SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(SERRANO José) "

Sökning: WFRF:(SERRANO José)

  • Resultat 1-50 av 60
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Baenas, Isabel, et al. (författare)
  • Impact of COVID-19 Lockdown in Eating Disorders : A Multicentre Collaborative International Study
  • 2022
  • Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. Aims. (1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography. Methods. The sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES). Results. Patients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient. Conclusions. The psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients.
  •  
3.
  • Maxwell, Tania L., et al. (författare)
  • Global dataset of soil organic carbon in tidal marshes
  • 2023
  • Ingår i: Scientific Data. - : Springer Nature. - 2052-4463. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Tidal marshes store large amounts of organic carbon in their soils. Field data quantifying soil organic carbon (SOC) stocks provide an important resource for researchers, natural resource managers, and policy-makers working towards the protection, restoration, and valuation of these ecosystems. We collated a global dataset of tidal marsh soil organic carbon (MarSOC) from 99 studies that includes location, soil depth, site name, dry bulk density, SOC, and/or soil organic matter (SOM). The MarSOC dataset includes 17,454 data points from 2,329 unique locations, and 29 countries. We generated a general transfer function for the conversion of SOM to SOC. Using this data we estimated a median (± median absolute deviation) value of 79.2 ± 38.1 Mg SOC ha−1 in the top 30 cm and 231 ± 134 Mg SOC ha−1 in the top 1 m of tidal marsh soils globally. This data can serve as a basis for future work, and may contribute to incorporation of tidal marsh ecosystems into climate change mitigation and adaptation strategies and policies.
  •  
4.
  • Boza-Serrano, Antonio, et al. (författare)
  • Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
  • 2019
  • Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 138:2, s. 251-273
  • Tidskriftsartikel (refereegranskat)abstract
    • Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer’s disease) mice and found specifically expressed in microglia associated with Aβ plaques. Single-nucleotide polymorphisms in the LGALS3 gene, which encodes gal3, were associated with an increased risk of AD. Gal3 deletion in 5xFAD mice attenuated microglia-associated immune responses, particularly those associated with TLR and TREM2/DAP12 signaling. In vitro data revealed that gal3 was required to fully activate microglia in response to fibrillar Aβ. Gal3 deletion decreased the Aβ burden in 5xFAD mice and improved cognitive behavior. Interestingly, a single intrahippocampal injection of gal3 along with Aβ monomers in WT mice was sufficient to induce the formation of long-lasting (2 months) insoluble Aβ aggregates, which were absent when gal3 was lacking. High-resolution microscopy (stochastic optical reconstruction microscopy) demonstrated close colocalization of gal3 and TREM2 in microglial processes, and a direct interaction was shown by a fluorescence anisotropy assay involving the gal3 carbohydrate recognition domain. Furthermore, gal3 was shown to stimulate TREM2–DAP12 signaling in a reporter cell line. Overall, our data support the view that gal3 inhibition may be a potential pharmacological approach to counteract AD.
  •  
5.
  • Burguillos Garcia, Miguel, et al. (författare)
  • Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
  • 2015
  • Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 10:9, s. 1626-1638
  • Tidskriftsartikel (refereegranskat)abstract
    • Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous paracrine TLR4 ligand. Gal3-TLR4 interaction was further confirmed in a murine neuroinflammatory model (intranigral lipopolysaccharide [LPS] injection) and in human stroke subjects. Depletion of Gal3 exerted neuroprotective and anti-inflammatory effects following global brain ischemia and in the neuroinflammatory LPS model. These results suggest that Gal3-dependent-TLR4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain.
  •  
6.
  • Espinosa-Oliva, Ana M., et al. (författare)
  • Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain
  • 2024
  • Ingår i: Neuropathology and Applied Neurobiology. - 0305-1846. ; 50:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods: We have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS-based rat model of gut inflammation in terms of α-syn pathology. Results: Our data support the existence of pathogenic α-syn in both the gut and the brain, thus reinforcing the potential role of the ENS as a contributing factor in PD aetiology. Additionally, we have analysed the effect of a DSS-based rat model of gut inflammation to demonstrate (i) the appearance of P-α-syn inclusions in both Auerbach's and Meissner's plexuses (gut), (ii) an increase in α-syn expression in the ventral mesencephalon (brain) and (iii) the degeneration of nigral dopaminergic neurons, which all are considered classical hallmarks in PD. Conclusion: These results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut-brain axis in initiating α-syn aggregation and transport to the substantia nigra, resulting in neurodegeneration.
  •  
7.
  • Fernández-Aranda, Fernando, et al. (författare)
  • COVID Isolation Eating Scale (CIES) : Analysis of the impact of confinement in eating disorders and obesity—A collaborative international study
  • 2020
  • Ingår i: European Eating Disorders Review. - : Wiley. - 1072-4133 .- 1099-0968. ; 28:6, s. 871-883
  • Tidskriftsartikel (refereegranskat)abstract
    • Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explore the general acceptation of the use of telemedicine during confinement. The sample comprised 121 participants (87 ED patients and 34 patients with obesity) recruited from six different centres. Confirmatory Factor Analyses (CFA) tested the rational-theoretical structure of the CIES. Adequate goodness-of-fit was obtained for the confirmatory factor analysis, and Cronbach alpha values ranged from good to excellent. Regarding the effects of confinement, positive and negative impacts of the confinement depends of the eating disorder subtype. Patients with anorexia nervosa (AN) and with obesity endorsed a positive response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology. Furthermore, AN patients expressed the greatest dissatisfaction and accommodation difficulty with remote therapy when compared with the previously provided face-to-face therapy. The present study provides empirical evidence on the psychometric robustness of the CIES tool and shows that a negative confinement impact was associated with ED subtype, whereas OSFED patients showed the highest impairment in eating symptomatology and in psychopathology.
  •  
8.
  • Gonzalez-Ramirez, Israel, et al. (författare)
  • On the photoproduction of DNA/RNA cyclobutane pyrimidine dimers
  • 2011
  • Ingår i: Theoretical Chemistry accounts. - : Springer Science and Business Media LLC. - 1432-881X .- 1432-2234. ; 128:4-6, s. 705-711
  • Tidskriftsartikel (refereegranskat)abstract
    • The UV photoreactivity of different pyrimidine DNA/RNA nucleobases along the singlet manifold leading to the formation of cyclobutane pyrimidine dimers has been studied by using the CASPT2 level of theory. The initially irradiated singlet state promotes the formation of excimers between pairs of properly oriented nucleobases through the overlap between the pi structures of two stacked nucleobases. The system evolves then to the formation of cyclobutane pyrimidine dimers via a shearing-type conical intersection activating a [2 + 2] photocycloaddition mechanism. The relative location of stable excimer conformations or alternative decay channels with respect to the reactive degeneracy region explains the differences in the photoproduction efficiency observed in the experiments for different nucleobases sequences. A comparative analysis of the main structural parameters and energetic profiles in the singlet manifold is carried out for thymine, uracil, cytosine, and 5-methylcytosine homodimers. Thymine and uracil dimers display the most favorable paths, in contrast to cytosine. Methylation of the nucleobases seems to increase the probability for dimerization.
  •  
9.
  • Idelfonso-García, Osiris Germán, et al. (författare)
  • Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver
  • 2024
  • Ingår i: Antioxidants. - 2076-3921. ; 13:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Aging is characterized by increased reactive species, leading to redox imbalance, oxidative damage, and senescence. The adverse effects of alcohol consumption potentiate aging-associated alterations, promoting several diseases, including liver diseases. Nucleoredoxin (NXN) is a redox-sensitive enzyme that targets reactive oxygen species and regulates key cellular processes through redox protein–protein interactions. Here, we determine the effect of chronic alcohol consumption on NXN-dependent redox interactions in the liver of aged mice. We found that chronic alcohol consumption preferentially promotes the localization of NXN either into or alongside senescent cells, declines its interacting capability, and worsens the altered interaction ratio of NXN with FLII, MYD88, CAMK2A, and PFK1 proteins induced by aging. In addition, carbonylated protein and cell proliferation increased, and the ratios of collagen I and collagen III were inverted. Thus, we demonstrate an emerging phenomenon associated with altered redox homeostasis during aging, as shown by the declining capability of NXN to interact with partner proteins, which is enhanced by chronic alcohol consumption in the mouse liver. This evidence opens an attractive window to elucidate the consequences of both aging and chronic alcohol consumption on the downstream signaling pathways regulated by NXN-dependent redox-sensitive interactions.
  •  
10.
  • Marto, João Pedro, et al. (författare)
  • Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry.
  • 2023
  • Ingår i: Neurology. - 1526-632X. ; 100:7
  • Tidskriftsartikel (refereegranskat)abstract
    • COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).Of a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour mortality (OR 2.47; 95% CI 1.58-3.86), and 3-month mortality (OR 1.88; 95% CI 1.52-2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60).Patients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis.The study was registered under ClinicalTrials.gov identifier NCT04895462.
  •  
11.
  • Nieminen, Markku S., et al. (författare)
  • The patient perspective : Quality of life in advanced heart failure with frequent hospitalisations
  • 2015
  • Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 191, s. 256-264
  • Forskningsöversikt (refereegranskat)abstract
    • End of life is an unfortunate but inevitable phase of the heart failure patients' journey. It is often preceded by a stage in the progression of heart failure defined as advanced heart failure, and characterised by poor quality of life and frequent hospitalisations. In clinical practice, the efficacy of treatments for advanced heart failure is often assessed by parameters such as clinical status, haemodynamics, neurohormonal status, and echo/MRI indices. From the patients' perspective, however, quality-of-life-related parameters, such as functional capacity, exercise performance, psychological status, and frequency of re-hospitalisations, are more significant. The effects of therapies and interventions on these parameters are, however, underrepresented in clinical trials targeted to assess advanced heart failure treatment efficacy, and data are overall scarce. This is possibly due to a non-universal definition of the quality-of-life-related endpoints, and to the difficult standardisation of the data collection. These uncertainties also lead to difficulties in handling trade-off decisions between quality of life and survival by patients, families and healthcare providers. A panel of 34 experts in the field of cardiology and intensive cardiac care from 21 countries around the world convened for reviewing the existing data on quality-of-life in patients with advanced heart failure, discussing and reaching a consensus on the validity and significance of quality-of-life assessment methods. Gaps in routine care and research, which should be addressed, were identified. Finally, published data on the effects of current i.v. vasoactive therapies such as inotropes, inodilators, and vasodilators on quality-of-life in advanced heart failure patients were analysed.
  •  
12.
  • Suarez, David Orozco, et al. (författare)
  • CMAG : A Mission to Study and Monitor the Inner Corona Magnetic Field
  • 2023
  • Ingår i: Aerospace. - 2226-4310. ; 10:12
  • Tidskriftsartikel (refereegranskat)abstract
    • Measuring magnetic fields in the inner corona, the interface between the solar chromosphere and outer corona, is of paramount importance if we aim to understand the energetic transformations taking place there, and because it is at the origin of processes that lead to coronal heating, solar wind acceleration, and of most of the phenomena relevant to space weather. However, these measurements are more difficult than mere imaging because polarimetry requires differential photometry. The coronal magnetograph mission (CMAG) has been designed to map the vector magnetic field, line-of-sight velocities, and plane-of-the-sky velocities of the inner corona with unprecedented spatial and temporal resolutions from space. This will be achieved through full vector spectropolarimetric observations using a coronal magnetograph as the sole instrument on board a spacecraft, combined with an external occulter installed on another spacecraft. The two spacecraft will maintain a formation flight distance of 430 m for coronagraphic observations, which requires a 2.5 m occulter disk radius. The mission will be preferentially located at the Lagrangian L5 point, offering a significant advantage for solar physics and space weather research. Existing ground-based instruments face limitations such as atmospheric turbulence, solar scattered light, and long integration times when performing coronal magnetic field measurements. CMAG overcomes these limitations by performing spectropolarimetric measurements from space with an external occulter and high-image stability maintained over time. It achieves the necessary sensitivity and offers a spatial resolution of 2.5 '' and a temporal resolution of approximately one minute, in its nominal mode, covering the range from 1.02 solar radii to 2.5 radii. CMAG relies on proven European technologies and can be adapted to enhance any other solar mission, offering potential significant advancements in coronal physics and space weather modeling and monitoring.
  •  
13.
  • Aghaali, Habib, 1981-, et al. (författare)
  • Evaluation of different heat transfer conditions on an automotive turbocharger
  • 2014
  • Ingår i: International Journal of Engine Research. - : Sage Publications. - 1468-0874 .- 2041-3149. ; 16:2, s. 137-151
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper presents a combination of theoretical and experimental investigations for determining the main heat fluxes within a turbocharger. These investigations consider several engine speeds and loads as well as different methods of conduction, convection, and radiation heat transfer on the turbocharger. A one-dimensional heat transfer model of the turbocharger has been developed in combination with simulation of a turbocharged engine that includes the heat transfer of the turbocharger. Both the heat transfer model and the simulation were validated against experimental measurements. Various methods were compared for calculating heat transfer from the external surfaces of the turbocharger, and one new method was suggested.The effects of different heat transfer conditions were studied on the heat fluxes of the turbocharger using experimental techniques. The different heat transfer conditions on the turbocharger created dissimilar temperature gradients across the turbocharger. The results show that changing the convection heat transfer condition around the turbocharger affects the heat fluxes more noticeably than changing the radiation and conduction heat transfer conditions. Moreover, the internal heat transfers from the turbine to the bearing housing and from the bearing housing to the compressor are significant, but there is an order of magnitude difference between these heat transfer rates.
  •  
14.
  •  
15.
  • Andres-Martin, Miguel, et al. (författare)
  • Uncertainty in surface wind speed projections over the Iberian Peninsula: CMIP6 GCMs versus a WRF-RCM
  • 2023
  • Ingår i: Annals of the New York Academy of Sciences. - 0077-8923 .- 1749-6632. ; 1529:1, s. 101-108
  • Tidskriftsartikel (refereegranskat)abstract
    • This study assessed the projected near-surface wind speed (SWS) changes and variability over the Iberian Peninsula for the 21st century. Here, we compared Coupled Model Intercomparison Project Phase 6 global climate models (GCMs) with a higher spatial resolution regional climate model (RCM; ∼20km), known as WRF-CESM2, which was created by a dynamic downscaling of the Community Earth System Model version 2 (CESM2) using the Weather Research and Forecasting (WRF) model. Our analysis found that the GCMs tended to overestimate observed SWS for 1985–2014, while the higher spatial resolution of the WRF-CESM2 did not improve the accuracy and underestimated the SWS magnitude. GCMs project a decline of SWS under highshared socioeconomic pathways (SSPs) greenhouse concentrations, such as SSP370 and SSP585, while an interdecadal oscillation appears in SSP126 and SSP245 for the end of the century. The WRF-CESM2 under SSP585 predicts the opposite increasing SWS. Our results suggest that 21st-century projections of SWS are uncertain even for regionalized products and should be taken with caution.
  •  
16.
  • Azinović, Boris, et al. (författare)
  • INNOCROSSLAM : Adding knowledge towards increased use of cross laminated timber (CLT)
  • 2023
  • Ingår i: Proceedings from the 13th World Conference on Timber Engineering (2023). - 9781713873297 - 9781713873273 ; , s. 2432-2441
  • Konferensbidrag (refereegranskat)abstract
    • The research project Innovative Solutions for Cross Laminated Timber Structures (InnoCrossLam) wasrecently finished. The project aimed at increasing the competitiveness of CLT as a versatile engineered product, byincreasing its predictability in demanding design situations not covered by the guidelines of today, or standards and codesforeseeable in the near future (e.g., second generation of European design standards). This paper summarises the mainproject findings in the context of innovative CLT structures, such as: i. contemporary design approaches ii. the use of(non)linear FE modelling iii. experimental investigation of complex details for CLT structures, iv. investigation ofmultifunctional CLT. In this paper, the motivation behind the research topics within the project InnoCrossLam isexplained and backed-up by exemplary results and discussion on future work.
  •  
17.
  • Azorin-Molina, Cesar, et al. (författare)
  • Biases in wind speed measurements due to anemometer changes
  • 2023
  • Ingår i: Atmospheric Research. - 0169-8095. ; 289
  • Tidskriftsartikel (refereegranskat)abstract
    • This research presents a case study of the biases and discontinuities that were introduced in observed long-term mean wind-speed and gust data-series due to anemometer changes in a meteorological station in northern Spain, operated by the Spanish State Meteorological Agency: San Sebastian-Igueldo. Field and wind-tunnel experiments with predefined conditions have been presented in the literature, however this research uses a real case study to assess the impact of anemometer changes on wind speed measurements due to three factors being: (i) the 3-cup anemometer model (SEAC vs. THIES companies); (ii) sensor height (∼19.95 m vs. ∼20.45 m) and (iii) sensor age (20-years old vs. new). Our results show (a) substantial biases in the measured wind speed and daily peak wind gusts, with the new THIES anemometer reporting stronger surface winds than the old SEAC anemometer; (b) opposing biases under weak (negative) and moderate-strong (positive) winds; and (c) significant breakpoints in the long-term wind data-series, which highlight the importance of data homogenization. National Weather Services and climate assessment groups will benefit from these findings since errors in wind speed and gust measurements can be minimized by implementing systematic observation protocols. Robust anemometer observations provide a basis for accurate quantification of the magnitude of changes and the variability of surface winds.
  •  
18.
  • Borrego-Ecija, Sergi, et al. (författare)
  • Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity
  • 2024
  • Ingår i: Alzheimer's and Dementia. - 1552-5260. ; 20:3, s. 1515-1526
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. Our study aimed to investigate Gal-3 levels in patients with FTD and assess its diagnostic potential. METHODS: We examined Gal-3 levels in brain, serum, and cerebrospinal fluid (CSF) samples of patients with FTD and controls. Multiple linear regressions between Gal-3 levels and other FTD markers were explored. RESULTS: Gal-3 levels were increased significantly in patients with FTD, mainly across brain tissue and CSF, compared to controls. Remarkably, Gal-3 levels were higher in cases with tau pathology than TAR-DNA Binding Protein 43 (TDP-43) pathology. Only MAPT mutation carriers displayed increased Gal-3 levels in CSF samples, which correlated with total tau and 14-3-3. DISCUSSION: Our findings underscore the potential of Gal-3 as a diagnostic marker for FTD, particularly in MAPT cases, and highlights the relation of Gal-3 with neuronal injury markers.
  •  
19.
  • Boza-serrano, Antonio, et al. (författare)
  • Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer’s disease
  • 2022
  • Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 1432-0533 .- 0001-6322.
  • Tidskriftsartikel (refereegranskat)abstract
    • Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous system(CNS). We previously demonstrated the crucial deleterious role of Gal-3 in microglial activation in Alzheimer’s disease(AD). Under AD conditions, Gal-3 is primarily expressed by microglial cells clustered around Aβ plaques in both humanand mouse brain, and knocking out Gal-3 reduces AD pathology in AD-model mice. To further unravel the importance ofGal-3-associated infammation in AD, we aimed to investigate the Gal-3 infammatory response in the AD continuum. First,we measured Gal-3 levels in neocortical and hippocampal tissue from early-onset AD patients, including genetic and sporadiccases. We found that Gal-3 levels were signifcantly higher in both cortex and hippocampus in AD subjects. Immunohistochemistry revealed that Gal-3+microglial cells were associated with amyloid plaques of a larger size and more irregularshape and with neurons containing tau-inclusions. We then analyzed the levels of Gal-3 in cerebrospinal fuid (CSF) fromAD patients (n=119) compared to control individuals (n=36). CSF Gal-3 levels were elevated in AD patients comparedto controls and more strongly correlated with tau (p-Tau181 and t-tau) and synaptic markers (GAP-43 and neurogranin)than with amyloid-β. Lastly, principal component analysis (PCA) of AD biomarkers revealed that CSF Gal-3 clustered andassociated with other CSF neuroinfammatory markers, including sTREM-2, GFAP, and YKL-40. This neuroinfammatory component was more highly expressed in the CSF from amyloid-β positive (A+), CSF p-Tau181 positive (T+), andbiomarker neurodegeneration positive/negative (N+/−) (A+T+N+/−) groups compared to the A+T−N− group. Overall,Gal-3 stands out as a key pathological biomarker of AD pathology that is measurable in CSF and, therefore, a potential targetfor disease-modifying therapies involving the neuroinfammatory response.
  •  
20.
  • Boza-Serrano, Antonio, et al. (författare)
  • The role of Galectin-3 in α-synuclein-induced microglial activation
  • 2014
  • Ingår i: Acta Neuropathologica Communications. - : Springer Science and Business Media LLC. - 2051-5960. ; 2
  • Forskningsöversikt (refereegranskat)abstract
    • Background: Parkinson's disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology is characterized by intraneuronal protein aggregates of α-synuclein and progressive degeneration of dopaminergic neurons within the substantia nigra. Previous studies have shown that extracellular α-synuclein aggregates can activate microglial cells, induce inflammation and contribute to the neurodegenerative process in PD. However, the signaling pathways involved in α-synuclein-mediated microglia activation are poorly understood. Galectin-3 is a member of a carbohydrate-binding protein family involved in cell activation and inflammation. Therefore, we investigated whether galectin-3 is involved in the microglia activation triggered by α-synuclein. Results: We cultured microglial (BV2) cells and induced cell activation by addition of exogenous α-synuclein monomers or aggregates to the cell culture medium. This treatment induced a significant increase in the levels of proinflammatory mediators including the inducible Nitric Oxide Synthase (iNOS), interleukin 1 Beta (IL-1β) and Interleukin-12 (IL-12). We then reduced the levels of galectin-3 expression using siRNA or pharmacologically targeting galectin-3 activity using bis-(3-deoxy-3-(3-fluorophenyl-1H-1,2,3-triazol-1-yl)-β-D-galactopyranosyl)-sulfane. Both approaches led to a significant reduction in the observed inflammatory response induced by α-synuclein. We confirmed these findings using primary microglial cells obtained from wild-type and galectin-3 null mutant mice. Finally, we performed injections of α-synuclein in the olfactory bulb of wild type mice and observed that some of the α-synuclein was taken up by activated microglia that were immunopositive for galectin-3. Conclusions: We show that α-synuclein aggregates induce microglial activation and demonstrate for the first time that galectin-3 plays a significant role in microglia activation induced by α-synuclein. These results suggest that genetic down-regulation or pharmacological inhibition of galectin-3 might constitute a novel therapeutic target in PD and other synucleinopathies.
  •  
21.
  • Brito de Figueirêdo, M. C., et al. (författare)
  • Environmental assessment of tropical perennial crops : The case of the Brazilian cashew
  • 2015
  • Ingår i: Journal of Cleaner Production. - : Elsevier. - 0959-6526 .- 1879-1786.
  • Tidskriftsartikel (refereegranskat)abstract
    • This study is an original environmental assessment of the Brazilian cashew, a perennial tree cultivated in 30 tropical countries that yields four products: nuts, apples, gum and wood. While economic and agronomic data regarding cashew are available worldwide, the environmental issues related to the main production systems and products commercialized by Brazilian farms have not been discussed consistently. This environmental assessment is important to guide the efforts of researchers and farmers for improving the environmental performance of cashew cropping systems and products. Life cycle assessment is applied to assess the environmental impacts of cashew systems and products, considering multi-cropping systems, agriculture functions and allocation procedures. Two cashew cropping systems are compared: (i) a high-input system, or reference system, developed through 20 years of research, and (ii) a low input system, as defined by a sample of farms practicing multi-cropping systems. Aspects and impacts of these systems are reported via the following production stages: nursery, establishment, and low and full production. Two agriculture functions are adopted to analyze the cropping systems: land management (impacts per hectare) and financial (impact per US$ from total sales receipts). The impacts of cashew products are evaluated using the crop production function (per kilogram of product). The impacts of products are measured using both mass and economic allocation. This study shows that the low and full production stages account for the majority of impact in both cropping systems, but land transformation for the establishment of cashew orchards is the main contributor of climate change. The analysis of multiple agriculture function shows different results for the study of cashew production systems and products. Considering the land management function (impacts per hectare), the low-input system causes less significant environmental impact, when compared to the high-input system, in all categories but toxicity. When the financial function is analyzed (impacts per US$ from total sales receipts from one ha), the low-input system achieves better performance for only eutrophication and water depletion impact categories. The analysis of the crop production function (impacts per kilogram of product) shows that the choice of allocation procedure also affects the results when comparing the impact values of products from different cropping systems. If the choice is for mass allocation, products from the low-input system achieve better environmental performance, but if economic allocation is chosen, products from the high-input system perform equal or better than when produced in the low-input system. From the joint analysis of agriculture functions, the conclusion is that the best option to improve the environmental performance of the Brazilian cashew production is to adjust the high-input system with modifications regarding fertilization and pest management. From this case study, the benefits of considering multi-agriculture functions and accounting for all production stages in the study of perennial crops are highlighted. The importance of developing emission and characterization factors to reduce uncertainty when estimating pollutant loads and evaluating impacts of perennial crops cultivated in tropical regions is also discussed. This study advances the knowledge base on the environmental assessment of perennial crops in general, and on cashew crops specifically.
  •  
22.
  • Cirulli, Elizabeth T., et al. (författare)
  • A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury
  • 2019
  • Ingår i: Gastroenterology. - : W B SAUNDERS CO-ELSEVIER INC. - 0016-5085 .- 1528-0012. ; 156:6, s. 1707-1716
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility.METHODS: We performed a genome-wide association study of 2048 individuals with DILI (cases) and 12,429 individuals without (controls). Our analysis included subjects of European (1806 cases and 10,397 controls), African American (133 cases and 1,314 controls), and Hispanic (109 cases and 718 controls) ancestry. We analyzed DNA from 113 Icelandic cases and 239,304 controls to validate our findings.RESULTS: We associated idiosyncratic DILI with rs2476601, a nonsynonymous polymorphism that encodes a substitution of tryptophan with arginine in the protein tyrosine phosphatase, nonreceptor type 22 gene (PTPN22) (odds ratio [OR] 1.44; 95% confidence interval [CI] 1.28-1.62; P = 1.2 x 10(-9) and replicated the finding in the validation set (OR 1.48; 95% CI 1.09-1.99; P =.01). The minor allele frequency showed the same effect size (OR > 1) among ethnic groups. The strongest association was with amoxicillin and clavulanate-associated DILI in persons of European ancestry (OR 1.62; 95% CI 1.32-1.98; P = 4.0 x 10(-6); allele frequency = 13.3%), but the polymorphism was associated with DILI of other causes (OR 1.37; 95% CI 1.21-1.56; P = 1.5 x 10(-6); allele frequency = 11.5%). Among amoxicillin-and clavulanate-associated cases of European ancestry, rs2476601 doubled the risk for DILI among those with the HLA risk alleles A* 02: 01 and DRB1* 15: 01.CONCLUSIONS: In a genome-wide association study, we identified rs2476601 in PTPN22 as a non-HLA variant that associates with risk of liver injury caused by multiple drugs and validated our finding in a separate cohort. This variant has been associated with increased risk of autoimmune diseases, providing support for the concept that alterations in immune regulation contribute to idiosyncratic DILI.
  •  
23.
  • Crary, John F., et al. (författare)
  • Primary age-related tauopathy (PART) : a common pathology associated with human aging
  • 2014
  • Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 128:6, s. 755-766
  • Tidskriftsartikel (refereegranskat)abstract
    • We recommend a new term, "primary age-related tauopathy" (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer's disease (AD), in the absence of amyloid (A beta) plaques. For these "NFT+/A beta-aEuroe brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as "tangle-only dementia" and "tangle-predominant senile dementia", are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of A beta accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.
  •  
24.
  • Díaz-Cruz, José Manuel, et al. (författare)
  • Electroanalysis from the past to the twenty-first century : challenges and perspectives
  • 2020
  • Ingår i: Journal of Solid State Electrochemistry. - : Springer Science and Business Media Deutschland GmbH. - 1432-8488 .- 1433-0768. ; 24:11-12, s. 2653-2661
  • Tidskriftsartikel (refereegranskat)abstract
    • A personal mini-review is presented on the history of electroanalysis and on their present achievements and future challenges. The manuscript is written from the subjective view of two generations of electroanalytical chemists that have witnessed for many years the evolution of this discipline.
  •  
25.
  • Fernández-Calle, Rosalía, et al. (författare)
  • APOE in the bullseye of neurodegenerative diseases : impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
  • 2022
  • Ingår i: Molecular Neurodegeneration. - : Springer Science and Business Media LLC. - 1750-1326. ; 17:1
  • Forskningsöversikt (refereegranskat)abstract
    • ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). Neuroinflammation has become the third hallmark of AD, together with Amyloid-β plaques and neurofibrillary tangles of hyperphosphorylated aggregated tau protein. This review aims to broadly and extensively describe the differential aspects concerning apoE. Starting from the evolution of apoE to how APOE's single-nucleotide polymorphisms affect its structure, function, and involvement during health and disease. This review reflects on how APOE's polymorphisms impact critical aspects of AD pathology, such as the neuroinflammatory response, particularly the effect of APOE on astrocytic and microglial function and microglial dynamics, synaptic function, amyloid-β load, tau pathology, autophagy, and cell-cell communication. We discuss influential factors affecting AD pathology combined with the APOE genotype, such as sex, age, diet, physical exercise, current therapies and clinical trials in the AD field. The impact of the APOE genotype in other neurodegenerative diseases characterized by overt inflammation, e.g., alpha- synucleinopathies and Parkinson's disease, traumatic brain injury, stroke, amyotrophic lateral sclerosis, and multiple sclerosis, is also addressed. Therefore, this review gathers the most relevant findings related to the APOE genotype up to date and its implications on AD and CNS pathologies to provide a deeper understanding of the knowledge in the APOE field.
  •  
26.
  • García-Revilla, Juan, et al. (författare)
  • Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
  • 2022
  • Ingår i: Cell Death and Disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 13:7
  • Forskningsöversikt (refereegranskat)abstract
    • The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in neuroprotection/neurotoxicity is a matter of high interest in the microglia community. In this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, TLR4 and TREM2 and the importance of galectin-3 in the regulation of microglia activation. Finally, we discuss increasing evidence supporting the involvement of this lectin in the main neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury, and stroke.
  •  
27.
  • García-Revilla, Juan, et al. (författare)
  • Galectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease
  • 2023
  • Ingår i: Acta Neuropathologica. - 0001-6322. ; 146:1, s. 51-75
  • Tidskriftsartikel (refereegranskat)abstract
    • Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated α-synuclein (αSYN) is known to be the main component of the LB. It has also been reported to interact with several proteins and organelles. Galectin-3 (GAL3) is known to have a detrimental function in neurodegenerative diseases. It is a galactose-binding protein without known catalytic activity and is expressed mainly by activated microglial cells in the central nervous system (CNS). GAL3 has been previously found in the outer layer of the LB in post-mortem brains. However, the role of GAL3 in PD is yet to be elucidated. In post-mortem samples, we identified an association between GAL3 and LB in all the PD subjects studied. GAL3 was linked to less αSYN in the LB outer layer and other αSYN deposits, including pale bodies. GAL3 was also associated with disrupted lysosomes. In vitro studies demonstrate that exogenous recombinant Gal3 is internalised by neuronal cell lines and primary neurons where it interacts with endogenous αSyn fibrils. In addition, aggregation experiments show that Gal3 affects spatial propagation and the stability of pre-formed αSyn fibrils resulting in short, amorphous toxic strains. To further investigate these observations in vivo, we take advantage of WT and Gal3KO mice subjected to intranigral injection of adenovirus overexpressing human αSyn as a PD model. In line with our in vitro studies, under these conditions, genetic deletion of GAL3 leads to increased intracellular αSyn accumulation within dopaminergic neurons and remarkably preserved dopaminergic integrity and motor function. Overall, our data suggest a prominent role for GAL3 in the aggregation process of αSYN and LB formation, leading to the production of short species to the detriment of larger strains which triggers neuronal degeneration in a mouse model of PD.
  •  
28.
  • Garcia-Revilla, Juan, et al. (författare)
  • Hyperinflammation and Fibrosis in Severe COVID-19 Patients : Galectin-3, a Target Molecule to Consider
  • 2020
  • Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 11
  • Tidskriftsartikel (refereegranskat)abstract
    • COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.
  •  
29.
  • Granero, Roser, et al. (författare)
  • Is pathological gambling moderated by age?
  • 2014
  • Ingår i: Journal of Gambling Studies. - : Springer-Verlag New York. - 1050-5350 .- 1573-3602. ; 30:2, s. 475-92
  • Tidskriftsartikel (refereegranskat)abstract
    • The age of a patient is a strong moderator of both the course and the evolution of disorders/diseases. However, the effects of current age in pathological gambling (PG) have rarely been examined. The aim of this study is to explore the moderating effects of the patients' current age in relation to personality traits and clinical outcomes of PG. A total sample of 2,309 treatment-seeking patients for PG, diagnosed according to DSM-IV criteria, participated in this study and were assessed with the Diagnostic Questionnaire for Pathological Gambling according to DSM-IV criteria, the South Oaks Gambling Screen, the Symptom Checklist, the Temperament and Character Inventory-R, and other clinical and psychopathological measures. Orthogonal polynomial contrasts showed linear trends in the relationship between age and PG: the older the patient, the more comorbid health problems were visible. The presence of additional quadratic trends also suggests that age plays a significant role in moderating the possibility of existing PG problems and general psychopathology. No interaction term was found between age and sex, but it was present for age and some personality traits: self-transcendence and reward dependence (these two traits were only relevant to the level of impairment due to PG at specific ages). This study suggests that the patients' age influences psychopathological and clinical aspects associated to PG. Intervention in the earliest manifestations of this complex problem is essential in order to better address the need of successful treatment planning.
  •  
30.
  • Hamdan, May, et al. (författare)
  • Development and validation of a nutritional questionnaire for the Palestine population
  • 2014
  • Ingår i: Public Health Nutrition. - 1368-9800 .- 1475-2727. ; 17:11, s. 2512-2518
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: Dietary habits vary widely among regions and cultural groups, and FFQ need to be designed for specific populations. The objectives of the present study were to develop and test the repeatability and relative validity of a medium-length semi-quantitative FFQ for measuring the energy and macronutrient intakes of a specific population and to contribute a methodological framework for this procedure.Setting: Palestinian families in the Hebron area.Design: After a preliminary survey of a subgroup of homemakers using 3 d diet recall, stepwise multiple regression analysis was used for selected nutrients to choose foods for inclusion in the FFQ.Subjects: The FFQ was administered to a study population of 169 women representing the same number of families.Results: The Wilcoxon test and Bland-Altman plots were used to compare the FFQ results with the mean 3 d diet recall results. A high level of concordance was found, validating the FFQ. In this population, the mean consumption of SFA was above recommendations and the intakes of vitamin D, folic acid, Ca, Fe and K were deficient.Conclusions: The availability of diet assessment instruments designed for specific populations and cultures is of immense value to researchers and policy makers. The study describes a simple and effective method to develop and validate an FFQ for a given population of interest.
  •  
31.
  • Kilpeläinen, Tuomas O, et al. (författare)
  • Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
  • 2011
  • Ingår i: PLoS medicine. - : Public Library of Science (PLoS). - 1549-1676 .- 1549-1277. ; 8:11
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) =0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio =1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio =1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.
  •  
32.
  • Knoll, Fabien, et al. (författare)
  • A diminutive perinate European Enantiornithes reveals an asynchronous ossification pattern in early birds
  • 2018
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9
  • Tidskriftsartikel (refereegranskat)abstract
    • Fossils of juvenile Mesozoic birds provide insight into the early evolution of avian development, however such fossils are rare. The analysis of the ossification sequence in these early-branching birds has the potential to address important questions about their comparative developmental biology and to help understand their morphological evolution and ecological differentiation. Here we report on an early juvenile enantiornithine specimen from the Early Cretaceous of Europe, which sheds new light on the osteogenesis in this most species-rich clade of Mesozoic birds. Consisting of a nearly complete skeleton, it is amongst the smallest known Mesozoic avian fossils representing post-hatching stages of development. Comparisons between this new specimen and other known early juvenile enantiornithines support a clade-wide asynchronous pattern of osteogenesis in the sternum and the vertebral column, and strongly indicate that the hatchlings of these phylogenetically basal birds varied greatly in size and tempo of skeletal maturation.
  •  
33.
  • Kun-Rodrigues, Celia, et al. (författare)
  • A comprehensive screening of copy number variability in dementia with Lewy bodies.
  • 2019
  • Ingår i: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 75
  • Tidskriftsartikel (refereegranskat)abstract
    • The role of genetic variability in dementia with Lewy bodies (DLB) is now indisputable; however, data regarding copy number variation (CNV) in this disease has been lacking. Here, we used whole-genome genotyping of 1454 DLB cases and 1525 controls to assess copy number variability. We used 2 algorithms to confidently detect CNVs, performed a case-control association analysis, screened for candidate CNVs previously associated with DLB-related diseases, and performed a candidate gene approach to fully explore the data. We identified 5 CNV regions with a significant genome-wide association to DLB; 2 of these were only present in cases and absent from publicly available databases: one of the regions overlapped LAPTM4B, a known lysosomal protein, whereas the other overlapped the NME1 locus and SPAG9. We also identified DLB cases presenting rare CNVs in genes previously associated with DLB or related neurodegenerative diseases, such as SNCA, APP, and MAPT. To our knowledge, this is the first study reporting genome-wide CNVs in a large DLB cohort. These results provide preliminary evidence for the contribution of CNVs in DLB risk.
  •  
34.
  • Kun-Rodrigues, Celia, et al. (författare)
  • Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies
  • 2017
  • Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 49
  • Tidskriftsartikel (refereegranskat)abstract
    • . C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of . C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of . C9orf72 repeat expansions in a large cohort of DLB cases and identified no pathogenic repeat expansions in neuropathologically or clinically defined cases, showing that . C9orf72 repeat expansions are not causally associated with DLB.
  •  
35.
  • Lam, K. W.F., et al. (författare)
  • GJ 367b: A dense, ultrashort-period sub-Earth planet transiting a nearby red dwarf star
  • 2021
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6572, s. 1271-1275
  • Tidskriftsartikel (refereegranskat)abstract
    • Ultrashort-period (USP) exoplanets have orbital periods shorter than 1 day. Precise masses and radii of USP exoplanets could provide constraints on their unknown formation and evolution processes. We report the detection and characterization of the USP planet GJ 367b using high-precision photometry and radial velocity observations. GJ 367b orbits a bright (V-band magnitude of 10.2), nearby, and red (M-type) dwarf star every 7.7 hours. GJ 367b has a radius of 0.718 ± 0.054 Earth-radii and a mass of 0.546 ± 0.078 Earth-masses, making it a sub-Earth planet. The corresponding bulk density is 8.106 ± 2.165 grams per cubic centimeter—close to that of iron. An interior structure model predicts that the planet has an iron core radius fraction of 86 ± 5%, similar to that of Mercury’s interior.
  •  
36.
  • LAURENT, Marion, et al. (författare)
  • Novel indices reveal that pollinator exposure to pesticides varies across biological compartments and crop surroundings
  • 2024
  • Ingår i: Science of the Total Environment. - 0048-9697. ; 927
  • Tidskriftsartikel (refereegranskat)abstract
    • Declines in insect pollinators have been linked to a range of causative factors such as disease, loss of habitats, the quality and availability of food, and exposure to pesticides. Here, we analysed an extensive dataset generated from pesticide screening of foraging insects, pollen-nectar stores/beebread, pollen and ingested nectar across three species of bees collected at 128 European sites set in two types of crop. In this paper, we aimed to (i) derive a new index to summarise key aspects of complex pesticide exposure data and (ii) understand the links between pesticide exposures depicted by the different matrices, bee species and apple orchards versus oilseed rape crops. We found that summary indices were highly correlated with the number of pesticides detected in the related matrix but not with which pesticides were present. Matrices collected from apple orchards generally contained a higher number of pesticides (7.6 pesticides per site) than matrices from sites collected from oilseed rape crops (3.5 pesticides), with fungicides being highly represented in apple crops. A greater number of pesticides were found in pollen-nectar stores/beebread and pollen matrices compared with nectar and bee body matrices. Our results show that for a complete assessment of pollinator pesticide exposure, it is necessary to consider several different exposure routes and multiple species of bees across different agricultural systems.
  •  
37.
  • Lorente, Almudena, et al. (författare)
  • Microwave radiation-assisted synthesis of levulinic acid from microcrystalline cellulose : Application to a melon rind residue
  • 2023
  • Ingår i: International Journal of Biological Macromolecules. - : Elsevier BV. - 0141-8130 .- 1879-0003. ; 237
  • Tidskriftsartikel (refereegranskat)abstract
    • The circular economy considers waste to be a new raw material for the development of value-added products. In this context, agroindustrial lignocellulosic waste represents an outstanding source of new materials and platform chemicals, such as levulinic acid (LA). Herein we study the microwave (MW)-assisted acidic conversion of microcrystalline cellulose (MCC) into LA. The influence of acidic catalysts, inorganic salt addition and ball -milling pre-treatment of MCC on LA yield was assessed. Depolymerization and disruption of cellulose was monitored by FTIR, TGA and SEM, whereas the products formed were analyzed by HPLC and NMR spectroscopy. The parameters that afforded the highest LA yield (48 %, 100 % selectivity) were: ball-milling pre-treatment of MCC for 16 min at 600 rpm, followed by MW-assisted thermochemical treatment for 20 min at 190 degrees C, aqueous p-toluenesulfonic acid (p-TSA) 0.25 M as catalyst and saturation with KBr. These optimal conditions were further applied to a lignocellulosic feedstock, namely melon rind, to afford a 51 % yield of LA. These results corroborate the suitability of this method to obtain LA from agroindustrial wastes, in line with a circular economy-based approach.
  •  
38.
  • Marana, Patricia, et al. (författare)
  • Towards a resilience management guideline - Cities as a starting point for societal resilience
  • 2019
  • Ingår i: Sustainable cities and society. - : ELSEVIER SCIENCE BV. - 2210-6707. ; 48
  • Tidskriftsartikel (refereegranskat)abstract
    • Unexpected crises and risks affect the urban population. Critical infrastructure dependency, climate change and social dynamics have captured the attention of city decision makers across different disciplines, sectors, and scales. Addressing these challenges mandates an increase in resilience. This article presents the development of the novel European Resilience Management Guideline (ERMG) developed by the European H2020 Smart Mature Resilience (SMR) project. It encompasses five supporting tools for city resilience. The purpose of this article is threefold. First, it describes the extensive co-creation methods used to establish, validate and test the five ERMG tools as collaborations among seven city stakeholders and researchers in Europe. Second, it explains concisely the features of each tool and its use and applicability in the city resilience building process. Third, it shows how EMRG supports strategic management in encouraging the visibility of risk dependencies, identifying vicious loops and potential cascading effects, and promoting collaboration between stakeholders to share resources. The article concludes with a discussion of SMR standardization activities to support the transfer of these research results to wider audiences. It covers guidance on local resilience planning and supporting efforts in building and operationalizing resilience at the city level.
  •  
39.
  • Marqués, Antonio, et al. (författare)
  • NOBEL - A Neighborhood Oriented Brokerage ELectricity and Monitoring System
  • 2011. - 17
  • Ingår i: Energy-Efficient Computing and Networking. - Berlin, Heidelberg : Springer Berlin Heidelberg. ; 54, s. 187-196
  • Tidskriftsartikel (refereegranskat)abstract
    • Distributed generation of energy coming from various vendors, even private homes, is a big challenge for tomorrows power management systems that, unlike today, will not dispatch energy centrally or under central control. On the contrary, the production, distribution and management of energy will be treated and optimized in a distributed manner using local data. Even today, parts of the power system are highly nonlinear with fast changing dynamics. It is hard to predict disturbances and undertake countermeasures on time. In existing approaches electricity is distributed to the final users according to its expected estimated demand. Such non-dynamic approaches, are difficult to evolve and can not accommodate rapid changes in the system. By having a cross-layer and open information flow among the different actors involved we can make better and more timely predictions, and inject new dynamics in the system that will lead to better energy management and achieve better energy savings. The NOBEL project is building an energy brokerage system with which individual energy prosumers can communicate their energy needs directly to both large-scale and small-scale energy producers, thereby making energy use more efficient.
  •  
40.
  • Martinez, Emilio A., et al. (författare)
  • Achievements and future perspectives of embryo transfer technology in pigs
  • 2019
  • Ingår i: Reproduction in domestic animals. - : WILEY. - 0936-6768 .- 1439-0531. ; 54
  • Tidskriftsartikel (refereegranskat)abstract
    • Commercial embryo transfer (ET) has unprecedented productive and economic implications for the pig sector. However, pig ET has been considered utopian for decades mainly because of the requirements of surgical techniques for embryo collection and embryo deposition into recipients, alongside challenges to preserve embryos. This situation has drastically changed in the last decade since the current technology allows non-surgical ET and short- and long-term embryo preservation. Here, we provide a brief review of the improvements in porcine ET achieved by our laboratory in the past 20 years. This review includes several aspects of non-surgical ET technology and different issues affecting ET programmes and embryo preservation systems. The future perspectives of ET technology are also considered. We will refer only to embryos produced in vivo since they are the only type of embryos with possible short-term use in pig production.
  •  
41.
  • Miranda-Martinez, Andres, et al. (författare)
  • Portable Quartz Crystal Resonator Sensor for Characterising the Gelation Kinetics and Viscoelastic Properties of Hydrogels
  • 2022
  • Ingår i: Gels. - : MDPI AG. - 2310-2861. ; 8:11, s. 718-
  • Tidskriftsartikel (refereegranskat)abstract
    • Hydrogel biomaterials have found use in various biomedical applications partly due to their biocompatibility and tuneable viscoelastic properties. The ideal rheological properties of hydrogels depend highly on the application and should be considered early in the design process. Rheometry is the most common method to study the viscoelastic properties of hydrogels. However, rheometers occupy much space and are costly instruments. On the other hand, quartz crystal resonators (QCRs) are devices that can be used as low-cost, small, and accurate sensors to measure the viscoelastic properties of fluids. For this reason, we explore the capabilities of a low-cost and compact QCR sensor to sense and characterise the gelation process of hydrogels while using a low sample amount and by sensing two different crosslink reactions: covalent bonds and divalent ions. The gelation of covalently crosslinked mucin hydrogels and physically crosslinked alginate hydrogels could be monitored using the sensor, clearly distinguishing the effect of several parameters affecting the viscoelastic properties of hydrogels, including crosslinking chemistry, polymer concentrations, and crosslinker concentrations. QCR sensors offer an economical and portable alternative method to characterise changes in a hydrogel material's viscous properties to contribute to this type of material design, thus providing a novel approach.
  •  
42.
  • Mosca, Roberto (författare)
  • Numerical Investigation of Radial Turbines Subject to Pulsating Flow
  • 2022
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • In the optic of a more sustainable society, research and development of highly efficient fluid machines represent a fundamental process to satisfy the rapidly growing energy needs of the modern world. Radial turbines are characterized by higher efficiencies for a larger range of inflow conditions compared to axial turbines. Due to this favorable characteristic, they find their natural application in turbocharger systems, where the flow is inherently unsteady due to the engine reciprocating. In a turbocharged engine, to exploit the residual energy contained in the exhaust gases, the radial turbine is fed by the exhaust gases from the cylinders of the engine. The particular inflow conditions to which a turbocharger turbine is exposed, i.e. pulsating flow and high gas temperatures, make the turbocharger turbine a unique example in the turbomachinery field. Indeed, pulsating flow causes performance deviations from quasi-steady to pulsating flow conditions, while heat transfer deteriorates the turbine performance. Modeling correctly these phenomena is essential to enhance turbocharger-engine matching. The problem is further complicated since, due to the geometrical diversity of the different parts of the system, each component represents a stand-alone problem both in terms of flow characteristics and design optimization. In this thesis, high-fidelity numerical simulations are used to characterize the performance of a single-entry radial turbine applied in a commercial 4-cylinder engine for a passenger car under engine-like conditions. By treating the hot-side system as a stand-alone device, parametrization of the pulse shape imposed as inlet boundary conditions has let to highlight specific trends of the system response to pulse amplitude and frequency variations. Reduced-order models to predict the deviations of the turbine performance from quasi-steady to pulsating flow conditions are developed. At first, a simple algebraic model demonstrates the proportionality between the intensity of the deviations and the normalized reduced frequency. Then, a neural network model is demonstrated to accurately predict the unsteady turbine performance given a limited number of training data. Lastly, a gradient-based optimization method is developed to identify the optimum working conditions, in terms of pulse shape, to maximize the power output of the turbine. High-fidelity LES simulations are used to improve the understanding of flow physics. The flow at the rotor blade experiences different characteristics between continuous and pulsating flow conditions. In particular, large separations and secondary flows develop on both the pressure and suction sides of the blade as a consequence of the large range of relative inflow angles the blade is exposed to. Such secondary flows are addressed as the main cause of the drop of the isentropic efficiency from continuous to pulsating flow conditions.
  •  
43.
  • Nicoletti, Paola, et al. (författare)
  • Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study
  • 2017
  • Ingår i: Gastroenterology. - : W B SAUNDERS CO-ELSEVIER INC. - 0016-5085 .- 1528-0012. ; 152:5, s. 1078-1089
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND & AIMS: We performed a genome-wide association study (GWAS) to identify genetic risk factors for druginduced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. METHODS: We performed a GWAS of 862 persons with DILI and 10,588 population-matched controls. The first set of cases was recruited before May 2009 in Europe (n = 137) and the United States (n = 274). The second set of cases were identified from May 2009 through May 2013 from international collaborative studies performed in Europe, the United States, and South America. For the GWAS, we included only cases with patients of European ancestry associated with a particular drug (but not flucloxacillin or amoxicillin-clavulanate). We used DNA samples from all subjects to analyze HLA genes and single nucleotide polymorphisms. After the discovery analysis was concluded, we validated our findings using data from 283 European patients with diagnosis of DILI associated with various drugs. RESULTS: We associated DILI with rs114577328 (a proxy for A* 33: 01 a HLA class I allele; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.9 - 3.8; P = 2.4 x 10(-8)) and with rs72631567 on chromosome 2 (OR, 2.0; 95% CI, 1.6 - 2.5; P = 9.7 x 10(-9)). The association with A* 33: 01 was mediated by large effects for terbinafine-, fenofibrate-, and ticlopidine-related DILI. The variant on chromosome 2 was associated with DILI from a variety of drugs. Further phenotypic analysis indicated that the association between DILI and A* 33: 01 was significant genome wide for cholestatic and mixed DILI, but not for hepatocellular DILI; the polymorphism on chromosome 2 was associated with cholestatic and mixed DILI as well as hepatocellular DILI. We identified an association between rs28521457 (within the lipopolysaccharide-responsive vesicle trafficking, beach and anchor containing gene) and only hepatocellular DILI (OR, 2.1; 95% CI, 1.6 - 2.7; P = 4.8 x 10(-9)). We did not associate any specific drug classes with genetic polymorphisms, except for statin-associated DILI, which was associated with rs116561224 on chromosome 18 (OR, 5.4; 95% CI, 3.0 - 9.5; P = 7.1 x 10(-9)). We validated the association between A* 33: 01 terbinafine-and sertraline-induced DILI. We could not validate the association between DILI and rs72631567, rs28521457, or rs116561224. CONCLUSIONS: In a GWAS of persons of European descent with DILI, we associated HLA-A* 33: 01 with DILI due to terbinafine and possibly fenofibrate and ticlopidine. We identified polymorphisms that appear to be associated with DILI from statins, as well as 2 non-drug-specific risk factors.
  •  
44.
  • Palmer, Nicholette D, et al. (författare)
  • A genome-wide association search for type 2 diabetes genes in African Americans.
  • 2012
  • Ingår i: PloS one. - San Francisco : Public Library of Science (PLoS). - 1932-6203. ; 7:1, s. e29202-
  • Tidskriftsartikel (refereegranskat)abstract
    • African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
  •  
45.
  • Pau, C., et al. (författare)
  • Ivory ornament objects from the Cerro de la Virgen site (Orce, Granada)
  • 2018
  • Ingår i: Complutum. - : Universidad Complutense de Madrid (UCM). - 1131-6993 .- 1988-2327. ; 29:2, s. 267-298
  • Tidskriftsartikel (refereegranskat)abstract
    • The totality (31) of the ivory objects recovered in Cerro de la Virgen (Orce, Gramada) site during the archaeological interventions made between 1963 and 1970 have been studied here. Morpho-typological study, raw material characterization and the traceological analysis have been carried out. Two different categories of ornaments (pendants and buttons) have been identified, in some cases with subdivisions. Temporal differences can be suggested with the increase in variability in Beaker moments (phase 2) and the presence of some types only in certain phases. The last phases of manufacturing and repair processes have been identified, and traceological analysis supports the relationship of the so-called "buttons" with the clothing. As for the raw material, the optical study has been able to determine the use of elephant and hippopotamus ivory, in addition to elements made on cetaceans and wild boar samples. Through FTIR, it has been possible to distinguish between Asian and African elephant ivory. In contrast to what has been observed in other sites, hippopotamus ivory use can be seen from the beginning of the site occupation in a pre-Beaker moment and Asian elephant ivory continues to be used until Early Bronze Age.
  •  
46.
  • Persson, Carina, 1964, et al. (författare)
  • TOI-2196 b: Rare planet in the hot Neptune desert transiting a G-type star
  • 2022
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 666
  • Tidskriftsartikel (refereegranskat)abstract
    • The hot Neptune desert is a region hosting a small number of short-period Neptunes in the radius-instellation diagram. Highly irradiated planets are usually either small (R less than or similar to 2 R-circle plus) and rocky or they are gas giants with radii of greater than or similar to 1 R-J. Here, we report on the intermediate-sized planet TOI-2196 b (TIC 372172128.01) on a 1.2 day orbit around a G-type star (V = 12.0, [Fe/H] = 0.14 dex) discovered by the Transiting Exoplanet Survey Satellite in sector 27. We collected 41 radial velocity measurements with the HARPS spectrograph to confirm the planetary nature of the transit signal and to determine the mass. The radius of TOI-2196 b is 3.51 +/- 0.15 R-circle plus, which, combined with the mass of 26.0 +/- 1.3 M-circle plus, results in a bulk density of 3.31(-0.43)(+0.51) g cm(-3). Hence, the radius implies that this planet is a sub-Neptune, although the density is twice than that of Neptune. A significant trend in the HARPS radial velocity measurements points to the presence of a distant companion with a lower limit on the period and mass of 220 days and 0.65 M-J, respectively, assuming zero eccentricity. The short period of planet b implies a high equilibrium temperature of 1860 +/- 20 K, for zero albedo and isotropic emission. This places the planet in the hot Neptune desert, joining a group of very few planets in this parameter space discovered in recent years. These planets suggest that the hot Neptune desert may be divided in two parts for planets with equilibrium temperatures of greater than or similar to 1800 K: a hot sub-Neptune desert devoid of planets with radii of approximate to 1.8-3 R-circle plus and a sub-Jovian desert for radii of approximate to 5-12 R-circle plus. More planets in this parameter space are needed to further investigate this finding. Planetary interior structure models of TOI-2196 b are consistent with a H/He atmosphere mass fraction between 0.4% and 3%, with a mean value of 0.7% on top of a rocky interior. We estimated the amount of mass this planet might have lost at a young age and we find that while the mass loss could have been significant, the planet had not changed in terms of character: it was born as a small volatile-rich planet and it remains one at present.
  •  
47.
  • Rodriguez Serrano, Juan Jose, et al. (författare)
  • Inputs of Terrestrial Dissolved Organic Matter Enhance Bacterial Production and Methylmercury Formation in Oxic Coastal Water
  • 2022
  • Ingår i: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 13
  • Tidskriftsartikel (refereegranskat)abstract
    • Methylmercury (MeHg) is a potent neurotoxin commonly found in aquatic environments and primarily formed by microbial methylation of inorganic divalent mercury (Hg(II)) under anoxic conditions. Recent evidence, however, points to the production of MeHg also in oxic pelagic waters, but the magnitude and the drivers for this process remain unclear. Here, we performed a controlled experiment testing the hypothesis that inputs of terrestrial dissolved organic matter (tDOM) to coastal waters enhance MeHg formation via increased bacterial activity. Natural brackish seawater from a coastal area of the Baltic Sea was exposed to environmentally relevant levels of Hg(II) and additions of tDOM according to climate change scenarios. MeHg formation was observed to be coupled to elevated bacterial production rates, which, in turn, was linked to input levels of tDOM. The increased MeHg formation was, however, not coupled to any specific change in bacterial taxonomic composition nor to an increased abundance of known Hg(II) methylation genes. Instead, we found that the abundance of genes for the overall bacterial carbon metabolism was higher under increased tDOM additions. The findings of this study may have important ecological implications in a changing global climate by pointing to the risk of increased exposure of MeHg to pelagic biota.
  •  
48.
  • Serrano, Aurelio, et al. (författare)
  • H+-PPases : Yesterday, today and tomorrow
  • 2007
  • Ingår i: IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology. - : Wiley. - 1521-6543 .- 1521-6551. ; 59:2, s. 76-83
  • Forskningsöversikt (refereegranskat)abstract
    • Suggestions by Calvin about a role of inorganic pyrophosphate (PPi) in early photosynthesis and by Lipmann that P]Pi may have been the original energy-rich phosphate donor in biological energy conversion, were followed in the mid-1960s by experimental results with isolated chromatophore membranes from the purple photosynthetic bacterium Rhodospirillum rubrum. PPi was shown to be hydrolysed in an uncoupler stimulated reaction by a membrane-bound inorganic pyrophosphatase (PPase), to be formed at the expense of light energy in photophosphorylation and to be utilized as an energy donor for various energy-requiring reactions, as a firs known alternative to ATP. This direct link between PPi and photosynthesis led to increasing attention concerning the role of PPi in both early and present biological energy transfer. In the 1970s, the PPase was shown to be a proton pump and to be present also in higher plants. In the 1990s, sequences of H+-PPase genes were obtained from plants, protists, bacteria and archaea and two classes of H+-PPases differing in K+ sensitivity were established. Over 200 H+-PPase sequences have now been determined. Recent biochemical and biophysical results have led to new progress and questions regarding the H+-PPase family, as well as the families of soluble PPases and the inorganic polyphosphatases, which hydrolyse inorganic linear high-molecular-weight polyphosphates (HMW-polyP). Here we will focus attention on the H+-PPases, their evolution and putative active site motifs, response to monovalent cations, genetic regulation and some very recent results, based on new methods for obtaining large quantities of purified protein, about their tertiary and quaternary structures.
  •  
49.
  • Serrano-Claumarchirant, José F., et al. (författare)
  • Thermoelectric Inks and Power Factor Tunability in Hybrid Films through All Solution Process
  • 2022
  • Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 14:17, s. 19295-19303
  • Tidskriftsartikel (refereegranskat)abstract
    • Thermoelectric (TE) materials can have a strong benefit to harvest thermal energy if they can be applied to large areas without losing their performance over time. One way of achieving large-area films is through hybrid materials, where a blend of TE materials with polymers can be applied as coating. Here, we present the development of all solution-processed TE ink and hybrid films with varying contents of TE Sb2Te3 and Bi2Te3 nanomaterials, along with their characterization. Using (1-methoxy-2-propyl) acetate (MPA) as the solvent and poly (methyl methacrylate) as the durable polymer, large-area homogeneous hybrid TE films have been fabricated. The conductivity and TE power factor improve with nanoparticle volume fraction, peaking around 60-70% solid material fill factor. For larger fill factors, the conductivity drops, possibly because of an increase in the interface resistance through interface defects and reduced connectivity between the platelets in the medium. The use of dodecanethiol (DDT) as an additive in the ink formulation enabled an improvement in the electrical conductivity through modification of interfaces and the compactness of the resultant films, leading to a 4-5 times increase in the power factor for both p- and n-type hybrid TE films, respectively. The observed trends were captured by combining percolation theory with analytical resistive theory, with the above assumption of increasing interface resistance and connectivity with polymer volume reduction. The results obtained on these hybrid films open a new low-cost route to produce and implement TE coatings on a large scale, which can be ideal for driving flexible, large-area energy scavenging technologies such as personal medical devices and the IoT. 
  •  
50.
  • Serrano, Nuria, et al. (författare)
  • MCR-ALS of voltammetric data for the study of environmentally relevant substances
  • 2020
  • Ingår i: Microchemical journal (Print). - : Elsevier BV. - 0026-265X .- 1095-9149. ; 158
  • Forskningsöversikt (refereegranskat)abstract
    • A critical revision is made on the main approaches and results arising from the combination of multivariate curve resolution by alternating least squares (MCR-ALS) and electroanalytical measurements in the field of environmental analytical chemistry. Although most of the work done has been focused on the study of the metal binding properties of metal bioregulators such as metallothioneins or phytochelatins, new perspectives appear in the evolving world of sensors for environmental monitoring.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-50 av 60
Typ av publikation
tidskriftsartikel (51)
forskningsöversikt (6)
konferensbidrag (1)
doktorsavhandling (1)
Typ av innehåll
refereegranskat (56)
övrigt vetenskapligt/konstnärligt (3)
Författare/redaktör
Deierborg, Tomas (11)
Boza-Serrano, Antoni ... (11)
Venero, José Luis (7)
Serrano, Jose (6)
Aithal, Guruprasad P ... (4)
Nicoletti, Paola (4)
visa fler...
Andrade, Raul J. (4)
Pirmohamed, Munir (4)
Stolz, Andrew (4)
Fontana, Robert J. (4)
Venero, José L. (4)
Ruiz, Rocío (4)
Leffler, Hakon (3)
Groop, Leif (3)
Fernández-Aranda, Fe ... (3)
Jiménez-Murcia, Susa ... (3)
Singleton, Andrew (3)
Wareham, Nicholas J. (3)
Kuusisto, Johanna (3)
Laakso, Markku (3)
Boehnke, Michael (3)
Tuomilehto, Jaakko (3)
Bjornsson, Einar (3)
Martin, Jennifer H. (3)
Cascorbi, Ingolf (3)
Dillon, John F. (3)
Laitinen, Tarja (3)
Molokhia, Mariam (3)
Ibanez, Luisa (3)
Qin, Shengying (3)
Bessone, Fernando (3)
Hernandez, Nelia (3)
Daly, Ann K. (3)
Froguel, Philippe (3)
Spector, Timothy D (3)
Tinahones, Francisco ... (3)
Trojanowski, John Q (3)
Loos, Ruth J F (3)
van Vliet-Ostaptchou ... (3)
Kumari, Meena (3)
Hallberg, Pär, 1974- (3)
Granero, Roser (3)
Sharp, Stephen J. (3)
Kanoni, Stavroula (3)
Tanaka, Toshiko (3)
Ferrucci, Luigi (3)
Watkins, Paul B. (3)
Masliah, Eliezer (3)
Florez, Jose C. (3)
Cairns, Nigel J. (3)
visa färre...
Lärosäte
Lunds universitet (23)
Uppsala universitet (12)
Göteborgs universitet (9)
Karolinska Institutet (8)
Kungliga Tekniska Högskolan (7)
Umeå universitet (5)
visa fler...
Stockholms universitet (5)
Linköpings universitet (4)
Sveriges Lantbruksuniversitet (3)
Chalmers tekniska högskola (2)
Örebro universitet (1)
RISE (1)
visa färre...
Språk
Engelska (59)
Spanska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (31)
Naturvetenskap (20)
Teknik (8)
Lantbruksvetenskap (1)
Humaniora (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy