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| 2. |
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| 3. |
- Sabri, M. H. M., et al.
(författare)
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Initial electric field changes of lightning flashes in tropical thunderstorms and their relationship to the lightning initiation mechanism
- 2019
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Ingår i: Atmospheric research. - : ELSEVIER SCIENCE INC. - 0169-8095 .- 1873-2895. ; 226, s. 138-151
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, the key finding is that all the examined first classic Initial Breakdown (IB) pulses in tropical flashes within the reversal distance were found to be initiated by a clearly detectable Initial E-field Change or IEC (45 -CG, 32 normal IC, and 3 IC initiated by +NBE). The durations of IECs for both -CG and IC flashes in tropical storms were longer than in Florida storms. On the other hand, for the magnitudes of the E-change, the values were smaller compared to Florida storms with averages of 0.30 V/m compared to 1.65 V/m for -CG flashes, and -0.81 V/m compared to -6.30 V/m for IC flashes. The IEC process of lightning flashes in tropical regions took longer to increase the local electric field in order to produce the first IB pulse because of the smaller magnitude of E-change. On the other hand, in Florida storms, the IEC process took a shorter time to increase the local electric field to produce the first IB pulse because of the larger magnitude of E-change. We found that very high frequency (VHF) pulses for tropical thunderstorms started sometime prior to the onset of the IECs. They started between 12.69 and 251.60 mu s before the initiation of the IEC for two normal IC flashes. The first two VHF pulses were detected alone without narrow IB pulses (fast antenna and slow antenna records) or any pulses from the B-field and dE/dt records. Furthermore, the VHF pulses for three IC flashes initiated by + NBEs were also detected before the onset of the IEC. The IEC started immediately after the detection of the + NBE. It is clear that the IEC is initiated by VHF pulses. It can be suggested that lightning is initiated by Fast Positive Breakdowns or FPBs (which emit strong VHF pulses and large + NBEs) and is followed by several negative breakdowns (weak VHF pulses and/or weak NBE-type pulses) before the IEC started. For the case of normal IC flashes, several weaker VHF pulses (mean values of 41.97 mV and 46.4 mV compared to the amplitudes of the VHF pulses of + NBEs of around 800 mV) were detected before the onset of the IEC. As FPBs can occur with a wide range of VHF strengths and E-change amplitudes, it can be suggested these weak VHF pulses accompanied by narrow IB pulses or weak NBE-type pulses detected before the onset of IEC are actually FPBs followed by negative breakdowns or several attempted FPBs.
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| 4. |
- Jansen, Willemijn J, et al.
(författare)
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Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
- 2022
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Ingår i: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 79:3, s. 228-243
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Tidskriftsartikel (refereegranskat)abstract
- One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates.This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria.Alzheimer disease biomarkers detected on PET or in CSF.Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations.Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%]) included, 10139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P=.04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P=.004), subjective cognitive decline (9%; 95% CI, 3%-15%; P=.005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P=.004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P=.18).This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies.
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| 5. |
- Kreins, AY, et al.
(författare)
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Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
- 2015
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 212:10, s. 1641-1662
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Tidskriftsartikel (refereegranskat)abstract
- Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1) with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES), including atopic dermatitis, high serum IgE levels, and staphylococcal abscesses. We identified seven other TYK2-deficient patients from five families and four different ethnic groups. These patients were homozygous for one of five null mutations, different from that seen in P1. They displayed mycobacterial and/or viral infections, but no HIES. All eight TYK2-deficient patients displayed impaired but not abolished cellular responses to (a) IL-12 and IFN-α/β, accounting for mycobacterial and viral infections, respectively; (b) IL-23, with normal proportions of circulating IL-17+ T cells, accounting for their apparent lack of mucocutaneous candidiasis; and (c) IL-10, with no overt clinical consequences, including a lack of inflammatory bowel disease. Cellular responses to IL-21, IL-27, IFN-γ, IL-28/29 (IFN-λ), and leukemia inhibitory factor (LIF) were normal. The leukocytes and fibroblasts of all seven newly identified TYK2-deficient patients, unlike those of P1, responded normally to IL-6, possibly accounting for the lack of HIES in these patients. The expression of exogenous wild-type TYK2 or the silencing of endogenous TYK2 did not rescue IL-6 hyporesponsiveness, suggesting that this phenotype was not a consequence of the TYK2 genotype. The core clinical phenotype of TYK2 deficiency is mycobacterial and/or viral infections, caused by impaired responses to IL-12 and IFN-α/β. Moreover, impaired IL-6 responses and HIES do not appear to be intrinsic features of TYK2 deficiency in humans.
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| 6. |
- Baharin, S. A. S., et al.
(författare)
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Wavelet Analysis of the Onset of VHF and Microwave Radiation Emitted by Lightning
- 2018
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Ingår i: 2018 INTERNATIONAL CONFERENCE ON ELECTRICAL ENGINEERING AND COMPUTER SCIENCE (ICECOS). - : IEEE. - 9781538657218 ; , s. 297-300
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Konferensbidrag (refereegranskat)abstract
- Lightning flash is an electrical discharge in air (dielectric breakdown) which emits electromagnetic (FM) fields across very wide spectra from a few Hertz up to visible wavelength. Electrical breakdown process is an important event that initiates lightning. For electrical breakdown process to occur, it must fulfill two conditions which are at least has one free electron and the electric field region is more than 3 MV/m. This process starts with electron avalanche in millimeter scale then grows into streamer in centimeter scale. Lastly, from streamer it will grow into leader in meter scale. It has already established that streamer emits intensely at Very High Frequency (VHF) band as it's already proven both theoretically and experimentally. A study by Cooray, theoretically proved that emission of electron avalanche peaks at microwave band. Air-gap parallel plate antenna which could operate at 1 GHz with remote sensing is designed and simulated to measure the microwave radiation emitted by lightning. Both temporal and wavelet analyses are used to compare the onset of microwave radiation and VHF radiation in both time and frequency domains to determine electron avalanche appears at which electromagnetic band.
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| 7. |
- Bailey, D. L., et al.
(författare)
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Combined PET/MRI : Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tubingen, Germany
- 2018
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Ingår i: Molecular Imaging and Biology. - : SPRINGER. - 1536-1632 .- 1860-2002. ; 20:1, s. 4-20
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Forskningsöversikt (refereegranskat)abstract
- The 6th annual meeting to address key issues in positron emission tomography (PET)/magnetic resonance imaging (MRI) was held again in Tubingen, Germany, from March 27 to 29, 2017. Over three days of invited plenary lectures, round table discussions and dialogue board deliberations, participants critically assessed the current state of PET/MRI, both clinically and as a research tool, and attempted to chart future directions. The meeting addressed the use of PET/MRI and workflows in oncology, neurosciences, infection, inflammation and chronic pain syndromes, as well as deeper discussions about how best to characterise the tumour microenvironment, optimise the complementary information available from PET and MRI, and how advanced data mining and bioinformatics, as well as information from liquid biomarkers (circulating tumour cells and nucleic acids) and pathology, can be integrated to give a more complete characterisation of disease phenotype. Some issues that have dominated previous meetings, such as the accuracy of MR-based attenuation correction (AC) of the PET scan, were finally put to rest as having been adequately addressed for the majority of clinical situations. Likewise, the ability to standardise PET systems for use in multicentre trials was confirmed, thus removing a perceived barrier to larger clinical imaging trials. The meeting openly questioned whether PET/MRI should, in all cases, be used as a whole-body imaging modality or whether in many circumstances it would best be employed to give an in-depth study of previously identified disease in a single organ or region. The meeting concluded that there is still much work to be done in the integration of data from different fields and in developing a common language for all stakeholders involved. In addition, the participants advocated joint training and education for individuals who engage in routine PET/MRI. It was agreed that PET/MRI can enhance our understanding of normal and disrupted biology, and we are in a position to describe the in vivo nature of disease processes, metabolism, evolution of cancer and the monitoring of response to pharmacological interventions and therapies. As such, PET/MRI is a key to advancing medicine and patient care.
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| 8. |
- Seah, B. Y., et al.
(författare)
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The Performance Evaluation of Capacitive Antenna with Various Structures and Permittivity Values
- 2018
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Ingår i: 2018 INTERNATIONAL CONFERENCE ON ELECTRICAL ENGINEERING AND COMPUTER SCIENCE (ICECOS). - : IEEE. - 9781538657218 ; , s. 457-460
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Konferensbidrag (refereegranskat)abstract
- This paper evaluates the capacitive antenna performance as a lightning sensor. The performance is evaluated by looking at two aspects, antenna structures and the background permittivity value of the antenna. Two experiments were carried out, Experiment A using two different structure antennas, one with its Bayonet Neill-Concelman (BNC) connector's core direct touching the top plate (DBNC) while the other was connected via single core wires (WBNC), capturing the electric field (E-field) generated by the small spark at a distance of 1 meter away from both antennas. Furthermore, both capacitive antennas with top plates directly soldered to their BNC cores were used to study their performance with and without being covered by plastic (dielectric constant of 2.25) during Experiment B. The result from Experiment A showed that WBNC has different onset polarity and significant decreased in amplitude of the signals captured compared to DBNC (mean ratio is 1.095 with range between 0.5838 and 4.528). Meanwhile, Experiment B shows that a comparable average ratio of 0.7835 and 0.7447 during the measurement where antenna A(wc) with and without the presence of plastic cover respectively.
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| 9. |
- Jansen, Willemijn J, et al.
(författare)
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Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
- 2018
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Ingår i: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 75:1, s. 84-95
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials.To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia.This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on cognitive tests. Mild cognitive impairment was diagnosed according to published criteria. Study inclusion began in 2013 and is ongoing. Data analysis was performed in January 2017.Global cognitive performance as assessed by the Mini-Mental State Examination (MMSE) and episodic memory performance as assessed by a verbal word learning test. Amyloid aggregation was measured with positron emission tomography or cerebrospinal fluid biomarkers and dichotomized as negative (normal) or positive (abnormal) according to study-specific cutoffs. Generalized estimating equations were used to examine the association between amyloid aggregation and low cognitive scores (MMSE score ≤27 or memory z score≤-1.28) and to assess whether this association was moderated by age, sex, educational level, or apolipoprotein E genotype.Among 2908 persons with normal cognition (mean [SD] age, 67.4 [12.8] years), amyloid positivity was associated with low memory scores after age 70 years (mean difference in amyloid positive vs negative, 4% [95% CI, 0%-7%] at 72 years and 21% [95% CI, 10%-33%] at 90 years) but was not associated with low MMSE scores (mean difference, 3% [95% CI, -1% to 6%], P=.16). Among 4133 patients with MCI (mean [SD] age, 70.2 [8.5] years), amyloid positivity was associated with low memory (mean difference, 16% [95% CI, 12%-20%], P<.001) and low MMSE (mean difference, 14% [95% CI, 12%-17%], P<.001) scores, and this association decreased with age. Low cognitive scores had limited utility for screening of amyloid positivity in persons with normal cognition and those with MCI. In persons with normal cognition, the age-related increase in low memory score paralleled the age-related increase in amyloid positivity with an intervening period of 10 to 15 years.Although low memory scores are an early marker of amyloid positivity, their value as a screening measure for early AD among persons without dementia is limited.
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| 10. |
- Jansen, Willemijn J, et al.
(författare)
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Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
- 2015
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Ingår i: JAMA. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 313:19, s. 1924-38
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.
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| 11. |
- Ong, J. Y., et al.
(författare)
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Performance Analysis of Stacked Capacitive Antenna for Lightning Remote Sensing
- 2018
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Ingår i: 2018 INTERNATIONAL CONFERENCE ON ELECTRICAL ENGINEERING AND COMPUTER SCIENCE (ICECOS). - : IEEE. - 9781538657218 ; , s. 305-308
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Konferensbidrag (refereegranskat)abstract
- Antennas are the important elements in the lightning detection system. To improve performance of the lightning detection system, it is so necessary to improve the efficiency of the antennas. There are two types of antennas used in the system which are capacitive antenna for electric field sensing and loop antenna for magnetic field sensing Pi. Both of these antennas arc big in size and causing inconvenient during set up. Thus, small and portable antennas are designed. It is so important to remain or improve the sensitivity of the antennas even though it is small in size. Stacking method is used in capacitive antenna by increase copper plate layer in between the parallel plate antenna. After prototype the multi stacked capacitive antenna, performance analysis is carried out. Performances of the antennas are compared using CST simulation and hardware set up. Multi-stacked capacitive antenna is compared with the single plate antenna and found that the performance of the antenna increases as the stacked number increases.
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| 12. |
- Sabri, M. H. M., et al.
(författare)
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VHF Emissions Prior to the Onset of Initial Electric Field Changes of Intracloud Flashes
- 2018
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Ingår i: 2018 INTERNATIONAL CONFERENCE ON ELECTRICAL ENGINEERING AND COMPUTER SCIENCE (ICECOS). - : IEEE. - 9781538657218 ; , s. 301-304
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Konferensbidrag (refereegranskat)abstract
- We present the observation of VHF impulses electric (E) field emissions found in two normal intracloud (IC) flashes accompanied by initial electric field changes (LECs) in a tropical thunderstorm. The data was collected on November 23rd, 2017 (within reversal distance) to our lightning sensor in Malacca, Malaysia. The durations from the onset of IECs to the first initial breakdown (IB) pulse are range between 0.68 and 0.69 ms and the magnitudes of IECs are range between 0.18 and 0.50 V/m. Besides that, before the onset of LECs there is small pulses was detected for IC flash (Nov_67) same with the VHF impulse for both IC flash. It was detected earlier before the onset of IEC by 12.69 and 251.60 mu s for the VHF impulse.
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| 17. |
- Perng, Bo Hao, et al.
(författare)
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Mapping distribution of woody plant species richness from field rapid assessment and machine learning
- 2024
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Ingår i: Taiwania. - 0372-333X. ; 69, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Sustainable forest management needs information on spatial distribution of species richness. The objectives of this study were to understand whether knowledge, method, and effort of a rapid assessment affected accuracy and consistency in mapping species richness. A simulation study was carried out with nine 25–50 ha census plots located in tropical, subtropical, and temperate zones. Each forest site was first tessellated into non-overlapping cells. Rapid assessment was conducted in all cells to generate a complete coverage of proxies of the underlying species richness. Cells were subsampled for census, where all plant individuals were identified to species in these census cells. An artificial neural network model was built using the census cells that contain rapid assessment and census information. The model then predicted species richness of cells that were not censused. Results showed that knowledge level did not improve the accuracy and consistency in mapping species richness. Rapid assessment effort and method significantly affected the accuracy and consistency. Increasing rapid assessment effort from 10 to 40 plant individuals could improve the accuracy and consistency up to 2.2% and 2.8%, respectively. Transect reduced accuracy and consistency by up to 0.5% and 0.8%, respectively. This study suggests that knowing at least half of the species in a forest is sufficient for a rapid assessment. At least 20 plant individuals per cell is recommended for rapid assessment. Lastly, a rapid assessment could be carried out by local communities that are familiar with their forests; thus, further supporting sustainable forest management.
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| 18. |
- Piponiot, Camille, et al.
(författare)
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Distribution of biomass dynamics in relation to tree size in forests across the world
- 2022
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Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 234, s. 1664-1677
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Tidskriftsartikel (refereegranskat)abstract
- Tree size shapes forest carbon dynamics and determines how trees interact with their environment, including a changing climate. Here, we conduct the first global analysis of among-site differences in how aboveground biomass stocks and fluxes are distributed with tree size. We analyzed repeat tree censuses from 25 large-scale (4–52 ha) forest plots spanning a broad climatic range over five continents to characterize how aboveground biomass, woody productivity, and woody mortality vary with tree diameter. We examined how the median, dispersion, and skewness of these size-related distributions vary with mean annual temperature and precipitation. In warmer forests, aboveground biomass, woody productivity, and woody mortality were more broadly distributed with respect to tree size. In warmer and wetter forests, aboveground biomass and woody productivity were more right skewed, with a long tail towards large trees. Small trees (1–10 cm diameter) contributed more to productivity and mortality than to biomass, highlighting the importance of including these trees in analyses of forest dynamics. Our findings provide an improved characterization of climate-driven forest differences in the size structure of aboveground biomass and dynamics of that biomass, as well as refined benchmarks for capturing climate influences in vegetation demographic models.
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| 21. |
- Amin, Fatin Aina Zulkhairi, et al.
(författare)
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In Vivo Toxicity Assessment of the Probiotic Bacillus amyloliquefaciens HTI-19 Isolated from Stingless Bee (Heterotrigona itama) Honey
- 2023
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Ingår i: Nutrients. - 2072-6643. ; 15:10
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Tidskriftsartikel (refereegranskat)abstract
- This study evaluated the acute and sub-acute toxicity of B. amyloliquefaciens HTI-19 (isolated from stingless bee honey) in female Sprague Dawley rats. In an acute toxicity study, the rats received a low dosage (1 x 109 CFU center dot mL 1), medium dosage (3 x 10(9) CFU center dot mL(-1)), or high dosage (1 x 10(10) CFU center dot mL(-1)) of B. amyloliquefaciens HTI-19 daily orally by syringe-feeding for 14 days. For the subacute toxicity study, rats received a low dosage (1 x 10(9) CFU center dot mL(-1)) or a high dosage (1 x 10(10) CFU center dot mL(-1)) for 28 days. The probiotic feeding in acute and sub-acute toxicity studies showed no mortality or significant abnormalities in rats throughout the experimental period. In week 2 of the acute study, the body weight of the rats showed a significant increase (p < 0.05) compared to the control. By gross and microscopic examination of organs, no evidently significant changes were observed in the morphology of organs. Serum biochemical tests and blood hematology tests also revealed no treatment-related changes. Overall, these data indicated that oral administration of B. amyloliquefaciens HTI-19 up to 1 x 10(9) CFU center dot mL(-1) for 28 days can be considered safe.
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| 22. |
- Benkner, S., et al.
(författare)
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Peppher: Performance Portability and Programmability for Heterogeneous Many-Core Architectures
- 2017
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Ingår i: Programming Multicore and Many-Core Computing Systems. - Hoboken, NJ, USA : John Wiley & Sons, Inc.. - 9781119332015 - 9780470936900 ; , s. 241-260
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- © 2017 by John Wiley & Sons, Inc. All rights reserved. PEPPHER takes a pluralistic and parallelization agnostic approach to programmability and performance portability for heterogeneous many-core architectures. The PEPPHER framework is in principle language independent but focuses on supporting C++ code with PEPPHER-specific annotations as pragmas or external annotations. The framework is open and extensible; the PEPPHER methodology details how new architectures are incorporated. The PEPPHER methodology consists of rules for how to extend the framework for new architectures. This mainly concerns adaptivity and autotuning for algorithm libraries, the necessary hooks and extensions for the run-time system and any supporting algorithms and data structures that this relies on. Offloading is a specific technique for programming heterogeneous platforms that can sometimes be applied with high efficiency. Offload as developed by the PEPPHER partner Codeplay is a particular, nonintrusive C++ extension allowing portable C++ code to support diverse heterogeneous multicore architectures in a single code base.
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| 23. |
- Benkner, S., et al.
(författare)
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The PEPPHER approach to programmability and performance portability for heterogeneous many-core architectures
- 2012
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Ingår i: Advances in Parallel Computing. - : IOS Press. - 1879-808X .- 0927-5452. ; 22, s. 361-368, s. 361-368
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Konferensbidrag (refereegranskat)abstract
- The European FP7 project PEPPHER is addressing programmability and performance portability for current and emerging heterogeneous many-core architectures. As its main idea, the project proposes a multi-level parallel execution model comprised of potentially parallelized components existing in variants suitable for different types of cores, memory configurations, input characteristics, optimization criteria, and couples this with dynamic and static resource and architecture aware scheduling mechanisms. Crucial to PEPPHER is that components can be made performance aware, allowing for more efficient dynamic and static scheduling on the concrete, available resources. The flexibility provided in the software model, combined with a customizable, heterogeneous, memory and topology aware run-time system is key to efficiently exploiting the resources of each concrete hardware configuration. The project takes a holistic approach, relying on existing paradigms, interfaces, and languages for the parallelization of components, and develops a prototype framework, a methodology for extending the framework, and guidelines for constructing performance portable software and systems-including paths to migration of existing software-for heterogeneous many-core processors. This paper gives a high-level project overview, and presents a specific example showing how the PEPPHER component variant model and resource-aware run-time system enable performance portability of a numerical kernel. © 2012 The authors and IOS Press. All rights reserved.
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| 35. |
- Sabri, N, et al.
(författare)
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Evidence for a Posttranscription Role of a TFIIIC-like Protein in Chironomus tentans.
- 2002
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Ingår i: Molecular Biology of the Cell. - : American Society for Cell Biology (ASCB). - 1059-1524 .- 1939-4586. ; 13, s. 1765-1777
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Tidskriftsartikel (refereegranskat)abstract
- We have cloned and sequenced a cDNA that encodes for a nuclear protein of 238 kDa in the dipteran Chironomus tentans. This protein, that we call p2D10, is structurally similar to the α subunit of the general transcription factor TFIIIC. Using immunoelectron microscopy we have shown that a fraction of p2D10 is located at sites of transcription, which is consistent with a possible role of this protein in transcription initiation. We have also found that a large fraction of p2D10 is located in the nucleoplasm and in the nuclear pore complexes. Using gel filtration chromatography and coimmunoprecipitation methods, we have identified and characterized two p2D10-containing complexes that differ in molecular mass and composition. The heavy p2D10-containing complex contains at least one other component of the TFIIIC complex, TFIIIC-ε. Based on its molecular mass and composition, the heavy p2D10-containing complex may be the Pol III holoenzyme. The light p2D10-containing complex contains RNA together with at least two proteins that are thought to be involved in mRNA trafficking, RAE1 and hrp65. The observations reported here suggest that this new TFIIIC-α-like protein is involved in posttranscriptional steps of premRNA metabolism in Chironomus tentans.
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| 37. |
- Sonderegger, S, et al.
(författare)
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Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation
- 2010
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Ingår i: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 151:1, s. 211-220
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Tidskriftsartikel (refereegranskat)abstract
- Invasion of human trophoblasts is promoted through activation of wingless (Wnt) signaling, suggesting a role of the pathway in placental development and morphogenesis. However, details on the process such as involvement of canonical and/or noncanonical Wnt signaling cascades as well as their target genes are largely unknown. Hence, signal transduction via canonical Wnt signaling or phosphatidylinositide 3-kinase (PI3K)/AKT and their cross talk as well as trophoblast-specific protease expression were investigated in trophoblastic SGHPL-5 cells and primary extravillous trophoblasts purified from first-trimester placentas. Western blot analyses revealed that the recombinant Wnt ligand Wnt-3A increased phosphorylation of AKT and the downstream kinase glycogen synthase kinase (GSK)-3β as well as accumulation of activated, nuclear β-catenin. In accordance, luciferase expression of a canonical Wnt/TCF reporter and cell migration in first-trimester villous explant cultures and of SGHPL-5 cells were stimulated. Chemical inhibition of PI3K abolished Wnt-dependent phosphorylation of AKT and GSK-3β and trophoblast motility but did not affect appearance of activated β-catenin or Wnt/TCF reporter activity. In contrast, inhibition of the canonical pathway through soluble Dickkopf-1 did not influence AKT and GSK-3β phosphorylation but reduced Wnt reporter activity, accumulation of active β-catenin, and cell migration. Both inhibitors decreased Wnt-3A-induced secretion of pro- and active matrix metalloproteinase-2 from SGHPL-5 cells and pure EVT. The data suggest that Wnt-3A may activate canonical Wnt signaling and PI3K/AKT through distinct receptors. The two signaling cascades act independently in trophoblasts; however, both pathways promote Wnt-dependent migration and the release of matrix metalloproteinase-2, which has been identified as novel Wnt target in invasive trophoblasts.
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