogens and saprotrophs decreased with latitude.Conclusions: Changes in community composition between leaf flushes and along the latitudinal gradient were mostly a result of species turnover. Overall, our findings demonstrate that leaf flush and latitude explain 5%–22% of the small- and large-scale spatial variation in the foliar fungal community on a foundation tree within the temperate region. Using space-for-time substitution, we expect that foliar fungal community structure will change with climate warming, with an increase in the abundance of plant pathogens and mycoparasites at higher latitudes, with major consequences for plant health, species interactions and ecosystem dynamics.
11.	Gaytán, Álvaro, 1988-, et al. (author) The co-existence of multiple oak leaf flushes contributes to the large within-tree variation in chemistry, insect attack and pathogen infection 2022 In: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 235:4, s. 1615-1628 Journal article (peer-reviewed)abstract Many plant species produce multiple leaf flushes during the growing season, which might have major consequences for within-plant variation in chemistry and species interactions. Yet, we lack a theoretical or empirical framework for how differences among leaf flushes might shape variation in damage by insects and diseases.We assessed the impact of leaf flush identity on leaf chemistry, insect attack and pathogen infection on the pedunculate oak Quercus robur by sampling leaves from each leaf flush in 20 populations across seven European countries during an entire growing season.The first leaf flush had higher levels of primary compounds, and lower levels of secondary compounds, than the second flush, whereas plant chemistry was highly variable in the third flush. Insect attack decreased from the first to the third flush, whereas infection by oak powdery mildew was lowest on leaves from the first flush. The relationship between plant chemistry, insect attack and pathogen infection varied strongly among leaf flushes and seasons.Our findings demonstrate the importance of considering differences among leaf flushes for our understanding of within-tree variation in chemistry, insect attack and disease levels, something particularly relevant given the expected increase in the number of leaf flushes with climate change.
12.	Gross, A, et al. (author) Psychological Care, Patient Education, Orthotics, Ergonomics and Prevention Strategies for Neck Pain: A Systematic Overview : Update as part of the ICON* Project. 2013 In: The Open Orthopaedics Journal. - : Bentham Science Publishers Ltd.. - 1874-3250. ; 7:Suppl 4:M12, s. 530-561 Journal article (peer-reviewed)abstract To conduct an overview on psychological interventions, orthoses, patient education, ergonomics, and 1⁰/2⁰ neck pain prevention for adults with acute-chronic neck pain.Search Strategy:Computerized databases and grey literature were searched (2006-2012).Selection Criteria:Systematic reviews of randomized controlled trials (RCTs) on pain, function/disability, global perceived effect, quality-of-life and patient satisfaction were retrieved.Data Collection & Analysis:Two independent authors selected articles, assessed risk of bias using AMSTAR tool and extracted data. The GRADE tool was used to evaluate the body of evidence and an external panel to provide critical review.Main Results:We retrieved 30 reviews (5-9 AMSTAR score) reporting on 75 RCTs with the following moderate GRADE evidence. For acute whiplash associated disorder (WAD), an education video in emergency rooms (1RCT, 405participants] favoured pain reduction at long-term follow-up thus helping 1 in 23 people [Standard Mean Difference: -0.44(95%CI: -0.66 to -0.23)). Use of a soft collar (2RCTs, 1278participants) was not beneficial in the long-term. For chronic neck pain, a mind-body intervention (2RCTs, 1 meta-analysis, 191participants) improved short-term pain/function in 1 of 4 or 6 participants. In workers, 2-minutes of daily scapula-thoracic endurance training (1RCT, 127participants) over 10 weeks was beneficial in 1 of 4 participants. A number of psychosocial interventions, workplace interventions, collar use and self-management educational strategies were not beneficial.Reviewers' Conclusions:Moderate evidence exists for quantifying beneficial and non-beneficial effects of a limited number of interventions for acute WAD and chronic neck pain. Larger trials with more rigorous controls need to target promising interventions
13.	Hasenbring, M. I., et al. (author) Pain, mind, and movement in musculoskeletal pain : Is physical activity always health-promoting or are there detrimental aspects? 2015 In: The Clinical Journal of Pain. - 0749-8047 .- 1536-5409. ; 31:2, s. 95-96 Journal article (other academic/artistic)
14.	Ilander, M, et al. (author) Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia. 2017 In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 31:5, s. 1108-1116 Journal article (peer-reviewed)abstract Recent studies suggest that a proportion of chronic myeloid leukemia (CML) patients in deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment without disease relapse. In this multi-center, prospective clinical trial (EURO-SKI, NCT01596114) we analyzed the function and phenotype of T and NK cells and their relation to successful TKI cessation. Lymphocyte subclasses were measured from 100 imatinib-treated patients at baseline and 1 month after the discontinuation, and functional characterization of NK and T cells was done from 45 patients. The proportion of NK cells was associated with the molecular relapse-free survival as patients with higher than median NK-cell percentage at the time of drug discontinuation had better probability to stay in remission. Similar association was not found with T or B cells or their subsets. In non-relapsing patients the NK-cell phenotype was mature, whereas patients with more naïve CD56(bright) NK cells had decreased relapse-free survival. In addition, the TNF-α/IFN-γ cytokine secretion by NK cells correlated with the successful drug discontinuation. Our results highlight the role of NK cells in sustaining remission and strengthen the status of CML as an immunogenic tumor warranting novel clinical trials with immunomodulating agents.Leukemia advance online publication, 16 December 2016; doi:10.1038/leu.2016.360.
15.	Montiel I Ponsoda, Joan J., et al. (author) A novel all-vapor phase fabrication process for ytterbium-doped fibers with atomic layer deposition method 2013 In: Optics InfoBase Conference Papers. - Washington, D.C. : Optical Society of America (OSA). - 9781557529848 Conference paper (peer-reviewed)abstract We present a novel all-vapor phase fabrication method for producing Yb-doped fibers by atomic layer deposition (ALD) in combination with the well-established modified chemical vapor deposition (MCVD) technique. An MCVD soot-preform with a porous layer of SiO2 is coated with layers of Yb2O3 and Al2O3 prior to sintering, using a gas-phase ALD method. An Ybdoped fiber fabricated by this technique shows low background attenuation, uniform longitudinal Yb-doping profile, and good laser characteristics with a slope efficiency of 80%.
16.	Montiel I Ponsoda, Joan J., et al. (author) Ytterbium-doped fibers fabricated with atomic layer deposition method 2012 In: Optics Express. - 1094-4087. ; 20:22, s. 25085-95 Journal article (peer-reviewed)abstract We report on a new fabrication method of producing ytterbium doped fibers by atomic layer deposition (ALD) in combination with the conventional modified chemical vapor deposition (MCVD) technique. An MCVD soot-preform with a porous layer of SiO2 is coated with layers of Yb2O3 and Al2O3 prior to sintering, using the gas-phase ALD method. An SEM/EDS material analysis study shows that the dopants successfully penetrate the full thickness of 320 μm of the soot layer. An Yb-doped fiber fabricated by this technique shows a background attenuation of 20 dB/km, a uniform longitudinal Yb-doping profile, and good laser characteristics with a slope efficiency of 80%. Furthermore, we present a comparison in terms of photodarkening between the MCVD-ALD fiber and a solution doped fiber, fabricated with the same MCVD recipe. The new MCVD-ALD fiber appears to be more photodarkening resistant.
17.	Mårtensson, Johanna, et al. (author) Diffusion tensor imaging and tractography of the white matter in normal aging : The rate-of-change differs between segments within tracts 2018 In: Magnetic Resonance Imaging. - : Elsevier BV. - 0730-725X .- 1873-5894. ; 45, s. 113-119 Journal article (peer-reviewed)abstract Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13 and 84years of age. Segments of the CB and the IFO were extracted and parameters for each segment were averaged across the hemispheres. The data was analysed as a function of age. Results show that age-related changes differ both between and within individual tracts. Different age trajectories were observed in all segments of the analysed tracts for all DTI parameters. In conclusion, aging does not affect white matter tracts uniformly but is regionally specific; both between and within white matter tracts.
18.	Ritchie, C., et al. (author) A systematic review shows minimal evidence for measurement properties of psychological functioning outcomes in whiplash 2022 In: Journal of Clinical Epidemiology. - : Elsevier Inc.. - 0895-4356 .- 1878-5921. ; 151, s. 29-44 Journal article (peer-reviewed)abstract Objectives: The aim of this study was to systematically identify, synthesize, and appraise studies on the measurement properties of patient-reported outcome measures (PROMs) for anxiety, depression, fear of movement, pain catastrophizing, post-traumatic stress, self-efficacy, and stress in people with whiplash-associated disorders (WAD). Study Design and Setting: PsycINFO, MEDLINE, EMBASE, CINAHL, PILOTS, Web of Science, and Scopus were searched (November 9, 2021). Studies evaluating any measurement property of relevant PROMs in WAD were included. Two reviewers independently screened the studies and assessed the measurement properties in accordance with the COSMIN guidelines. Results: Measurement properties of 10 PROMs were evaluated in WAD: Pictorial Fear of Activity Scale-Cervical (PFActS-C), Tampa Scale of Kinesiophobia-11, Pain Catastrophizing Scale (PCS), Pain Self-Efficacy Questionnaire (PSEQ), PSEQ-4 item, PSEQ-2a, PSEQ-2b, Self-Efficacy Scale, Harvard Trauma Questionnaire, and Post-Traumatic Stress Diagnostic Scale. Content validity was not examined in any of these PROMs in whiplash. Moderate- or high-quality evidence showed adequate internal structure for the PSEQ, PCS, and PFActS-C, whereas the original structures of the remaining seven PROMs were not confirmed in whiplash. Conclusion: Until further research on the measurement properties of these PROMs is available, researchers may opt to use the PSEQ, PCS, or PFActS-C if the construct is aligned with research aims. © 2022 Elsevier Inc.
19.	Sterling, M., et al. (author) Recommendations for a core outcome measurement set for clinical trials in whiplash associated disorders 2023 In: Pain. - : NLM (Medline). - 0304-3959 .- 1872-6623. ; 164:10, s. 2265-2272 Journal article (peer-reviewed)abstract ABSTRACT: Inconsistent reporting of outcomes in clinical trials of treatments for whiplash associated disorders (WAD) hinders effective data pooling and conclusions about treatment effectiveness. A multidisciplinary International Steering Committee recently recommended 6 core outcome domains: Physical Functioning, Perceived Recovery, Work and Social Functioning, Psychological Functioning, Quality of Life and Pain. This study aimed to reach consensus and recommend a core outcome set (COS) representing each of the 6 domains. Forty-three patient-reported outcome measures (PROMs) were identified for Physical Functioning, 2 for perceived recovery, 37 for psychological functioning, 17 for quality of life, and 2 for pain intensity. They were appraised in 5 systematic reviews following COSMIN methodology. No PROMs of Work and Social Functioning in WAD were identified. No PROMs had undergone evaluation of content validity in patients with WAD, but some had moderate-to-high-quality evidence for sufficient internal structure. Based on these results, the International Steering Committee reached 100% consensus to recommend the following COS: Neck Disability Index or Whiplash Disability Questionnaire (Physical Functioning), the Global Rating of Change Scale (Perceived Recovery), one of the Pictorial Fear of Activity Scale-Cervical, Pain Self-Efficacy Questionnaire, Pain Catastrophizing Scale, Harvard Trauma Questionnaire, or Posttraumatic Diagnostic Scale (Psychological Functioning), EQ-5D-3L or SF-6D (Quality of Life), numeric pain rating scale or visual analogue scale (Pain), and single-item questions pertaining to current work status and percent of usual work (Work and Social Functioning). These recommendations reflect the current status of research of PROMs of the 6 core outcome domains and may be modified as evidence grows.
20.	Söderlund, C., et al. (author) Patterns of Acute Cellular Rejection the First Year after Heart Transplantation: A Single Center Retrospective Study at Skane University Hospital in Lund 1988-2010 2013 In: Journal of Heart and Lung Transplantation. - : Elsevier BV. - 1053-2498. ; 32:4S, s. 260-260 Conference paper (peer-reviewed)
21.	Söderlund, U, et al. (author) Baddeleyite U-Pb dates of Meso- and Neoproterozoic mafic dykes and sills in the Fennoscandian Shield 2005 In: Fifth Intern. Dyke Conf. Rovanniemi 050731-050803, Abstracts vol.. ; , s. p.48- Conference paper (other academic/artistic)
22.	Söderlund, U, et al. (author) U-Pb baddeleyite ages and Hf, Nd isotope chemistry constraining repeated mafic magmatism in the Fennoscandian Shield from 1.6 to 0.9 Ga 2005 In: Contr. Mineral. Petrol.. ; 150, s. 174-194 Journal article (peer-reviewed)
23.	Söderlund, Z, et al. (author) Controlled release of growth factors using synthetic glycosaminoglycans in a modular macroporous scaffold for tissue regeneration 2022 In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1 Journal article (peer-reviewed)abstract Healthy regeneration of tissue relies on a well-orchestrated release of growth factors. Herein, we show the use of synthetic glycosaminoglycans for controlled binding and release of growth factors to induce a desired cellular response. First, we screened glycosaminoglycans with growth factors of interest to determine kon (association rate constant), koff (dissociation rate constant), and Kd (equilibrium rate constant). As proof-of-concept, we functionalized an elastin-like recombinamer (ELR) hydrogel with a synthetic glycosaminoglycan and immobilized fibroblast growth factor 2 (FGF2), demonstrating that human umbilical vein endothelial cells cultured on top of ELR hydrogel differentiated into tube-like structures. Taking this concept further, we developed a tunable macroporous ELR cryogel material, containing a synthetic glycosaminoglycan and FGF2 that showed increased blood vessel formation and reduced immune response compared to control when implanted in a subcutaneous mouse model. These results demonstrated the possibility for specific release of desired growth factors in/from a modular 3D scaffold in vitro and in vivo.
24.	Adiels, Martin, 1976, et al. (author) Role of apolipoprotein C-III overproduction in diabetic dyslipidaemia 2019 In: Diabetes, obesity and metabolism. - : Wiley. - 1462-8902 .- 1463-1326. ; 21:8, s. 1861-1870 Journal article (peer-reviewed)abstract - Aims: To investigate how apolipoprotein C-III (apoC-III) metabolism is altered in subjects with type 2 diabetes, whether the perturbed plasma triglyceride concentrations in this condition are determined primarily by the secretion rate or the removal rate of apoC-III, and whether improvement of glycaemic control using the glucagon-like peptide-1 analogue liraglutide for 16 weeks modifies apoC-III dynamics. Materials and Methods: Postprandial apoC-III kinetics were assessed after a bolus injection of [5,5,5- 2 H 3 ]leucine using ultrasensitive mass spectrometry techniques. We compared apoC-III kinetics in two situations: in subjects with type 2 diabetes before and after liraglutide therapy, and in type 2 diabetic subjects with matched body mass index (BMI) non-diabetic subjects. Liver fat content, subcutaneous abdominal and intra-abdominal fat were determined using proton magnetic resonance spectroscopy. Results: Improved glycaemic control by liraglutide therapy for 16 weeks significantly reduced apoC-III secretion rate (561 ± 198 vs. 652 ± 196 mg/d, P = 0.03) and apoC-III levels (10.0 ± 3.8 vs. 11.7 ± 4.3 mg/dL, P = 0.035) in subjects with type 2 diabetes. Change in apoC-III secretion rate was significantly associated with the improvement in indices of glucose control (r = 0.67; P = 0.009) and change in triglyceride area under the curve (r = 0.59; P = 0.025). In line with this, the apoC-III secretion rate was higher in subjects with type 2 diabetes compared with BMI-matched non-diabetic subjects (676 ± 208 vs. 505 ± 174 mg/d, P = 0.042). Conclusions: The results reveal that the secretion rate of apoC-III is associated with elevation of triglyceride-rich lipoproteins in subjects with type 2 diabetes, potentially through the influence of glucose homeostasis on the production of apoC-III. © 2019 John Wiley & Sons Ltd
25.	André, A M, et al. (author) Arkeologi och kulturmiljövård : Vad och varför 2001 In: Fornvännen. - 0015-7813 .- 1404-9430. ; 96, s. 177-180 Journal article (other academic/artistic)
26.	Arnesen, EK, et al. (author) Nuts and seeds consumption and risk of cardiovascular disease, type 2 diabetes and their risk factors: a systematic review and meta-analysis 2023 In: Food & nutrition research. - 1654-661X. ; 67 Journal article (peer-reviewed)
27.	Atlas, A, et al. (author) Sustained elevation of kynurenic Acid in the cerebrospinal fluid of patients with herpes simplex virus type 1 encephalitis 2013 In: International journal of tryptophan research : IJTR. - 1178-6469. ; 6, s. 89-96 Journal article (peer-reviewed)
28.	Berggren, Christian, 1950-, et al. (author) Lagomizing, organic integration, and systems emergency wards, and the practice of project management 2008 In: PMI Research Conference,2008. Conference paper (peer-reviewed)
29.	Bergman, Stefan, et al. (author) Långvarig smärta i nacke, skuldror och rygg i Nationella riktlinjer för rörelseorganens sjukdomar 2010 – stöd för styrning och ledning : Preliminär version 2010 Reports (peer-reviewed)
30.	Bergman, Stefan, et al. (author) Långvarig smärta i nacke, skuldror och rygg i Nationella riktlinjer för rörelseorganens sjukdomar 2010 – stöd för styrning och ledning : Preliminär version 2010 Reports (other academic/artistic)abstract Nationella riktlinjer för rörelseorganens sjukdomar belyser områden där behovet av vägledning är stort på grund av att det finns praxisskillnader, kontroversiella frågor eller behov av kvalitetsutveckling.De här riktlinjerna berör åtgärder som utförs inom hälso- och sjukvården och utgår från diagnostik, behandling och rehabilitering. Nationella riktlinjer för rörelseorganens sjukdomar omfattar:reumatoid artritankyloserande spondylitpsoriasisartritartros i höft och knäosteoporos (benskörhet)långvarig smärta i nacke, skuldror och rygg
31.	Bergman, Stefan, et al. (author) Långvarig smärta i nacke, skuldror och rygg i Nationella riktlinjer för rörelseorganens sjukdomar 2012 : Osteoporos, artros, inflammatorisk ryggsjukdom och ankyloserande spondylit ,psoriasisartrit och reumatoid artrit - Stöd för styrning och ledning 2012 Reports (other academic/artistic)abstract Dessa riktlinjer innehåller rekommendationer om åtgärder vid sjukdomar i rörelseorganen. De innehåller också bedömningar av rekommendatio-nernas ekonomiska och organisatoriska konsekvenser och indikatorer för uppföljning. Riktlinjerna omfattar följande diagnosområden:osteoporos (benskörhet)artros i knä och höft (nedbrytning av ledbrosk)inflammatorisk ryggsjukdom (axial spondylartrit) och ankylose-rande spondylitpsoriasisartrit (en kombination av psoriasis och ledinflammationer)reumatoid artrit (ledgångsreumatism)
32.	Borén, Jan, 1963, et al. (author) Effects of pnpla3 i148m on hepatic lipid and very low-density lipoprotein metabolism in humans. 2022 In: Journal of internal medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 291:2, s. 218-223 Journal article (peer-reviewed)abstract The PNPLA3-148M variant is associated with liver steatosis but its influence on metabolism of triglyceride-rich lipoproteins remains unclear. Here we investigated the kinetics of large, triglyceride-rich VLDL1 and smaller VLDL2 in homozygotes for the PNPLA3-148M variant.The kinetics of apoB100 and triglyceride in VLDL subfractions was analysed in nine subjects homozygous for PNPLA3-148M and nine subjects homozygous for PNPLA3-148I (controls). Liver fat was >3-fold higher in the 148M subjects. Production rates for apoB100 and triglyceride in VLDL1 did not differ significantly between the two groups. Likewise, production rates for VLDL2 -apoB100 and -triglyceride, and fractional clearance rates for both apoB100 and triglyceride in VLDL1 and VLDL2 , were not significantly different.Despite the higher liver fat content in PNPLA3-148M homozygotes, there was no increase in VLDL production. Equally, VLDL production was maintained at normal levels despite the putative impairment in cytosolic lipid hydrolysis in these subjects. This article is protected by copyright. All rights reserved.
33.	Borén, Jan, 1963, et al. (author) Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans. 2020 In: JCI insight. - : American Society for Clinical Investigation. - 2379-3708. ; 5:24 Journal article (peer-reviewed)abstract Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation. The transmembrane 6 superfamily member 2 (TM6SF2) E167K genetic variant associates with NAFLD and with reduced plasma triglyceride levels in humans. However, the molecular mechanisms underlying these associations remain unclear. We hypothesized that TM6SF2 E167K affects hepatic very low-density lipoprotein (VLDL) secretion, and studied the kinetics of apolipoprotein B100 (apoB100) and triglyceride metabolism in VLDL in homozygous subjects. In 10 homozygote TM6SF2 E167K carriers and 10 matched controls, we employed stable-isotope tracer and compartmental modeling techniques to determine apoB100 and triglyceride kinetics in the two major VLDL subfractions: large triglyceride-rich VLDL1 and smaller, less triglyceride-rich VLDL2. VLDL1-apoB100 production was markedly reduced in homozygote TM6SF2 E167K carriers compared to controls. Likewise, VLDL1-triglyceride production was 35% lower in the TM6SF2 E167K carriers. In contrast, the direct production rates for VLDL2-apoB100 and triglyceride were not different between carriers and controls. In conclusion, the TM6SF2 E167K genetic variant was linked to a specific reduction in hepatic secretion of large triglyceride-rich VLDL1. The impaired secretion of VLDL1 explains the reduced plasma triglyceride concentration, and provides a basis for understanding the lower risk of cardiovascular disease associated with the TM6SF2 E167K genetic variant.Trial registration: Clinical Trials NCT04209816.
34.	Dahlén, P, et al. (author) Sensitive detection of genes by sandwich hybridization and time-resolved fluorometry 1987 In: Molecular and Cellular Probes. - : Elsevier BV. - 0890-8508 .- 1096-1194. ; 1:2, s. 159-168 Journal article (peer-reviewed)abstract Europium has been used as a non-radioactive marker in immunoassays as this metal can be detected with high sensitivity by time-resolved fluorometry. In this work streptavidin labeled with europium was used to detect biotinylated probes in a sandwich nucleic-acid hybridization assay with microtitration strips as the solid phase. pBR 322 plasmids were detected with a sensitivity of 4 × 105 molecules. As the sample is added in solution in sandwich hybridization, fast and simple sample pre-treatment can be used without encountering background problems. The method was applied to test bacterial samples of uropathogenic Escherichia coli strains for the presence of the β-lactamase gene.
35.	Dinér, Peter, 1976, et al. (author) Preparation of 3-Substituted-1-Isopropyl-1H-pyrazolo 3,4-d pyrimidin-4-amines as RET Kinase Inhibitors 2012 In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 55:10, s. 4872-4876 Journal article (peer-reviewed)abstract A series of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines have been designed, synthesized, and evaluated as RET protein kinase inhibitors. On the basis of docking results, a small library of pyrazolopyrimidine compounds with an extended hydrophobic side arm was synthesized. The most promising of the compounds (7a) displayed efficient inhibition in vitro and good selectivity when tested on a panel of kinases. Furthermore, 7a inhibited GDNF-induced RET phosphorylation of ERK1/2 in MCF-7 breast cancer cells at concentrations as low as 100 nM.
36.	Ernst, R. E., et al. (author) Long-lived connection between southern Siberia and northern Laurentia in the Proterozoic 2016 In: Nature Geoscience. - : Springer Science and Business Media LLC. - 1752-0894 .- 1752-0908. ; 9:6, s. 464-469 Journal article (peer-reviewed)abstract Precambrian supercontinents Nuna-Columbia (1.7 to 1.3 billion years ago) and Rodinia (1.1 to 0.7 billion years ago) have been proposed. However, the arrangements of crustal blocks within these supercontinents are poorly known. Huge, dominantly basaltic magmatic outpourings and intrusions, covering up to millions of square kilometres, termed Large Igneous Provinces, typically accompany (super) continent breakup, or attempted breakup and offer an important tool for reconstructing supercontinents. Here we focus on the Large Igneous Province record for Siberia and Laurentia, whose relative position in Nuna-Columbia and Rodinia reconstructions is highly controversial. We present precise geochronology - nine U-Pb and six Ar-Ar ages - on dolerite dykes and sills, along with existing dates from the literature, that constrain the timing of emplacement of Large Igneous Province magmatism in southern Siberia and northern Laurentia between 1,900 and 720 million years ago. We identify four robust age matches between the continents 1,870, 1,750, 1,350 and 720 million years ago, as well as several additional approximate age correlations that indicate southern Siberia and northern Laurentia were probably near neighbours for this 1.2-billion-year interval. Our reconstructions provide a framework for evaluating the shared geological, tectonic and metallogenic histories of these continental blocks.
37.	Evans, D. A D, et al. (author) Return to Rodinia? Moderate to high palaeolatitude of the São Francisco/Congo craton at 920 Ma 2015. - 1 In: Geological Society Special Publication. - 0305-8719. ; 424:1, s. 167-190 Book chapter (peer-reviewed)abstract Moderate to high palaeolatitudes recorded in mafic dykes, exposed along the coast of Bahia, Brazil, are partly responsible for some interpretations that the São Francisco/Congo craton was separate from the low-latitude Rodinia supercontinent at about 1050 Ma. We report new palaeomagnetic data that replicate the previous results. However, we obtain substantially younger U-Pb baddeleyite ages from five dykes previously thought to be 1.02-1.01 Ga according to the 40Ar/39Ar method. Specifically, the so-called «A-normal» remanence direction from Salvador is dated at 924.2±3.8 Ma, within error of the age for the «C» remanence direction at 921.5±4.3 Ma. An «A-normal» dyke at Ilh»us is dated at 926.1±4.6 Ma, and two «A-normal» dykes at Olivença have indistinguishable ages with best estimate of emplacement at 918.2±6.7 Ma. We attribute the palaeomagnetic variance of the «A-normal» and «C» directions to lack of averaging of geomagnetic palaeosecular variation in some regions. Our results render previous 40Ar/39Ar ages from the dykes suspect, leaving late Mesoproterozoic palaeolatitudes of the São Francisco/Congo craton unconstrained. The combined «A-normal» palaeomagnetic pole from coastal Bahia places the São Francisco/Congo craton in moderate to high palaeolatitudes at c. 920 Ma, allowing various possible positions of that block within Rodinia.
38.	Fraenkel, C-J, et al. (author) Risk of environmental transmission of norovirus infection from prior room occupants 2021 In: Journal of Hospital Infection. - : Elsevier BV. - 0195-6701. ; 117, s. 74-80 Journal article (peer-reviewed)abstract BACKGROUND: Environmental contamination of norovirus (NoV) is believed to be a significant source for further transmission in hospitals.AIM: To investigate the risk of acquiring NoV in a cleaned room previously occupied by a patient with NoV infection. The risk of having a roommate with recent NoV infection was also assessed.METHODS: In a retrospective cohort, comprising 33,788 room stays at five infectious Disease wards in southern Sweden from 2013 to 2018, the risk of acquiring NoV infection after admission to an exposed or non-exposed room was analysed with uni- and multivariable statistical analysis, controlling for age, colonization pressure and any roommate. RNA sequencing of the NoV strains involved in suspected room transmission was also performed.RESULTS: Five of the 1106 patients exposed to a room with a prior occupant with NoV infection and 49 in the non-exposed group acquired NoV infection. An association between NoV acquisition was found in the univariable analysis (odds ratio (OR) 3.3, P=0.01), but not when adjusting for potential confounders (OR 1.9, P=0.2). Sequencing of the NoV samples showed that only two of the five exposed patients with acquired NoV infection were infected by identical strains to the prior room occupant, inferring a room transmission risk of 0.2% (95% confidence interval 0.05-0.78%). None of the 52 patients who shared room with a roommate with NoV symptoms resolved for ≥48 h acquired NoV infection.CONCLUSIONS: In absolute terms, the risk of room transmission of NoV is low. Discontinuation of isolation ≥48 h after resolution of symptoms seems adequate.
39.	Gaytan, Álvaro, et al. (author) Changes in the foliar fungal community between oak leaf flushes along a latitudinal gradient in Europe Other publication (other academic/artistic)
40.	Gladkochub, D. P., et al. (author) Large igneous province of about 1750 Ma in the Siberian Craton 2010 In: Doklady Earth Sciences. - 1028-334X. ; 430:2, s. 168-171 Journal article (peer-reviewed)
41.	Gladkochub, D.P., et al. (author) Proterozoic Large Igneous Provinces (LIPs) of Siberia 2009 Reports (other academic/artistic)
42.	Holm, Sara, et al. (author) Treating youth in pain : Comparing tailored behavioural medicine treatment provided by physical therapists in primary care with physical exercises 2016 In: European Journal of Pain. - : Wiley-Blackwell. - 1090-3801 .- 1532-2149. ; 20:4, s. 626-638 Journal article (peer-reviewed)abstract Objectives: To study the efficacy of tailored behavioural medicine treatment within a physical therapy framework.Methods: The study was a randomized controlled study (RCT): tailored behavioural medicine treatment (EXT) delivered by physical therapists (PTs) was compared with exercise-based treatment (CT). Thirty-two adolescents (mean age 14.3 years) with persistent pain participated. Data on pain-related disability and school attendance (primary outcomes), pain intensity, catastrophizing, fear of movement and self-efficacy were collected.Results: The pain-related disability measured by the Functional Disability Inventory (FDI) resulted in mean score change of EXT = -18 and CT = -11, respectively. A significant change within both groups was found (EXT p = 0.003, CT p = 0.001), and a large effect size for FDI between the conditions was demonstrated (AUC of 0.77). For school attendance post-treatment, no difference was found between conditions. For secondary outcomes, a significant improvement in pain intensity and pain catastrophizing was found for the EXT and self-efficacy for the CT groups but no statistically significant difference between the two conditions was detected. Caution should be given to the small sample size, as it may affect the interpretation and generalizability of the results.Conclusion: In this study, differences between tailored behavioural medicine treatment delivered by PTs and exercise-based treatment could not be demonstrated, although the effect size was large. Patients who received either treatment demonstrated significant changes over time in pain-related disability. The low number of participants and suboptimal tailoring of the psychological components may partly explain the failure to demonstrate differences between groups, and future studies are warranted.
43.	Holm, Sara, et al. (author) Treating youth in pain : A randomized controlled feasibility trial of a behavioral medicine approach in primary care Other publication (other academic/artistic)
44.	Holst, Michael J., et al. (author) Convergence analysis of finite element approximations of the Joule heating problem in three spatial dimensions 2010 In: BIT Numerical Mathematics. - : Springer. - 0006-3835 .- 1572-9125. ; 50:4, s. 781-795 Journal article (peer-reviewed)abstract In this paper we present a finite element discretization of the Joule-heating problem. We prove existence of solution to the discrete formulation and strong convergence of the finite element solution to the weak solution, up to a sub-sequence. We also present numerical examples in three spatial dimensions. The first example demonstrates the convergence of the method in the second example we consider an engineering application.
45.	Huuhtanen, Jani, et al. (author) IFN-alfa with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia 2022 In: Journal of Clinical Investigation. - : AMER SOC CLINICAL INVESTIGATION INC. - 0021-9738 .- 1558-8238. ; 132:17 Journal article (peer-reviewed)abstract In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-alpha is one promising candidate, as it has long-lasting effects on both malignant and immune cells. In connection with a multicenter clinical trial combining dasatinib with IFN-alpha in 40 patients with chronic-phase CML (NordCML007, NCT01725204), we performed immune monitoring with single-cell RNA and T cell receptor (TCR) sequencing (n = 4, 12 samples), bulk TCR beta sequencing (n = 13, 26 samples), flow cytometry (n = 40, 106 samples), cytokine analyses (n = 17, 80 samples), and ex vivo functional studies (n = 39, 80 samples). Dasatinib drove the immune repertoire toward terminally differentiated NK and CD8+ T cells with dampened functional capabilities. Patients with dasatinib-associated pleural effusions had increased numbers of CD8(+) recently activated effector memory T (Temra) cells. In vitro, dasatinib prevented CD3-induced cell death by blocking TCR signaling. The addition of IFN-alpha reversed the terminally differentiated phenotypes and increased the number of costimulatory intercellular interactions and the number of unique putative epitope-specific TCR clusters. In vitro IFN-alpha had costimulatory effects on TCR signaling. Our work supports the combination of IFN-alpha with TKI therapy, as IFN-alpha broadens the immune repertoire and restores immunological function.
46.	Jalanko, A, et al. (author) Screening for defined cystic fibrosis mutations by solid-phase minisequencing 1992 In: Clinical Chemistry. - 0009-9147 .- 1530-8561. ; 38:1, s. 39-43 Journal article (peer-reviewed)abstract We have developed a rapid method for the quantitative detection of point mutations and deletions. In this minisequencing method, enzymatically amplified DNA, 5'-biotinylated in one strand, is bound to a solid phase and denatured. A detection primer, constructed to end immediately before the mutation, is annealed to the immobilized single-stranded template and elongated with a single, labeled deoxynucleoside residue. We have applied the solid-phase minisequencing method to the detection of the major mutation, delta F508, causing cystic fibrosis (CF). In the presence of the allele with the delta F508 mutation, [3H]dTTP is incorporated; with the nonmutated allele, [3H]dCTP is incorporated. Thus, samples from heterozygous individuals allow the incorporation of both labels. The method was evaluated by analyzing 59 coded DNA specimens collected from 20 Finnish CF patients and their parents. The ratio of [3H]C to [3H]T gave unambiguously the allele combination. The solid-phase minisequencing method was also applicable to the analysis of three CF mutations simultaneously, i.e., delta F508, G542X, and G551D. We conclude that the microtiter-plate-based minisequencing test is an accurate method for the screening of defined sequence alterations in the CF gene.
47.	Jauhiainen, MK, et al. (author) The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas 2021 In: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. - 1423-0380. ; 43:1, s. 249-259 Journal article (peer-reviewed)
48.	Johansen, EJ, et al. (author) Water-in-crude oil emulsions from the Norwegian continental shelf. Part I. Formation, characterization and stability correlations 1988 In: Colloids and Surfaces. - 0166-6622 .- 1873-4340. ; 34:4, s. 353-370 Journal article (peer-reviewed)
49.	Kish, L B, et al. (author) Detection of chemicals based on resistance fluctuation-spectroscopy 1999 Patent (pop. science, debate, etc.)
50.	Kish, L.B, et al. (author) Noise Spectroscopy for Chemical Sensors and Sensor Systems 1999 In: Proc.Sensor (AMA Service GmbH, Wunstorf, Germany). ; , s. 145-148 Conference paper (other academic/artistic)

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