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Sökning: WFRF:(Sadreddini Sanam)

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1.
  • Bahrami, Behdokht, et al. (författare)
  • Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy
  • 2015
  • Ingår i: Tumor Biology. - Stockholm : Karolinska Institutet, Dept of Oncology-Pathology. - 1423-0380 .- 1010-4283.
  • Tidskriftsartikel (refereegranskat)abstract
    • The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.
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2.
  • Yousefi, Mehdi, et al. (författare)
  • The skewed balance between regulatory T cells and Th17 in chronic lymphocytic leukemia
  • 2015
  • Ingår i: Future Oncology. - Stockholm : Karolinska Institutet, Dept of Oncology-Pathology. - 1479-6694 .- 1744-8301.
  • Tidskriftsartikel (refereegranskat)abstract
    • While Tregs maintain self-tolerance and inhibit antitumor responses, T helper (Th)17 cells may enhance inflammatory and antitumor responses. The balance between these two important T-cell subsets has been skewed in many immunopathologic conditions such as autoimmune and cancer diseases. B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the western world and is characterized with monoclonal expansion of B lymphocytes. There is evidence which implies that the progression of CLL is associated with expansion of Treg and downregulation of Th17 cells. In this review, we will discuss about immunobiology of Treg and Th17 cells and their role in immunopathogenesis of CLL as well as their reciprocal changes during disease progression.
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