| 1. |
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| 2. |
- Akner, Gunnar, 1953-, et al.
(författare)
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Vi står gärna bakom en utfallsbaserad vård
- 2017
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Ingår i: Dagens Samhälle. - 1652-6511.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Jörgen Nordenström försöker få det till att vår kritik av värdebaserad vård egentligen handlar om att vi vill ha mer resurser. Han har helt missuppfattat oss, skriver 26 specialistläkare i en replik.
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| 3. |
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| 4. |
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| 5. |
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| 6. |
- Sandberg, Mats, et al.
(författare)
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Experimental methods in ventilation
- 2008
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Ingår i: Advances in building energy research. - London ; Sterling, VA : Earthscan. - 1751-2549 .- 1756-2201. - 9781844073894 ; 2, s. 159-210
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Ahmadi, Zainab, et al.
(författare)
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Agreement of the modified Medical Research Council and New York Heart Association scales for assessing the impact of self-rated breathlessness in cardiopulmonary disease
- 2022
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Ingår i: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The functional impact of breathlessness is assessed using the modified Medical Research Council (mMRC) scale for chronic respiratory disease and with the New York Heart Association Functional Classification (NYHA) scale for heart failure. We evaluated agreement between the scales and their concurrent validity with other clinically relevant patient-reported outcomes in cardiorespiratory disease.Methods: Outpatients with stable chronic respiratory disease or heart failure were recruited. Agreement between the mMRC and NYHA scales was analysed using Cramér's V and Kendall's tau B tests. Concurrent validity was evaluated using correlations with clinically relevant measures of breathlessness, anxiety, depression, and health-related quality of life. Analyses were conducted for all participants and separately in chronic obstructive pulmonary disease (COPD) and heart failure.Results: In a total of 182 participants with cardiorespiratory disease, the agreement between the mMRC and NYHA scales was moderate (Cramér's V: 0.46; Kendall's tau B: 0.57) with similar results for COPD (Cramér's V: 0.46; Kendall's tau B: 0.66) and heart failure (Cramér's V: 0.46; Kendall's tau B: 0.67). In the total population, the scales correlated in similar ways to other patient-reported outcomes.Conclusion: In outpatients with cardiorespiratory disease, the mMRC and NYHA scales show moderate to strong correlations and similar associations with other patient-reported outcomes. This supports that the scales are comparable when assessing the impact of breathlessness on function and patient-reported outcomes.
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| 8. |
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| 9. |
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| 10. |
- Antoniou, Nestoras, et al.
(författare)
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CFD and wind-tunnel analysis of outdoor ventilation in a real compact heterogeneous urban area : evaluation using “air delay”
- 2017
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323 .- 1873-684X. ; 126, s. 355-372
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Tidskriftsartikel (refereegranskat)abstract
- Outdoor urban ventilation in a real complex urban area is investigated by introducing a new ventilation indicator – the "air delay". Computational Fluid Dynamics (CFD) simulations are performed using the 3D steady Reynolds-Averaged Navier-Stokes (RANS) and Large Eddy Simulation (LES) approaches. The up-to-date literature shows the lack of detailed evaluations of the two approaches for real compact urban areas. This study further presents a systematic evaluation of steady RANS and LES for the assessment of the ventilation conditions in a dense district in Nicosia, Cyprus. The ventilation conditions within the urban area are investigated by calculating the distribution of the age of air. To better assess the outdoor ventilation, a new indicator, the "air delay" is introduced as the difference between the local mean age of air at an urban area and that in an empty domain with the same computational settings, allowing the comparison of the results in different parts of the domain, without impact of the boundary conditions. CFD results are validated using wind-tunnel measurements of mean wind speed and turbulence intensity performed for the same urban area. The results show that LES can accurately predict the mean wind speed and turbulence intensity with the average deviations of about 6% and 14%, respectively, from the wind-tunnel measurements while for the steady RANS, these are 8% and 31%, respectively. The steady RANS simulations overestimate the local mean air delay. The deviation between the two approaches is 52% at pedestrian level (2 m).
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| 11. |
- Asplund, Maria, 1978-, et al.
(författare)
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Biocompatibility of PEDOT/biomolecular composites intended for neural communication electrodes
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Annan publikation (populärvet., debatt m.m.)abstract
- Electrodes of the conjugated polymer poly(3,4-ethylene dioxythiophene) (PEDOT) have been shown to possess very attractive electrochemical properties for functional electrical stimulation (FES) or recording in the nervous system. Biomolecules already present in nervous tissue, added as counter ions in PEDOT electropolymerisation, could be a route to further improve the biomaterial properties of PEDOT, eliminating the need of surfactant counter ions like docedyl benzene sulphonate (DBS) or polystyrene sulphonate (PSS) in the polymerisation process. Such PEDOT/biomolecular composites using heparin, or hyaluronic acid, have been electrochemically investigated in a previous study and have been shown to retain the attractive electrochemical properties already proven for PEDOT:PSS. The aim of the present study is to evaluate biocompatibility of these PEDOT/biomolecular composites in vitro and also evaluate PEDOT:heparin biocompatibility in cortical tissue in vivo. Hereby, we also aim to identify a suitable test protocol, that can be used in future evaluations when further material developments are made. Material toxicity was first tested on cell lines, both through a standardised agarose overlay assay on L929 fibroblasts, and through elution tests on human neuroblastoma SH-SY5Y cells. Subsequently, a biocompatibility in vivo test was performed using PEDOT:heparin coated platinum probes implanted in the cerebral cortex of Sprague-Dawley rats. Tissue was collected at three weeks and six weeks of implantation and evaluated by immunohistochemistry. No cytotoxic response was seen to any of the PEDOT:biomolecular composites tested here. Furthermore, elution tests were found to be a practical and effective way of screening materials for toxicity and had a clear advantage over the agarose overlay assay, which was difficult to apply on other cell types than fibroblasts. Elution tests would therefore be recommendable as a screening method, at all stages of material development. In the in vivo tests, the stiffness of the platinum substrate was a significant problem, and extensive glial scarring was seen in most cases irrespective of implant material. However, quantification of immunological response through distance measurements from implant site to closest neuron, and counting of macrophage densities in proximity to polymer surface, was comparable to those of platinum controls. These results indicate that PEDOT:heparin surfaces were as compatible with cortical tissue as pure platinum controls.
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| 12. |
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| 13. |
- Bergenholtz, Gunnar, 1939, et al.
(författare)
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Treatment of pulps in teeth affected by deep caries - A systematic review of the literature.
- 2013
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Ingår i: Singapore dental journal. - : World Scientific Pub Co Pte Lt. - 0377-5291. ; 34:1, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: This systematic review assesses the effect of methods commonly used to manage the pulp in cases of deep caries lesions, and the extent the pulp chamber remains uninfected and does not cause pulpal or periapical inflammatory lesions and associated tooth-ache over time.STUDY DESIGN: An electronic literature search included the databases PubMed, EMBASE, The Cochrane Central Register of Controlled Trials and Cochrane Reviews from January 1950 to March 2013. In addition, hand searches were carried out. Two reviewers independently evaluated abstracts and full-text articles. An article was read in full if at least one of the two reviewers considered the abstract potentially relevant. Altogether, 161 articles were read in full text. Of these, 24 studies fulfilled established inclusion criteria. Based on studies of at least moderate quality, the quality of evidence of each procedure was rated in four levels according to GRADE.RESULTS: No study reached the high quality level. Twelve were of moderate quality. The overall evidence was insufficient to assess which of indirect pulp capping, stepwise excavation, direct excavation and pulp capping/partial pulpotomy, pulpotomy or pulpectomy is the most effective treatment approach for teeth with deep caries.CONCLUSIONS: Because of the lack of good studies it is not possible to determine whether an injured pulp by deep caries can be maintained or whether it should be removed and replaced with a root canal filling. Both randomized studies and prospective observational studies are needed to investigate whether a pulp exposed to deep caries is best treated by measures intended to preserve it or by pulpectomy and root filling.
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| 14. |
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| 15. |
- Blomqvist, Lars, 1962-
(författare)
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Laminated Veneer Products : Shape Stability and Effect of Enhanced Formability on Bond-Line Strength
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis concerns two aspects of the manufacture of laminated veneer products (LVPs). The first aspect is related to the possible improvement of the shape stability of LVPs, and the second has its starting point in the modification of the veneer for enhanced formability as well as the question of whether and how these modifications affect the bond-line strength.LVPs are veneers bonded with adhesive into predetermined shapes, mostly for the production of furniture and interior fittings. Since any deviation from the intended shape is a problem for both manufacturer and customer, various studies have sought to evaluate the influence of different materials and process parameters on shape stability. Parameters studied have included wood species (beech and birch), an adhesive system based on urea formaldehyde, the adhesive distribution on the veneer, climate, moisture content and fibre orientations of the veneers, as well as the orientation of the individual veneers in a multiply.Manufacturers of LVPs must consider some basic facts about wood in orders adequately to provide shape-stable LVPs to customers. Wood emits and absorbs moisture in relation to the surrounding climate, and this can lead to shrinkage and swelling. Such moisture induced movements differ in the wood’s different directions, and the magnitude is specific for the species. A thorough understanding of this is the basis for achieving shape-stable LVPs.Symmetry is defined in this thesis such that the veneer properties are balanced in the laminate. This means that opposite veneers on either side of the centre veneer have similar characteristic. An LVP will become distorted if the veneers are asymmetrically oriented before the press. Deviation from the desired shape can be small immediately after the pressing, but it may increase significantly with moisture content (MC) variations. Asymmetry may result when veneers with different fibre orientations are included in the laminate or when the veneers are placed asymmetrically. It may also occur if veneers with different MCs are bonded together asymmetrically. One aggravating factor is that the lathe checks that are introduced when the veneers are peeled or sliced from the log affect the shape stability. In 3-ply crosswise-oriented plywood, the veneer surfaces on which the lathe checks occur should be oriented in the same way for high shape stability.Based on existing knowledge, the production of shape-stable LVPs requires that the veneers are conditioned to a uniform MC and sorted with regard to fibre orientation and the side with lathe checks before bonding. End-user climates should govern the MC of the veneers and the moisture added with the adhesive during the process. Straight-grain veneers and symmetry should always be the goal.Moulding can cause stretching, i.e. strain, of the veneers depending on the curvature of the mould. To prevent the veneers from rupture, there are various ways to strengthen the veneers particularly in the transverse direction in which the veneer is weakest. However, tests have shown that these pre-treatments of veneers for enhanced formability can prevent the adhesive from penetrating the wood surface. It is therefore important to confirm that the pre-treatment does not affect the bond-line strength.
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| 16. |
- Bonagas, Nadilly, et al.
(författare)
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
- 2022
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Ingår i: NATURE CANCER. - : Springer Science and Business Media LLC. - 2662-1347. ; 3:2, s. 156-
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Tidskriftsartikel (refereegranskat)abstract
- The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to identify potent and selective nanomolar MTHFD2 inhibitors; protein cocrystal structures demonstrated binding to the active site of MTHFD2 and target engagement. MTHFD2 inhibitors reduced replication fork speed and induced replication stress followed by S-phase arrest and apoptosis of acute myeloid leukemia cells in vitro and in vivo, with a therapeutic window spanning four orders of magnitude compared with nontumorigenic cells. Mechanistically, MTHFD2 inhibitors prevented thymidine production leading to misincorporation of uracil into DNA and replication stress. Overall, these results demonstrate a functional link between MTHFD2-dependent cancer metabolism and replication stress that can be exploited therapeutically with this new class of inhibitors. Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.
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| 17. |
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| 18. |
- Buccolieri, Riccardo, et al.
(författare)
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Direct measurements of the drag force over aligned arrays of cubes exposed to boundary-layer flows
- 2017
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Ingår i: Environmental Fluid Mechanics. - : Springer Science and Business Media LLC. - 1567-7419 .- 1573-1510. ; 17:2, s. 373-394
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Tidskriftsartikel (refereegranskat)abstract
- Wind tunnel measurements of the total drag force for aligned arrays of cubes exposed to two different boundary-layer flows at three flow velocities are discussed. The drag force for eight different building packing densities λp (from 0.028 to 1) is measured with a standard load cell generating a novel dataset. Different λp are reproduced by increasing the number of buildings on the same lot area; this represents a real situation that an urban planner is faced with when a lot area of a given (fixed) size is allocated to the development of new built areas. It is assumed that the surrounding terrain is uniform and there is a transition from a given roughness (smooth) to a new roughness (rough). The approaching flow will adjust itself over the new surface within a distance that in general may be larger than the horizontal length covered by the array. We investigate the region where the flow adjustment occurs. The wide range of packing densities allowed us to analyse in detail the evolution of the drag force. The drag force increases with increasing packing densities until it reaches a maximum at an intermediate packing density (λp = 0.25 in our case) followed by a slight decrease at larger packing densities. The value of the drag force depends on the flow adjustment along the array which is evaluated by introducing the parameter “drag area” to retrieve information about the drag distribution at different λp. Results clearly suggest a change of the distribution of the drag force, which is found to be relatively uniform at low packing densities, while most of the force acts on first rows of the arrays at large packing densities. The drag area constitutes the basis for the formulation of a new adjustment length scale defined as the ratio between the volume of the air within the array and the drag area. The proposed adjustment length scale automatically takes into account the change in drag distribution along the array for a better parameterization of urban effects in dispersion models.
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| 19. |
- Buccolieri, Riccardo, et al.
(författare)
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Drag force rose representing the interaction between urban geometries and wind
- 2021
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Ingår i: 15th ROOMVENT (Roomvent 2020) virtual conference. - 9788894612301 ; , s. 85-88
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Konferensbidrag (refereegranskat)abstract
- The drag force generated by aligned arrays of cubes of different packing density and exposed to different wind directions in a wind tunnel is discussed. Results allowed to build a drag force rose which shows that the drag force increases with increasing packing density till λp = 0.25 for any wind direction. It is also shown that, independent of the packing density, the drag force increases with increases deviation of WD from the perpendicularity.
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| 20. |
- Buccolieri, R., et al.
(författare)
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Flow and pollutant dispersion within the canal grande channel in venice (Italy) via CFD techniques
- 2010
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Ingår i: HARMO 2010 - Proceedings of the 13th International Conference on Harmonisation within Atmospheric Dispersion Modelling for Regulatory Purposes. ; , s. 760-764
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Konferensbidrag (refereegranskat)abstract
- The present paper is aimed at the analysis of flow and pollutant dispersion in a portion of the Canal Grande (Grand Canal) in Venice (Italy) by means of both Computational Fluid Dynamics (CFD) FLUENT simulations and wind tunnel experiments performed at the University of Gävle (Sweden). For this application, Canal Grande can be viewed as a sort of street canyon where the bottom surface is water and bus boat emissions are the major source of pollution. Numerical investigations were made to assess the effect of the water surface on air flow and pollutant concentrations in the atmosphere. One of the challenges has been to deal with the interface between two immiscible fluids which requires ad-hoc treatment of the wall in terms of the numerical scheme adopted and the grid definition which needs to be much finer than in typical numerical airflow simulations in urban street canyons. Preliminary results have shown that the presence of water at the bottom of the street canyon modifies airflow and turbulence structure with direct consequences on concentration distribution within the domain.
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| 21. |
- Buccolieri, R., et al.
(författare)
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On the drag force distribution over arrays of cubical buildings : Wind tunnel experiments
- 2017
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Ingår i: HARMO 2017 - 18th International Conference on Harmonisation within Atmospheric Dispersion Modelling for Regulatory Purposes, Proceedings. - : Hungarian Meteorological Service. ; , s. 384-388
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Konferensbidrag (refereegranskat)abstract
- In this paper we discuss the distribution of drag force along aligned arrays of cubes of different packing density. The distribution is evaluated via wind tunnel measurements performed on individual cubes located along the middle column of the array using a balance provided by a standard load cell. Results are compared with the drag force estimated by a pressure-derived method and clearly show a change of the distribution of the drag force. The force is uniform at low packing densities, while mostly acting on first rows of the arrays at large packing densities. This work leaves room for research tailored to a better parameterization of urban effects in dispersion models.
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| 22. |
- Buccolieri, Riccardo, et al.
(författare)
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The drag force distribution within regular arrays of cubes and its relation to cross ventilation – Theoretical and experimental analyses
- 2019
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Ingår i: Journal of Wind Engineering and Industrial Aerodynamics. - : Elsevier. - 0167-6105 .- 1872-8197. ; 189, s. 91-103
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Tidskriftsartikel (refereegranskat)abstract
- A novel set of wind tunnel measurements of the drag force and its spatial distribution along aligned arrays of cubes of height H and planar area index λ p (air gap between cubes) equal to 0.028 (5H) to 0.69 (0.2H) is presented and analysed. Two different types of measurements are compared: one type where the drag force is obtained using the standard load cell method, another type where the drag force is estimated by measuring the pressure difference between windward and the leeward façades. Results show that the drag force is nearly uniformly distributed for lower λ p (0.028 and 0.0625), it decreases up to 50% at the second row for λ p = 0.11, and it sharply decreases for larger λ p (from 0.25 to 0.69) where the force mostly acts on the first row. It follows that for the lowest λ p the drag force typically formulated as a drag area corresponds to the total frontal area of the array, whereas for large λ p the drag area corresponds to the area of the first row. By assessing the driving pressure for ventilation from the drag force, the analysis is extended to estimate the cross ventilation as an example of application of this type of measurements.
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| 23. |
- Bächle, Susanna M., et al.
(författare)
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Elevated levels of iNKT cell and NK cell activation correlate with disease progression in HIV-1 and HIV-2 infections
- 2016
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Ingår i: AIDS. - 0269-9370. ; 30:11, s. 1713-1722
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:: In this study we aimed to investigate the frequency and activation of invariant natural killer T (iNKT) cells and natural killer (NK) cells among HIV-1, HIV-2, or dually HIV-1/HIV-2 (HIV-D)-infected individuals, in relation to markers of disease progression. DESIGN:: Whole blood samples were collected from treatment-naïve HIV-1 (n?=?23), HIV-2 (n?=?34) and HIV-D (n?=?11) infected individuals, as well as HIV-seronegative controls (n?=?25), belonging to an occupational cohort in Guinea-Bissau. METHODS:: Frequencies and activation levels of iNKT and NK cell subsets were analysed using multi-colour flow cytometry and results were related to HIV-status, CD4+ T cell levels, viral load, and T cell activation. RESULTS:: HIV-1, HIV-D, and viremic HIV-2 individuals had lower numbers of CD4+ iNKT cells in circulation compared to seronegative controls. Numbers of CD56 NK cells were also reduced in HIV-infected individuals as compared to control subjects. Notably, iNKT cell and NK cell activation levels, assessed by CD38 expression, were increased in HIV-1 and HIV-2 single, as well as dual, infections. HIV-2 viremia was associated with elevated activation levels in CD4+ iNKT cells, CD56 and CD56 NK cells, as compared to aviremic HIV-2 infection. Additionally, disease markers such as CD4+ T cell percentages, viral load, and CD4+ T cell activation were associated with CD38 expression levels of both iNKT and NK cells, which activation levels also correlated with each other. CONCLUSIONS:: Our data indicate that elevated levels of iNKT cell and NK cell activation are associated with viremia and disease progression markers in both HIV-1 and HIV-2 infections.
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| 24. |
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| 25. |
- Carsten, Hobohm, et al.
(författare)
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Land Use Change and the Future of Biodiversity
- 2021
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Ingår i: Perspectives for Biodiversity and Ecosystems. - Cham : Springer. - 2214-2827 .- 2214-2835. - 9783030577094 ; , s. 451-483
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This synthesis report is a meta-analysis of perspectives for biodiversity and ecosystems, with a strong focus on human impacts on the environment, and a work order to enable and manage the protection, survival and evolution of all species on Earth. The goal is to protect nature without any further species loss (Zero Extinction). With this report, we assess alarming signals from the environment; determine the needs of threatened biota and the required actions to manage and protect landscapes and ecosystems; and identify some inescapable tendencies, challenges but also possibilities. The story of humans on Earth is at a critical juncture. Human behaviour is inherently dependent on physical and societal relations, including orientation and positioning within the physical environment. There is no single cultural benefit that is independent of provisioning through ecosystem services. Humans are part of the environment, acquire all needs from it and, as such, depend on its integrity and management for life and well-being. Moreover, if human impacts to the environment continue to increase the risk of rebound effects impacting human life and health will increase as well. Whenever a biome, ecosystem, habitat or species is heavily impacted or threatened with irreversible transformation or extinction, prevailing environmental conditions are relevant and should be observed, analysed and remedied as necessary and where possible. Ecology examines the evolutionary, historical and more recent interplay between biological life and the abiotic environment, while the role of social science and the humanities is to question the physical and social landscape, and how and why it should be protected or influenced, e.g. by nature conservation measures under political and economic, ethical and legal considerations. Thus, for all inter-relationships between natural and sociocultural processes, a joint venture in the form of social-ecological thinking is necessary to combine natural sciences and the humanities. With this contribution, we combine ecological knowledge with social science knowledge (s.l.) through the participation of scientists of many different disciplines. We analyse history and current processes to assess risks, threats and possibilities, and call for an array of regulations and measures that can contribute to halting of biodiversity loss and that assist in achieving a sustainable future. Regulations comprise creativity, cultural incentives, social norms, environmental education and economic investments—such as payments for sustainable agriculture, forestry, and fishery; investments in water, soil and air purity; and much clearer and stronger legal restrictions and consequences around waste streams and environmental degradation. Moreover, a gradual change from profit-oriented economies in the short-run to environmentally-sensitive policies that include systematic environmental programmes in the long term might help to decrease pressure on ecosystems and biota. Such economics might also include the real costs of consumerism, including the impacts of particular products on the environment and on human health. The greatest hurdle for the continued existence of many critically endangered species is the impact of widespread anthropogenic-driven change in the usage of water, air and land, and industry intensification in agriculture, aquaculture, forestry, urbanisation, transportation and mining sectors. However, there is not one simple solution to solve these issues. We conclude that many of the current developments have to be adjusted or gradually altered in a step-wise manner, especially with respect to existing sociocultural behaviours. Therefore, various concepts, decisions and measures should be discussed and implemented at all scales from local to supranational and among researchers, practitioners and politicians.
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| 26. |
- Cehlin, Mathias, Doktor, 1974-, et al.
(författare)
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Urban Morphology and City Ventilation
- 2020
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Konferensbidrag (refereegranskat)abstract
- The purpose of the paper is to examine the relation between urban morphology, wind direction and air flow rates. In the study a highly idealized city model was used consisting of a circular block divided into two or four equally large sectors. Wind tunnel experiments and CFD predictions have been conducted. The interaction between the atmospheric boundary layer and a city is considered to be both a function of the overall shape and the internal resistance to the flow caused by the friction when the wind flows over the urban surfaces. Flow along the streets is generated by pressure differences. In the wind tunnel, velocity measurements have been recorded in the streets at several points and pressure on the ground was registered in 400 points. The wind tunnel measurements were used to validate the CFD model. The CFD predictions provided complete flow and pressure fields for different configurations and wind directions. The flow balance is presented considering both the horizontal air flow and the vertical air flow (subsidence and updraft). Special attention was on the pressure distribution at ground level (pressure footprint), which is believed to provide valuable information that can be used for qualitative city ventilation analyses.
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| 27. |
- Chen, DeJiu, et al.
(författare)
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DySCAS System Architecture
- 2007
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Rapport (refereegranskat)abstract
- This deliverable provides an architectural strategy and overall system design forthe DySCAS middleware system as a first step towards a complete systemspecification. The DySCAS Basic Architecture captures both the systemconceptualization and an initial function-level outline without consideringimplementation and technology details. It defines the middleware system in termsof its application and operational contexts, expected features, middleware servicesthat group functions, behaviours, as well as the structuring and implementationdecisions that are most crucial to satisfy the given set of requirements. In thisdocument, we also outline some fundamental strategies for binding themiddleware components to the target platforms and infrastructures and forhandling potential errors at both initialization-time and rum-time, while taking thetechnology support and domain needs into consideration.This deliverable also covers the rationale behind the architecture solutions andprovides a generic framework that relates architecture principles and styles, wellknownmechanisms, and reference models to the expected functionalities andqualities of DySCAS. The aim is to consolidate the proposed solutions and also tofacilitate the communications between DySCAS partners and to third-parties.
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| 28. |
- Chen, DeJiu, et al.
(författare)
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Integrated safety and architecture modeling for automotive embedded systems
- 2011
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Ingår i: Elektrotechnik und Informationstechnik. - : Springer. - 0932-383X .- 1613-7620. ; 128:6, s. 196-202
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Tidskriftsartikel (refereegranskat)abstract
- EAST-ADL is an architecture description language (ADL) for model-based development of automotive embedded systems.The formalization of domain-specific engineering information and methodology brings a potential for a wide range of benefitsfor information management, system design and integration, tool interaction, documentation and communication. This paper describesthe EAST-ADL language support for safety requirements, faults/failures, hazards and safety constraints in the context of ISO/DIS 26262reference safety lifecycle. Based on the language support, the safety related information can be derived and managed seamlessly alongwith its target nominal system architecture model with multiple abstraction levels and view extensions. Through model transformationand tool integration, automated safety analysis is allowed.
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| 29. |
- Chen, Lan, et al.
(författare)
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The impacts of building height variations and building packing densities on flow adjustment and city breathability in idealized urban models
- 2017
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323 .- 1873-684X. ; 118, s. 344-361
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Tidskriftsartikel (refereegranskat)abstract
- Improving city breathability has been confirmed as one feasible measure to improve pollutant dilution in the urban canopy layer (UCL). Building height variability enhances vertical mixing, but its impacts remain not completely explored. Therefore, both wind tunnel experiments and computational fluid dynamic (CFD) simulations are used to investigate the effect of building height variations (six height standard deviations σH = 0%–77.8%) associated to building packing densities namely λp/λf = 0.25/0.375 (medium-density) and 0.44/0.67 (compact) on city breathability. Two bulk variables (i.e. the in-canopy velocity (UC) and exchange velocity (UE)) are adopted to quantify the horizontal and vertical city breathability respectively, which are normalized by the reference velocity (Uref) in the free flow, typically set at z = 2.5H0 where H0 is the mean building height. Both flow quantities and city breathability experience a flow adjustment process, then reach a balance. The adjustment distance is at least three times longer than four rows documented in previous literature. The medium-density arrays experience much larger UC and UE than the compact ones. UE is found mainly induced by vertical turbulent fluxes, instead of vertical mean flows. In height-variation cases, taller buildings experience larger drag force and city breathability than lower buildings and those in uniform-height cases. For medium-density and compact models with uniform height, the balanced UC/Uref are 0.124 and 0.105 respectively, moreover the balanced UE/Uref are 0.0078 and 0.0065. In contrast, the average UC/Uref in height-variation cases are larger (115.3%–139.5% and 125.7%–141.9% of uniform-height cases) but UE/Uref are smaller (74.4%–79.5% and 61.5%–86.2% of uniform-height cases) for medium-density and compact models.
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| 30. |
- Cuapio, Angelica, et al.
(författare)
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NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals
- 2022
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Ingår i: Molecular Medicine. - : BioMed Central (BMC). - 1076-1551 .- 1528-3658. ; 28:1
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Tidskriftsartikel (refereegranskat)abstract
- Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies have assessed the effects on innate immune cells. Here, we characterized NK cells in healthy individuals and immunocompromised patients in the course of an anti-SARS-CoV-2 BNT162b2 mRNA prospective, open-label clinical vaccine trial. See trial registration description in notes. Results revealed preserved NK cell numbers, frequencies, subsets, phenotypes, and function as assessed through consecutive peripheral blood samplings at 0, 10, 21, and 35 days following vaccination. A positive correlation was observed between the frequency of NKG2C+ NK cells at baseline (Day 0) and anti-SARS-CoV-2 Ab titers following BNT162b2 mRNA vaccination at Day 35. The present results provide basic insights in regards to NK cells in the context of mRNA vaccination, and have relevance for future mRNA-based vaccinations against COVID-19, other viral infections, and cancer.Trial registration: The current study is based on clinical material from the COVAXID open-label, non-randomized prospective clinical trial registered at EudraCT and clinicaltrials.gov (no. 2021–000175-37). Description: https://clinicaltrials.gov/ct2/show/NCT04780659?term=2021-000175-37&draw=2&rank=1.
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| 31. |
- Ekström, Magnus, et al.
(författare)
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Minimal clinically important differences for Dyspnea-12 and MDP scores are similar at 2 weeks and 6 months : follow-up of a longitudinal clinical study
- 2021
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 57:3
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Tidskriftsartikel (refereegranskat)abstract
- Chronic breathlessness is a dominating symptom that restricts daily life for many people with cardiorespiratory disease [1]. Different dimensions of the symptom, such as the intensity, sensory qualities and emotional responses, can be assessed using the instruments Dyspnea-12 (D-12) [2] and the Multidimensional Dyspnea Profile (MDP) [3], which share similarities in the underlying constructs of what is measured [4] and have emerged as widely used instruments for multi-dimensional measurement of breathlessness
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| 32. |
- Ekström, Magnus P., et al.
(författare)
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Minimal Clinically Important Differences and Feasibility of Dyspnea-12 and the Multidimensional Dyspnea Profile in Cardiorespiratory Disease
- 2020
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Ingår i: Journal of Pain and Symptom Management. - : Elsevier. - 0885-3924 .- 1873-6513. ; 60:5, s. 968-975
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Tidskriftsartikel (refereegranskat)abstract
- Context: Breathlessness is a cardinal symptom in cardiorespiratory disease and consists of multiple dimensions that can be measured using the instruments Dyspnea-12 (D12) and the Multidimensional Dyspnea Profile (MDP). Objectives: The objective of the study is to determine the minimal clinically important differences (MCIDs) of all D12 and MDP summary and subdomain scores as well as the instruments' feasibility in patients with cardiorespiratory disease. Methods: Prospective multicenter cohort study of outpatients with diagnosed cardiorespiratory disease and breathlessness in daily life. D12 and MDP were assessed at baseline, after 30-90 minutes and two weeks. MCIDs were calculated using anchor-based and distributional methods for summary and subdomain scores. Feasibility was assessed as rate of missing data, help required, self-reported difficulty, and completion time. Results: A total 182 outpatients (53.3% women) were included; main diagnoses were chronic obstructive pulmonary disease (COPD; 25%), asthma (21%), heart failure (19%), and idiopathic pulmonary fibrosis (19%). Anchor-based MCIDs were for D12 total score 2.83 (95% CI 1.99-3.66); D12 physical 1.81 (1.29-2.34); D12 affective 1.07 (0.64-1.49); MDP A1 unpleasantness 0.82 (0.56-1.08); MDP perception 4.63 (3.21-6.05), and MDP emotional score 2.37 (1.10-3.64). The estimates were consistent with small-to-moderate effect sizes using distributional analysis, and MCIDs were similar between COPD and non-COPD patients. The instruments were generally feasible and quick to use. Conclusion: D12 and MDP are responsive to change and feasible for use for assessing multidimensional breathlessness in outpatients with cardiorespiratory disease. MCIDs were determined for use as endpoints in clinical trials.
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| 33. |
- Ekström, Magnus, et al.
(författare)
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Validation of the Swedish Multidimensional Dyspnea Profile (MDP) in outpatients with cardiorespiratory disease
- 2019
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Ingår i: BMJ Open Respiratory Research. - : BMJ. - 2052-4439. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Breathlessness is a cardinal symptom in cardiorespiratory disease. An instrument for measuring different aspects of breathlessness was recently developed, the Multidimensional Dyspnea Profile (MDP). This study aimed to validate the MDP in terms of the underlying factor structure, internal consistency, test-retest reliability and concurrent validity in Swedish outpatients with cardiorespiratory disease. Methods Outpatients with stable cardiorespiratory disease and breathlessness in daily life were recruited. Factor structure of MDP was analysed using confirmatory factor analysis; internal consistency was analysed using Cronbach's alpha; and test-retest reliability was analysed using intraclass correlation coefficients (ICCs) for patients with unchanged breathlessness between assessments (baseline, after 30-90 min and 2 weeks). Concurrent validity was evaluated using correlations with validated scales of breathlessness, anxiety, depression and health-related quality of life. Results In total, 182 outpatients with cardiorespiratory disease and breathlessness in daily life were included; 53.3% were women; main diagnoses were chronic obstructive pulmonary disease (24.7%), asthma (21.4%), heart failure (19.2%) and idiopathic pulmonary fibrosis (18.7%). The MDP total, immediate perception and emotional response scores, and individual item scores showed expected factor structure and acceptable measurement properties: internal consistency (Cronbach's alpha, range 0.80-0.93); test-retest reliability at 30-90 min and 2 weeks (ICC, range 0.67-0.91); and concurrent validity. There was no evidence of a learning effect. Findings were similar between diagnoses. Discussion MDP is a valid instrument for multidimensional measurement of breathlessness in Swedish outpatients across cardiorespiratory diseases.
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| 34. |
- Engholm, Magnus, et al.
(författare)
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A bio-compatible fiber optic pH sensor based on a thin core interferometric technique
- 2019
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Ingår i: Photonics. - : MDPI AG. - 2304-6732. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- There is an increasing demand for compact, reliable and versatile sensor concepts for pH-level monitoring within several industrial, chemical as well as bio-medical applications. Many pH sensors concepts have been proposed, however, there is still a need for improved sensor solutions with respect to reliability, durability and miniaturization but also for multiparameter sensing. Here we present a conceptual verification, which includes theoretical simulations as well as experimental evaluation of a fiber optic pH-sensor based on a bio-compatible pH sensitive material not previously used in this context. The fiber optic sensor is based on a Mach-Zehnder interferometric technique, where the pH sensitive material is coated on a short, typically 20-25 mm thin core fiber spliced between two standard single mode fibers. The working principle of the sensor is simulated by using COMSOL Multiphysics. The simulations are used as a guideline for the construction of the sensors that have been experimentally evaluated in different liquids with pH ranging from 1.95 to 11.89. The results are promising, showing the potential for the development of bio-compatible fiber optic pH sensor with short response time, high sensitivity and broad measurement range. The developed sensor concept can find future use in many medical- or bio-chemical applications as well as in environmental monitoring of large areas. Challenges encountered during the sensor development due to variation in the design parameters are discussed. © 2019 by the authors.
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| 35. |
- Frisk, Fredrik, 1971, et al.
(författare)
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Pulp exposures in adults--choice of treatment among Swedish dentists.
- 2013
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Ingår i: Swedish dental journal. - : Sveriges tandläkarförbund. - 0347-9994. ; 37:3, s. 153-60
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Tidskriftsartikel (refereegranskat)abstract
- This study comprises a survey of Swedish dentists'treatment preferences in cases of carious exposure of the dental pulp in adults.The survey was conducted as part of a comprehensive report on methods of diagnosis and treatment in endodontics, published in 2010 by the Swedish Council on Health Technology Assessment. A questionnaire was mailed to a random subsample of 2012 dental offices where one dentist at each office was requested to answer all questions. Each questionnaire contained one of three sets of questions about endodontic practice routines.Thus around one-third of the subsample received case-specific questions about treating carious exposure. Only general practitioners aged below 70 years were included.The final study sample comprised 412 participants.The dentists were presented with two case scenarios. In Case 1 a 22-year old patient had a deep carious lesion in tooth 36 and in Case 2 a 50-year old patient had a deep carious lesion in tooth 14.The participants were asked to nominate their treatment of choice: pulp capping, partial pulpotomy or pulpectomy. For Case 1, 17 per cent of the respondents selected pulpectomy; the corresponding rate for Case 2 was 47 per cent. Female gender and age group 25-49 years were predictive of selection of less invasive treatment options. However, according to recent guidelines (2011) from the National Board of Health and Wellfare, Swedish dentists are recommended to elect pulpectomy prior to pulp capping/partial pulpotomy when confronted with a tooth having a cariously exposed pulp in adults.
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| 36. |
- Fritzell, Peter, et al.
(författare)
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Cost-effectiveness of lumbar fusion and nonsurgical treatment for chronic low back pain in the Swedish lumbar spine study : A multicenter, randomized, controlled trial from the Swedish Lumbar Spine Study Group
- 2004
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Ingår i: Spine. - : Lippincott Williams & Wilkins. - 0362-2436 .- 1528-1159. ; 29:4, s. 421-434
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Tidskriftsartikel (refereegranskat)abstract
- Study Design. A cost-effectiveness study was performed from the societal and health care perspectives. Objective. To evaluate the costs-effectiveness of lumbar fusion for chronic low back pain (CLBP) during a 2-year follow-up. Summary of Background Data. A full economic evaluation comparing costs related to treatment effects in patients with CLBP is lacking. Patients and Methods. A total of 284 of 294 patients with CLBP for at least 2 years were randomized to either lumbar fusion or a nonsurgical control group. Costs for the health care sector ( direct costs), and costs associated with production losses ( indirect costs) were calculated. Societal total costs were identified as the sum of direct and indirect costs. Treatment effects were measured using patient global assessment of improvement, back pain ( VAS), functional disability (Owestry), and return to work. Results. The societal total cost per patient ( standard deviations) in the surgical group was significantly higher than in the nonsurgical group: Swedish kroner (SEK) 704,000 ( 254,000) vs. SEK 636,000 ( 208,000). The cost per patient for the health care sector was significantly higher for the surgical group, SEK 123,000 ( 60,100) vs. 65,200 ( 38,400) for the control group. All treatment effects were significantly better after surgery. The incremental cost-effectiveness ratio ( ICER), illustrating the extra cost per extra effect unit gained by using fusion instead of nonsurgical treatment, were for improvement: SEK 2,600 ( 600 - 5,900), for back pain: SEK 5,200 ( 1,100 - 11,500), for Oswestry: SEK 11,300 ( 1,200 - 48,000), and for return to work: SEK 4,100 ( 100 21,400). Conclusion. For both the society and the health care sectors, the 2-year costs for lumbar fusion was significantly higher compared with nonsurgical treatment but all treatment effects were significantly in favor of surgery. The probability of lumbar fusion being cost-effective increased with the value put on extra effect units gained by using surgery.
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| 37. |
- Gao, Yu, et al.
(författare)
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Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
- 2022
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Ingår i: Immunity. - : Elsevier. - 1074-7613 .- 1097-4180. ; 55:9, s. 1732-1746.e5
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Tidskriftsartikel (refereegranskat)abstract
- Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies. Impaired vaccine-induced cell-mediated immunity was observed in many immunocompromised patients, particularly in solid-organ transplant and chronic lymphocytic leukemia patients. Notably, individuals with an inherited lack of mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed highly functional spike-specific T cell responses. Single-cell RNA-sequencing further revealed that mRNA vaccination induced a broad functional spectrum of spike-specific CD4+ and CD8+ T cells in healthy individuals and patients with XLA. These responses were founded on polyclonal repertoires of CD4+ T cells and robust expansions of oligoclonal effector-memory CD45RA+ CD8+ T cells with stem-like characteristics. Collectively, our data provide the functional continuum of SARS-CoV-2-specific T cell responses post-mRNA vaccination, highlighting that cell-mediated immunity is of variable functional quality across immunodeficiency syndromes.
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| 38. |
- Hammarling, Krister, 1968-, et al.
(författare)
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Broad-range hydrogel-based pH sensor with capacitive readout manufactured on a flexible substrate
- 2018
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Ingår i: Chemosensors. - Basel, Switzerland : MDPI AG. - 2227-9040. ; 6:3
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Tidskriftsartikel (refereegranskat)abstract
- Environmental monitoring of land, water and air, is an area receiving greater attention because of human health and safety concerns. Monitoring the type of pollution and concentration levels is vital, so that appropriate contingency plans can be determined. To effectively monitor the environment, there is a need for new sensors and sensor systems that suits these type of measurements. However, the diversity of sensors suitable for low, battery powered- and large area sensor systems are limited. We have manufactured and characterized a flexible pH sensor using laser processing and blade coating techniques that is able to measure pH between 2.94 and 11.80. The sensor consists of an interdigital capacitance with a pH sensitive hydrogel coating. Thin sensors can reach 95% of their final value value within 3 min, and are stable after 4 min. Good repeatability was achieved in regard to cycling of the sensor with different pH and multiple measurements from dry state. We have also studied the relation between an interdigital capacitance penetration depth and hydrogels expansion. We believe that our passive sensor is suitable to be used in low power and large area sensor networks.
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| 39. |
- Hammarling, Krister, 1968-, et al.
(författare)
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Synthesis, Curing Behavior and Swell Tests of pH-Responsive Coatings from Acryl-Terminated Oligo(beta-Amino Esters)
- 2018
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Ingår i: CHEMOSENSORS. - : MDPI AG. - 2227-9040. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- The ability of acryl-terminated oligo(beta-amino esters) (AOBAE) to be coated on fibers and printed electronics without solvents and to be cross-linked to a pH-responsive coatings, makes AOBAE-based coatings a potential type of pH-sensor coating. However, there are currently no reports of AOBAEs used as a pH-responsive coating material in sensor applications. Here we present an investigation of the synthesis, curing behavior and swell tests of AOBAEs. AOBAEs were synthesized from reacting an excess of asymmetric diacrylates with piperazine without the use of any solvents. They were then cross-linked to an insoluble network by UV-curing. Nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) spectroscopy were used to characterize the AOBAEs. NMR was used to clarify the irregular structure of the AOBAE. FTIR was used to monitor the effects of UV-curing dose and air exposure on monomer conversion during curing. An interferometric technique was used to monitor the swelling behavior of the coating in response to pH variations. Swell experiments showed that the AOBAE also responded to pH variations after polymerization. Therefore, AOBAE is an interesting class of material with potential use as a pH responsive coating in optical-and printed electronics pH-sensors applications.
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| 40. |
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| 41. |
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| 42. |
- Hilmersson, Mikael, 1981-, et al.
(författare)
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Experiential knowledge profiles in internationalizing SMEs : The ability to sustain market positions in the new turbulent era of global business
- 2011
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Ingår i: Entrepreneurship in the Global Firm. - : Emerald Group Publishing Limited. - 9781780521145 ; , s. 77-96
-
Bokkapitel (refereegranskat)abstract
- Purpose – This study sets out to establish experiential knowledge profiles of small- and medium-sized enterprises (SMEs) entering emerging markets and to examine how the different abilities contained in these profiles impact the sustainability of market positions in the new turbulent era of global business.Methodology – We analyse a sample of 203 entries into emerging markets by Swedish SMEs. The data collected on site at all sample firms is analysed in two sequential stages. First, an exploratory factor analysis is performed to derive four types of experiential knowledge. Second, a cluster analysis is performed to establish experiential knowledge profiles among the entering SMEs.Findings – The result of the analysis shows that experiential knowledge is a multi-dimensional construct consisting of four main types. Moreover, emerging market entering SMEs are shown to develop different knowledge profiles. We suggest that Masters are well prepared for such periods. Learners most probably will experience high levels of uncertainty, whereas Country and Customer Experts face less uncertainty due to their specialisation on either host market or customer knowledge.Originality – The chapter shows that the experiential knowledge base of emerging market entering SMEs is an important indicator of the readiness for turbulent times. Firms will be able to sustain market positions differently depending on which type of knowledge profile they belong to.
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| 43. |
- Hindér, Gustav, et al.
(författare)
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On Ski–Snow Contact Mechanics During the Double Poling Cycle in Cross-Country Skiing
- 2024
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Ingår i: Tribology letters. - : Springer. - 1023-8883 .- 1573-2711. ; 72:2
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Tidskriftsartikel (refereegranskat)abstract
- Of the medals awarded during the Winter Olympics Games, most are awarded for sports involving cross-country (XC) skiing. The Double Poling (DP) technique, which is one of the sub-techniques used most frequently in XC skiing, has not yet been studied using simulations of the ski–snow contact mechanics. This work introduces a novel method for analysing how changes in the distribution of pressure on the sole of the foot (Plantar Pressure Distribution or PPD) during the DP motion affect the contact between the ski and the snow. The PPD recorded as the athlete performed DP, along with an Artificial Neural Network trained to predict the geometry of the ski (ski-camber profile), were used as input data for a solver based on the boundary element method, which models the interaction between the ski and the snow. This solver provides insights into how the area of contact and the distribution of pressure on the ski-snow interface change over time. The results reveal that variations in PPD, the type of ski, and the stiffness of the snow all have a significant impact on the contact between the ski and the snow. This information can be used to improve the Double Poling technique and make better choices of skis for specific snow conditions, ultimately leading to improved performance.
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| 44. |
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| 45. |
- Holmberg, Hans, 1963-, et al.
(författare)
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Kvistars frekvens, form och beskaffenhet i trekantprofil av furu (Pinus silvestris L) och gran (Picea abies Karst).
- 1995
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Frequency and Character of Knots in Triangular Profiles of Pine (Pinus silvestris L) and Spruce (Picea abies Karst).byHansHolmberg Dick SandbergAbstractThis report describes the structure and amount of knots in triangular profiles from StarSawing of pine (Pinus silvestris L) and spruce (Picea abies Karst). The yield of blanks is determined mainly with a defined knot structure and the fibre aberration around knots. In addition a minor investigation of the amount of pitch pockets has been carried out.The specimens comprise of butt logs from three different areas in Sweden. The specimens are taken from normal grown pine, and both normal and fast grown spruce.Large amounts of the knots found in triangular profiles from butt logs are unacceptable for further refinement. Thus, the knots have to be removed. When producing blanks free from knots there is a volume decrease of 8 and 21 percent in average for pine and spruce respectively, referring to the original volume. Further refinement including fibre aberration increases the volume loss by another 5 percent for pine and 6 percent for spruce. The length of the refined blanks varies between 2 and 500 centimetres for pine and between 2 and 400 centimetres for spruce.Measurement results are included in the report for calculating the volume yield of blanks free from knots, with or without fibre aberration. The distributions of lengths of blanks and corresponding volume yields are shown in different graphs.
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| 46. |
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| 47. |
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| 48. |
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| 49. |
- Holmberg, Hans, 1963-, et al.
(författare)
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Utvärdering av en ny ströläggningsmetod för stjärnsågad trekantprofil.
- 1995
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- En ny typ av ströläggning för trekantprofiler har undersökts. Profilema har torkats i buntar om tre där man alltid har lagt de tangentiella sidoma inåtvända för att minska risken för sprickbiIdning.Trekantprofilema som undersökts hade sidomåttet 120 mm. Torken som använts var en kammartork som styrs med ett torkschemat anpassat för furu med tjockleken 100 mm. Slutfuktkvoten var avsedd att bli 18 % om man torkat 100 mm virke.Efter torkning har prover tagits i rot, mitt och topp för att mata fuktkvotsgradienten i virket. I samband med fuktkvotsmätningen har även densiteten för virket bestämts. Resultaten visar att furu erhåller en större fuktkvotsgradient an gran för det parti som undersökts. Medelfuktkvoten för furn var efter torkning 15,8 % medan gran erhöll en medelfuktkvot på 13,0 %. Fuktkvotsskillnaden mellan torraste och fuktigaste parti i tvärsnittet var för furu 6,4 % och för gran 2,1 %.I undersökningen jämfördes trekantprofilemas slutfuktkvot med avsseende på placering i grupperna och med avseende på densitet. Med ett 95 % konfidensintervall kan man inte säkerställa att det finns skillnad mellan de olika placeringama i gruppen. Det går vidare inte att finna några samband mellan densiteten för virket och dess slutfuktkvot.En undersökning av ungefär tio kubikmeter virke visar att cirka 15 % av de torkade trekantprofilerma hade lättare angrepp av mögelsvampar. Mindre an 5 % av det genomgångna virket hade angrepp av blånad. Tryckskador fran strön förekom på två tredjedelar av virket och dessa skador kan i många fall härledas till dåIig måttnoggrannhet på profilema.
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| 50. |
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