| 1. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
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| 3. |
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| 4. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 5. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 6. |
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| 7. |
- Kahl, L, et al.
(författare)
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Safety, tolerability, efficacy and pharmacodynamics of the selective JAK1 inhibitor GSK2586184 in patients with systemic lupus erythematosus
- 2016
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Ingår i: Lupus. - : SAGE Publications. - 1477-0962 .- 0961-2033. ; 25:13, s. 1420-1430
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Tidskriftsartikel (refereegranskat)abstract
- We aimed to evaluate the pharmacodynamics, efficacy, safety and tolerability of the JAK1 inhibitor GSK2586184 in adults with systemic lupus erythematosus (SLE). In this adaptive, randomized, double-blind, placebo-controlled study, patients received oral GSK2586184 50–400 mg, or placebo twice daily for 12 weeks. Primary endpoints included interferon-mediated messenger RNA transcription over time, changes in Safety of Estrogen in Lupus National Assessment-SLE Disease Activity Index score, and number/severity of adverse events. A pre-specified interim analysis was performed when ≥ 5 patients per group completed 2 weeks of treatment. In total, 84–92% of patients were high baseline expressors of the interferon transcriptional biomarkers evaluated. At interim analysis, GSK2586184 showed no significant effect on mean interferon transcriptional biomarker expression (all panels). The study was declared futile and recruitment was halted at 50 patients. Shortly thereafter, significant safety data were identified, including elevated liver enzymes in six patients (one confirmed and one suspected case of Drug Reaction with Eosinophilia and Systemic Symptoms), leading to immediate dosing cessation. Safety of Estrogen in Lupus National Assessment-SLE Disease Activity Index scores were not analysed due to the small number of patients completing the study. The study futility and safety data described for GSK2586184 do not support further evaluation in patients with SLE. Study identifiers: GSK Study JAK115919; ClinicalTrials.gov identifier: NCT01777256.
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| 9. |
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| 10. |
- Bosma, A. L., et al.
(författare)
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Mapping exercise and status update of eight established registries within the TREatment of ATopic eczema (TREAT) Registry Taskforce
- 2023
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Ingår i: Journal of the European Academy of Dermatology and Venereology. - : Blackwell Publishing. - 0926-9959 .- 1468-3083. ; 37:1, s. 123-136
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: the TREatment of ATopic eczema (TREAT) Registry Taskforce is a collaborative international network of registries collecting data of atopic eczema (AE) patients receiving systemic and phototherapy with the common goal to provide long-term real-world data on the effectiveness, safety and cost-effectiveness of therapies. A core dataset, consisting of domains and domain items with corresponding measurement instruments, has been developed to harmonize data collection.OBJECTIVES: we aimed to give an overview of the status and characteristics of the eight established TREAT registries, and to perform a mapping exercise to examine the degree of overlap and pooling ability between the national registry datasets. This will allow us to determine which research questions can be answered in the future by pooling data.METHODS: all eight registries were asked to share their dataset and information on the current status and characteristics. The overlap between the core dataset and each registry dataset was identified (according to the domains, domain items and measurement instruments of the TREAT core dataset).RESULTS AND CONCLUSIONS: a total of 4,702 participants have been recruited in the 8 registries as of 1st of May 2022. Of the 69 core dataset domain items, data pooling was possible for 69 domain item outcomes in TREAT NL (the Netherlands), 61 items in A-STAR (UK and Ireland), 38 items in TREATgermany (Germany), 36 items in FIRST (France), 33 items in AtopyReg (Italy), 29 items in Biobadatop (Spain), 28 items in SCRATCH (Denmark) and 20 items in SwedAD (Sweden). Pooled analyses across all registries can be performed on multiple important domain items, covering the main aims of analyzing data on the (cost-)effectiveness and safety of AE therapies. These results will facilitate future comparative or joint analyses.
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| 11. |
- Bucaioni, Alessio, 1987-, et al.
(författare)
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Continuous Conformance of Software Architectures
- 2024
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Ingår i: Proceedings - IEEE 21st International Conference on Software Architecture, ICSA 2024. - : Institute of Electrical and Electronics Engineers Inc.. - 9798350359169 ; , s. 112-122
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Konferensbidrag (refereegranskat)abstract
- Software architectures are pivotal in the success of software-intensive systems and serve as foundational elements that significantly impact the overall software quality. Reference architectures abstract software elements, define main responsibilities and interactions within a domain, and guide the architectural design of new systems. Using reference architectures offers advantages like enhanced interoperability, cost reduction through reusability, decreased project risks, improved communication, and adherence to best practices. However, these benefits are most pronounced when software architectures align with reference architectures. Deviations from prescribed reference architectures can nullify these benefits. Uncontrolled misalignment can become prohibitively expensive, necessitating costly redevelopments, with maintenance costs reaching up to 90% of development costs. Conformance-checking processes and identifying and resolving violations in the software architecture are essential to mitigate misalignment. To address these challenges, we introduce the concept of continuous conformance that is expressed as a distance function, together with a process supporting it. Continuous conformance quantifies the degree to which a software architecture adheres to a designated reference architecture. The conformance concept enables multi-level, incremental, and non-blocking checking and restoration tasks and allows the check of partial architectures without obstructing the design process. We operationalize this process through an assistive modeling tool to architect an Internet of things-based system.
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| 12. |
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| 13. |
- Agostoni, C, et al.
(författare)
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Enteral nutrient supply for preterm infants : commentary from the European society of paediatric gastroenterology, hepatology and nutrition committee on nutrition
- 2010
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Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - New York : Raven P.. - 0277-2116 .- 1536-4801. ; 50:1, s. 85-91
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Tidskriftsartikel (refereegranskat)abstract
- The number of surviving children born prematurely has increased substantially during the last 2 decades. The major goal of enteral nutrient supply to these infants is to achieve growth similar to foetal growth coupled with satisfactory functional development. The accumulation of knowledge since the previous guideline on nutrition of preterm infants from the Committee on Nutrition of the European Society of Paediatric Gastroenterology and Nutrition in 1987 has made a new guideline necessary. Thus, an ad hoc expert panel was convened by the Committee on Nutrition of the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition in 2007 to make appropriate recommendations. The present guideline, of which the major recommendations are summarised here (for the full report, see http://links.lww.com/A1480), is consistent with, but not identical to, recent guidelines from the Life Sciences Research Office of the American Society for Nutritional Sciences published in 2002 and recommendations from the handbook Nutrition of the Preterm Infant. Scientific Basis and Practical Guidelines, 2nd ed, edited by Tsang et al, and published in 2005. The preferred food for premature infants is fortified human milk from the infant's own mother, or, alternatively, formula designed for premature infants. This guideline aims to provide proposed advisable ranges for nutrient intakes for stable-growing preterm infants up to a weight of approximately 1800 g, because most data are available for these infants. These recommendations are based on a considered review of available scientific reports on the subject, and on expert consensus for which the available scientific data are considered inadequate.
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| 14. |
- Bucaioni, Alessio, 1987-, et al.
(författare)
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Joint Workshop on Model-Driven Engineering for Software Architecture (MDE4SA) and International Workshop on Automotive System/Software Architectures (WASA)
- 2023
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Ingår i: Proc. - IEEE Int. Conf. Softw. Archit. Companion, ICSA-C. - : Institute of Electrical and Electronics Engineers Inc.. - 9781665464598 ; , s. 246-247
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Current society heavily relies on software and software systems. Due to its increasing complexity, the design and operation of software systems are becoming challenging. In the last decades, a great deal of effort has been put into addressing software systems design, development, and maintenance challenges. Empirical evidence shows that one of the most critical success factors when developing software systems is their Software Architecture (SA). A SA describes software systems in terms of software components, their interactions, and critical quality attributes. Among other benefits, SAs improve the overall communication among different stakeholders, are the carriers of significant design decisions, promote the use of different abstraction levels, and allow for the early assessment of the software under development.
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| 15. |
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| 17. |
- Wendt, A., et al.
(författare)
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Isospin Symmetry in the sd Shell: Transition Strengths in the Neutron-deficient sd Shell Nucleus 33Ar
- 2014
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 90:5
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Tidskriftsartikel (refereegranskat)abstract
- Reduced transition strengths of the deexciting transitions from the first two excited states in 33Ar were measured in a relativistic Coulomb excitation experiment at the GSI Helmholtz center. The radioactive ion beam was produced by fragmentation of a primary 36Ar beam on a 9Be target followed by the selection of the reaction product of interest via the GSI Fragment Separator. The 33Ar beam hit a secondary 197Au target with an energy of approximately 145 MeV/nucleon. An array of high-purity germanium cluster detectors and large-volume BaF2 scintillator detectors were employed for γ -ray spectroscopy at the secondary target position. The Lund-York-Cologne Calorimeter was used to track the outgoing ions and to identify the nuclear reaction channels. For the two lowest energy excited states of 33Ar the reduced transition strengths have been determined. With these first results the Tz = −3/2 nucleus 33Ar is now, together with 21Na (Tz = −1/2), the only neutron-deficient odd-A sd shell nucleus in which experimental transition strengths are available. The experimental values are compared to results of shell-model calculations which describe simultaneously mirror-energy differences and transition-strength values of mirror pairs in the sd shell in a consistent way.
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