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Sökning: WFRF:(Sahlström Johan Fredrik)

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  • Luth, Stefan, et al. (författare)
  • Building 3D geomodels using XRF-XRT-generated drillcore data : The Lovisa-Håkansboda base metal- and Stråssa-Blanka iron deposits in Bergslagen, Sweden
  • 2019
  • Ingår i: Life with Ore Deposits on Earth: Proceedings of the 15th SGA Biennial Meeting 2019, Glasgow, Scotland, 2019, Vol. 3, s. 1282-1485.
  • Konferensbidrag (refereegranskat)abstract
    • 3D geological models based on data fromgeological field observations, magnetic airborne surveys and combined XRF-XRT scanning of drill core arepresented for the Lovisa-Håkansboda and the Stråssa-Blanka mineral systems (1.9 - 1.8 Ga). At first, the 3D architecture of several deposits was derived primarilyfrom surface data and mine-level maps. Secondly, geochemical and structural constrains from drill corescanning (XRF-XRT) were used to refine the modelslocally to a detailed, in-mine scale. The constructed models were then placed in a regional context providingvaluable insight on the area’s local and regional deformation pattern. All modelled deposits are plunging 50-60° towards the south-southeast reflecting D2 deformation (vertical shearing) during NW-SE-directed shortening and are locally overprinted by D3 (lateral shearing) during N-S-directed shortening.
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  • Sahlström, Thomas, et al. (författare)
  • Bacteremia with ESBL-producing Enterobacterales is associated with IgG antibodies reacting with CTX-M-15 and/or CTX-M-27
  • 2020
  • Ingår i: International Journal of Medical Microbiology. - : Elsevier BV. - 1438-4221. ; 310:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: The adaptive humoral immune response following clinical infection with extended spectrum beta-lactamase (ESBL)-producing Enterobacterales (EPE) has not been thoroughly investigated. The aim of this study was to investigate the presence of anti-CTX-M-15 and/or anti-CTX-M-27 IgG antibodies in bacteremia patients diagnosed with EPE compared to a control group consisting of patients suffering from bacteremia with third generation cephalosporin-susceptible Escherichia coli (3GCSE). Methods: Patientswith EPE (n = 59) or 3GCSE (n = 42) bacteremia were recruited in this case control study in the Skåne County (South of Sweden). Sera were collected 1–26 months after bacteremia. Enzyme-linked immunosorbent assay (ELISA) was used for detection of specific IgG antibodies directed against recombinant beta-lactamases CTX-M-15 and CTX-M-27. The beta-lactamase resistance genes of the corresponding EPE blood isolates were determined by DNA sequencing. Results: The majority (n = 47; 80 %) of the 59 EPE blood isolates carried blaCTX-M-15 or blaCTX-M-27 genes. IgG antibodies reacting to the corresponding CTX-M enzyme was seen in 28 % (13/47) of patients suffering from EPE-bacteremia, while antibodies were detected in only 9.5 % (4/42) of patients with 3GCSE (p = 0.03). Patients with EPE had a statistically significantly higher median Charlson comorbidity index and prevalence of renal disease (p = 0.01), compared to the 3GCSE control group. Conclusion: This study implies that EPE bacteremia can trigger production of IgG antibodies targeting ESBL. Further investigations are required to determine the functional role of anti-ESBL antibodies against EPE bacteremia.
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